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| 1 | Alcohol and hepatocellular carcinoma:A review and a point of view显示文摘It is well recognized that one cause of chronic liver disease and hepatocellular carcinoma(HCC)is alcohol consumption.Research in Italy and the United States concludes that the most common cause of HCC(responsible for 32%to 45%of HCC)is alcohol.It has recently been shown that a significant relationship between alcohol intake,metabolic changes,and hepatitis virus infection does exist.Alcohol may be a factor in the development of HCC via direct(genotoxic)and indirect mechanisms(cirrhosis).There is only one way of diagnosing HCC,which is early identification through surveillance,when curative treatments become possible.After stopping alcohol intake the risk of liver cancer decreases by 6%to 7%a year,and an estimated time period of 23 years is also needed.Therefore,surveillance is also important in former drinkers and,in our opinion,independently from the presence of compensated cirrhosis.In cases of very early stage(VES)and early stage with portal hypertension,liver transplantation is the optimal option;and in cases of associated disease,percutaneous ethanol injections,radiofrequency and microwave ablation are the ideal treatments.Despite the possibility of detecting microvascular invasion with HR,several studies and some randomized controlled trials revealed that overall survival and DSF rates in patients with VES HCC are much the same after ablation and HR.Therefore,ablation can be regarded as a firstline choice for patients with VES HCC.It is important to emphasize that the choice of treatment should be weighed carefully in the context of a multidisciplinary cancer team. | Gianni Testino Silvia Leone Paolo Borro | 2014 | World Journal of Gastroenterology2014，20，43： | 21 |
| 2 | Single-lung transplantation in emphysema:Retrospective study analyzing survival and waiting list mortality显示文摘AIM: To performed remains a subject of debate and is the principal aim of the study. METHODS: This retrospective analysis included 73 patients with emphysema(2000-2012). The outcomes of patients undergoing single-lung transplantation(SL)(n = 40) or double-lung transplant(DL)(n = 33) were compared in a Cox multivariate analysis to study the impact of the technique, postoperative complications and acute and chronic rejection on survival rates. Patients were selected for inclusion in the waiting list according to the International Society of Heart Lung Transplantation criteria. Pre and postoperative rehabilitation and prophylaxis, surgical technique and immunosuppressive treatment were similar in every patients. Lung transplantation waiting list information on a national level and retrospective data on emphysema patient survival transplanted in Spain during the study period, was obtained from the lung transplantation registry managed by the National Transplant Organization(ONT). RESULTS: Both groups were comparable in terms of gender and clinical characteristics. We found significant differences in the mean age between the groups, the DL patients being younger as expected from the inclusion criteria. Perioperative complications occurred in 27.6% SL vs 54% DL(P = 0.032). Excluding perioperative mortality, median survival was 65.3 mo for SL and 59.4 mo for DL(P = 0.96). Bronchiolitis obliterans and overall 5-year survival were similar in both groups. Bacterialrespiratory infection, cytomegalovirus and fungal infection rates were higher but not significant in SL. No differences were found between type of transplant and survival(P = 0.48). To support our results, national data on all patients with emphysema in waiting list were obtained(n = 1001). Mortality on the waiting list was 2.4% for SL vs 6.2% for DL. There was no difference in 5 year survival between 235 SL and 430 DL patients transplanted(P = 0.875).CONCLUSION: Our results suggest that SL transplantation in emphysema produce similar survival than DL with less postoperative complication and significant lower mortality in waiting list. | José M Borro María Delgado Elisabeth Coll Salvador Pita | 2016 | World Journal of Transplantation2016，6，2： | 6 |
| 3 | Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: An Italian position statement显示文摘Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis,fibrosis,and cirrhosis to hepatocellular carcinoma.Forty-four per cent of all deaths from cirrhosis are attributed to alcohol.Alcoholic liver disease is the second most common diagnosis among patients undergoing liver transplantation(LT).The vast majority of transplant programmes(85%)require 6 mo of abstinence prior to transplantation;commonly referred to as the'6-mo rule'.Both in the case of progressive end-stage liver disease(ESLD)and in the case of severe acute alcoholic hepatitis(AAH),not responding to medical therapy,there is a lack of evidence to support a 6-mo sobriety period.It is necessary to identify other risk factors that could be associated with the resumption of alcohol drinking.The'Group of Italian Regions'suggests that:in a case of ESLD with model for end-stage liver disease<19 a 6-mo abstinence period is required;in a case of ESLD,a 3-mo sober period before LT may be more ideal than a 6-mo period,in selected patients;and in a case of severe AAH,not respond-ing to medical therapies(up to 70%of patients die within 6 mo),LT is mandatory,even without achieving abstinence.The multidisciplinary transplant team must include an addiction specialist/hepato-alcohologist.Patients have to participate in self-help groups. | Gianni Testino Patrizia Burra Ferruccio Bonino Francesco Piani Alessandro Sumberaz Roberto Peressutti Andrea Giannelli Castiglione Valentino Patussi Tiziana Fanucchi Ornella Ancarani Giovanna De Cerce Anna Teresa Iannini Giovanni Greco Antonio Mosti Marilena Durante Paola Babocci Mariano Quartini Davide Mioni Sarino Aricò Aniello Baselice Silvia Leone Fabiola Lozer Emanuele Scafato Paolo Borro | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 4 | Application of the platelet count/spleen diameter ratio to rule out the presence of oesophageal varices in patients with cirrhosis: A validation study based on follow-up显示文摘 | E.G. Giannini F. Botta P. Borro P. Dulbecco E. Testa C. Mansi V. Savarino R. Testa | 2005 | Digestive and Liver Disease2005，，10： | 3 |
| 5 | Chemoprevention of hepatocellular carcinoma in patients with hepatitis C virus related cirrhosis显示文摘Interferon(IFN) therapy has been reported to decrease the risk of hepatocellular carcinoma(HCC) and improve survival by preventing liver-related deaths in patients with chronic hepatitis C virus(HCV) infection, while the role of IFN therapy on the natural history of hepatitis C related cirrhosis is still under debate. The ideal goal of therapy is to prevent the progression into end-stage disease. The use of IFN in patients with HCV compensated cirrhosis reduces the negative clinical evolution independently of the type of laboratoristic and virological response. In our experience, IFN therapy in HCV compensated cirrhosis is barely useful in prevention of HCC, as cirrhosis itself represents a risk of cancer.Some authors noted that IFN treatment reduces the risk of HCC independently of the virological response. It would probably be interesting to evaluate the efficacy of weekly low-dose pegylated(PEG)-IFN therapy in patients with HCV cirrhosis and to assess potential benefits of long-term PEG-IFN plus Ribavirin treatment. | Gianni Testino Paolo Borro | 2013 | World Journal of Hepatology2013，5，10： | 3 |
| 6 | The two-incision approach for video-assisted thoracoscopic lobectomy:an initial experience显示文摘 | Borro JM Gonzalez D Paradela M | 2011 | Eur J Cardiothorac Surg2011，39，1： | 1 |
| 7 | Serum thrombopoietin levels are linked to liver function in untreated patients with hepatitis C virus-related chronic hepatitis显示文摘 | Giannini E Borro P Botta F | 2002 | J Hepatol2002，37，： | 1 |
| 8 | 13 C-galactose breath test and 13 C-aminopyrine breath test for the study of liver function in chronic liver disease显示文摘 | Edoardo G. Giannini Alberto Fasoli Paolo Borro Federica Botta Federica Malfatti Alessandra Fumagalli Emanuela Testa Simone Polegato Tiziana Cotellessa Sara Milazzo Domenico Risso Roberto Testa | 2005 | Clinical Gastroenterology and Hepatology2005，，： | 1 |
| 9 | Platelet count/spleen diame- ter ratio: proposal and validation of a non-invasive parameter to predict the presence of oesophageal varices in patients with liver cirrhosis显示文摘 | Giannini E Botta F Borro P | 2003 | Gut2003，52，8： | 1 |
| 10 | Proton-conducting polymersbased on benzimidazoles and sulfonated benzimidazoles显示文摘 | Juan Antonio Asensio Salvador Borros Pedro Gomez-Romero | 2002 | Journal of Polymer Science2002，40，21： | 1 |
| 11 | Application of the platelet count/spleen diameter ratio to rule out the presence of oesophageal varices in patients with cirrhosis:a validation study based on followup显示文摘 | Giannini EG Botta F Borro P | 2005 | Dig Liver Dis2005，37，10： | 1 |
| 12 | The two-incision approach for video-assisted thoracoscopic lobectomy : an initial experi- ence显示文摘 | Borro JM Gonzalez D Paradela M | 2011 | Eur J Cardiothorac Surg2011，39，1： | 1 |
| 13 | Steroid withdrawal in lung transplant recipients显示文摘 | Borro JM Sole A De la Torre M | 2005 | Transplant Proc2005，37，9： | 1 |
| 14 | 13C-ga- lactose breath test and 13 C-aminopyrine breath test for the study of liver function in chronic liver dis- ease显示文摘 | Giannini EG Fasoli AA Borro P | 2005 | Clin Gastroenterol Hepatol2005，3，27： | 1 |
| 15 | Comparative effects of levosulpiride and cisapride on gastric emltying and symptoms in patients with Functional dyspepsia and gastroparesis 显示文摘 | Mansi C Borro P Giacomini M | 2000 | Aliment Pharmacol Ther2000，14，5： | 1 |
| 16 | Mapping shallow lakes in a large South American floodplain:A frequency approach on multitemporal Landsat TM/ETM data显示文摘 | Borro M Morrandeira M Salvia M | 2014 | Journal of Hydrology2014，512，： | 1 |
| 17 | Treatment of alcohol dependence: recent progress and reduction of consumption 显示文摘 | Testino G Leone S Borro P | 2014 | Minerva Med2014，105，6： | 1 |
| 18 | Regioselective symmetrical bromination of protected 2,2'-biimidazole显示文摘 | Sanchez G D Borros S Nonell S | 2002 | J heterocyclic chem2002，39，： | 1 |
| 19 | The two-incision approach for video-assisted thoracoscopic lobectomy: an initial experience 显示文摘 | Borro JM Gonzalez D Pradela M | 2011 | Eur J Cardiothorac Surg2011，39，： | 1 |
| 20 | Multi-frequency soil water inversion from SAR measurements with the use of IEM显示文摘 | Bindlish R Borros A P | 2000 | Remote Sensing Environ2000，71，1： | 1 |
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