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| 1 | Evidence based medicine and surgical approaches for colon cancer: Evidences, benefits and limitations of the laparoscopic vs open resection显示文摘AIM:To report a meta-analysis of the studies that compared the laparoscopic with the open approach for colon cancer resection.METHODS:Forty-seven manuscripts were reviewed,33 of which employed for meta-analysis according to the PRISMA guidelines.The results were differentiated according to the study design(prospective randomized trials vs case-control series)and according to the tu-mor’s location.Outcome measures included:(1)shortterm results(operating times,blood losses,bowel function recovery,post-operative pain,return to the oral intake,complications and hospital stay);(2)oncological adequateness(number of nodes harvested in the surgical specimens);and(3)long-term results(including the survivals’rates and incidence of incisional hernias)and(4)costs.RESULTS:Meta-analysis of trials provided evidences in support of the laparoscopic procedures for a several short-term outcomes including:a lower blood loss,an earlier recovery of the bowel function,an earlier return to the oral intake,a shorter hospital stay and a lower morbidity rate.Opposite the operating time has been confirmed shorter in open surgery.The same trend has been reported investigating case-control series and cancer by sites,even though there are some concerns regarding the power of the studies in this latter field due to the small number of trials and the small sample of patients enrolled.The two approaches were comparable regarding the mean number of nodes harvested and long-term results,even though these variables were documented reviewing the literature but were not computable for meta-analysis.The analysis of the costs documented lower costs for the open surgery,however just few studies investigated the incidence of postoperative hernias.CONCLUSION:Laparoscopy is superior for the majority of short-term results.Future studies should better differentiate these approaches on the basis of tumors’location and the post-operative hernias. | Laura Lorenzon Marco La Torre Vincenzo Ziparo Francesco Montebelli Paolo Mercantini Genoveffa Balducci Mario Ferri | 2014 | World Journal of Gastroenterology2014，20，13： | 8 |
| 2 | Survival after radiotherapy in gastric cancer: Systematic review and meta-analysis显示文摘 | Vincenzo Valentini Francesco Cellini Bruce D. Minsky Gian Carlo Mattiucci Mario Balducci Giuseppe D’Agostino Elisa D’Angelo Nicola Dinapoli Nicola Nicolotti Chiara Valentini Giuseppe La Torre | 2009 | Radiotherapy and Oncology2009，，2： | 4 |
| 3 | Hypofractionated and Low Dose Radiotherapy Combined with Temozolomide in Naive Unresectable Glioblastoma:A Pilot Study显示文摘Background/Aim: To assess safety of hypo-fractionated radiotherapy( HyRT) followed by low dose radiation therapy( LD-FRT) plus Temozolomide( TMZ) in naive unresectable Glioblastoma. Methods: Patients( ECOG < 2,age > 18) undergone to biopsy or with gross residual tumor after surgery were enrolled. HyRT( 30 Gy in ten fraction) plus TMZ was administered. From the second adjuvant cycle of TMZ,patients received LD-FRT( 0. 40 Gy twice daily over 5 days,every 28 days) for two cycles. The primary endpoints were safety and toxicity. Moreover we analyzed response,overall survival( OS) and progression-free survival( PFS). Results: Twenty patients were enrolled. Median dose of LD-FRT was 12 Gy. All toxicities were reversible. Four out of 20 patients had Partial Response( PR)and 6 experienced a stable disease( SD). Median OS and PFS were 14 and 11 months,respectively.Conclusions: HyRT followed by LD-FRT plus TMZ is safe and shows good clinical outcomes. A new study is ongoing. | Silvia Chiesa Milena Ferro Stefano Luzi Barbara Diletto Francesco Beghella Bartoli Nicola Dinapoli Gian Carlo Mattiucci Vincenzo Frascino Francesco Miccichè Cesare Colosimo Carmelo Anile Alessandro Olivi Vincenzo Valentini Mario Balducci | 2017 | 肿瘤预防与治疗2017，30，1： | 2 |
| 4 | Oral contra-ceptives and colorectal cancer risk:a meta-analysis显示文摘 | Fernandez E La Vecchia C Balducci A | 2001 | Br J Cancer2001，84，5： | 1 |
| 5 | All trans-retinoic acid modulates the procoagulant activity of human breast cancer cells显示文摘 | Marchetti M Russo L Balducci D | | 0，，04： | 1 |
| 6 | Death and dying: what the patient wants 显示文摘 | Balducci L | 2012 | AnnOncol2012，233，： | 1 |
| 7 | Carbons and electrolytes for ad- vanced supercapacitors 显示文摘 | Bguin F Presser V Balducci A | 2014 | Advanced Materials2014，26，： | 1 |
| 8 | Myeloid growth factors 显示文摘 | Crawford J Armitage J Balducci L | 2013 | Natl Compr Canc Netw2013，11，10： | 1 |
| 9 | Senior adult oneology clinical practice guide- lines inoneology显示文摘 | Balducci L | 2007 | Natl Compr Cane Netw2007，1，： | 1 |
| 10 | Extramammary Paget's disease:an annotated review显示文摘 | Balducci L Crawford E D Smith G F | 1988 | Cancer Invest1988，6，3： | 1 |
| 11 | Apracticalapproach to the older with cancer显示文摘 | Balducci L Extermann M | 2002 | Curr Proll Cancer2002，25，1： | 1 |
| 12 | Nongenomic effects of thy- roid hormones on the immune system cells: New targets, old play- ers 显示文摘 | De Vito P Balducci V Leone S | 2012 | Steroids2012，77，10： | 1 |
| 13 | Computer simulation study of bulk reduction and oxygen migration in CeO2-ZrO2 solid solution显示文摘 | Balducci G Kaspar J Forniasero P | 1997 | J Phys Chem1997，101，10： | 1 |
| 14 | Self-expandable metallic stents in pregnant patients with obstructing colorectal cancer显示文摘 | Virgilio E P F Salvi G Balducci | 2013 | World J Surg2013，37，9： | 1 |
| 15 | Swelling of the arcuate nerve fiber layer after internal limiting membrane peeling 显示文摘 | Clark A Balducci N Piehi F | 2012 | Retina2012，32，： | 1 |
| 16 | Geriatric oncology: challenges for the new century显示文摘 | Balducci L | 2000 | Eur J Cancer2000，36，： | 1 |
| 17 | Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein显示文摘 | Balducci C Beeg M Stravalaci M | | 0，，： | 1 |
| 18 | Biological markers for evaluation of root resorption 显示文摘 | Balducci L Ramachandra A Hao JJ | 2007 | Archives of Oral Biology2007，52，3： | 1 |
| 19 | Distribution of electrically active detects in chemical vapor deposition diamond: model and measurement显示文摘 | Balducci A Marinelli M Milani E | 2005 | Appl Phys Lett2005，86，02： | 1 |
| 20 | A WebGIS for the dissemination of information on historical landslides and floods in Umbria, Italy显示文摘 | Paola Salvati Vinicio Balducci Cinzia Bianchi | 2009 | Geoinformatica2009，13，： | 1 |
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