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| 1 | Branched tetraether lipids in Chinese soils:Evaluating the fidelity of MBT/CBT proxies as paleoenvironmental proxies显示文摘The ubiquitous occurrence of branched glycerol dialkyl glycerol tetraethers(br GDGTs) in soils has allowed development of new proxies for reconstruction of past climate and environment. The methylation and cyclization degrees of br GDGTs, expressed as MBT and CBT, respectively, are reported to be mainly controlled by mean annual air temperature(MAAT) and soil p H. However, the br GDGT-derived temperatures and soil p H scatter widely when data from different environmental conditions are considered. In this study, we collected over 300 soil samples from China, which are representative of humid(Xishuangbanna, Guangzhou, and Shanghai), semi-arid(Dongying) and semi-arid/arid(Lanzhou, Tibetan Plateau) regions. Collectively we have the most extensive dataset that broadly characterizes the distribution of br GDGTs according to climate zones in China. The overall data demonstrate that the MBT/CBT derived temperatures better match the measured MAATs in humid and non-alkaline regions than those from regions of low MAP(<400 mm/yr) and above neutral soil p H(>7.0–7.5). Similarly, CBT describes soil p H much better in humid and non-alkaline soils than in semi-arid/arid and alkaline soils; the semi-arid/arid and alkaline soils tend to show a positive correlation between soil p H and CBT, which contradicts that in the humid and non-alkaline soils. While soil p H, MAAT and mean annual precipitation(MAP) are dominating factors controlling the br GDGT distribution across all climate zones, conductivity, total organic carbon and total nitrogen, as well as soil water content can also play an important role locally. Removing br GDGT-II resulted in a revised CBT index that provides more accurate estimation of p H, especially in semi-arid/arid and alkaline soils. The overall Chinese dataset demonstrates that continental air temperature derived from br GDGT-proxies can vastly deviate from real measurements and should be used with extreme caution in paleo-climate or-environment studies. | ZHENG FengFeng ZHANG ChuanLun CHEN YuFei LI FuYan MA CenLing PU Yang ZHU YuanQing WANG YongLi LIU WeiGuo | 2016 | Science China Earth Sciences2016，59，7： | 10 |
| 2 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 3 | Pathogen Spectrum of Hand,Foot,and Mouth Disease Based on Laboratory Surveillance—China,2018显示文摘What is already known about this topic?Enterovirus 71(EV-A71)is the main causative pathogen for severe and fatal patients with Hand,Foot,and Mouth Disease(HFMD)in China's Mainland from 2008 to 2017.Non-EV-A71 and non-CV-A16(other enterovirus)serotypes were the major causativeserotypes for mild HFMD in years of 2013,2015,and 2017.What is added by this report?In 2018,other enterovirus serotypes replaced EV-A71 for the first time as the major cause of severe HFMD with a proportion of 70.7%.However,at the national level,only a small proportion of the other enterovirus serotypes were further identified as CV-A6 and CVA10.What are the limitations for public health practice?Further identification of other enterovirus serotypes is highly recommended for provincial CDCs,especially for severe HFMD.Studies contributing to a multivalent vaccine for HFMD should be prioritized. | Fengfeng Liu Minrui Ren Shumin Chen Taoran Nie Jinzhao Cui Lu Ran Zhongjie Li Zhaorui Chang | 2020 | China CDC weekly2020，2，11： | 8 |
| 4 | An investigation of the effects of dust storms on rat lung using HRCT and blood gas analysis显示文摘The increasing intensity and frequency of sand-dust storms in China has led to greater prominence of associated environmental and health issues. Many studies have focused on the health effects of air particulate contaminants, but few formal investigations have studied the effects of sand-dust storms on human and animal health. The aim of this study was to investigate the effects of dust storms on rat lung by using high resolution computed tomography(HRCT) and blood gas analysis through a wind tunnel simulating. We found that the rat lung damage effects can be detected by the HRCT imaging after exposure to sand-dust storm environments, but had no obvious result through blood gas analysis. Exposure durations positively correlated with the damage degree to lung tissue. These will provide some evidence for clinical diagnosis of non-occupational pneumoconiosis. | FengFeng Lei WanYin Luo ZhiBao Dong YingZhu Sang LiZhu Luo Gang Huang Hua Liu QiZhang Chen | 2016 | Research in Cold and Arid Regions2016，8，4： | 5 |
| 5 | Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice显示文摘The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells(OPCs) to differentiate, since OPCs and oligodendrocytelineage cells that are unable to fully differentiate are found in the areas of demyelination. Thus, promoting the differentiation of OPCs is vital for the treatment of demyelinating diseases. Shikimic acid(SA) is mainly derived from star anise, and is reported to have antiinfluenza, anti-oxidation, and anti-tumor effects. In the present study, we found that SA significantly promoted the differentiation of cultured rat OPCs without affecting their proliferation and apoptosis. In mice, SA exerted therapeutic effects on experimental autoimmune encephalomyelitis(EAE), such as alleviating clinical EAE scores, inhibiting inflammation, and reducing demyelination in the CNS. SA also promoted the differentiation of OPCs as well as their remyelination after lysolecithin-induced demyelination.Furthermore, we showed that the promotion effect of SA on OPC differentiation was associated with the up-regulation of phosphorylated m TOR. Taken together, our resultsdemonstrated that SA could act as a potential drug candidate for the treatment of demyelinating diseases. | Fengfeng Lu Dou Yin Yingyan Pu Weili Liu Zhenghao Li Qi Shao Cheng He Li Cao | 2019 | Neuroscience Bulletin2019，35，3： | 4 |
| 6 | Mechanism of the Rpn13-induced activation of Uch37显示文摘 | Lianying Jiao Songying Ouyang Neil Shaw Gaojie Song Yingang Feng Fengfeng Niu Weicheng Qiu Hongtao Zhu Li-Wei Hung Xiaobing Zuo V. Eleonora Shtykova Ping Zhu Yu-Hui Dong Ruxiang Xu Zhi-Jie Liu | 2014 | Protein & Cell2014，5，8： | 4 |
| 7 | Temperature-induced Lifshitz transition in topological insulator candidate HfTe_5显示文摘The ongoing discoveries and studies of novel topological quantum materials have become an emergent and important field of condensed matter physics.Recently,HfTe_5 ignited renewed interest as a candidate of a novel topological material.The single-layer HfTe_5 is predicted to be a two-dimensional large band gap topological insulator and can be stacked into a bulk that may host a temperature-driven topological phase transition.Historically,HfTe_5 attracted considerable interest for its anomalous transport properties characterized by a peculiar resistivity peak accompanied by a sign reversal carrier type.The origin of the transport anomaly remains under a hot debate.Here we report the first high-resolution laser-based angle-resolved photoemission measurements on the temperature-dependent electronic structure in HfTe_5.Our results indicated that a temperature-induced Lifshitz transition occurs in HfTe_5,which provides a natural understanding on the origin of the transport anomaly in HfTe_5.In addition,our observations suggest that HfTe_5 is a weak topological insulator that is located at the phase boundary between weak and strong topological insulators at very low temperature. | Yan Zhang Chenlu Wang Guodong Liu Aiji Liang Lingxiao Zhao Jianwei Huang Qiang Gao Bing Shen Jing Liu Cheng Hu Wenjuan Zhao Genfu Chen Xiaowen Jia Li Yu Lin Zhao Shaolong He Fengfeng Zhang Shenjin Zhang Feng Yang Zhimin Wang Qinjun Peng Zuyan Xu Chuangtian Chen Xingjiang Zhou | 2017 | Science Bulletin2017，62，13： | 4 |
| 8 | Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) emissions from electric arc furnaces for steelmaking显示文摘The proportion of steel produced using electric arc furnaces(EAFs)is increasing.In this study,polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs)concentrations and patterns in stack gas samples from three typical EAFs in steelmaking plants were determined to allow the contributions of EAFs in steelmaking plants to PCDD/Fs emissions in China to be assessed.Samples collection was accomplished by adopting the automatic isokinetic sampling technique,then the PCDD/Fs congeners concentrations were analyzed qualitatively and quantitatively by isotope dilution high-resolution gas chromatography high-resolution mass spectrometry(HRGC-HRMS).The mean PCDD/Fs mass concentrations in stack gases emitted during the scrap preheating phase of plants E1,E2,and E3 were 0.48,385.55,and 0.34 ng Nm^-3,respectively,and the total toxic equivalent(WHO2005-TEQ)concentrations were 0.05,33.16,and 0.03 ng Nm^-3,respectively.The PCDD/Fs mass concentration in stack gases emitted during the melting phase at plant E3 was 0.12 ng Nm^-3(0.02 ng WHO2005-TEQ Nm^-3).The operational temperature of the bag filter of the preheating in the E2 EAF was as high as 230℃,which is conducive to the generation of PCDD/Fs,whether the temperature in the bag filter of E1(150℃)and E3(120℃)are not.Moreover,the bag filter temperature is suggested to be best controlled to below 150℃.The emission factors(EF)for PCDD/Fs released into the air during the scrap preheating phase for plants E1,E2,and E3 were 0.13,52,and 0.10 mg WHO2005-TEQ t1,respectively,and the EF for the smelting phase from plant E3 was 0.14 mg WHO2005-TEQ t1.The emission factor in E2 is 5 times higher than the highest current UNEP toolkit factor for EAFs(10 mg TEQ/tonne steel).Therefore,an update for the UNEP toolkit emission factor for a few case plants is suggested.Several congeners,including 2,3,7,8-TeCDF,1,2,3,4,6,7,8-HpCDF,and 1,2,3,4,6,7,8-HpCDD,were dominant during the preheating phase,while 2,3,7,8-TeCDF,1,2,3,7,8-PeCDF,and 2,3,4,7,8-PeCDF were dominant during the smelting phase.The monitoring data from the case plants helps to better understand the PCDD/Fs emissions of EAFs using preheating process stages.However,a more complete emission inventory requires more case investigations on the PCDD/Fs emissions from representative EAFs steelmaking plants. | Qiuting Yang Lili Yang Jia Shen Yuanping Yang Minxiang Wang Xiaoyun Liu Xuejing Shen Changliang Li Jia Xu Fengfeng Li Da Li Guorui Liu Minghui Zheng | 2020 | Emerging Contaminants2020，6，1： | 3 |
| 9 | Interrogating a cell signalling network sensitively monitors cell fate transition during early differentiation of mouse embryonic stem cells显示文摘The different cell types in an animal are often considered to be specified by combinations of transcription factors,and defined by marker gene expression.This paradigm is challenged,however,in stem cell research and application.Using a mouse embryonic stem cell(mESC) culture system,here we show that the expression level of many key stem cell marker genes/transcription factors such as Oct4,Sox2 and Nanog failed to monitor cell status transition during mESC differentiation.On the other hand,the response patterns of cell signalling network to external stimuli,as monitored by the dynamics of protein phosphorylation,changed dramatically.Our results also suggest that an irreversible alternation in the cell signalling network precedes the adjustment of transcription factor levels.This is consistent with the notion that signal transduction events regulate cell fate specification.We propose that interrogating a cell signalling network can assess the cell property more precisely,and provide a sensitive measurement for the early events in cell fate transition.We wish to bring attention to the potential problem of cell identification using a few marker genes,and suggest a novel methodology to address this issue. | YUE ZhiCao ZHUANG FengFeng LIU Yi-Hsin HO Chih-ming | 2010 | Science China(Life Sciences)2010，53，1： | 3 |
| 10 | Sol-gel preparation and phosphorescence property of Mn^(2+)-doped zinc boro-silicate glass thin films显示文摘Mn2+-doped zinc borosilicate (ZBSM) glass thin films were first synthesized by sol-gel method. In the experiment, a thin gel film was depos-ited onto quartz glass substrates by dip-coating method and then heat-treated to form a Mn2+-doped zinc borosilicate glass thin film. Long lasting phosphorescence (LLP) and photo-stimulated long lasting phosphorescence (PSLLP) were found in the film sample. According to fluorescence spectra, LLP emission spectra, and PSLLP emission spectra, both LLP and PSLLP emissions are attributed to the energy level transition of 4Eg→4A1g from Mn2+. Both the phosphorescence intensity decay curves contain a fast decay component and another slow decay one. The thermoluminescence (TL) spectra show that the sample has two kinds of traps at least and their energy level values are about 0.8 eV and 1.02 eV, which could be estimated by the Randall and Willcins formula. The infrared absorption spectra (IR) consist of characteristic vi-bration bands of Si-O-Si, Si-O-Zn, B-O in [BO3], B-O group, and Zn-O in [ZnO4]. Moreover, image storage and logical operation of the ZBSM film were carried out successfully through an experiment analogues of optical storage. | LI Fengfeng ZHANG Mingxi HOU Guiqin SHEN Yi LIU Zhigang LI Hongsheng | 2011 | Rare Metals2011，30，3： | 2 |
| 11 | Community structure of picoplankton abundance and biomass in the southern Huanghai Sea during the spring and autumn of 2006显示文摘During spring and autumn of 2006,the investigations on abundance,carbon biomass and distribution of picoplankton were carried out in the southern Huanghai Sea(Yellow Sea,sHS) . Three groups of picoplankton-Synechococcus(Syn) ,Picoeukaryotes(PEuk) and heterotrophic bacteria(BAC) were identified,but Prochlorococcus(Pro) was undetected. The average abundance of Syn and PEuk was lower in spring(5.0 and 1.3 × 10 3 cells/cm 3,respectively) than in autumn(92.4 and 2.7 × 10 3 cells/cm 3,respectively) ,but it was opposite for BAC(1.3 and 0.7 × 10 6 cells/cm 3 in spring and autumn,respectively) . And the total carbon biomass of picoplankton was higher in spring(37.23 ± 11.67) mg/m 3 than in autumn(21.29 ± 13.75) mg/m 3 . The ratios of the three cell abundance were 5:1:1 341 and 30:1:124 in spring and autumn,respectively. And the ratios of carbon biomass of them were 5:7:362 and 9:4:4 in spring and autumn,respectively. Seasonal distribution characteristics of Syn,PEuk,BAC were quite different from each other. In spring,Syn abundance decreased in turn in the central waters(where phytoplankton bloom in spring occurred) ,the southern waters and inshore waters of the Shandong Peninsula(where even Syn was undetected) ;the high values of PEuk abundance appeared in the central and southern waters and the inshore of the Shandong Peninsula;the abundance of BAC was nearly three order of magnitude higher than that of photosynthetic picoplankton,and high values appeared in the central waters. In autumn,Syn abundance in central waters was higher than that in surrounding waters,while for PEuk abundance,it decreased in turn in the inshore waters of the Shandong Peninsula,the southern waters and the central waters;BAC presented a complicated blocky type distribution. Sub-surface maximum of each group of picopalnkton appeared in both spring and autumn. Compared with the available literatures concerning the studied area,the range of Syn abundance was larger,and the abundance of BAC was higher. In addition,the conversion factors for calculating picoplanktonic carbon biomass were discussed,with the conversion factors which are different from previous studies in the same surveyed waters. The result of regression analysis showed that there was distinct positive correlation between BAC and photosynthetic picoplankton in spring(r=0.61,P <0.001) ,but no correlation was found in autumn. | LE Fengfeng NING Xiuren LIU Chenggang HAO Qiang SHI Junxian | 2010 | Acta Oceanologica Sinica2010，29，1： | 2 |
| 12 | The biology of bone morphogenetic protein signaling pathway in cerebrovascular system显示文摘Bone morphogenetic protein belongs to transcription growth factor superfamilyβ;bone morphogenetic protein signal pathway regulates cell proliferation,differentiation,and apoptosis among different tissues.Cerebrovascular system supplies sufficient oxygen and blood into brain to maintain its normal function.The disorder of cerebrovascular system will result into serious cerebrovascular diseases,which is gradually becoming a major threat to human health in modern society.In recent decades,many studies have revealed the underlying biology and mechanism of bone morphogenetic protein signal pathway played in cerebrovascular system.This review will discuss the relationship between the two aspects,aiming to provide new perspective for non-invasive treatment and basic research of cerebrovascular diseases. | Haishuang Tang Xiaoxi Zhang Gaici Xue Fengfeng Xu Qingsong Wang Pengfei Yang Bo Hong Yi Xu Qinghai Huang Jianmin Liu Qiao Zuo | 2021 | Chinese Neurosurgical Journal2021，7，4： | 2 |
| 13 | Preliminary design and analysis of a cubic deployable support structure based on shape memory polymer composite显示文摘The deployable structures based on shape memory polymer com-posites(SMPCs)have been developed for its unique properties,such as high reliability,low-cost,lightweight,and self-deployment without complex mechanical devices compared with traditional deployable structures.In order to increase the inflatable structure system’s robustness and light the weight of it,a cubic deployable support structure based on SMPC is designed and analyzed pre-liminarily.The cubic deployable support structure based on SMPC consists of four dependent spatial cages,each spatial cage is composed of 12 three-longeron SMPC truss booms and end con-nections.The shape recovery of arc-shaped deployable laminates drive the three-longeron SMPC truss booms to unfold,thus realize the expansion of the deployable support structure.The concept and operation of the cubic deployable support structure are described in detail.A series of experiments are performed on the three-longeron deployable laminates unit and the simplified cubic deployable support structure to investigate the shape recovery behavior in the deployment process.Results indicate that the cubic deployable support structure has a high deployment-tgo-stowage volume ratio and can achieve self-deployment,package,and deploy without complex mechanical devices. | Fengfeng Li Liwu Liu Xin Lan Xiaojun Zhou Wenfeng Bian Yanju Liu Jinsong Leng | 2016 | International Journal of Smart and Nano Materials2016，7，2： | 1 |
| 14 | Hand, foot, and mouth disease in China, 2008–12: an epidemiological study显示文摘 | Weijia Xing Qiaohong Liao Cécile Viboud Jing Zhang Junling Sun Joseph T Wu Zhaorui Chang Fengfeng Liu Vicky J Fang Yingdong Zheng Benjamin J Cowling Jay K Varma Jeremy J Farrar Gabriel M Leung Hongjie Yu | 2014 | The Lancet Infectious Diseases2014，，： | 1 |
| 15 | Emergence of superconductivity from fully incoherent normal state in an iron-based superconductor (Ba_(0.6)K_(0.4))Fe_2As_2显示文摘In unconventional superconductors, it is generally believed that understanding the physical properties of the normal state is a pre-requisite for understanding the superconductivity mechanism. In conventional superconductors like niobium or lead, the normal state is a Fermi liquid with a well-defined Fermi surface and well-defined quasipartcles along the Fermi surface. Superconductivity is realized in this case by the Fermi surface instability in the superconducting state and the formation and condensation of the electron pairs(Cooper pairing). The high temperature cuprate superconductors, on the other hand, represent another extreme case that superconductivity can be realized in the underdoped region where there is neither well-defined Fermi surface due to the pseudogap formation nor quasiparticles near the antinodal regions in the normal state. Here we report a novel scenario that superconductivity is realized in a system with well-defined Fermi surface but without quasiparticles along the Fermi surface in the normal state.High resolution laser-based angle-resolved photoemission measurements have been performed on an optimally-doped iron-based superconductor(Ba_(0.6)K_(0.4))Fe_2As_2. We find that, while sharp superconducting coherence peaks emerge in the superconducting state on the hole-like Fermi surface sheets, no quasiparticle peak is present in the normal state. Its electronic behaviours deviate strongly from a Fermi liquid system. The superconducting gap of such a system exhibits an unusual temperature dependence that it is nearly a constant in the superconducting state and abruptly closes at Tc. These observations have provided a new platform to study unconventional superconductivity in a non-Fermi liquid system. | Jianwei Huang Lin Zhao Cong Li Qiang Gao Jing Liu Yong Hu Yu Xu Yongqing Cai Dingsong Wu Ying Ding Cheng Hu Huaxue Zhou Xiaoli Dong Guodong Liu Qingyan Wang Shenjin Zhang Zhimin Wang Fengfeng Zhang Feng Yang Qinjun Peng Zuyan Xu Chuangtian Chen Xingjiang Zhou | 2019 | Science Bulletin2019，64，1： | 1 |
| 16 | Interpretation of the Protocol for Prevention and Control of COVID-19 in China(Edition 8)显示文摘BACKGROUND Since the release of Protocol for Prevention and Control of COVID-19(Edition 7),coronavirus disease 2019(COVID-19)control and prevention has been facing new challenges in China with evolving domestic and global epidemiological situations.Since September 2020,China has experienced more than 20 local outbreak waves,all of which were able to be contained within a few weeks. | Fengfeng Liu Canjun Zheng Liping Wang Mengjie Geng Hui Chen Sheng Zhou Lu Ran Zhongjie Li Yanping Zhang Zijian Feng George FGao Zhaorui Chang | 2021 | China CDC weekly2021，3，25： | 1 |
| 17 | Analysis of Dig- itizing Errors of a Laser Scanning System 显示文摘 | His-Yung Feng Yixin Liu Fengfeng Xi | 2001 | Journal of the International Societies for Precision Engineering and Nanotechnology2001，25，： | 1 |
| 18 | 显示文摘 | Liu Fengfeng Tang Xiaozhen | 2010 | Journal of Macromo-lecular Science Part B:2010，49，5： | 1 |
| 19 | Analysis of digitizing errors of a laser scanning system显示文摘 | Feng His-Yung Liu Yixin Xi Fengfeng | 2001 | Precision Engineering2001，25，： | 1 |
| 20 | Overexpression of CaWRKY27 , a subgroup IIe WRKY transcription factor of Capsicum annuum , positively regulates tobacco resistance to Ralstonia solanacearum infection显示文摘 | Fengfeng Dang Yuna Wang Jianju She Yufen Lei Zhiqin Liu Thomas Eulgem Yan Lai Jing Lin Lu Yu Dan Lei Deyi Guan Xia Li Qian Yuan Shuilin He | 2014 | Physiol Plantarum2014，，3： | 1 |
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