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| 1 | Discovery and Significance of High CH_4 Primary Fluid Inclusions in Reservoir Volcanic Rocks of the Songliao Basin,NE China显示文摘Comparing compositions of the fluid inclusions in volcanic rocks to the contents and isotopes of the gases in corresponding volcanic reservoirs using microthermometry, Raman microspectroscopy and mass spectrum analysis, we found that: (1) up to 82 mole% methane exists in the primary inclusions hosted in the reservoir volcanic rocks; (2) high CH4 inclusions recognized in the volcanic rocks correspond to CH4-bearing CO2 reservoirs that are rich in helium and with a high 3He/4He ratio and which show reversed order of δ 13C in alkane; (3) in gas reservoirs of such abiotic methane (>80%) and a mix of CH4 and CO2, the enclosed content of CH4 in the volcanic inclusions is usually below 42 mole%, and the reversed order of δ 13C in alkane is sometimes irregular in the corresponding gas pools; (4) a glassy inclusion with a homogeneous temperature over 900°C also contains a small portion of CH4 although predominantly CO2. This affinity between gas pool and content of inclusion in the same volcanic reservoirs demonstrates that magma-originated gases, both CH4 and CO2, have contributed significantly to the corresponding gas pools and that the assumed hydrocarbon budget of the bulk earth might be much larger than conventionally supposed. | WANG Pujun HOU Qijun WANG Keyong CHEN Shumin CHENG Rihui LIU Wanzhu LI Quanlin | 2007 | Acta Geologica Sinica(English Edition)2007，81，1： | 14 |
| 2 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 3 | Microvessel changes in the gerbil hippocampus after cerebral ischemia and reperfusion by Buyang Huanwu decoction pretreatment显示文摘Buyang Huanwu decoction(BYHWD) is a classic recipe for the prevention and treatment of ischemic cerebrovascular disease.Gerbils were pretreated with BYHWD,and then subjected to cerebral ischemia and reperfusion.Microvascular changes were determined with laser Doppler monitoring,tannic acid-ferric chloride mordant,and electron microscopy.Results showed that BYHWD pretreatment could enhance the function of hippocampal microvessels,prevent injury,and increase microvasular density and microvasular area density.Thus,these results suggest that BYHWD pretreatment could prevent microvascular occlusion,enhance the capacity of microvascular reperfusion,increase cerebral blood flow,and inhibit neuronal damage,and may be an effective therapy against brain ischemic injury. | Xiaoguang Wu Yixue Li Haixia Liu Yuhua Yin Shumin Zhao Yuanyuan Guo | 2011 | Neural Regeneration Research2011，6，9： | 11 |
| 4 | Microglial migration mediated by ATP-induced ATP release from lysosomes显示文摘Microglia 是在中央神经系统充当活跃有免疫力的防卫的主要形式的高度能动的房间。由免除损坏房间的因素吸引了, microglia 向损坏或感染的地点被招募,在他们涉及退化、再生的回答和房间碎片的 phagocytotic 清理的地方。从损坏神经纸巾的 ATP 版本被建议了调停向损害的地点的 microglial 过程的快速的延期。然而, microglia 的远程的迁居的机制尚待被澄清。这里,我们发现在 microglia 的 lysosomes 响应各种各样的刺激包含丰富的 ATP 和展览 Ca 2+-dependent exocytosis。由建立一在 vitro 趋化性试金有效,我们证明从 microglia 的 释放endogenously 的 ATP 由 ATPγ 的本地 microinjection 被触发; S 为 microglia 的远程的趋化性是批评的,显著地在与导致 lysosome osmodialysis 的一个代理人或在房间对待的 microglia 被禁止的回答源于在 Rab 27a (灰老鼠)缺乏的老鼠,为能分泌的 lysosomes 的 trafficking 和 exocytosis 要求的小 GTPase 。这些结果建议 microglia 由通过 lysosomal exocytosis 自己释放 ATP 对细胞外的 ATP 作出回应,从而提供积极反馈机制为吸引远 microglia 移居向并且在损害的地点积累产生一个远程的细胞外的信号。 | Ying Dou Hang-jun wu Hui-quan Li Song Qin Yin-er Wang Jing Li Hui-fang LOU Zhong Chew Xiao-ming Li Qing-ming Luo Shumin Duan | 2012 | Cell Research2012，22，6： | 10 |
| 5 | Protein microarrays for systems biology显示文摘系统生物学为在系统水平上理解生物系统拿钥匙。它最后为象癌症,糖尿病,肥胖,心理混乱,和许多其它那样的复杂疾病的治疗和痊愈拿钥匙。-omics' 技术例如 genomics, transcriptomics, proteomics,和 metabonomics,在系统生物学的主要驱动力之中。是展示了高产量,使小型化,并且能够平行分析,蛋白质 microarrays 已经为系统成为了一个重要技术平台生物学。在这评论,我们将用蛋白质 microarrays 集中于系统水平或生物系统的全球分析。蛋白质 microarrays 的四种主要类型将被讨论:proteome microarrays,抗体 microarrays,反向阶段的蛋白质数组,和 lectin microarrays。我们将也为系统生物学讨论挑战和蛋白质 microarray 技术和他们的应用的未来方向。我们强烈相信蛋白质 microarrays 将很快为系统生物学成为一个不可缺少、无价的工具。 | Lina Yang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 9 |
| 6 | Variation in cis-regulation of a NAC transcription factor contributes to drought tolerance in wheat显示文摘Drought is a major environmental factor limiting wheat production worldwide,and developing drought-tolerant cultivars is a central challenge for wheat breeders globally.Therefore,it is important to identify genetic components determining drought tolerance in wheat.In this study,we identified a wheat NAC gene(TaNAC071-A)that is tightly associated with drought tolerance by a genome-wide association study.Knockdown of TaNAC071-A in wheat attenuated plant drought tolerance,whereas its overexpression significantly enhanced drought tolerance through improved water-use efficiency and increased expression of stress-responsive genes.This heightened water-saving mechanism mitigated the yield loss caused by water deficit.Further candidate gene association analysis showed that a 108-bp insertion in the promoter of TaNAC071-A alters its expression level and contributes to variation in drought tolerance among wheat accessions.This insertion contains two MYB cis-regulatory elements(CREs)that can be directly bound by the MYB transcription activator,TaMYBL1,thereby leading to increased TaNAC071-A expression and plant drought tolerance.Importantly,introgression of this 108-bp insertion allele,TaNAC071-AIn-693,into drought-sensitive cultivars could improve their drought tolerance,demonstrating that it is a valuable genetic resource for wheat breeding.Taken together,our findings highlight a major breakthrough in determining the genetic basis underlying phenotypic variation in wheat drought tolerance and showcase the potential of exploiting CRE-containing indels for improving important agronomical traits. | Hude Mao Shumin Li Bin Chen Chao Jian Fangming Mei Yifang Zhang Fangfang Li Nan Chen Tian Li Linying Du Li Ding Zhongxue Wang Xinxiu Cheng Xiaojing Wang Zhensheng Kang | 2022 | Molecular Plant2022，15，2： | 9 |
| 7 | Pathogen Spectrum of Hand,Foot,and Mouth Disease Based on Laboratory Surveillance—China,2018显示文摘What is already known about this topic?Enterovirus 71(EV-A71)is the main causative pathogen for severe and fatal patients with Hand,Foot,and Mouth Disease(HFMD)in China's Mainland from 2008 to 2017.Non-EV-A71 and non-CV-A16(other enterovirus)serotypes were the major causativeserotypes for mild HFMD in years of 2013,2015,and 2017.What is added by this report?In 2018,other enterovirus serotypes replaced EV-A71 for the first time as the major cause of severe HFMD with a proportion of 70.7%.However,at the national level,only a small proportion of the other enterovirus serotypes were further identified as CV-A6 and CVA10.What are the limitations for public health practice?Further identification of other enterovirus serotypes is highly recommended for provincial CDCs,especially for severe HFMD.Studies contributing to a multivalent vaccine for HFMD should be prioritized. | Fengfeng Liu Minrui Ren Shumin Chen Taoran Nie Jinzhao Cui Lu Ran Zhongjie Li Zhaorui Chang | 2020 | China CDC weekly2020，2，11： | 8 |
| 8 | Mammalian ALKBH1 serves as an N^6-mA demethylase of unpairing DNA显示文摘N^6-methyladenine(N^6-mA)of DNA is an emerging epigenetic mark in mammalian genome.Levels of N^6-mA undergo drastic fluctuation during early embryogenesis,indicative of active regulation.Here we show that the 2-oxoglutarate-dependent oxygenase ALKBH1 functions as a nuclear eraser of N^6-mA in unpairing regions(e.g.,SIDD,Stress-Induced DNA Double Helix Destabilization regions)of mammalian genomes.Enzymatic profiling studies revealed that ALKBH1 prefers bubbled or bulged DNAs as substrate,instead of single-stranded(ss-)or double-stranded(ds-)DNAs.Structural studies of ALKBH1 revealed an unexpected“stretch-out”conformation of its“Flip1”motif,a conserved element that usually bends over catalytic center to facilitate substrate base flipping in other DNA demethylases.Thus,lack of a bending“Flip1”explains the observed preference of ALKBH1 for unpairing substrates,in which the flipped N^6-mA is primed for catalysis.Co-crystal structural studies of ALKBH1 bound to a 21-mer bulged DNA explained the need of both flanking duplexes and a flipped base for recognition and catalysis.Key elements(e.g.,an ALKBH1-specificα1 helix)as well as residues contributing to structural integrity and catalytic activity were validated by structurebased mutagenesis studies.Furthermore,ssDNA-seq and DIP-seq analyses revealed significant co-occurrence of base unpairing regions with N^6-mA in mouse genome.Collectively,our biochemical,structural and genomic studies suggest that ALKBH1 is an important DNA demethylase that regulates genome N^6-mA turnover of unpairing regions associated with dynamic chromosome regulation. | Min Zhang Shumin Yang Raman Nelakanti Wentao Zhao Gaochao Liu Zheng Li Xiaohui Liu Tao Wu Andrew Xiao Haitao Li | 2020 | Cell Research2020，30，3： | 6 |
| 9 | Arbitrary polarization conversion dichroism metasurfaces for all-in-one full Poincare sphere polarizers显示文摘The control of polarization,an essential property of light,is of broad scientific and technological interest.Polarizers are indispensable optical elements for direct polarization generation.However,arbitrary polarization generation,except that of common linear and circular polarization,relies heavily on bulky optical components such as cascading linear polarizers and waveplates.Here,we present an effective strategy for designing all-in-one full Poincare sphere polarizers based on perfect arbitrary polarization conversion dichroism and implement it in a monolayer all-dielectric metasurface.This strategy allows preferential transmission and conversion of one polarization state located at an arbitrary position on the Poincare sphere to its handedness-flipped state while completely blocking its orthogonal state.In contrast to previous methods that were limited to only linear or circular polarization,our method manifests perfect dichroism of nearly 100%in theory and greater than 90%experimentally for arbitrary polarization states.By leveraging this attractive dichroism,our demonstration of the generation of polarization beams located at an arbitrary position on a Poincare sphere directly from unpolarized light can substantially extend the scope of meta-optics and dramatically promote state-of-the-art nanophotonic devices. | Shuai Wang Zi-Lan Deng Yujie Wang Qingbin Zhou Xiaolei Wang Yaoyu Cao Bai-Ou Guan Shumin Xiao Xiangping Li | 2021 | Light(Science & Applications)2021，10，2： | 6 |
| 10 | Subaquatic volcanic eruptions in continental facies and their influence on high quality source rocks shown by the volcanic rocks of a faulted depression in Northeast China显示文摘This paper reports the analysis on cores and rock slices,data on seismic and logging activities,characteristics of core samples,and the paleogeographic background of the Yingcheng Formation of the Xujiaweizi faulted depression in the Songliao Basin.The results show that some of the volcanic rocks were formed during subaquatic eruptions.These subaqueous volcanic rocks are further characterized by the interbedded black mudstone and tuffite,the presence of double-layer perlite enclosing aphyric or sparsely phyric rhyolite,the presence of a bentonite layer,and the coefficient of oxidation(Fe2O3/FeO).The types of rocks are volcanic breccia,lava breccias,perlite,rhyolite,tuff and sedimentary tuff.The subaquatic eruptions are distributed mainly in Wangjiatun,Shengping,Xuxi,Xuzhong,and Xudong.The XS-1 area is the most typical.The organic abundance of overburden mud rocks within the volcanic rocks of the Yingcheng Formation indicates that these rocks represent high-quality source rocks.The analysis also shows that continental subaquatic volcanic eruptions provide a rich supply of minerals and energies for the lake basin and increase the organic matter content in the water.Moreover,the water differentiation provides a good reducing environment for the conservation of organic matter,and is beneficial for the formation of high-quality source rocks.Finally,we propose a hypothesis to describe the mode of subaquatic eruptions and the formation of high-quality source rocks. | SHAN XuanLong LI JiYan CHEN ShuMin RAN QingChang CHEN GuiBiao LIU Chao | 2013 | Science China Earth Sciences2013，56，11： | 6 |
| 11 | Adaptive dynamic surface control for air-breathing hypersonic vehicle显示文摘This paper describes an adaptive control approach for an air-breathing hypersonic vehicle.The control objective is to provide robust altitudes and velocity tracking in the presence of model uncertainties and varying disturbances.A fuzzy-neural disturbance observer is developed to estimate uncertainties and disturbances,and the adaptive controller is synthesized by the dynamic surface approach combing with the observer.The tracking error at the steady state can be guaranteed to converge to inside of a small residue set which the size of the set can be an arbitrary small value.Simulation results demonstrate the effectiveness of the presented approach. | Li Zhou Shumin Fei | 2013 | Journal of Systems Engineering and Electronics2013，24，3： | 6 |
| 12 | Synthesis of Mg-based composite material with in-situ formed LaH_3 and its hydrogen storage characteristics显示文摘In this work,a Mg-based composite material with in-situ formed LaH3, Mg_2 NiH_4-LiBH_4 + 20 wt% LaH3,was prepared by ball milling LiBH_4 and hydrogenated LaMg_2 Ni and Mg_2 Ni powder mixture, followed by heat treatment at 573 K. The onset dehydrogenation temperature of the composite is reduced by 50 K compared with that of Mg_2 NiH_4-LiBH_4. The LaH3-doped composite shows faster kinetics,absorbing1.43 wt% hydrogen within 100 s at 423 K,which is 6.5 times faster than Mg_2 NiH_4-LiBH4. Moreover,the composite releases 1.24 wt% hydrogen within 500 s at 573 K,0.69 wt% higher than Mg_2 NiH_4-LiBH_4. The activation energy of the composite is reduced by 8.2 and 80 kJ/mol compared with that of Mg_2 NiH_4-LiBH_4 and commercial MgH_2, respectively. The improvement in hydrogen storage properties is attributed to the fact that LaH_3 promotes the generation of nano-sized spongy Mg structure, which has good catalytic activity during the subsequent hydrogenation/dehydrogenation process. | Jiasheng Wang Yuan Li Ting Liu DANDan Peng Shumin Han | 2018 | Journal of Rare Earths2018，36，7： | 5 |
| 13 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 14 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 15 | Differentiation of neuron-like cells from mouse parthenogenetic embryonic stem cells显示文摘Parthenogenetic embryonic stem cells have pluripotent differentiation potentials,akin to fertilized embryo-derived embryonic stem cells.The aim of this study was to compare the neuronal differentiation potential of parthenogenetic and fertilized embryo-derived embryonic stem cells.Before differentiation,karyotype analysis was performed,with normal karyotypes detected in both parthenogenetic and fertilized embryo-derived embryonic stem cells.Sex chromosomes were identified as XX.Immunocytochemistry and quantitative real-time PCR detected high expression of the pluripotent gene,Oct4,at both the mRNA and protein levels,indicating pluripotent differentiation potential of the two embryonic stem cell subtypes.Embryonic stem cells were induced with retinoic acid to form embryoid bodies,and then dispersed into single cells.Single cells were differentiated in N2 differentiation medium for 9 days.Immunocytochemistry showed parthenogenetic and fertilized embryo-derived embryonic stem cells both express the neuronal cell markers nestin,βIII-tubulin and myelin basic protein.Quantitative real-time PCR found expression of neurogenesis related genes(Sox-1,Nestin,GABA,Pax6,Zic5 and Pitx1) in both types of embryonic stem cells,and Oct4 expression was significantly decreased.Nestin and Pax6 expression in parthenogenetic embryonic stem cells was significantly higher than that in fertilized embryo-derived embryonic stem cells.Thus,our experimental findings indicate that parthenogenetic embryonic stem cells have stronger neuronal differentiation potential than fertilized embryo-derived embryonic stem cells. | Xingrong Yan Yanhong Yang Wei Liu Wenxin Geng Huichong Du Jihong Cui Xin Xie Jinlian Hua Shumin Yu Liwen Li Fulin Chen | 2013 | Neural Regeneration Research2013，8，4： | 4 |
| 16 | Phase structure and hydrogen storage properties of LaMg_(3.70)Ni_(1.18) alloy显示文摘The phase structure and hydrogen storage properties of LaMg 3.70 Ni 1.18 alloy were investigated. The LaMg 3.70 Ni 1.18 alloy consists of main LaMg 2 Ni phase, minor La 2 Mg 17 and LaMg 3 phases. The alloy can be activated in the first hydriding/dehydriding process, and initial LaMg 2 Ni, La 2 Mg 17 , and LaMg 3 phases transfer to LaH 2.34 , Mg, and Mg 2 Ni phases after activation. The reversible hydrogen storage capacity of the LaMg 3.70 Ni 1.18 alloy is 2.47 wt.% at 558 K, which is higher than that of the LaMg 2 Ni alloy. The pressure-composition-temperature (PCT) curves display two hydriding plateaus, corresponding to the formation of MgH 2 and Mg 2 NiH 4 . However, only one dehydriding plateau is observed, owing to the synergetic effect of hydrogen desorption between MgH 2 and Mg 2 NiH 4 . The uptake time for hydrogen content to reach 99% of saturated state is less than 250 s, and 90% hydrogen can be released in 1200 s in the experimental conditions, showing fast kinetics in hydriding and dehydriding. The activation energies of the LaMg 3.70 Ni 1.18 alloy are -51.5 ± 1.1 kJ/mol and -57.0 ± 0.6 kJ/mol for hydriding and dehydriding, respectively. The hydriding/dehydriding kinetics of the LaMg 3.70 Ni 1.18 alloy is better than that of the Mg 2 Ni alloy, owing to the lower activation energy values. | LI Jinhua LIU Baozhong HAN Shumin HU Lin ZHAO Xin WANG Mingzhi | 2011 | Rare Metals2011，30，5： | 4 |
| 17 | Removal of p-Nitrophenol Using Persulfate Activated by Biochars Prepared from Different Biomass Materials显示文摘 | SHI Chenfei LI Yumeng FENG Haiyao JIA Shumin XUE Ruijie LI Gang WANG Guoxiang | 2018 | Chemical Research in Chinese Universities2018，34，1： | 4 |
| 18 | Rabdosia serra alleviates dextran sulfate sodium salt-induced colitis in mice through anti-inflammation,regulating Th17/Treg balance,maintaining intestinal barrier integrity,and modulating gut microbiota显示文摘Rabdosia serra(R.serra),an important component of Chinese herbal tea,has traditionally been used to treat hepatitis,jaundice,cholecystitis,and colitis.However,the chemical composition of R.serra and its effect against colitis remain unclear.In this study,the chemical composition of the water extract of R.serra was analyzed using ultra performance liquid chromatography coupled with a hybrid linear ion trap quadrupole-orbitrap mass spectrometer(UPLC-LTQ-Orbitrap-MS).A total of 46 compounds,comprising ent-kaurane diterpenoids,flavonoids,phenolic acids,and steroids,were identified in the water extract of R.serra,and the extract could significantly alleviate dextran sulfate sodium salt-induced colitis by improving colon length,upregulating anti-inflammatory factors,downregulating proinflammatory factors,and restoring the balance of T helper 17/T regulatory cells.R.serra also preserved intestinal barrier function by increasing the level of tight junction proteins(zonula occludens 1 and occludin)in mouse colonic tissue.In addition,R.serra modulated the gut microbiota composition by increasing bacterial richness and diversity,increasing the abundance of beneficial bacteria(Muribaculaceae,Bacteroides,Lactobacillus,and Prevotellaceae_UCG-001),and decreasing the abundance of pathogenic bacteria(Turicibacter,Eubacterium_fissicatena_group,and Eubacterium_xylanophilum_group).Gut microbiota depletion by antibiotics further confirmed that R.serra alleviated colitis in a microbiota-dependent manner.Overall,our findings provide chemical and biological evidence for the potential application of R.serra in the management of colitis. | Hongyi Li Yi Wang Shumin Shao Hui Yu Deqin Wang Chuyuan Li Qin Yuan Wen Liu Jiliang Cao Xiaojuan Wang Haibiao Guo Xu Wu Shengpeng Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 4 |
| 19 | A New Understanding of Channel Patterns and Facies Models of the Shallow Lake Delta Facies of Fuyu Oil Reservoir in Songliao Basin,China显示文摘摘要:在 Songliao 盆的 Fuyu 水库,在那里发生一系列开发得好的古怪的浅湖三角洲外形,它能被划分到象上面的三角洲平原 subfacies,更低的三角洲平原 subfacies,和三角洲前面 subfacies 的如此的三。在他们之中,上面的三角洲平原 subfacies 主要种近似支流隧道;更低的三角洲平原 subfacies 主要增长远侧的。全部 Fuyu 水库主要开发了 7 种支流隧道模式:proximal/ 远侧的蜿蜒地流类型支流隧道,近似 / 远侧的低蜿蜒的类型支流隧道,近似 / 远侧的直类型支流隧道,和水下的支流隧道。在这些模式之中,近似、远侧的蜿蜒地流的类型支流隧道有点酒吧并且更好的排序和泥的低内容的更大的厚度;而且,他们是主要水库并且发生在 Quan-4th 的底部成员。水下的支流隧道的沙洲有更高的泥内容,并且用作更差的水库,并且主要发生在 Quan-4th 成员的顶。 | LI Yanping CHEN Shumin SONG Yongzhong ZHANG Erhua SHEN Jiagang ZHENG Jianbin | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 3 |
| 20 | Defensive deception framework against reconnaissance attacks in the cloud with deep reinforcement learning显示文摘Implementing defensive deception in the cloud is promising to proactively counter reconnaissance attack. This technique presents decoys to camouflage cloud assets and distracts attack resource. However,the major challenge is to develop an effective deception strategy to orchestrate digital decoys. To address this issue, we propose a deep reinforcement learning(DRL)-based defensive deception framework. First,we formulate a utility function, which mathematically models underlying threats associated with common vulnerabilities among virtual machines in the cloud. Then, we customize training interfaces and the neural networks for a DRL agent. The reward function reflects the effectiveness of asset concealment and the waste of attack resources, referring to a comprehensive defense goal. Finally, the well-trained DRL agent generates the optimal defense strategy. It specifies a more granular deception strategy than existing proposals. Simulation results show that the proposed framework leads to a 7.87% average advantage in realizing the comprehensive defense goal. Moreover, it can stably improve the concealment degree of cloud assets up to 20.58%, and increase the attack cost up to 40.40%. This study shows that it is promising to improve cloud security with deception defense and artificial intelligence techniques. | Huanruo LI Yunfei GUO Shumin HUO Hongchao HU Penghao SUN | 2022 | Science China(Information Sciences)2022，65，7： | 3 |
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