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| 1 | Is transient elastography a useful tool for screening liver disease?显示文摘Transient elastography(TE)is a new non invasive tool for measuring liver stiffness,which is correlated to the histologic stage of liver fibrosis.Several studies in chronic liver disease(CLD)have determined a good accuracy of TE in predicting significant fibrosis and an optimal accuracy in predicting cirrhosis.Normal liver stiffness ranges between 3.3-7.8 KPa and using a cut off of 7.1 KPa,significant fibrosis and cirrhosis can be excluded with a very high negative predictive value(NPV).Positive predictive value(PPV)for the diagnosis of cirrhosis is lower using just a single scan but increases to 90% if high stiffness values are confirmed by a second independent scan.However the presence of fatty liver and metabolic syndrome slightly increases the readings and may reduce the accuracy of the test.It is uncertain if this increase is related to the presence of steatofibrosis or ifit is caused by steatosis itself.TE can be used in screening patients attending the liver clinics to identify those with signifi cant fi brosis or cirrhosis and may be particularly useful in discriminating HBV inactive carriers from chronic hepatitis B patients.TE,however,is not reliable in predicting the presence of esophageal varices in cirrhotics.Another potential indication for TE is the systematic screening of populations at high risk for CLD,such as intravenous drug users and alcoholics,but further studies are needed to determine its diagnostic accuracy in these settings. | Paolo Del Poggio Silvia Colombo | 2009 | World Journal of Gastroenterology2009，15，12： | 5 |
| 2 | Development of Genus/Species-Specific PCR Analysis for Identification of Carnobacterium Strains显示文摘 | Mauro Scarpellini Diego Mora Silvia Colombo Laura Franzetti | 2002 | Current Microbiology2002，，1： | 3 |
| 3 | Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B显示文摘AIM: To study the efficacy of tenofovir disoproxil fumarate (TDF) at low dose in a small open trial of chronic hepatitis B patients with advanced stage disease. METHODS: Eleven patients were treated with TDF 75 mg for a median period of 80 (range, 24-576) wk and then 7 cases were shifted to an adefovir 10 mg treatment group. All patients had been pre-treated with lamivudine: 5 had YMDD resistant mutants and 6 wild- type virus. When TDF was started, 4 patients had low- level viremia and 6 were PCR-negative. RESULTS: During TDF treatment, PCR remained negative in 10 patients, transaminase levels were normal and no significant viral breakthrough was observed. The drug was well tolerated in all cases. When TDF 75 mg was substituted with adefovir 10 mg, 3 out of 7 patients had a persistent viral rebound (2700-130 000 copies/mL), in whom lamivudine had to be reintroduced. CONCLUSION: Low-dose TDF monotherapy can control HBV viremia for an extended period of time without the emergence of resistance and is more potent than adefovir at the standard dosage. The use of a reduced dose of TDF could diminish the cost of therapy in low-income countries, but further studies in a larger population and in HBeAg-positive subjects are needed. | Paolo Del Poggio Maurizio Zaccanelli Maria Oggionni Silvia Colombo Carlo Jamoletti Vesna Puhalo | 2007 | World Journal of Gastroenterology2007，13，30： | 3 |
| 4 | Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis显示文摘 | Silvia Colombo Marco Buonocore Anna Poggio Carlo Jamoletti Stefano Elia Mario Mattiello Davide Zabbialini Paolo Poggio | 2012 | Journal of Gastroenterology2012，，4： | 2 |
| 5 | Pupil lightreflex produced by glare under mesopic adaptation 显示文摘 | Colombo E Silvia A C Issolio Luis | 2007 | Journal of Light & Visual Environment2007，31，2： | 1 |
| 6 | Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis显示文摘 | Silvia Colombo Marco Buonocore Anna Poggio Carlo Jamoletti Stefano Elia Mario Mattiello Davide Zabbialini Paolo Poggio | 2012 | Journal of Gastroenterology2012，，4： | 1 |
| 7 | Enhanced endoscopic ultrasound imaging for pancreatic lesions: The road to artificial intelligence显示文摘Early detection of pancreatic cancer has long eluded clinicians because of its insidious nature and onset.Often metastatic or locally invasive when symptomatic,most patients are deemed inoperable.In those who are symptomatic,multi-modal imaging modalities evaluate and confirm pancreatic ductal adenocarcinoma.In asymptomatic patients,detected pancreatic lesions can be either solid or cystic.The clinical implications of identifying small asymptomatic solid pancreatic lesions(SPLs)of<2 cm are tantamount to a better outcome.The accurate detection of SPLs undoubtedly promotes higher life expectancy when resected early,driving the development of existing imaging tools while promoting more comprehensive screening programs.An imaging tool that has matured in its reiterations and received many image-enhancing adjuncts is endoscopic ultrasound(EUS).It carries significant importance when risk stratifying cystic lesions and has substantial diagnostic value when combined with fine needle aspiration/biopsy(FNA/FNB).Adjuncts to EUS imaging include contrast-enhanced harmonic EUS and EUS-elastography,both having improved the specificity of FNA and FNB.This review intends to compile all existing enhancement modalities and explore ongoing research around the most promising of all adjuncts in the field of EUS imaging,artificial intelligence. | Marco Spadaccini Glenn Koleth James Emmanuel Kareem Khalaf Antonio Facciorusso Fabio Grizzi Cesare Hassan Matteo Colombo Benedetto Mangiavillano Alessandro Fugazza Andrea Anderloni Silvia Carrara Alessandro Repici | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 8 | Effects of probiotic administration in swine显示文摘 | Gloria Romina Ross Carlos Gusils Rubén Oliszewski Silvia Colombo de Holgado Silvia Nelina González | 2009 | Journal of Bioscience and Bioengineering2009，，6： | 1 |
| 9 | Patatin‐like phospholipase domain‐containing 3 I148M affects liver steatosis in patients with chronic hepatitis B显示文摘 | Mauro Viganò Luca Valenti Pietro Lampertico Floriana Facchetti Benedetta Maria Motta Roberta D’Ambrosio Solange Romagnoli Paola Dongiovanni Benedetta Donati Silvia Fargion Massimo Colombo | 2013 | Hepatology2013，，4： | 1 |
| 10 | Spray dried amikacin powder for inhalation in cystic fibrosis patients: A quality by design approach for product construction显示文摘 | Silvia Belotti Alessandra Rossi Paolo Colombo Ruggero Bettini Dimitrios Rekkas Stavros Politis Gaia Colombo Anna Giulia Balducci Francesca Buttini | 2014 | International Journal of Pharmaceutics2014，，： | 1 |
| 11 | Effects of probiotic administration in swine显示文摘 | Gloria Romina Ross Carlos Gusils Rubén Oliszewski Silvia Colombo de Holgado Silvia Nelina González | 2009 | Journal of Bioscience and Bioengineering2009，，6： | 1 |
| 12 | Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis显示文摘 | Silvia Colombo Marco Buonocore Anna Poggio Carlo Jamoletti Stefano Elia Mario Mattiello Davide Zabbialini Paolo Poggio | 2012 | Journal of Gastroenterology2012，，4： | 1 |
| 13 | Segmental Transcatheter Arterial Chemoembolization Treatment in Patients with Cirrhosis and Inoperable Hepatocellular Carcinomas显示文摘 | Silvia Saccheri Andrea Lovaria Angelo Sangiovanni Antonio Nicolini Cristina De Fazio Guido Ronchi Pierangelo Fasani Ersilio Del Ninno Massimo Colombo | 2002 | Journal of Vascular and Interventional Radiology2002，，10： | 1 |
| 14 | Lungultrasound is an accurate diagnostic tool for the diagnosis ofpneumonia in the emergency department 显示文摘 | Francesca Cortellaro Silvia Colombo Daniele Coen | 2012 | Emerg Med J2012，29，： | 1 |
| 15 | Percutaneous endoscopic gastrostomy and jejunostomy:Indications and techniques显示文摘Nutritional support is essential in patients who have a limited capability to maintain their body weight.Therefore,oral feeding is the main approach for such patients.When physiological nutrition is not possible,positioning of a nasogastric,nasojejunal tube,or other percutaneous devices may be feasible alternatives.Creating a percutaneous endoscopic gastrostomy(PEG)is a suitable option to be evaluated for patients that need nutritional support for more than 4 wk.Many diseases require nutritional support by PEG,with neurological,oncological,and catabolic diseases being the most common.PEG can be performed endoscopically by various techniques,radiologically or surgically,with different outcomes and related adverse events(AEs).Moreover,some patients that need a PEG placement are fragile and are unable to express their will or sign a written informed consent.These conditions highlight many ethical problems that become difficult to manage as treatment progresses.The aim of this manuscript is to review all current endoscopic techniques for percutaneous access,their indications,postprocedural follow-up,and AEs. | Alessandro Fugazza Antonio Capogreco Annalisa Cappello Rosangela Nicoletti Leonardo Da Rio Piera Alessia Galtieri Roberta Maselli Silvia Carrara Gaia Pellegatta Marco Spadaccini Edoardo Vespa Matteo Colombo Kareem Khalaf Alessandro Repici Andrea Anderloni | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，5： | 1 |
| 16 | Amniotic Mesenchymal Stem Cells: A New Source for Hepatocyte-Like Cells and Induction of CFTR Expression by Coculture with Cystic Fibrosis Airway Epithelial Cells显示文摘 | Valentina Paracchini Annalucia Carbone Federico Colombo Stefano Castellani Silvia Mazzucchelli Sante Di Gioia Dario Degiorgio Manuela Seia Laura Porretti Carla Colombo Massimo Conese Ken-ichi Isobe | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 1 |
| 17 | Microencapsulation with spray-chilling as an innovative strategy for probiotic low sodium requeijao cremoso processed cheese processing显示文摘The effect of sodium reduction and Lactobacillus acidophilus addition(free or microencapsulated)on the quality parameters of requeijao cremoso processed cheese was assessed for 90 days at 5℃.Three formulations were prepared:(CONT)regular salt content and curd fusion(90℃/2 min),(FREE)reduced salt content+free probiotic culture added after curd fusion(90℃/2 min),and(MICRO)reduced salt content+microencapsulated probiotic culture added before curd fusion(70℃/5 min).FREE and MICRO formulations showed increased monounsaturated and polyunsaturated fatty acid content,improved health indices(decreases in thrombogenic index and increases in desirable fatty acid index),and altered rheological properties(higher consistency index,apparent viscosity,elastic properties,and gel strength).In addition,the MICRO formulation showed higher texture sensory acceptance and probiotic counts higher than 6 log CFU/g during storage and simulated gastrointestinal conditions.Overall,microencapsulation of probiotics with spray chilling represents an innovative solution in requeijao cremoso processed cheese. | Ramon Silva Tatiana Colombo Pimentel Fernando Eust´aquio de Matos Junior Erick Almeida Esmerino Monica Q.Freitas Carmen Silvia F´avaro-Trindade M´arcia Cristina Silva Adriano Gomes Cruz | 2022 | Food Bioscience2022，46，2： | 0 |
| 18 | Endoscopic management of benign biliary strictures:Looking for the best stent to place显示文摘Benign biliary strictures(BBS)might occur due to different pancreaticobiliary conditions.The etiology and location of biliary strictures are responsible of a wide array of clinical manifestations.The endoscopic approach endoscopic retrograde cholangiopancreatography represents the first-line treatment for BBS,considering interventional radiology and surgery when endoscopic treatment fails or it is not suitable.The purpose of this review is to provide an overview of possible endoscopic treatments for the optimal management of this subset of patients. | Matteo Colombo Edoardo Forcignanò Leonardo Da Rio Marco Spadaccini Marta Andreozzi Carmelo Marco Giacchetto Silvia Carrara Roberta Maselli Piera Alessia Galtieri Gaia Pellegatta Antonio Capogreco Davide Massimi Kareem Khalaf Cesare Hassan Andrea Anderloni Alessandro Repici Alessandro Fugazza | 2023 | World Journal of Clinical Cases2023，11，31： | 0 |
| 19 | Role of endoscopic ultrasound in vascular interventions:Where are we now?显示文摘From a mere diagnostic tool to an imperative treatment modality,endoscopic ultrasound(EUS)has evolved and revolutionized safer efficient options for vascular interventions.Currently it is an alternative treatment option in the management of gastrointestinal bleeding,primarily variceal type bleeding.Conventional treatment option prior to EUS incorporation had limited efficiency and high adverse events.The characterization and detail provided by EUS gives a cutting edge towards a holistically successful management choice.Data indicates that EUS-guided combination therapy of coil embolization and glue injection has the higher efficacy for the treatment of varices.Conversely,similar treatment options that exist for esophageal and other ectopic variceal bleeding was also outlined.In conclusion,many studies refer that a combination therapy of coil and glue injection under EUS guidance provides higher technical success with fewer recurrence and adverse events,making its adaptation in the guideline extremely favorable.Endo-hepatology is a novel disciple with a promising future outlook,we reviewed topics regarding portal vein access,pressure gradient measurement,and thrombus biopsy that are crucial interventions as alternative of radiological procedures.The purpose of this review is to provide an update on the latest available evidence in the literature regarding the role of EUS in vascular interventions.We reviewed the role of EUS in variceal bleeding in recent studies,especially gastric varices and novel approaches aimed at the portal vein. | Alessandro Fugazza Kareem Khalaf Matteo Colombo Silvia Carrara Marco Spadaccini Glenn Koleth Edoardo Troncone Roberta Maselli Alessandro Repici Andrea Anderloni | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，6： | 0 |
| 20 | Artificial intelligence and inflammatory bowel disease: Where are we going?显示文摘Inflammatory bowel diseases,namely ulcerative colitis and Crohn’s disease,are chronic and relapsing conditions that pose a growing burden on healthcare systems worldwide.Because of their complex and partly unknown etiology and pathogenesis,the management of ulcerative colitis and Crohn’s disease can prove challenging not only from a clinical point of view but also for resource optimization.Artificial intelligence,an umbrella term that encompasses any cognitive function developed by machines for learning or problem solving,and its subsets machine learning and deep learning are becoming ever more essential tools with a plethora of applications in most medical specialties.In this regard gastroenterology is no exception,and due to the importance of endoscopy and imaging numerous clinical studies have been gradually highlighting the relevant role that artificial intelligence has in inflammatory bowel diseases as well.The aim of this review was to summarize the most recent evidence on the use of artificial intelligence in inflammatory bowel diseases in various contexts such as diagnosis,follow-up,treatment,prognosis,cancer surveillance,data collection,and analysis.Moreover,insights into the potential further developments in this field and their effects on future clinical practice were discussed. | Leonardo Da Rio Marco Spadaccini Tommaso Lorenzo Parigi Roberto Gabbiadini Arianna Dal Buono Anita Busacca Roberta Maselli Alessandro Fugazza Matteo Colombo Silvia Carrara Gianluca Franchellucci Ludovico Alfarone Antonio Facciorusso Cesare Hassan Alessandro Repici Alessandro Armuzzi | 2023 | World Journal of Gastroenterology2023，29，3： | 0 |
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