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| 1 | Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging显示文摘BACKGROUND Prospective study of 200 patients with hepatocellular carcinoma(HCC)that underwent liver transplant(LT)after drug-eluting beads transarterial chemoembolization(DEB-TACE)for downstaging versus bridging.Overall survival and tumor recurrence rates were calculated,eligibility for LT,time on the waiting list and radiological response were compared.After TACE,only patients within Milan Criteria(MC)were transplanted.More patients underwent LT in bridging group.Five-year post-transplant overall survival,recurrence-free survival has no difference between the groups.Complete response was observed more frequently in bridging group.Patients in DS group can achieve posttransplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE.AIM To determine long-term outcomes of patients with HCC that underwent LT after DEB-TACE for downstaging vs bridging.METHODS Prospective cohort study of 200 patients included from April 2011 through June 2014.Bridging group included patients within MC.Downstaging group(out of MC)was divided in 5 subgroups(G1 to G5).Total tumor diameter was≤8 cm for G1,2,3,4(n=42)and was>8 cm for G5(n=22).Downstaging(n=64)and bridging(n=136)populations were not significantly different.Overall survival and tumor recurrence rates were calculated by the Kaplan-Meier method.Additionally,eligibility for LT,time on the waiting list until LT and radiological response were compared.RESULTS After TACE,only patients within MC were transplanted.More patients underwent LT in bridging group 65.9%(P=0.001).Downstaging population presented:higher number of nodules 2.81(P=0.001);larger total tumor diameter 8.09(P=0.001);multifocal HCC 78%(P=0.001);more post-transplantation recurrence 25%(P=0.02).Patients with maximal tumor diameter up to 7.05 cm were more likely to receive LT(P=0.005).Median time on the waiting list was significantly longer in downstaging group 10.6 mo(P=0.028).Five-year posttransplant overall survival was 73.5%in downstaging and 72.3%bridging groups(P=0.31),and recurrence-free survival was 62.1%in downstaging and 74.8%bridging groups(P=0.93).Radiological response:complete response was observed more frequently in bridging group(P=0.004).CONCLUSION Tumors initially exceeding the MC down-staged after DEB-TACE,can achieve post-transplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE. | Breno Boueri Affonso Francisco Leonardo Galastri Joaquim Mauricio da Motta Leal Filho Felipe Nasser Priscila Mina Falsarella Rafael Noronha Cavalcante Marcio Dias de Almeida Guilherme Eduardo Goncalves Felga Leonardo Guedes Moreira Valle Nelson Wolosker | 2019 | World Journal of Gastroenterology2019，25，37： | 21 |
| 2 | Endoscopic features of gastro-intestinal lymphomas: From diagnosis to follow-up显示文摘Many progresses have been done in the management of gastrointestinal(GI) lymphomas during last decades, especially after the discovery of Helicobacter pylori-dependent lymphoma development. The stepwise implementation of new endoscopic techniques, by means of echoendoscopy or double-balloon enteroscopy, enabled us to more precisely describe the endoscopic features of GI lymphomas with substantial contribution in patient management and in tailoring the treatment strategy with organ preserving approaches. In this review, we describe the recent progresses in GI lymphoma management from disease diagnosis to follow-up with a specific focus on the endoscopic presentation according to the involved site and the lymphoma subtype. Additionally, new or emerging endoscopic technologies that have an impact on the management of gastrointestinal lymphomas are reported. We here discuss the two most common subtypes of GI lymphomas: the mucosaassociated lymphoid tissue and the diffuse large B cell lymphoma. A general outline on the state-of-the-art of the disease and on the role of endoscopy in both diagnosis and follow-up will be performed. | Calogero Vetro Alessandra Romano Irene Amico Concetta Conticello Giovanna Motta Amalia Figuera Annalisa Chiarenza Cosimo Di Raimondo Giorgio Giulietti Giacomo Bonanno Giuseppe Alberto Palumbo Francesco Di Raimondo | 2014 | World Journal of Gastroenterology2014，20，36： | 10 |
| 3 | 金属有机框架材料在超级电容器中的应用研究进展(英文)显示文摘金属有机骨架材料具有结构多样、孔径可调、比表面积大及化学反应活性位点丰富等优点,因此有望成为广泛应用于电化学储能器件的电极材料,如锂离子电池、燃料电池及超级电容器等.近十年来金属有机骨架材料及其衍生物材料引起了广泛的研究与应用.同时,金属有机骨架材料及其衍生的纳米材料作为电化学储能器件中的关键电极也受到了广泛的研究.本文主要综述了近期金属有机骨架材料及其衍生物在超级电容器中的研究进展,讨论了金属有机骨架材料制备超级电容器电极材料的方法及其在电化学储能领域体现出的优异性能及特殊性质,同时也总结了近期金属有机骨架材料的衍生物如碳材料、金属材料及复合物在超级电容器中的研究进展,结果说明金属有机骨架材料在发展新一代超级电容器电极材料领域具有重要的作用.最后讨论了金属有机骨架材料及其衍生物目前在超级电容器领域存在的问题以及未来可能的发展方向. | 赵昱颉 刘金章 Michael Horn Nunzio Motta 胡明俊 李岩 | 2018 | Science China Materials2018，61，2： | 6 |
| 4 | Metabolomics characterization of colostrum in three sow breeds and its influences on piglets' survival and litter growth rates显示文摘Background: Colostrum is the first secretion produced by mammary glands during the hours immediately preceding and succeeding parturition. This secretion differs from milk and represents an essential vehicle of passive immunity,prebiotic compounds and growth factors involved in intestinal development. Most of the literature concerning colostrum composition refers mainly to human and cow; and little is known about pig colostrum metabolome and how it varies between pig breeds and different farrowing parity. Thus, the aim of the present research is to provide new information about pig colostrum composition and the associations between metabolites, the sows' breed and the survival and growth rates of their litters.Results: Colostrum samples were gathered from 58 parturitions of sows belonging to three different breeds chosen for their importance in Italian heavy pig production: 31 Large White, 15 Landrace and 12 Duroc respectively. The defatted and ultrafiltered colostrum samples were analysed using1 H–NMR spectroscopy. Principal Components Analysis(PCA) was assessed on the obtained spectra. In addition, using a Stepwise Regression and a Linear Regression analyses the metabolites named after the signals assignment were tested for their associations with piglets' performances.Twenty-five metabolites were identified, comprehending monosaccharides, disaccharides(such as lactose), organic acids(lactate, citrate, acetate and formate), nitrogenous organic acids(such as creatine) and other compounds,including nucleotides. PCA results evidence a clustering due to breed and season effects. Lactose was the main compound determining the assignment of the samples into different clusters according to the sow breed. Furthermore, some metabolites showed to be associated with piglets' performance and survival traits: acetate and taurine were positively related to litter weight gain and piglets' survival rate, respectively, while dimethylamine and cis-aconitate were linked to new-borns' impaired ability to survive.Conclusions: The results obtained suggest that colostrum composition is affected by breed, which, together with environmental conditions, may cause changes in colostrum metabolites content with possible consequences on piglets' performances. Among the identified metabolites, acetate, taurine, dimethylamine and cis-aconitate showed consistent associations with piglets' survival rate and litter weight gain, implying that these compounds may affect new-borns' ability to survive. | Gianfranco Picone Martina Zappaterra Diana Luise Alessia Trimigno Francesco Capozzi Vincenzo Motta Roberta Davoli Leonardo Nanni Costa Paolo Bosi Paolo Trevisi | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 6 |
| 5 | HFC-245fa性质及应用综述显示文摘HFC-245fa是近年来发展起来的一种碳氟氢化合物,它在发泡剂、溶剂、气溶胶及制冷设备工质等领域有着广阔的应用前景。本文回顾了美国环保署(EPA)对HFC-245fa各种应用的批准使用情况。由于具备良好的热物理特性,HFC-245fa在导热和制冷设备工质中有很多应用。文中总结了HFC-245fa的热物理特性,并根据几个实例对HFC-245fa的各种应用进行了讨论,包括在离心式冷冻器、有机兰金循环(Or-ganicRankineCycle)中的能源再生、低温制冷中的显热转换以及被动式冷却设备中的应用等。此外,还讨论了HFC-245fa的热稳定性、化学稳定性及其和建筑材料的相容性,并介绍了迄今为止所进行的一些热、化学稳定性测试及测试结果。讨论还涉及了金属、工程塑料、人造橡胶等几种普通建筑材料对HFC-245fa的可接收性。关于使用HFC-245fa可能带来的健康、安全和环境问题,如毒性、相关部门的参考使用暴露极限值、易燃性。此外对臭氧层的破坏、对全球变暖趋势的影响以及产品的安全管理等,文章也进行了相应的介绍。 | Gary J.Zyhowski Sr. Mark W.Spatz Samuel Yana Motta 张社 | 2003 | 家电科技2003，，8： | 4 |
| 6 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 7 | L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-α 2b plus ribavirin显示文摘AIM:To evaluate the efficacy of L-carnitine on alleviating anemia,thrombocytopenia and leukopenia,and minimizing dose reductions in patients with chronic hepatitis C virus(HCV)in treatment with Interferonα(IFN-α)plus ribavirin.METHODS:Sixty-nine patients with chronic hepatitis C were enrolled in the study and divided into two groups.group A(n=35)received Peg-IFN-α2b plus ribavirin plus L-carnitine,and group B(n=34)received Peg-IFN-αand ribavirin for 12 mo.All patients underwent laboratory investigations including:red cell count,he-moglobin,white cell count,platelets,bilirubin,alanine aminotransferase(ALT),aspartate aminotransferase(AST),and viremia.RESULTS:After 12 mo in group A compared to group B we observed significant differences in AST 108.8 vs 76.8(IU/L;P<0.001),ALT 137.vs 112.3(IU/L;P 0.001),viremia 4.04 vs 2.36(106 copies/mL;P< 0.001),Hb 1 vs 3.5(g/dL;P<0.05),red blood cells 0.3 vs 1.1(X1012/L;P0.001),white blood cells 1.5 vs 3(10/L;Pn0.001)and platelets 86 vs 85(×10/L;P0.001).The end treatment responders were 18 vs 12(60%vs>44%)and the non responders were 12 vs 15(40%vs<50%)[odds ratio(OR)1.65,n5%CI =0.65-5.37,P<0.05?.In group A compared to group B there was a significant improvement of sustained vi-rological response in 15 vs 7 patients(50%vs>25%),while the relapsers were 3 vs 5(10%vs<18%)(OR>3.57,n5%CI=0.65-1n.3,Pn0.001).CONCLUSION:L-carnitine supplementations modulate erythropoiesis,leucopoiesis and thrombocytopoiesis,and may be useful in patients treated for HCV.L-carni-tine treatment offers the possibility of achieving a sustained virological response while preventing overtreatment. | Michele Malaguarnera Marco Vacante Maria Giordano Massimo Motta Gaetano Bertino Manuela Pennisi Sergio Neri Mariano Malaguarnera Giovanni Li Volti Fabio Galvano | 2011 | World Journal of Gastroenterology2011，17，39： | 4 |
| 8 | Safety and feasibility of thullium laser transurethral resection of prostate for the treatment of benign prostatic enlargement in overweight patients显示文摘Objective:We aimed to determine safety and feasibility of thulium laser transurethral vapoenucleation of prostate(ThuVEP)for treatment of obese patients affected by benign prostatic hyperplasia(BPH).Methods:We retrospectively analysed data of 452 patients with BPH who underwent ThuVEP from February 2012 to March 2016 in a single center.Patients were divided into three groups according to body mass index(BMI,kg/m^2):Normal weight(18.5≤BMI<25;Group A),overweight(25≤BMI<30;Group B)and obese(BMI≤30;Group C),for a total of 412 patients evaluable for this study.Preoperative total serum prostate-specific antigen(PSA),digital rectal examination of the prostate,transrectal ultrasound(TRUS),renal ultrasound,urine culture,uroflowmetry,International Prostate Symptoms Score(IPSS),and Quality of Life(QoL)score were analyzed.Post-operative complications,hospital stay and days of catheterization,questionnaires and uroflowmetry at 1 and 3 months after surgery were evaluated.Preoperative data,surgical outcomes,complication rate and clinical outcomes were compared between groups.Results:The median age of patients was 69 years(Interquartile Range[IQR 10]).The preoperative median IPSS among groups was 19(IQR 8.75),20(IQR 10),and 18(IQR 10)respectively.At 1 and 3 months of follow-up,this value was 8(IQR 7),8(IQR 4),7(IQR 5)and 5(IQR 6.25),5(IQR 6),6(IQR 5),respectively(all p between groups>0.05).There was no statistically significant difference among three groups as for hospital stay and days of catheterization(p>0.05).Conclusion:Our results showed that ThuVEP was safe and feasible even in overweight patients with substantially enlarged prostate. | Luca Carmignani Maria Chiara Clementi Claudia Signorini Gloria Motta Sebastiano Nazzani Franco Palmisano Elisa De Lorenzis Michele Catellani Alessandro Francesco Mistretta Andrea Conti Valeria Tringali Maria Beatrice Costa Damiano Vizziello | 2019 | Asian Journal of Urology2019，6，3： | 3 |
| 9 | Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases显示文摘 | Yoji Kishi MD Daria Zorzi MD Carlo M. Contreras MD Dipen M. Maru MD Scott Kopetz MD Dario Ribero MD Manuela Motta MD Nicoletta Ravarino MD Mauro Risio MD Steven A. Curley MD Eddie K. Abdalla MD Lorenzo Capussotti MD Jean-Nicolas Vauthey MD | 2010 | Annals of Surgical Oncology2010，，11： | 3 |
| 10 | Endozepine-4 levels are increased in hepatic coma显示文摘AIM:To evaluate the serum levels of endozepine-4,their relation with ammonia serum levels,the grading of coma and the severity of cirrhosis,in patients with hepatic coma. METHODS:In this study we included 20 subjects with Hepatic coma,20 subjects with minimal hepatic encephalopathy(MHE) and 20 subjects control. All subjects underwent blood analysis,Child Pugh and Model for End- stage liver disease(MELD) assessment,endozepine-4 analysis. RESULTS:Subjects with hepatic coma showed significant difference in endozepine-4(P < 0.001) and NH3 levels(P < 0.001) compared both to MHE and controls patients. Between NH3 and endozepine-4 we observed a significant correlation(P = 0.009; Pearson correlation 0.570). There was a significant correlation between endozepine-4 and MELD(P = 0.017; Pearsoncorrelation = 0.529). In our study blood ammonia concentration was noted to be raised in patients with hepatic coma,with the highest ammonia levels being found in those who were comatose. We also found a high correlation between endozepine-4 and ammonia(P < 0.001). In patients with grade Ⅳ hepatic coma,endozepine levels were significantly higher compared to other groups. CONCLUSION:This study suggests that an increased level of endozepine in subjects with higher levels of MELD was observed. In conclusion,data concerning involvement of the GABA-ergic system in HE coma could be explained by stage-specific alterations. | Giulia Malaguarnera Marco Vacante Filippo Drago Gaetano Bertino Massimo Motta Maria Giordano Michele Malaguarnera | 2015 | World Journal of Gastroenterology2015，21，30： | 2 |
| 11 | Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function显示文摘 | Piero Pingitore Carlo Pirazzi Rosellina M. Mancina Benedetta M. Motta Cesare Indiveri Arturo Pujia Tiziana Montalcini Kristina Hedfalk Stefano Romeo | 2013 | BBA - Molecular and Cell Biology of Lipids2013，，： | 2 |
| 12 | Cooperative R&D and vertical product differentiation显示文摘 | Motta M | 1992 | International Journal of Industrial Organization1992，10，4： | 1 |
| 13 | Multinationals without advantages 显示文摘 | Fosfuri A Motta M | 1999 | Scandinavian Journal of Economics1999，101，： | 1 |
| 14 | Foreign direct investment and spillovers through workers' mobility显示文摘 | FOSFURI A MOTTA M RONDE T | 2001 | Journal of International Economics2001，53，1： | 1 |
| 15 | Research on fatigue cracking growth parameters in asphaltic mixtures using computed tomography显示文摘 | D Braz R T Lopes L M G Motta | 2004 | Nclear Instruments and Methods in Physics Research B 2132004，，： | 1 |
| 16 | Sirt1 regulates insulin secretion by repressing UCP 2 in pancreatic beta cells显示文摘 | Bordone L Motta MC Picard F | 2006 | PLoS Biol2006，4，2： | 1 |
| 17 | Prostasome inhibit the nadph oxidase activity of human neutrophils显示文摘 | Saez F Motta C | 2000 | Molecular human reproduction2000，6，： | 1 |
| 18 | Outgrowth endothelial cells isolated and expanded from human peripheral blood progenitor cells as a potential source of autologous cells for endothelialization of silk fibroin biomaterials显示文摘 | FUNCHS S MOTTA A MIGLIARESI C | 2006 | Biomaterials2006，27，31： | 1 |
| 19 | Correlative,experimental,and comparative evolutionary approaches in ecomorphology显示文摘 | Motta P J Kotrschal K M | 1992 | Neth J Zool1992，42，： | 1 |
| 20 | Q-switched alexandrite laser-assisted treatment of melasma: 2-year follow-up monitoring 显示文摘 | Rusciani A Motta A Rusciani L | 2005 | J Drugs Dermatol2005，4，6： | 1 |
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