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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | Removal of p-Nitrophenol Using Persulfate Activated by Biochars Prepared from Different Biomass Materials显示文摘 | SHI Chenfei LI Yumeng FENG Haiyao JIA Shumin XUE Ruijie LI Gang WANG Guoxiang | 2018 | Chemical Research in Chinese Universities2018，34，1： | 4 |
| 3 | Phase structure and hydrogen storage properties of REMg8.35Ni2.18Al0.21 (RE=La, Ce, Pr, and Nd) hydrogen storage alloys显示文摘REMg8.35Ni2.18Al0.21 (RE=La, Ce, Pr,和 Nd ) 合金被感应的融化并且列在后面退火准备。X 光检查衍射(XRD ) 和扫描电子显微镜学(SEM ) 结果证明合金由 Mg2Ni 组成,(La, Pr, Nd ) Mg2Ni,(La, Ce ) 2Mg17,(Ce, Pr, Nd ) Mg12 和 Ce2Ni7 阶段。上述阶段是进 Mg2NiH4, MgH2 和 REHx 的 disproportioned (x=2.51 或 3 ) 在 hydriding 的阶段。而 LaH3, PrH3 和 NdH3 阶段仍然保持未改变, CeH2.51 阶段在 dehydriding 转变了成 CeH2.29 阶段。当 CeMg8.35Ni2.18Al0.21 合金介绍了最好的 hydriding/dehydriding 可逆性时, PrMg8.41Ni2.14Al0.20 合金有最快的 hydriding 动力学和最高的 dehydriding 高原压力。CeMg8.35Ni2.18Al0.21 氢化物的发作氢解吸附作用温度由于在 CeH2.51 和 CeH2.29 之间的阶段转变显著地减少了。 | LIU Yanqing HAN Shumin HU Lin LIU Baozhong ZHAO Xin JIA Yanhong | 2013 | Journal of Rare Earths2013，31，8： | 3 |
| 4 | Shifting from homogeneous to heterogeneous surfaces in estimating terrestrial evapotranspiration: Review and perspectives显示文摘Terrestrial evapotranspiration(ET)is a crucial link between Earth’s water cycle and the surface energy budget.Accurate measurement and estimation remain a major challenge in geophysical,biological,and environmental studies.Pioneering work,represented by Dalton and Penman,and the development of theories and experiments on turbulent exchange in the atmospheric boundary layer(ABL),laid the foundation for mainstream methodologies in ET estimation.Since the 1990s,eddy covariance(EC)systems and satellite remote sensing have been widely applied from cold to tropical and from arid to humid regions.They cover water surfaces,wetlands,forests,croplands,grasslands,barelands,and urban areas,offering an exceptional number of reports on diverse ET processes.Surface nocturnal ET,hysteresis between ET and environmental forces,turbulence intermittency,island effects on heterogeneous surfaces,and phase transition between underlying surfaces are examples of reported new phenomena,posing theoretical and practical challenges to mainstream ET methodologies.Additionally,based on non-conventional theories,new methods have emerged,such as maximum entropy production and nonparametric approaches.Furthermore,high-frequency on-site observation and aerospace remote sensing technology in combination form multi-scale observations across plant stomata,leaves,plants,canopies,landscapes,and basins.This promotes an insightful understanding of diverse ET processes and synthesizes the common mechanisms of the processes between and across spatial and temporal scales.All the recent achievements in conception,model,and technology serve as the basis for breaking through the known difficulties in ET estimation.We expect that they will provide a rigorous,reliable scientific basis and experimental support to address theoretical arguments of global significance,such as the water-heat-carbon cycle,and solve practical needs of national importance,including agricultural irrigation and food security,precise management of water resources and eco-environmental protection,and regulation of the urban thermal environment and climate change adaptation. | Yuanbo LIU Guoyu QIU Hongsheng ZHANG Yonghui YANG Yinsheng ZHANG Quan WANG Wenzhi ZHAO Li JIA Xibin JI Yujiu XIONG Chunhua YAN Ning MA Shumin HAN Yifan CUI | 2022 | Science China Earth Sciences2022，65，2： | 2 |
| 5 | The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA PolⅡfrom Binding to HIV-1 LTR显示文摘The CREB-regulated transcriptional co-activators(CRTCs),including CRTC1,CRTC2 and CRTC3,enhance transcription of CREB-targeted genes.In addition to regulating host gene expression in response to cAMP,CRTCs also increase the infection of several viruses.While human immunodeficiency virus type 1(HIV-1)long terminal repeat(LTR)promoter harbors a cAMP response element and activation of the cAMP pathway promotes HIV-1 transcription,it remains unknown whether CRTCs have any effect on HIV-1 transcription and HIV-1 infection.Here,we reported that CRTC2 expression was induced by HIV-1 infection,but CRTC2 suppressed HIV-1 infection and diminished viral RNA expression.Mechanistic studies revealed that CRTC2 inhibited transcription from HIV-1 LTR and diminished RNA PolⅡoccupancy at the LTR independent of its association with CREB.Importantly,CRTC2 inhibits the activation of latent HIV-1.Together,these data suggest that in response to HIV-1 infection,cells increase the expression of CRTC2 which inhibits HIV-1 gene expression and may play a role in driving HIV-1 into latency. | Ling Ma Shumin Chen Zhen Wang Saisai Guo Jianyuan Zhao Dongrong Yi Quanjie Li Zhenlong Liu Fei Guo Xiaoyu Li Pingping Jia Jiwei Ding Chen Liang Shan Cen | 2021 | Virologica Sinica2021，36，4： | 1 |
| 6 | Anchoring polysulfide with artificial solid electrolyte interphase for dendrite-free and low N/P ratio Li-S batteries显示文摘Lithium sulfur batteries are regarded as a promising candidate for high-energy-density energy storage devices.However,the lithium metal anode in lithium-sulfur batteries encounters the problem of lithium dendrites and lithium metal consumption caused by polysulfide corrosion.Herein we design a dualfunction PMMA/PPC/LiNO3composite as an artificial solid electrolyte interphase(PMCN-SEI)to protect Li metal anode.This SEI offers multiple sites of C=O for polysulfide anchoring to constrain corrosion of Li metal anode.The lithiated polymer group and Li3N in PMCN-SEI can homogenize lithium-ion deposition behavior to achieve a dendrite-free anode.As a result,the PMCN-SEI protected Li metal anode enables the Li||Li symmetric batteries to maintain over 300 cycles(1300 h)at a capacity of 5 m Ah cm^(-2),corresponding to a cumulative capacity of 3.25 Ah cm^(-2).Moreover,Li-S batteries assembled with 20μm of Li metal anode(N/P=1.67)still deliver an initial capacity of 1166 m A h g-1at 0.5C.Hence,introducing polycarbonate polymer/inorganic composite SEI on Li provides a new solution for achieving the high energy density of Li-S batteries. | Wei Lu Zhao Wang Guiru Sun Shumin Zhang Lina Cong Lin Lin Siru Chen Jia Liu Haiming Xie Yulong Liu | 2023 | Journal of Energy Chemistry2023，，5： | 1 |
| 7 | A Comparative Study of Supervised Learning as Applied to Acronym Expansion in Clinical Repo 显示文摘 | Mou Shumin Wei Junping Liu Fang Wan Xiuzhi Cao Aimei Liu Yajun Wang Jia Chen Liang Liu Do | 2008 | Sichuan2008，，11： | 1 |
| 8 | Fabrication and application of MFe2O4 (M?=?Zn, Cu) nanoparticles as anodes for Li ion batteries显示文摘 | Hongxiao Zhao Huimin Jia Shumin Wang Dengqi Xue Zhi Zheng | 2011 | Journal of Experimental Nanoscience2011，，1： | 1 |
| 9 | Development of mapped simple sequence repeat markers from common bean ( Phaseolus vulgaris L.) based on genome sequences of a Chinese landrace and diversity evaluation显示文摘 | Mingli Chen Jing Wu Lanfeng Wang Xiaoyan Zhang Matthew W. Blair Jizeng Jia Shumin Wang | 2014 | Molecular Breeding2014，，2： | 1 |
| 10 | Synthesis of CdS hollow/solid nanospheres and their chain-structures by membrane technique 显示文摘 | Duan Shumin Wu Qingsheng Jia Runping | 2008 | J Nanopart Res2008，10，： | 1 |
| 11 | Accelerated Evolution of H7N9 Subtype Influenza Virus under Vaccination Pressure显示文摘No avian H7 N9 outbreaks have occurred since the introduction of H7 N9 inactivated vaccine in the fall of 2017.However,H7 N9 is still prevalent in poultry.To surveil the prevalence,genetic characteristics,and antigenic changes of H7 N9,over7000 oropharyngeal and cloaca swab specimens were collected from live poultry markets and farms in 15 provinces of China from 2017 to 2019.A total of 85 influenza virus subtype H7 N9 strains were isolated and 20 representative strains were selected for genetic analysis and antigenicity evaluation.Results indicated the decreased prevalence of low-pathogenic H7 N9 strains while highly-pathogenic H7 N9 strains became dominated since the introduction of vaccine.Phylogenetic analysis showed that strains from 2019 formed an independent small branch and were genetically distant to strains isolated in 2013–2018.Analysis of key amino acid sites showed that the virus strains may adapt to the host environment evolutionally through mutation.Our analysis predicted additional potential glycosylation sites for HA and NA genes in the 2019 strains.Sequence analysis of HA gene in strains isolated from 2018 to 2019 showed that there were an increased nucleotide substitution rate and an increased mutation rate in the first and second nucleotides of coding codons within the open reading frame.The hemagglutination inhibition(HI)assay showed that H7-Re1 and H7-Re2 exhibited a lower HI titer for isolates from 2019,while H7-Re3 and r LN79 showed a high HI titer.The protective effect of the vaccine decreased after15 months of use.Overall,under vaccination pressure,the evolution of influenza virus subtype H7 N9 has accelerated. | Yifan Wu Jingkai Hu Xuanjiang Jin Xiao Li Jinfeng Wang Mengmeng Zhang Jianglin Chen Shumin Xie Wenbao Qi Ming Liao Weixin Jia | 2021 | Virologica Sinica2021，36，5： | 0 |
| 12 | A case of Gitelman syndrome with homozygous SLC12A3 deletion presenting with epilepsy显示文摘Background Gitelman syndrome(GS)is a rare autosomal recessive hereditary renal tubular disorder characterized by hypokalemia,metabolic alkalosis,hypomagnesemia,and hypocalciuria.Case presentation We report a rare case of GS with homozygous loss of SLC12A3 presenting with epilepsy.The patient was a 21-year-old female who sought medical attention for seizures.Her condition primarily manifested as epilepsy,diarrhea,and weakness of limbs.Through genetic analysis,we confirmed the diagnosis of this case and formulated a comprehensive approach for its management.Conclusions This case report extends the clinical symptoms of GS and provides a complete family of GS as a reference for subsequent studies. | Ying Wang Wenting Huang Jia Li Shumin Mao Wenqiang Fang Huiqin Xu | 2023 | Acta Epileptologica2023，6，4： | 0 |
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