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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases显示文摘 | Carmela Rita Balistreri Calogero Caruso Giuseppina Candore Gema Frühbeck | 2010 | Mediators of Inflammation2010，，： | 1 |
| 3 | Aging,longevitg,inflammation and cancer显示文摘 | CALOGERO CARUSO Caruso | 2004 | Ann N Y Acad2004，1028，： | 1 |
| 4 | Changes of Inflammatory Mediators in Obese Patients After Laparoscopic Cholecystectomy显示文摘 | Gaetano Di Vita Rosalia Patti Fausto Famà Carmela Rita Balistreri Giuseppina Candore Calogero Caruso | 2010 | World Journal of Surgery2010，，9： | 1 |
| 5 | Interleukin-10 and interleukin-18 promoter polymorphisms in an Italian cohort of patients with undifferentiated carcinoma of nasopharyngeal type显示文摘 | Chiara Pratesi Maria Teresa Bortolin Ettore Bidoli Rosamaria Tedeschi Emanuela Vaccher Riccardo Dolcetti Massimo Guidoboni Gianni Franchin Luigi Barzan Stefania Zanussi Calogero Caruso Paolo De Paoli | 2006 | Cancer Immunology Immunotherapy2006，，1： | 1 |
| 6 | IL-10 and TNF-α polymorphisms and the recovery from HCV infection显示文摘 | Domenico Lio Calogero Caruso Rosa Di Stefano Giuseppina Colonna Romano Donatella Ferraro Letizia Scola Antonio Crivello Anna Licata L.Mario Valenza Giuseppina Candore Antonio Craxì Piero L Almasio | 2003 | Human Immunology2003，，7： | 1 |
| 7 | Involvement of ?308 TNF-α and 1267 Hsp70-2 polymorphisms and zinc status in the susceptibility of coronary artery disease (CAD) in old patients显示文摘 | Robertina Giacconi Catia Cipriano Elisa Muti Laura Costarelli Marco Malavolta Calogero Caruso Domenico Lio Eugenio Mocchegiani | 2006 | Biogerontology2006，，： | 1 |
| 8 | 一例罕见的位于网膜的胃肠道外间质瘤:PDGFRA基因14外显子双突变显示文摘Introduction Gastrointestinal stromal tumors(GISTs)are neoplasms arising from mesenchymal cells localized into the muscularis propria of the gastrointestinal(GI)tract[1];5%of GISTs are extra-GISTs(EGISTs),as they differently originate from adipose tissue adjacent to the GI tract(omentum and mesentery)or from the pancreas[2].So far,both GISTs and EGISTs have been managed indistinctively by combining surgery,histopathological distinctive features,imaging,and molecular analysis.Moreover. | Gianluca Caruso Luca Pacini Angelo Iossa Claudio Di Cristofano Daniela Bastianelli Gianfranco Silecchia Maria Mele Vincenzo Petrozza Antonella Calogero Elena De Falco | 2021 | Gastroenterology Report2021，9，4： | 0 |
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