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| 1 | Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study显示文摘AIM: To investigate the long-term oncologic outcomes and prognostic factors in patients with obstructive colorectal cancer(CRC) at multiple Japanese institutions.METHODS: We identified 362 patients diagnosed with obstructive colorectal cancer from January 1, 2002 to December 31, 2012 in Yokohama Clinical Oncology Group's department of gastroenterological surgery. Among them, 234 patients with stage Ⅱ/Ⅲ disease who had undergone surgical resection of their primary lesions were analyzed, retrospectively. We report the long-term outcomes, the risk factors for recurrence, and the prognostic factors.RESULTS: The five-year disease free survival and cancer-specific survival were 50.6% and 80.3%, respectively. A multivariate analysis showed the ASAPS(HR = 2.23, P = 0.026), serum Albumin ≤ 4.0 g/d L(HR = 2.96, P = 0.007), T4 tumor(HR = 2.73, P = 0.002) and R1 resection(HR = 6.56, P = 0.02) to be independent risk factors for recurrence. Furthermore, poorly differentiated cancers(HR = 6.28, P = 0.009), a T4 tumor(HR = 3.46, P = 0.011) and R1 resection(HR = 6.16, P = 0.006) were independent prognostic factors in patients with obstructive CRC.CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC. | Ishibe Atsushi Ota Mitsuyoshi Yamaguchi Kazuya Kaida Syuhei Kamiya Noriyuki Momiyama Masashi Watanabe Akira Sekizawa Kentaro Kamimukai Nobuyuki Sugimasa Natsuko Watanabe Jun Ichikawa Yasushi Kunisaki Chikara Endo Itaru | 2016 | World Journal of Gastroenterology2016，22，22： | 9 |
| 2 | Lipopolysaccharide Enhances the Production of Nicotine-Induced Prostaglandin E2 by an Increase in Cyclooxygenase-2 Expression in Osteoblasts显示文摘以前的研究显示了那脂肪的多糖(LPS ) 在匾的 fromGram 否定的细菌导致前列腺素 E_2 (PGE_2 ) 的版本,它在吸烟的 periodontitis,和那棵烟草支持牙槽的骨头再吞可能是为 periodontitis 的发展和严厉的一个重要风险因素。我们在碱性磷酸酶(ALPase ) 上决定了烟碱 andLPS 的效果活动, PGE_2 生产,和表示 ofcyclooxygenase (COX-1, COX-2 ) , PGE_2 受体 Ep1-4,和在人的 osteoblastic Saos-2 房间的巨噬细胞殖民地刺激因素(M-CSF ) 。房间与 10 ~ 是有教养的(-3) M 烟碱面对 0, 1,或 10 μ g /ml LPS,或与 LPS 独自一个。ALPase 活动独自在与烟碱或 LPS 有教养的房间减少了,并且在与烟碱和 LPS 有教养的那些进一步减少了,而 PGE_2 生产显著地在前者增加了并且在后者进一步增加了。由自己,烟碱没影响 COX-1, COX-2,任何 PGE_2 受体,或 M-CSF 的表示,但是烟碱和 LPS 什么时候是现在, COX-2 的表示, Ep3, Ep4,和 M-CSF,显著地增加。10 ~ 的同时的增加(-4) M 消炎痛在 ALPase 活动, PGE_2 生产,和 M-CSF 表示消除了烟碱和 LPS 的效果。proteinkinase A 的 Phosphorylation 在与烟碱和 LPS 有教养的房间高。这些结果建议 LPS 由造骨细胞的 COX-2 表示的增加提高导致烟碱的 PGE_2 的生产, thatnicotine-LPS-induced PGE_2 首先在 autocrine orparacnne 模式与造骨细胞 Ep4 受体交往,并且 nicotine-LPS-induced PGE_2 然后减少 ALPase 活动和 increasesM-CSF 表示。 | Maiko SHOJI Natsuko TANABE Narihiro MITSUI Naoto SUZUKI Osamu TAKEICHI Tomoko KATONO Akira MOROZUMI Masao MAENO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 9 |
| 3 | Elastography for the pancreas: Current status and future perspective显示文摘Elastography for the pancreas can be performed by either ultrasound or endoscopic ultrasound(EUS). There are two types of pancreatic elastographies based on different principles, which are strain elastography and shear wave elastography. The stiffness of tissue is estimated by measuring the grade of strain generated by external pressure in the former, whereas it is estimated by measuring propagation speed of shear wave, the transverse wave, generated by acoustic radiation impulse(ARFI) in the latter. Strain elastography is difficult to perform when the probe, the pancreas and the aorta are not located in line. Accordingly, a fine elastogram can be easily obtained in the pancreatic body but not in the pancreatic head and tail. In contrast, shear wave elastography can be easily performed in the entire pancreas because ARFI can be emitted to wherever desired. However, shear wave elastography cannot be performed by EUS to date. Recently, clinical guidelines for elastography specialized in the pancreas were published from Japanese Society of Medical Ultrasonics. The guidelines show us technical knacks of performing elastography for the pancreas. | Natsuko Kawada Sachiko Tanaka | 2016 | World Journal of Gastroenterology2016，22，14： | 8 |
| 4 | Nicotine Treatment Induces Expression of Matrix Metalloproteinases in Human Osteoblastic Saos-2 Cells显示文摘烟草吸烟是为发展的一个重要风险因素 severeperiodontitis.Recently,我们证明那烟碱影响了使矿物化的小瘤形成,和那烟碱,脂肪的多糖由增加巨噬细胞的生产刺激了像骨破折的房间的形成刺激殖民地的因素(M-CSF )和由 humanosteoblastic Saos-2 房间的前列腺素 E_2 ( PGE_2 )。在现在的学习,我们在矩阵 metalloproteinases ( MMP )的表示上检验了烟碱的效果,矩阵 metalloproteinases ( TIMP )的织物禁止者,包括织物类型 plasminogen ( tPA )的部件的 theplasminogen 激活系统,尿激类型 PA (在 A 上面),并且 PA 禁止者类型 1 ( PAI-1 ),高山哈 7 烟碱受体,和 c-fos.Wealso 在 MMP-1.Gene 的导致烟碱的表示上检验了烟碱对手 D-tubocurarine 的效果表示用对 estimatemRNA 层次的即时聚合酶链反应( PCR )被检验。另外, MMP 的表示, TIMP 在 A 上面, tPA,和 PAI-1 蛋白质被西方的弄污决定分析。烟碱处理引起了 MMP-1,2,3 的表示,并且 13 ,然而并非 MMP-14 ,在文化的 5 或 10 d 以后显著地增加; MMP-14 表示没由烟碱处理通过 MMP-1 表示的 day14.Enhancement 变化被同时的处理与 D-tubocurarine.In 消除烟碱的存在,表示在 A 上面, PAI-1 ,或 TIMP-1,2,3 ,或 4 没改变文化的超过 14 d ,而 tPA 的表示在白天显著地增加了 7 。烟碱也增加了高山的表示哈 7 烟碱受体和 c-fos 基因。这些结果建议那烟碱由增加 tPA 和 MMP-1,2,3 的生产刺激骨头矩阵周转, and13,从而向后者过程付小费给在骨头矩阵形成和再吞之间的平衡。 | Tomoko KATONO Takayuki KAWATO Natsuko TANABE Naoto SUZUKI Kazuhiro YAMANAKA Hitoshi OKA Masafumi MOTOHASHI Masao MAENO | 2006 | Acta Biochimica et Biophysica Sinica2006，38，12： | 5 |
| 5 | Delayed perforation after endoscopic submucosal dissection for early gastric cancer: Clinical features and treatment显示文摘Perforation is an important procedural complication of endoscopic submucosal dissection(ESD) for early gastric cancer. Although the incidence of delayed perforation after ESD is low, extreme caution is necessary because many cases require surgical intervention. Among 1984 lesions of early gastric cancer treated in our hospital by ESD in 1588 patients from September 2002 through March 2015, delayed perforation developed in 4 patients(4 lesions, 0.25%). A diagnosis of delayed perforation requires prompt action, including surgical intervention when required. | Takafumi Yano Satoshi Tanabe Kenji Ishido Mizutomo Azuma Takuya Wada Mizuto Suzuki Natsuko Kawanishi Sakiko Yamane Tohru Sasaki Chikatoshi Katada Tetsuo Mikami Natsuya Katada Wasaburo Koizumi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，8： | 4 |
| 6 | Clear cell adenocarcinoma of the colon:A case report and review of literature显示文摘A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. We herein report a case of such a tumor of the sigmoid colon in a 71-year-old woman who was successfully treated by an endoscopic polypectomy in our hospital. We also reviewed the published reports regarding cases of primary clear cell tumors in the colon. | Koichi Soga Hideyuki Konishi Natsuko Tatsumi Chika Konishi Keimei Nakano Naoki Wakabayashi Shoji Mitsufuji Keisho Kataoka Takeshi Okanoue Ken-Ichi Mukaisho Takanori Hattori | 2008 | World Journal of Gastroenterology2008，14，7： | 4 |
| 7 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 8 | DOING META-ANALYSIS IN SLA:PRACTICES,CHOICES,AND STANDARDS显示文摘Meta-analysis is a statistical method used to synthesize the cumulative effect of an interventional treatment or a certain relationship that has been subjected to empirical investigation.Notwithstanding the increasing popularity of meta-analysis in second language acquisition(SLA)research,there is considerable methodological inconsistency in the 22SLA meta-analyses published to date.Also,given the highly technical nature of some aspects of this statistical procedure and the specialized knowledge associated with it,it is a daunting task to conduct a meta-analysis and understand or interpret meta-analytic results.This paper seeks to solve the conundrum surrounding metaanalysis by explicating its basic procedure and technical aspects in an accessible manner.Utilizing SLA meta-analyses as examples,it discusses the methodological options of each stage of a meta-analysis,makes recommendations about how to handle some key issues,and points out the pitfalls that might undermine the robustness and credibility of meta-analytic findings. | SHAOFENG LI NATSUKO SHINTANI ROD ELLIS | 2012 | 当代外语研究2012，，12： | 3 |
| 9 | Efficacy of direct-acting antiviral treatment for chronic hepatitis C: A single hospital experience显示文摘AIM To evaluate the efficacy of direct-acting antivirals(DAAs) in Kanto Rosai Hospital. METHODS All patients with hepatitis C virus(HCV) who underwent DAA prescription were enrolled in this study. The present study was a single center retrospective analysis using patients infected with HCV genotype 1 or 2. Resistance analysis was performed by using direct sequencing and cycleave PCR in genotype 1 patients treated with interferon(IFN)-free DAA. The primary endpoint was sustained virologic response at 12 wk after therapy(SVR12).RESULTS A total of 117 patients participated in the study, including 135 with genotype 1 and 42 with genotype 2. Of the 135 patients with genotype 1, 16 received protease inhibitor + IFN + ribavirin and all achieved SVR. Of the 119 patients who received IFN-free DAA(in different combinations), 102 achieved SVR and 9 failed(7/9 were on daclatasvir/asunaprevir and 2/9 on ledipasvir/sofosbuvir). Efficacy analysis was done only for 43 patients who received daclatasvir/asunaprevir. From this analysis, Y93 resistance-associated substitutions were significantly correlated with SVR.CONCLUSION The SVR rate was 98% for genotype 1 and 100% for genotype 2. However, caution is needed for HCV NS5 A resistance-associated substitutions that are selected by HCV NS5 A inhibitors because cerebrovascular adverse events are induced by some DAA drugs. | Rena Kaneko Natsuko Nakazaki Risa Omori Yuichiro Yano Masazumi Ogawa Yuzuru Sato | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 10 | Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis显示文摘 | Natsuko Tokushige Robert Markham Peter Russell Ian S. Fraser | 2007 | Fertility and Sterility2007，，4： | 2 |
| 11 | The leaf extract of Mallotus japonicus and its major active constituent, rutin,suppressed on melanin production in murine B16F1 melanoma显示文摘Objective: To find anti-melanogenesis materials used in whitening cosmetics.Methods: The ethanolic leaf extract of Mallotus japonicus(M. japonicus) having an anti-melanogenesis activity was separated by a sephadex LH-20 chromatography. Each fraction was measured for its tyrosinase inhibitory activity together with its polyphenol content using the Folin–Ciocalteu method. The anti-melanogenesis activity of the active fractions was determined by the melanin content in the murine B16F1 melanoma. The active fractions were put together due to similar constituents, and then separated by high performance liquid chromatography using a C-18 ODS column. The major antimelanogenesis compound was identified using1 H and13C-NMR and liquid chromatography-mass spectrometry.Results: The ethanolic leaf extract of M. japonicus showed an anti-tyrosinase activity with a high polyphenol content, resulting in suppression of melanin production in the B16F1 melanoma. The extract was separated and the active compound was identical as rutin based on the1 H,13C-NMR and liquid chromatography-mass spectrometry analysis data. In addition, the rutin treatment with cells reduced the melanin content in a concentration dependent manner without any cell toxicity. The leaf extract of M. japonicus containing rutin would be useful in whitening cosmetics for protection from UV-light exposure to be limiting the accumulation of melanin in skin.Conclusions: The leaf extract of M. japonicus and/or rutin isolated from the extract as a key whitening agent would be useful as a whitening cosmetic material for protecting against disorder skin due to melanin accumulation. | Junsei Taira Eito Tsuchida Masatsugu Uehara Natsuko Ohhama Wakana Ohmine Takayuki Ogi | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，10： | 2 |
| 12 | Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms显示文摘 | Daisuke Yamasaki Natsuko Kawabe Hitomi Nakamura Keisuke Tachibana Kenji Ishimoto Toshiya Tanaka Hiroyuki Aburatani Juro Sakai Takao Hamakubo Tatsuhiko Kodama Takefumi Doi | 2011 | European Journal of Cell Biology2011，，8： | 2 |
| 13 | Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells显示文摘AIM: To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning. METHODS: The in vitro effect of H2O2 pretreatment was investigated in rat isolated hepatocytes subjected to anoxia/reoxygenation. Cell viability was assessed with propidium iodide fluorometry. In other experiments, rat livers were excised and subjected to warm ischemia/ reperfusion in an isolated perfused liver system to determine leakage of liver enzymes. Preconditioning was performed by H2O2 perfusion, or by stopping the perfusion for 10 min followed by 10 min of reperfusion. To inhibit Kupffer cell function or reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, gadolinium chloride was injected prior to liver excision, or diphenyleneiodonium, an inhibitor of NADPH oxidase, was added to the perfusate, respectively. Histological detection of oxygen radical formation in Kupffer cells was performed by perfusion with nitro blue tetrazolium. RESULTS: Anoxia/reoxygenation decreased hepatocyte viability compared to the controls. Pretreatment with H2O2 did not improve such hepatocyte injury. In liver perfusion experiments, however, H2O2 preconditioning reduced warm ischemia/reperfusion injury, which wasreversed by inhibition of Kupffer cell function or NADPH oxidase. Histological examination revealed that H2O2 preconditioning induced oxygen radical formation in Kupffer cells. NADPH oxidase inhibition also reversed hepatoprotection by ischemic preconditioning. CONCLUSION: H2O2 preconditioning protects hepato- cytes against warm ischemia/reperfusion injury via NADPH oxidase in Kupffer cells, and not directly. NADPH oxidase also mediates hepatoprotection by ischemic preconditioning. | Kazuaki Tejima Masahiro Arai Hitoshi Ikeda Tomoaki Tomiya Mikio Yanase Yukiko Inoue Takako Nishikawa Naoko Watanabe Natsuko Ohtomo Masao Omata Kenji Fujiwara | 2007 | World Journal of Gastroenterology2007，13，38： | 2 |
| 14 | Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis显示文摘 | Natsuko Kawada Kazuho Imanaka Tsukasa Kawaguchi Chie Tamai Ryu Ishihara Takashi Matsunaga Kunihito Gotoh Terumasa Yamada Yasuhiko Tomita | 2009 | Journal of Gastroenterology2009，，12： | 2 |
| 15 | Descending Branch of the Perforating Branch of the Peroneal Artery Perforator–Based Island Flap for Reconstruction of the Lateral Malleolus with Minimal Invasion显示文摘 | Shinsuke Akita Nobuyuki Mitsukawa Naoaki Rikihisa Juni Himeta Yoshitaka Kubota Natsuko Shimada Hideki Tokumoto Takane Suzuki Kaneshige Satoh | 2013 | Plastic and Reconstructive Surgery2013，，2： | 2 |
| 16 | Therapeutic outcomes of endoscopic resection for superficial non‐ampullary duodenal tumor显示文摘 | Yorimasa Yamamoto Natsuko Yoshizawa Hideomi Tomida Junko Fujisaki Masahiro Igarashi | 2014 | Digestive Endoscopy2014，，： | 2 |
| 17 | Success of the Orbicularis Oculi Myocutaneous Vertical V-Y Advancement Flap for Upper Eyelid Reconstruction 显示文摘 | Natsuko Kakudo Yutaka Ogawa Kenji Kusumoto | 2009 | Plast Reconstr Surg2009，123，： | 1 |
| 18 | Global pollution monitoring of polybrominated diphenyl ethers shipjack tuna as bioindicator显示文摘 | DAISUKE U NATSUKO K HIROYUKI T | 2004 | Environmental Science & Technology2004，38，8： | 1 |
| 19 | Analgesic effect of orexin A in the ratformalin test显示文摘 | Tatsuo Yamamoto Natsuko Chiba | 2002 | British Journal of Nozaki-Taguchi Tanemicbi intrathecally administered test and in the rat hot plate Pharmacology2002，137，： | 1 |
| 20 | Roles for LPS - dependent interaction and relocation of TLR4 and TRAM in TRIF - signaling显示文摘 | Natsuko T Shinichiroh S Fumi M | 2008 | Biochem Biophys Res Commun2008，368，： | 1 |
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