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| 1 | Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis显示文摘AIM: To examine the effects of anti-high mobility group box 1 (HMGB1) neutralizing antibody in experimental se-vere acute pancreatitis (SAP).METHODS: SAP was induced by creating closed duode-nal loop in C3H/HeN mice. SAP was induced immediately after intraperitoneal injection of anti-HMGB1 neutralizing antibody (200 μg). Severity of pancreatitis, organ injury (liver, kidney and lung), and bacterial translocation to pancreas was examined 12 h after induction of SAP.RESULTS: Anti-HMGB1 neutralizing antibody significant-ly improved the elevation of the serum amylase level and the histological alterations of pancreas and lung in SAP. Anti-HMGB1 antibody also significantly ameliorated the elevations of serum alanine aminotransferase and cre-atinine in SAP. However, anti-HMGB1 antibody worsened the bacterial translocation to pancreas.CONCLUSION: Blockade of HMGB1 attenuated the development of SAP and associated organ dysfunction, suggesting that HMGB1 may act as a key mediator for inflammatory response and organ injury in SAP. | Hidehiro Sawa Takashi Ueda Yoshifumi Takeyama Takeo Yasuda Makoto Shinzeki Takahiro Nakajima Yoshikazu Kuroda | 2006 | World Journal of Gastroenterology2006，12，47： | 45 |
| 2 | Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps显示文摘AIM:To elucidate the colonoscopic features of serrated lesions of the colorectum using magnifying colonoscopy.METHODS:Broad division of serrated lesions of the colorectum into hyperplastic polyps(HPs),traditional serrated adenomas(TSAs),and sessile serrated adenomas/polyps(SSA/Ps) has been proposed on the basis of recent molecular biological studies.However,few reports have examined the colonoscopic features of these divisions,including magnified colonoscopic findings.This study examined 118 lesions excised in our hospital as suspected serrated lesions after magnified observation between January 2008 and September 2011.Patient characteristics(sex,age),conventional colonoscopic findings(location,size,morphology,color,mucin) and magnified colonoscopic findings(pit pattern diagnosis) were interpreted by five colonoscopists with experience in over 1000 colonoscopies,and were compared with histopathological diagnoses.The pit patterns were categorized according to Kudo's classification,but a more detailed investigation was also performed using the subclassification [type Ⅱ-Open(type Ⅱ-O),type Ⅱ-Long(type Ⅱ-L),or type Ⅳ-Serrated(type Ⅳ-S)] proposed by Kimura T and Yamano H.RESULTS:Lesions comprised 23 HPs(23/118:19.5%),39 TSAs(39/118:33.1%:with cancer in one case),50 SSA/Ps(50/118:42.4%:complicated with cancer in three cases),and six others(6/118:5.1%).We excluded six others,including three regular adenomas,one hamartoma,one inflammatory polyp,and one juvenile polyp for further analysis.Conventional colonoscopy showed that SSA/Ps were characterized as larger in diameter than TSAs and HPs(SSA/P vs HP,13.62 ± 8.62 mm vs 7.74 ± 3.24 mm,P < 0.001;SSA/Ps vs TSA,13.62 ± 8.62 mm vs 9.89 ± 5.73 mm,P < 0.01);common in the right side of the colon [HPs,30.4%(7/23):TSAs,20.5%(8/39):SSA/P,84.0%(42/50),P < 0.001];flat-elevated lesion [HPs,30.4%(7/23):TSAs,5.1%(2/39):SSA/Ps,90.0%(45/50),P < 0.001];normal-colored or pale imucosa [HPs,34.8%(8/23):TSAs,10.3%(4/39):SSA/Ps,80%(40/50),P < 0.001];and with large amounts of mucin [HPs,21.7%(5/23):TSAs,17.9%(7/39):SSA/Ps,72.0%(36/50),P < 0.001].In magnified colonoscopic findings,17 lesions showed either type Ⅱ pit pattern alone or partial type Ⅱ pit pattern as the basic architecture,with 14 HPs(14/17,70.0%) and 3 SSA/Ps.Magnified colonoscopy showed the type Ⅱ-O pit pattern as characteristic of SSA/Ps [sensitivity 83.7%(41/49),specificity 85.7%(54/63)].Cancer was also present in three lesions,in all of which a type Ⅵ pit pattern was also present within the same lesion.There were four HPs and four TSAs each.The type Ⅳ-S pit pattern was characteristic of TSAs [sensitivity 96.7%(30/31),specificity 89.9%(72/81)].Cancer was present in one lesion,in which a type Ⅵ pit pattern was also present within the same lesion.In our study,serrated lesions of the colorectum also possessed the features described in previous reports of conventional colonoscopic findings.The pit pattern diagnosis using magnifying colonoscopy,particularly magnified colonoscopic findings using subclassifications of surface architecture,reflected the pathological characteristics of SSA/Ps and TSAs,and will be useful for colonoscopic diagnosis.CONCLUSION:We suggest that this system could be a good diagnostic tool for SSA/Ps using magnifying colonoscopy. | Shinya Ishigooka Masahito Nomoto Nobuyuki Obinata Yoshichika Oishi Yoshinori Sato Satoko Nakatsu Midori Suzuki Yoshiko Ikeda Tadateru Maehata Tomoaki Kimura Yoshiyuki Watanabe Takashi Nakajima Hiro-o Yamano Hiroshi Yasuda Fumio Itoh | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 3 | Sentinel Node Mapping Guided by Indocyanine Green Fluorescence Imaging in Gastric Cancer显示文摘 | Yusuke Tajima Kimiyasu Yamazaki Yuki Masuda Masanori Kato Daisuke Yasuda Takeshi Aoki Takashi Kato Masahiko Murakami Mitsuharu Miwa Mitsuo Kusano | 2009 | Annals of Surgery2009，，1： | 3 |
| 4 | Image-based autonomous navigation of Hayabusa2 using artificial landmarks: The design and brief in-flight results of the first landing on asteroid Ryugu显示文摘Hayabusa2 is an asteroid sample return mission carried out by the Japan Aerospace Exploration Agency.The spacecraft was launched in 2014 and arrived at the target asteroid Ryugu on June 27,2018.During the 1.5-year proximity phase,several critical operations(including two landing/sampling operations)were successfully performed.They were based on autonomous image-based descent and landing techniques.This paper describes an imagebased autonomous navigation scheme of the Hayabusa2 mission using artificial landmarks named target markers(TMs).Its basic algorithm,and the in-flight results of the first touchdown and its rehearsal,are shown. | Naoko Ogawa Fuyuto Terui Yuya Mimasu Kent Yoshikawa Go Ono Seiji Yasuda Kota Matsushima Tetsuya Masuda Hiroki Hihara Junpei Sano Takashi Matsuhisa Satoshi Danno Manabu Yamada Yasuhiro Yokota Yuto Takei Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，2： | 2 |
| 5 | Gastrointestinal stromal tumor presenting with prominent calcification显示文摘We present a rare case of a gastrointestinal stromal tumor (GIST) in the stomach with prominent calcifica-tion at presentation. A 61-year-old woman visited our hospital because of epigastric discomfort. A spherical calcified lesion with a diameter of about 30 mm was incidentally shown in the left upper quadrant on an abdominal X-ray. Computed tomography demonstrated that the tumor was growing from the upper gastric body, with calcification in the peripheral ring area. A laparoscopic partial gastrectomy was performed, and the resected specimen revealed a well-circumscribed tumor with exophytic growth from the gastric muscularis propria. Microscopic examination revealed spindle- shaped tumor cells with calcification and hemorrhage. Additionally, positive immunoreactivity of the tumor to KIT and CD34 and a low mitotic index resulted in the diagnosis of very low risk GIST. There are a few case reports of heavily calcified GIST, although solitary or punctate calcification of primary GIST has been reported in several case series. Dystrophic calcification of necrotic or degenerative tissue is the supposed cause of primary calcified GISTs. In contrast, appearance of calcification after administration of imatinib mesylate, which may be one indicator of disease response, is possibly caused by a different mechanism. | Naoki Izawa Takeshi Sawada Ryuichi Abiko Daisuke Kumon Mami Hirakawa Mika Kobayashi Nobuyuki Obinata Masahito Nomoto Tadateru Maehata Shun-ichi Yamauchi Takefumi Kouro Takashi Tsuda Satoshi Kitajima Hiroshi Yasuda Keiichi Tanaka Ichiro Tanaka Masahiro Hoshikawa Masayuki Takagi Fumio Itoh | 2012 | World Journal of Gastroenterology2012，18，39： | 2 |
| 6 | EMERGENCY ABDOMINAL SURGERY FOR SIGMOID MESOCOLIC HERNIA显示文摘 | TAKASHI YOKOTA YASUO YAMADA YASUSUKE MURAKAMI MITSUHIKO YASUDA SHIN TESHIMA YASUO KUNII HIDEMI YAMAUCHI | 2002 | American Journal of Emergency Medicine2002，，2： | 1 |
| 7 | Effect of characteristics of materials on fracture behavior and modeling using graphite-related materials with a high-velocity steel sphere显示文摘 | Keisuke Fujii Eiichi Yasuda Takashi Akatsu | 2003 | International Journal of Impact Engineering2003，28，98： | 1 |
| 8 | Prevention of welding defect by side gas flow and its monitoring method in continuous wave Nd:YAG laser welding显示文摘 | Kamimuki Kenichi Inoue Takashi Yasuda Kouzou | 2002 | Journal of Laser Applications2002，14，3： | 1 |
| 9 | Sentinel Node Mapping Guided by Indocyanine Green Fluorescence Imaging in Gastric Cancer显示文摘 | Yusuke Tajima Kimiyasu Yamazaki Yuki Masuda Masanori Kato Daisuke Yasuda Takeshi Aoki Takashi Kato Masahiko Murakami Mitsuharu Miwa Mitsuo Kusano | 2009 | Annals of Surgery2009，，1： | 1 |
| 10 | Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy显示文摘 | Masahiko Shimura Kanako Yasuda Toru Nakazawa Toshiaki Abe Takashi Shiono Tomohiro Iida Taiji Sakamoto Kohji Nishida | 2009 | Graefe’s Archive for Clinical and Experimental Ophthalmology2009，，12： | 1 |
| 11 | Posterior sub-tenon's capsule injection of triamcinolone acetonide prevents panretinal photocoagulation-induced visual dysfunction in patients with severe diabetic retinopathy and good Vision显示文摘 | Masahiko Shimura Kanako Yasuda Takashi Shiono | 2006 | Ophthalmology2006，11，3： | 1 |
| 12 | ALK Gene Translocation in Inflammatory Myofibroblastic Tumor of the Urinary Bladder: A Case Report显示文摘 | Kimiaki Takagi Manabu Takai Koji Kameyama Kengo Horie Mina Kikuchi Taku Kato Kosuke Mizutani Kensaku Seike Tomohiro Tsuchiya Mitsuru Yasuda Shigeaki Yokoi Natsuko Suzui Masahiro Nakano Takashi Deguchi | 2015 | Urology Case Reports2015，，5： | 1 |
| 13 | Struc- tural Colors from TiOJSiO2 Muhilayer Flakes Prepared by Sol- gel Process 显示文摘 | YASUDA Takashi NISHIKAWA Kei FURUKAWA Shoji | 2012 | Dyes and Pigments2012，92，： | 1 |
| 14 | Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin–Thrombomodulin Complexes显示文摘 | Takashi Ito Ko-ichi Kawahara Kohji Okamoto Shingo Yamada Minetsugu Yasuda Hitoshi Imaizumi Yuko Nawa Xiaojie Meng Binita Shrestha Teruto Hashiguchi Ikuro Maruyama | 2008 | Arteriosclerosis, Thrombosis, and Vascular Biology2008，，10： | 1 |
| 15 | Effect of characteristics of materials on fracture behavior and modeling using graphite-related materials with a high-velocity steel sphere显示文摘 | Keisuke Fujii Eiichi Yasuda Takashi Akatsu | 2003 | International Journal of Impact Engineering2003，28，9： | 1 |
| 16 | Structural colors from TiO2/SiO2 multilayer flakes prepared by sol-gel process 显示文摘 | YASUDA Takashi NISHIKAWA Kei FURUKAWA Shoji | 2012 | Dyes and Pigments2012，，92： | 1 |
| 17 | Complete primary structure of chicken cardiac C-protein (MyBP-C) and its expression in developing striated muscles显示文摘 | Mashiro Yasuda Sumito Koshida Naruki Sato Takashi Obinata | 1995 | Journal of Molecular and Cellular Cardiology1995，，10： | 1 |
| 18 | Stenosis after use of the double-stapling technique for reconstruction after laparoscopy-assisted total gastrectomy显示文摘 | Toru Zuiki Yoshinori Hosoya Yuji Kaneda Kentaro Kurashina Shin Saito Takashi Ui Hidenori Haruta Masanobu Hyodo Naohiro Sata Alan T. Lefor Yoshikazu Yasuda | 2013 | Surgical Endoscopy2013，，10： | 1 |
| 19 | Predictions and experimental studies of the tail pipe noise of an automotive muffler using a one dimensional CFD model显示文摘 | Yasuda Takashi Wu Chaoqun Nakagawa Nakagawa | 2010 | AppliedAcoustics2010，71，8： | 1 |
| 20 | Comparative Therapy Evaluation of Intravitreal Bevacizumab and Triamcinolone Acetonide on Persistent Diffuse Diabetic Macular Edema显示文摘 | Masahiko Shimura Toru Nakazawa Kanako Yasuda Takashi Shiono Tomohiro Iida Taiji Sakamoto Kohji Nishida | 2008 | American Journal of Ophthalmology2008，，5： | 1 |
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