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261篇 您的检索式：作者名="Mazzucchelli"

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	题名	作者	年代	出处	被引量
1	Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients显示文摘AIM:To investigate whether the evaluation of tumor budding can complement K-RAS analysis to improve the individualized prediction of response to anti-epidermal growth factor receptor based therapies in metastatic colorectal cancer (mCRC) patients. METHODS:Forty-three patients with mCRC treated with cetuximab or panitumumab were entered into this study. According to the Response Evaluation Criteria in Solid Tumors criteria, 30 patients had stable or progressive disease (non-responsive), while 13 patients had a partial response. Tumor buds were evaluated from whole tissue sections stained for pan-cytokeratin, evaluated in the densest region using a 40 × objective and 'high-grade' tumor budding was defi ned as 15 buds/high-power f ield.RESULTS: Tumor buds and K-RAS mutation both correctly classif ied 68% of patients. All patients with K-RAS mutation (n=7) or high-grade tumor budding (n=11) were non-responsive, of which 4 patients had both features. All 13 partial responders were K-RAS wild-type with low-grade tumor budding. Combined, the predictive value of K-RAS and tumor budding was 80%. Additionally, high-grade tumor budding was significantly related to worse progression-free survival [HR (95% CI): 2.8 (1.3-6.0, P=0.008)].CONCLUSION: If confirmed in larger cohorts, the addition of tumor budding to K-RAS analysis may represent an effective approach for individualized patient management in the metastatic setting.	Inti Zlobec Francesca Molinari Vittoria Martin Luca Mazzucchelli Piercarlo Saletti Rosangela Trezzi Sara De Dosso Tatjana Vlajnic Milo Frattini Alessandro Lugli	2010	World Journal of Gastroenterology2010，16，38：	4
2	HER2 expres- sion and gene amplification in pT2a Gleason score 6 prostate cancer incidentally detected in cystoprostatectomies: comparison with clin/cally detected androgen - dependent and androgen - independent cancer显示文摘	Montironi R Mazzucchelli R Barbisan F	2006	Hum Pathol2006，37，9：	1
3	Use of accurate diagnostic criteria may increase incidence of stercoral perforation of the colon显示文摘	Maurer C A Renzulli P Mazzucchelli L	2000	Dis Colon Rectum2000，43，7：	1
4	Expression of prostate stem cell antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer显示文摘	BARBISAN F MAZZUCCHELLI R SANTINELLI A	2010	Histopathology2010，57，4：	1
5	Use of real-time polymerase chain reaction to identify cell- and tissue-type-selec- ire peptides by phage display显示文摘	Jaye DL Nolte FS Mazzucchelli L et ol	2003	Am J Pathol2003，162，5：	1
6	HER- 2 expression and gene amplification in high -grade PIN and prostate cancer显示文摘	Montironi R Mazzucchelli R	2006	Arch Ital Urol Androl2006，78，4：	1
7	lsotopic evidence from the Ivrea Zone for a hybird lower crust formed by magmatic under- plating显示文摘	Voshage H Hofmann A W Mazzucchelli M	1990	Nature1990，347，：	1
8	Secondary neoplasms of the urinary system and male genital organs 显示文摘	Morichetti D Mazzucchelli R Lopez-Beltran A	2009	BJU Int2009，104，6：	1
9	Analysis of PWM techniques using uniform sampling in variable speed electrical drives with large speed range 显示文摘	FRANZO G MAZZUCCHELLI M PUGLISI L	1985	IEEE Transactions on Industry Applications1985，21，4：	1
10	The sensory perception of texture and mouth-feel显示文摘	Guinard J.X Mazzucchelli R		0，，07：	1
11	Invasion depth is the most important prognostic factor for transitional-cell carcinoma in a prospective trial of radical cystectomy and adjuvant chemotherapy 显示文摘	Mazzucchelli L Bacchi M Studer U E	1994	Int J Cancer1994，57，1：	1
12	Higher frequency of chro-mosomal aberrations in ovarian endometriosis compared to extrago-nadal endometriosis : a possible link to endometrioid adenocarcinoma显示文摘	Korner M Burckhardt E Mazzucchelli L	2006	Mod Pathol2006，19，12：	1
13	Expression of prostate stem cell antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer 显示文摘	Barbisan F Mazzucchelli R Santinelli A	2010	Histopathology2010，57，4：	1
14	Behavioral activation treat- ments for depression in adults : A meta - analysis and review 显示文摘	Mazzucchelli T G Kane R T Rees C S	2009	Clin Psycho12009，16，2：	1
15	Galectin-3 plasma levels and coronary artery disease: a new possible biomarker of acute coronary syndrome 显示文摘	Falcone C Lucibello S Mazzucchelli I	2011	lnt J lmmuuopathol Pharmacol2011，24，4：	1
16	Small-ceil undifferentiated carcinoma of the renal pelvis 26 years after subdiaphragmatic irradiation for non-Hodgkin's lymphoma显示文摘	Mazzucchelli L Studer UE Kraft R	1995	Br J Urol1995，76，3：	1
17	Development of regulatory T cells requires IL-TRalpha stimulation by IL-7 or TSLP显示文摘	Mazzucchelli R Hixon JA Spolski R	2008	Blood2008，112，8：	1
18	Atypical foci suspicious but not diagnostic of malignancy in prostate needle biopsies (also referred to as 'atypical small acinar proliferation suspicious for but not diagnostic of malignancy' ) 显示文摘	Montironi R Scattoni V Mazzucchelli R	2006	Eur Urol2006，50，4：	1
19	α -methylacyl-CoA racemase (P504S)/34 β E12/p63 triple cocktail stain in prostatic adenocarcinoma after hormonal therapy显示文摘	Ming-Tse Sung Zhong Jiang Rodolfo Montironi Gregory T. MacLennan Roberta Mazzucchelli Liang Cheng	2007	Human Pathology2007，，2：	1
20	Isotopic ev idence from the Ivrea zone for a hybrid lower crust formed by magmatic underplating显示文摘	Voshage H Hofmann A Mazzucchelli M	1990	Nature1990，347，：	1

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