|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B显示文摘AIM: To study the efficacy of tenofovir disoproxil fumarate (TDF) at low dose in a small open trial of chronic hepatitis B patients with advanced stage disease. METHODS: Eleven patients were treated with TDF 75 mg for a median period of 80 (range, 24-576) wk and then 7 cases were shifted to an adefovir 10 mg treatment group. All patients had been pre-treated with lamivudine: 5 had YMDD resistant mutants and 6 wild- type virus. When TDF was started, 4 patients had low- level viremia and 6 were PCR-negative. RESULTS: During TDF treatment, PCR remained negative in 10 patients, transaminase levels were normal and no significant viral breakthrough was observed. The drug was well tolerated in all cases. When TDF 75 mg was substituted with adefovir 10 mg, 3 out of 7 patients had a persistent viral rebound (2700-130 000 copies/mL), in whom lamivudine had to be reintroduced. CONCLUSION: Low-dose TDF monotherapy can control HBV viremia for an extended period of time without the emergence of resistance and is more potent than adefovir at the standard dosage. The use of a reduced dose of TDF could diminish the cost of therapy in low-income countries, but further studies in a larger population and in HBeAg-positive subjects are needed. | Paolo Del Poggio Maurizio Zaccanelli Maria Oggionni Silvia Colombo Carlo Jamoletti Vesna Puhalo | 2007 | World Journal of Gastroenterology2007，13，30： | 3 |
| 2 | Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis显示文摘 | Silvia Colombo Marco Buonocore Anna Poggio Carlo Jamoletti Stefano Elia Mario Mattiello Davide Zabbialini Paolo Poggio | 2012 | Journal of Gastroenterology2012，，4： | 2 |
| 3 | Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis显示文摘 | Silvia Colombo Marco Buonocore Anna Poggio Carlo Jamoletti Stefano Elia Mario Mattiello Davide Zabbialini Paolo Poggio | 2012 | Journal of Gastroenterology2012，，4： | 1 |
| 4 | Malignant transformation of Biliary cystadenoma:a difficult diagnosis显示文摘 | Del Poggio P Jamoletti C Forloni B | | 0，，： | 1 |
| 5 | Malignant transformation of biliary eystadenoma: a difficult diagnosis 显示文摘 | Del Poggio P Jamoletti C Forloni B | 2000 | Dig Liver Dis2000，32，8： | 1 |
| 6 | Malignant transformation of Biliary cystadenoma: a difficult diagnosis显示文摘 | Del Poggio P Jamoletti C Forloni B | 2000 | Dig Liver Dis2000，32，8： | 1 |
| 7 | Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis显示文摘 | Silvia Colombo Marco Buonocore Anna Poggio Carlo Jamoletti Stefano Elia Mario Mattiello Davide Zabbialini Paolo Poggio | 2012 | Journal of Gastroenterology2012，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员