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| 1 | Review of a challenging clinical issue:Intrahepatic cholestasis of pregnancy显示文摘Intrahepatic cholestasis of pregnancy(ICP) is a reversible pregnancy-specific cholestatic condition characterized by pruritus, elevated liver enzymes, and increased serum bile acids. It commences usually in the late second or third trimester, and quickly resolves after delivery. The incidence is higher in South American and Scandinavian countries(9.2%-15.6% and 1.5%, respectively) than in Europe(0.1%-0.2%). The etiology is multifactorial where genetic, endocrine, and environmental factors interact. Maternal outcome is usually benign, whereas fetal complications such as preterm labor, meconium staining, fetal distress, and sudden intrauterine fetal demise not infrequently lead to considerable perinatal morbidity and mortality. Ursodeoxycholic acid is shown to be the most efficient therapeutic agent with proven safety and efficacy. Management of ICP consists of careful monitoring of maternal hepatic function tests and serum bile acid levels in addition to the assessment of fetal well-being and timely delivery after completion of fetal pulmonary maturity. This review focuses on the current concepts about ICP based on recent literature data and presents an update regarding the diagnosis and management of this challenging issue. | Sebiha Ozkan Yasin Ceylan Orhan Veli Ozkan Sule Yildirim | 2015 | World Journal of Gastroenterology2015，21，23： | 53 |
| 2 | Clinical probability and risk analysis of patients with suspected pulmonary embolism显示文摘BACKGROUND: Pulmonary embolism(PE) is one of the most frequent diseases that could be missed in overcrowded emergency departments as in Turkey. Early and accurate diagnosis could decrease the mortality rate and this standard algorithm should be defi ned. This study is to fi nd the accurate, fast, non-invasive, cost-effective, easy-to-access diagnostic tests, clinical scoring systems and the patients who should be tested for clinical diagnosis of PE in emergency department.METHODS: One hundred and forty patients admitted to the emergency department with the fi nal diagnosis of PE regarding to anamnesis, physical examination and risk factors, were included in this prospective, cross-sectional study. The patients with a diagnosis of pulmonary embolism, acute coronary syndrome or infection and chronic obstructive pulmonary disease(COPD) were excluded from the study. The demographics, risk factors, radiological fi ndings, vital signs, symptoms, physicallaboratory fi ndings, diagnostic tests and clinical scoring systems of patients(Wells and Geneva) were noted. The diagnostic criteria for pulmonary emboli were: fi lling defect in the pulmonary artery lumen on spiral computed tomographic angiography and perfusion defect on perfusion scintigraphy.RESULTS: Totally, 90(64%) of the patients had PE. Age, hypotension, having deep vein thrombosis were the risk factors, and oxygen saturation, shock index, BNP, troponin and fi brinogen levels as for the biochemical parameters were signifi cantly different between the PE(+) and PE(–) groups(P<0.05).The Wells scoring system was more successful than the other scoring systems.CONCLUSION: Biochemical parameters, clinical findings, and scoring systems, when used altogether, can contribute to the diagnosis of PE. | Gulden Ozeren Yetgin Sule Akkose Aydin Ozlem Koksal Fatma Ozdemir Dilek Kostak Mert Gokhan Torun | 2014 | World Journal of Emergency Medicine2014，5，4： | 20 |
| 3 | Bilirubin in coronary artery disease:Cytotoxic or protective?显示文摘Bilirubin has traditionally been considered a cytotoxic waste product.However,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative functions.These properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative stress.In fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of CAD.In this article,we review the current literature exploring the association between levels of bilirubin and risk of CAD.We conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established. | Nancy Gupta Tavankit Singh Rahul Chaudhary Sushil K Garg Gurprataap Singh Sandhu Varun Mittal Rahul Gupta Roxana Bodin Sachin Sule | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 14 |
| 4 | Influence of Al-Ti-B addition on the microstructure and mechanical properties of A356 alloys显示文摘The mechanical properties (σb,σ0.2,and δ) and fracture behavior of tensile specimens of the refined A356 alloys were investigated as a function of the addition level of Al-Ti-B master alloy under both as-cast and T6 heat-treated conditions. The results show that as the addition level of Al-5Ti-1B master alloy increases from 0.1 wt.% to 5.0 wt.%,the mechanical properties of refined A356 alloys improve steadily and then decrease slightly under both as-cast and T6 heat-treated conditions. Also,they display excellent mechanical properties with σb = 231.30-258.30 MPa,σ0.2 =134.00-155.50 MPa,and δ = 8.5%-11.75% at T6 heat-treated state. The excellent mechanical properties of refined A356 alloys are ascribed to the formation of α-Al equiaxed dendrites,the improvement of eutectic structure from needle/plate-like to short-lathy/block-shaped,and the Mg2Si aging precipitation phase after T6 heat treatment. The fracture surface examined by SEM exhibits a mixed fracture mode of refined A356 alloys at as-cast state,while it reveals a ductile fracture mode after T6 heat treatment. | Zhu Man Yang Gencang Yao Lijuan Cheng Suling Zhou Yaohe | 2009 | Rare Metals2009，28，2： | 11 |
| 5 | The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells显示文摘癌症干细胞(CSC ) ,有开始 tumorigenesis 的能力的癌症房间的 subpopulation,包括乳癌在许多种肿瘤存在。癌症干细胞贡献治疗抵抗和恶化。常规治疗仅仅杀死区分的癌症房间,但是节省 CSC。有指向到 CSC 的治疗学的药的联合常规治疗将根除癌症房间更高效地。学习 CSC 规定的分子的机制为开发新治疗学的策略是必要的。显示出的 CSC 被非编码的 RNA (ncRNA ) 包括 microRNAs 和长非编码的 RNA (lncRNAs ) 调整的成长证据,和 histone 修饰词例如 let-7, miR-93, miR-100, HOTAIR, Bmi-1 和 EZH2。此处,我们特别考察 microRNAs, lncRNAs 和 histone 修饰词的角色在调整乳癌干细胞(BCSC ) 的 Polycomb 家庭蛋白质。 | Zhiju Zhao Shu Li Erwei Song Suling Liu | 2016 | Protein & Cell2016，7，2： | 9 |
| 6 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 7 | ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome显示文摘 | Christophe Ginestier Min Hee Hur Emmanuelle Charafe-Jauffret Florence Monville Julie Dutcher Marty Brown Jocelyne Jacquemier Patrice Viens Celina G. Kleer Suling Liu Anne Schott Dan Hayes Daniel Birnbaum Max S. Wicha Gabriela Dontu | 2007 | Cell Stem Cell2007，，5： | 5 |
| 8 | Characterization of T.aestivum-H.californicum chromosome addition lines DA2H and MA5H显示文摘In order to transfer useful genes of Hordeum californicum into common wheat(Triticum aestivum L.),the T.aestivum c.v.Chinese Spring(CS)-H.californicum amphiploid was crossed to CS,and its backcrossing and self-fertilized progenies were analyzed by morphological observation,cytological,biochemical and molecular marker techniques.Alien addition lines with two H.californicum chromosomes were identified and their genetic constitution was characterized.STS-PCR analysis using chromosome 2B specific markers indicated that chromosome H3 of H.californicum belongs to homoeologous group 2,and was thus designated 2H.SDS-PAGE showed that chromosome H2 of H.californicum belongs to homoeologous group 5,and was designated 5H.The CS-H.californicum amphiploid and the chromosome addition lines(DA2H and MA5H) identified were evaluated for powdery mildew(Erysiphe graminis f.sp.triticii) resistance in field.The preliminary results indicated that the amphiploid showed higher powdery mildew resistance than CS.However,chromosome addition lines DA2H and MA5H were highly susceptible to powdery mildew,indicating that major powdery mildew resistant genes of H.californicum should be located on chromosomes other than 2H and 5H. | Fang Kong Haiyan Wang Aizhong Cao Bi Qin Jianhui Ji Suling Wang Xiu-E Wang | 2008 | Journal of Genetics and Genomics2008，35，11： | 5 |
| 9 | Synthesis and photovoltaic properties of a star-shaped molecule based on a triphenylamine core and branched terthiophene end groups显示文摘A new star-shaped donor-acceptor molecule has been synthesized for application as the donor material in solution-processed bulk-heterojunction organic solar cells (OSCs). The molecule consists of a triphenylamine (TPA) unit as the core and a donor unit with three arms containing benzo[1,2,5]thiadiazole (BT) acceptor units and 5,5''-dihexyl-2,2′:3′,2″-terthiophene (tTh) end groups. The molecule, denoted S(TPA-BT-tTh), exhibits a broad absorption band in the wavelength range 300-650 nm and high hole mobility of 1.1×10 -4 cm2 V -1 s 1 . An OSC device based on S(TPA-BT-tTh) as donor and [6,6]-phenyl C71 -butyric acid methyl ester (PC 70 BM) as the acceptor (1:3, w/w) exhibited a power conversion efficiency of 2.28% with a short circuit current density of 6.39 mA/cm2 under illumination of AM.1.5, 100 mW/cm2 . | GAO Lei ZHANG Jing HE Chang SHEN SuLing ZHANG Yi LIU HongTao SUN QingJiang LI YongFang | 2013 | Science China Chemistry2013，56，7： | 4 |
| 10 | Prevalence and risk factors associated with malaria infection among pregnant women in a semi-urban community of north-western Nigeria显示文摘Background:Malaria during pregnancy remains a serious public health problem,with substantial risks for the mother,her foetus and the newborn.The aim of this study was to determine the prevalence of malaria and possible risk factors for malaria infection among pregnant women in a semi-urban area in north-western Nigeria.Pregnant women are among the most susceptible to malaria infection.Knowledge of their malaria infection status is an important yardstick to measure the effectiveness of any malaria control programme.Methods:We conducted a cross sectional study in the semi-urban area of Argungu,Kebbi State Nigeria.Two hundred and fifty five pregnant women were included in the study after informed verbal consent was obtained.For each participant,the socio-demographic profile,stage of pregnancy and attitude to the use of insecticide-treated nets(ITNs)were investigated using a questionnaire.Peripheral blood samples were collected and thick blood smears were prepared and stained with Giemsa stains to check for malaria parasitaemia.The associations between age,education level and use of ITNs with occurrence of malaria infection during pregnancy were analysed using the chi-square test.Results:One hundred and six(41.6%)out of 255 pregnant women were infected with malaria parasites,with a mean parasite density of 800 parasitesμl−1.It was found that prevalence and parasite density decreased as age increased.The chi-square test indicated that a lack of education and non-usage of ITNs were significantly associated with malaria infection.Conclusion:Malaria is still a major public health issue among pregnant women mainly due to illiteracy and non-compliance to using ITNs.Increasing awareness about malaria preventive measures and early attendance of antenatal care services will help to reduce malaria and,consequently,its associated morbidities and mortalities. | Sani Abdullahi Fana Mohammed Danladi Abubakar Bunza Sule Aliyu Anka Asiya Umar Imam Shehu Usman Nataala | 2015 | Infectious Diseases of Poverty2015，4，1： | 4 |
| 11 | High activity of hot electrons from bulk 3D graphene materials for efficient photocatalytic hydrogen production显示文摘为经由切开的水的氢生产的有效光催化剂的设计和合成从理论、实际的观点是很重要的。许多基于金属的半导体在最近的十年为这个目的被探索了。这里,第一次完全基于碳的材料,体积三在尺寸上的 cross-linked graphene (3DG ) ,为氢作为光催化剂被开发了生产。它展出 270 摩尔的显著的氢生产率 ??? 琠? 敧敮慲整挠瑹瑯硯捩稠湩 ? 潩獮愠摮爠慥瑣癩? 硯杹湥猠数楣獥 ? 佒 ? 。 | Yanhong Lu Bo Ma Yang Yang Erwei Huang Zhen Ge Tengfei Zhang Suling Zhang Landong Li Naijia Guan Yanfeng Ma Yongsheng Chen | 2017 | Nano Research2017，10，5： | 3 |
| 12 | FY-4A/GIIRS Temperature Validation in Winter and Application to Cold Wave Monitoring显示文摘In order to improve the operational application ability of the Fengyun-4A(FY-4A)new sounding dataset,in this paper,validation of the FY-4A Geosynchronous Interferometric Infrared Sounder(FY-4A/GIIRS)temperature was carried out using the balloon sounding temperature from meteorological sounding stations.More than 350,000 samples were obtained through time–space matching,and the results show that the FY-4A/GIIRS temperature mean bias(MB)is 0.07°C,the mean absolute error(MAE)is 1.80°C,the root-mean-square error(RMSE)is 2.546°C,and the correlation coefficient(RR)is 0.95.The FY-4A/GIIRS temperature error is relatively larger in the upper and lower troposphere,and relatively smaller in the middle troposphere;that is,the temperature at 500 hPa is better than that at 850 hPa.The temporal variation is smaller in the upper and middle troposphere than in the lower troposphere.The reconstruction of missing data of FY-4A/GIIRS temperature in cloudy areas is also carried out and the results are evaluated.The spatial distribution of reconstructed FY-4A/GIIRS temperature and the fifth generation ECMWF reanalysis(ERA5)data is consistent and completely retains the minimum temperature center with high precision of FY-4A/GIIRS.There are more detailed characteristics of intensity and position at the cold center than that of the reanalysis data.Therefore,an operational satellite retrieval temperature product with time–space continuity and high accuracy is formed.The reconstructed FY-4A/GIIRS temperature is used to monitor a strong cold wave event in November 2021.The results show that the product effectively monitors the movement and intensity of cold air activities,and it also has good indication for the phase transition of rain and snow triggered by cold wave. | Suling REN Jianying JIANG Xiang FANG Hui LIU Zhiqiang CAO | 2022 | Journal of Meteorological Research2022，36，4： | 3 |
| 13 | Tunable luminescence in co-doped Zn3Al2Ge2O10:Cr3+by controlling crystal field splitting and nephelauxetic effect显示文摘Ce3+/Dy3+/Tb3+/Eu3+/Mn2+and Cr3+ions co-doped Zn3 Al2 Ge2 O10 phosphor were prepared by a hightemperature solid-state method.X-ray diffraction patterns prove the cubic phase structure of prepared Zn3 Al2 Ge2 O10 phosphor,Emission,excitation spectra and decay curves confirm the tunable luminescence.Different degrees of the decrease of emission FWHM in Zn3 Al2 Ge2 O10:0.02 Cr3+,RE(RE=Ce3+,Dy3+,Tb3+,Eu3+)and Zn3 Al2 Ge2 O10:0.02 Cr3+,Mn2+are observed.The reason of variable FWHM is the effect of crystal field splitting and nephelauxetic effect,and the nephelauxetic effect is dominant.Therefore,the emission FWHM decreases with the increasing concentration of Mn2+/Tb3+/Eu3+in Zn3 Al2 Ge2 O10:0.02 Cr3+,and for Zn3 Al2 Ge2 O10:0.02 Cr3+,Ce3+and Zn3 Al2 Ge2 O10:0.02 Cr3+,Dy3+,it is a constant.The variation of Zn3 Al2 Ge2 O10:0.02 Cr3+,Tb3+is more obvious than that of Zn3 Al2 Ge2 O10:0.02 Cr3+,Eu3+,because Tb3+ion has smaller electronegativity.Thus,the tunable luminescence of Cr3+can be realized by co-doping different ions.And these phosphors have potential applications in light-emitting diodes for plant growth. | Qiongyu Bai Suling Zhao Zheng Xu Panlai Li | 2020 | Journal of Rare Earths2020，38，12： | 3 |
| 14 | An additive dripping technique using diphenyl ether for tuning perovskite crystallization for high-efficiency solar cells显示文摘 | Di Huang Tenghooi Goh Yifan Zheng Zilun Qin Jiao Zhao Suling Zhao Zheng Xu Andre D. Taylor | 2018 | Nano Research2018，11，5： | 3 |
| 15 | Treatment of pregnant women with a diagnosis of inflammatory bowel disease显示文摘The frequency of diagnosis of inflammatory bowel disease(IBD) has increased in younger populations.For this reason,pregnancy in patients with IBD is a topic of interest,warranting additional focus on disease management during this period.The main objective of this article is to summarize the latest findings and guidelines on the management of potential problems from pregnancy to the breastfeeding stage.Fertility is decreased in patients with active IBD.Disease remission prior to conception will likely decrease the rate of pregnancy-related complications.Most of the drugs used for IBD treatment are safe during both pregnancy and breastfeeding.Two exceptions are methotrexate and thalidomide,which are contraindicated in pregnancy.Antitumor necrosis factor agents are not advised during the third trimester as they exhibit increased transplacental transmission and potentially cause immunosuppression in the fetus.Radiological and endoscopic examinations and surgical interventions should be performed only when absolutely necessary.Surgery increases the fetal mortality rate.The delivery method should be determined with consideration of the disease site and presence of progression or flare up.Treatment planning should be a collaborative effort among the gastroenterologist,obstetrician,colorectal surgeon and patient. | Sule Poturoglu Asli Ciftcibasi Ormeci Ali Erkan Duman | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 16 | Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats显示文摘象 Glucagon 一样 peptide-2 (GLP-2 ) 有有势力反煽动性完成并且免于试验性的 ischemia/reperfusion (I/R ) 在肺、肠、心肌的织物的损害。然而,它对在肝的 I/R 损害的保护的能力是未知的。我们在老鼠在肝的 I/R 损害上调查了 GLP-2 预告的处理的潜在的角色。24 只老鼠的一个总数随机被划分成三个组(n = 8 ) 。第一个组是控制组;第二个组是对待车辆的肝的 ischemia/reperfusion (HIR,车辆盐对待) 组;并且第三个组是 GLP-2 pretreated I/R (GLP2 红外) 组。在第三个组的每只老鼠 intraperitoneally 被管理 5 ????? ???? 溜吗?? | Naci Topaloglu Adem Kucuk Sule Yildirm Mustafa Tekin Havva Erdem Mustafa Deniz | 2015 | Frontiers of Medicine2015，9，3： | 2 |
| 17 | Differential diagnosis in ulcerative colitis in an adolescent: Chronic granulomatous disease needs extra attention显示文摘Chronic granulomatous disease(CGD) is a primary immune deficiency that is commonly diagnosed under the age of 5 years(95%) and is rarely seen in adulthood. CGD may manifest as inflammatory bowel disease(IBD) in childhood. Without proper diagnosis, these patients may be monitored for years as IBD; some may even be regarded as steroid-resistant ulcerative colitis(UC) and end up having a colectomy. In this case report, we described a patient who had been followedup for years as UC and subsequently underwent colectomy, but was finally diagnosed in adulthood as primary immune deficiency. | Daniel Kotlarz Odul Egritas Gurkan Zehra Sule Haskologlu Ozgur Ekinci Aysel Aksu Unlusoy Neslihan Gürcan Kaya Jacek Puchalka Cristoph Klein Buket Dalgic | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 2 |
| 18 | PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway显示文摘Our previous studies have showed that C-C motif chemokine ligand 20(CCL20)advanced tumor progression and enhanced the chemoresistance of cancer cells by positively regulating breast cancer stem cell(BCSC)self-renewal.However,it is unclear whether CCL20 affects breast cancer progression by remodeling the tumor microenvironment(TME).Here,we observed that polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)were remarkably enriched in TME of CCL20-overexpressing cancer cell orthotopic allograft tumors.Mechanistically,CCL20 activated the differentiation of granulocyte-monocyte progenitors(GMPs)via its receptor C-C motif chemokine receptor 6(CCR6)leading to the PMN-MDSC expansion.PMN-MDSCs from CCL20-overexpressing cell orthotopic allograft tumors(CCL20-modulated PMN-MDSCs)secreted amounts of C-X-C motif chemokine ligand 2(CXCL2)and increased ALDH+BCSCs via activating CXCR2/NOTCH1/HEY1 signaling pathway.Furthermore,C-X-C motif chemokine receptor 2(CXCR2)antagonist SB225002 enhanced the docetaxel(DTX)effects on tumor growth by decreasing BCSCs in CCL20high-expressing tumors.These findings elucidated how CCL20 modulated the TME to promote cancer development,indicating a new therapeutic strategy by interfering with the interaction between PMN-MDSCs and BCSCs in breast cancer,especially in CCL20high-expressing breast cancer. | Rui Zhang Mengxue Dong Juchuanli Tu Fengkai Li Qiaodan Deng Jiahui Xu Xueyan He Jiajun Ding Jie Xia Dandan Sheng Zhaoxia Chang Wei Ma Haonan Dong Yi Zhang Lixing Zhang Lu Zhang Suling Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 19 | Impact of combining chlorine dioxide and chlorine on DBP formation in simulated indoor swimming pools显示文摘The main objective of this study was to assess the combined use of chlorine dioxide(ClO_2)and chlorine(Cl_2) on the speciation and kinetics of disinfection by-product(DBP) formation in swimming pools using synthetic pool waters prepared with a body fluid analog(BFA)and/or fresh natural water. At 1:25(mass ratio) of ClO_2 to Cl_2, there was no significant reduction in the formation of trihalomethanes(THMs) and haloacetic acids(HAAs) for both BFA solution and natural water compared to the application of Cl_2 alone. When the mass ratio of ClO_2 to Cl_2increased to 1:1, substantial decreases in both THMs and HAAs were observed in the natural water, while there was almost no change of DBP formations in the BFA solution. Haloacetonitriles and halonitromethanes levels in both water matrices remained similar. In the presence of bromide, the overall DBP formation increased in both BFA solution and natural water. For the DBP formation kinetics, after 72 hr of contact time,very low formation of THMs and HAAs was observed for the use of ClO_2 only. Compared to Cl_2 control, however, applying the 1:1 mixture of ClO_2/Cl_2 reduced THMs by > 60% and HAAs by > 50%. Chlorite was maintained below 1.0 mg/L, while the formation of chlorate significantly increased over the reaction time. Finally, in a bench-scale indoor pool experiment, applying ClO_2 and Cl_2simultaneously produced less THMs compared to Cl_2 control and kept chlorite at < 0.4 mg/L, while HAAs and chlorate accumulated over 4-week operation period. | Daekyun Kim Nuray Ates Sehnaz Sule Kaplan Bekaroglu Meric Selbes Tanju Karanfil | 2017 | Journal of Environmental Sciences2017，29，8： | 2 |
| 20 | Effect of heat-moisture treatment on the formation and physicochemical properties of resistant starch from mung bean ( Phaseolus radiatus ) starch显示文摘 | Suling Li Rachelle Ward Qunyu Gao | 2011 | Food Hydrocolloids2011，，7： | 2 |
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