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| 1 | Characteristics and prognosis of synchronous multiple early gastric cancer显示文摘AIM:To assess the clinicopathologic characteristics,risk factors,and prognosis for synchronous multiple early gastric cancer(SMGC).METHODS:A total of 146 patients with SMGC and1194 patients with single gastric cancer who had undergone gastrectomy between 1989 and 2008 were retrospectively analyzed to determine their clinicopathologic characteristics and postoperative survival.Tumors were classified into groups on the basis of location and histology.Smoking habits were evaluated using the Brinkman index.Clinical and pathological factors were compared using either Fisher’s exact test or Pearson’sχ2test.Logistic regression analysis was performed to identify independent risk factors.Survival rate was calculated using the Kaplan-Meier method.RESULTS:SMGCs accounted for 10.9%of gastric cancer cases and occurred predominantly in elderly male patients with a family history of gastric cancer who were both smokers and drinkers.These tumors were typically macroscopically elevated and histologically differentiated.There were no significant differences between SMGC and single gastric cancer patients with respect to tumor location,tumor size,lymph node metastasis,the number of metastatic lymph nodes,venous invasion,or tumor stage(P=0.052,P=0.347,P=0.595,P=0.805,P=0.559,and P=0.408,respectively).Further,there was no significant difference in postoperative survival between the patient groups(P=0.200).Of the 146SMGC patients,a single patient had remnant cancer.CONCLUSION:A careful preoperative endoscopy is necessary for patients who are at high risk of SMGC,and minimally invasive treatment may be indicated in some cases. | Taro Isobe Kousuke Hashimoto Junya Kizaki Naotaka Murakami Keishiro Aoyagi Kikuo Koufuji Yoshito Akagi Kazuo Shirouzu | 2013 | World Journal of Gastroenterology2013，19，41： | 17 |
| 2 | Molecular targeting therapy using bevacizumab for peritoneal metastasis from gastric cancer显示文摘AIM: To clarify the significance of vascular endothelial growth factor(VEGF) in peritoneal metastasis from gastric cancer, using the gastric cancer cell line MKN-45 compared with the high potential peritoneal dissemination gastric cancer cell line MKN-45 P. METHODS: The supernatant of culture medium of MKN-45 cells or MKN-45 P cells was collected and the concentrations were measured of various cytokines, matrix metalloproteinases, growth factor and angiogenic factors, including VEGF. We performed an initial pilot study to explore whether bevacizumab, a humanized monoclonal antibody against VEGF, had any suppressive effect on the peritoneal dissemination from gastric cancer in an experimental nude mouse modelof peritoneal metastasis. RESULTS: The concentrations of interleukin-6(IL-6), IL-8, VEGF and matrix metalloproteinase-2 protein in the culture supernatant were each significantly higher than each of those for MKN-45. In the in vivo study, the volume of ascites and the mitotic index were significantly lower in the therapy group than in the nontherapy group. The survival curve of the therapy group was significantly higher than that of the non-therapy group. These results suggested that VEGF was correlated with peritoneal metastasis from gastric cancer. CONCLUSION: Findings suggested that bevacizumab for inhibiting VEGF could suppress peritoneal dissemination from gastric cancer. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Junya Kizaki Taro Isobe Kousuke Hashimoto Kazuo Shirouzu | 2013 | World Journal of Critical Care Medicine2013，2，4： | 12 |
| 3 | 从人类动脉粥样硬化斑块中所分离出微粒的细胞起源和血栓形成活性显示文摘目的:在本研究中,评价微粒的细胞起源和血栓形成的可能性。背景:人类动脉粥样硬化斑块包含有在细胞活化或凋亡时所释放的亚微粒囊泡(微粒)。方法:自26例行颈动脉内膜切除术患者的斑块和无血小板血浆中提纯微粒。流式细胞分析显示,在斑块中存在大量的微粒,而在健康的血管中则没有。结果:大多数斑块微粒源于白细胞,其中29%±5%源于巨噬细胞,15%±3%源于淋巴细胞,8%±1%源于粒细胞。 | Leroyer A.S. Isobe H. Lesèche G. C.M.Boulanger 韩瑞娟 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，3，7： | 10 |
| 4 | 血清肌钙蛋白T对判断肺栓塞预后的临床意义显示文摘为探讨血清肌钙蛋白T(cTnT)对判断肺栓塞预后的临床意义,采用酶联免疫吸附分析法检测28例肺栓塞患者和28例同期非肺栓塞患者血清cTnT浓度。结果肺栓塞组患者血清cTnT浓度(0.28±0.13)ng/mL明显高于非肺栓塞组患者(0.04±0.01)ng/mL,肺栓塞组中死亡患者血清cTnT浓度(0.36±0.22)ng/mL高于非死亡患者(0.17±0.02)ng/mL(P<0.01)。测定血清cTnT对判断肺栓塞预后具有一定的临床意义。 | 陈丽君 苏彦风 Takeshi Isobe | 2009 | 宁夏医科大学学报2009，31，4： | 6 |
| 5 | Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry显示文摘 | Atsushi Nashimoto Kohei Akazawa Yoh Isobe Isao Miyashiro Hitoshi Katai Yasuhiro Kodera Shunichi Tsujitani Yasuyuki Seto Hiroshi Furukawa Ichiro Oda Hiroyuki Ono Satoshi Tanabe Michio Kaminishi | 2013 | Gastric Cancer2013，，1： | 6 |
| 6 | Cyclooxygenase 2 1195G〉A polymorphism is associated with chronic obstructive pulmonary disease in Japanese and Chinese patients显示文摘 | CHEN Li-jun XU Wang Yasuyuki Taooka Miki Ohe Hitoshi Takahashi Akihisa Sutani Takashige Kuraki Takeshi Isobe | 2013 | Chinese Medical Journal2013，，12： | 5 |
| 7 | Molecular targeting to treat gastric cancer显示文摘Trastuzumab that targets human epidermal growth factor receptor 2(HER2) protein is the only approved molecular targeting agent for treating gastric cancer in Japan and the outcomes have been favorable. However,trastuzumab is effective for only 10% to 20% of the population with gastric cancer that expresses HER2 protein. Molecular targeting therapy with bevacizumab against vascular endothelial growth factors(VEGF) and with cetuximab and panitumumab against the epidermal growth factors pathway that have been approved for treating colorectal cancer are not considered effective for treating gastric cancer according to several clinical trials. However,ramucirumab that targets VEGF receptor-2 prolonged overall survival in a large phase Ⅲ clinical trial and it might be an effective molecular targeting therapy for gastric cancer. The significance of molecular targeting therapy for gastric cancer remains controversial. A large-scale randomized clinical trial of novel molecular targeting agents with which to treat gastric cancer is needed. | Keishiro Aoyagi Kikuo Kouhuji Junya Kizaki Taro Isobe Kousuke Hashimoto Kazuo Shirouzu | 2014 | World Journal of Gastroenterology2014，20，38： | 5 |
| 8 | 三相IGBT逆变器中的尖峰电压分析显示文摘母线排的杂散电感和开关过程中较大的di/dt会在IGBT上引起很高的尖峰电压,从而增加了逆变器的开关损耗,降低了可靠性。提出针对三相IGBT逆变器中尖峰电压的分析方法。首先利用有限元法对三相IGBT逆变器中两种不同类型母线排建模,分析提取母线排的杂散参数,接着在PSpice中建立逆变器各部分等效电路模型,利用该模型对IGBT逆变器中的尖峰电压进行仿真分析。实验研究表明,在不同负载电流下,仿真和实测尖峰电压在峰值和波形上都具有良好的符合度,表明该方法能够较准确地分析和预测逆变器中的尖峰电压。 | 郭犇 李思奇 蒋晓华 Shinichi Isobe | 2010 | 电力电子技术2010，44，10： | 5 |
| 9 | Gastric cancer treated in 1991 in Japan: data analysis of nationwide registry显示文摘 | Keiichi Maruyama Michio Kaminishi Ken-ichi Hayashi Yoh Isobe Ichiro Honda Hitoshi Katai Kuniyoshi Arai Yasuhiro Kodera Atsushi Nashimoto | 2006 | Gastric Cancer2006，，2： | 2 |
| 10 | Formation of gas hydrate or ice by direct-contact evaporation of CFC alternatives 显示文摘 | Isobe F Mori Y H | 1992 | Int J Refrig1992，15，3： | 2 |
| 11 | Stereocontrolled radical polymerization of acrylamides and methacrylamides using Lewis acids显示文摘 | Shigeki Habaue Yutaka Isobe Yoshio Okamoto | 2002 | Tetrahedron2002，，41： | 2 |
| 12 | Architecture of baked breads depicted by a magnetic resonance imaging显示文摘 | Nobuaki Ishida Hiroyuki Takano Shigehiro Naito Seiichiro Isobe Kunihiko Uemura Tomoyuki Haishi Katsumi Kose Mika Koizumi Hiromi Kano | 2001 | Magnetic Resonance Imaging2001，，6： | 2 |
| 13 | Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?显示文摘 | Dario Siniscalco Anna Sapone Alessandra Cirillo Catia Giordano Sabatino Maione Nicola Antonucci Ken-ichi Isobe | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 2 |
| 14 | Characteristics and prognosis of gastric cancer in young patients显示文摘 | Taro Isobe Kousuke Hashimoto Junya Kizaki Motoshi Miyagi Keishiro Aoyagi Kikuo Koufuji Kazuo Shirouzu | 2013 | Oncology Reports2013，，1： | 2 |
| 15 | Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer显示文摘 | Kousuke Hashimoto Keishiro Aoyagi Taro Isobe Kikuo Kouhuji Kazuo Shirouzu | 2014 | Gastric Cancer2014，，1： | 2 |
| 16 | Gene transfer of TNF receptor for treatment of cancer by TNF显示文摘 | Fan Z H Emi N | 1994 | Biochem and Biophy Res Commmuni1994，202，： | 1 |
| 17 | Preparation of ultrafine Fe304 particles by precipitation in the presence of PVA at high pH 显示文摘 | Lee J Isobe T Senna M | 1996 | J Colloid Interface Sei1996，177，2： | 1 |
| 18 | Improvement of idiopathic thrombocytopenic purpura by antithyr therapy显示文摘 | SUGIMOTO K SASAKI M ISOBE Y et a1 | 2005 | Eur J Haematol2005，74，1： | 1 |
| 19 | Preparation and properties of Al2O3-Ni composite from NiAl2O4 spinel by in situ reaction sintering method显示文摘 | Toshihiro Isobe Keiji Daimon Kazunori Ito etc | 2006 | Ceramics International2006，，2430： | 1 |
| 20 | Pituitary adenylate cyclase-activating polypeptide induces gene expression of the catecholamine synthesizing enzymes,tyrosine hydroxylase and dopamine beta hydroxylase,through 3,5-cyclic adenosine monophosphate-and protein kinase C-dependent mechanisms in cultured porcine adrenal medullary chromaffin cells显示文摘 | Isobe K Yukimasa N Nakai T | 1996 | Neuropeptides1996，30，11： | 1 |
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