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| 1 | An Intra-Oceanic Subduction System Influenced by Ridge Subduction in the Diyanmiao Subduction Accretionary Complex of the Xar Moron Area,Eastern Margin of the Central Asian Orogenic Belt显示文摘This study focuses on the geology,geochemistry,Sr-Nd isotopes and their tectonic settings of three types of basalts in Diyanmiao ophiolite in the Xar Moron area located on the eastern margin of the Central Asian Orogenic Belt.Type I basalts are oceanic tholeiites with a depleted light rare earth element(LREE)pattern,which are similar to the typical N-mid-oceanic ridge basalt(MORB)and suggests that they were formed at a mid-oceanic ridge.The initial 87Sr/86Sr ratios of Type I basalts range from 0.703966 to 0.705276 and theεNd(t)values are from 16.49 to 17.15,indicating that they were derived from a depleted mantle source.Type II basalts belong to the medium-potassium calc-akaline series and have the geochem-ical characteristics of Nb-enriched basalt(NEB)with high Nb content(14.5 ppm)and strong enrichment in LREEs,implying that they were created by the partial melting of mantle wedge peridotite that previously metasomatized by slab melts.Type III basalts are high-Al basalt(HAB)with high-Al contents(Al_(2)0_(3)=16.75 wt.%-18.00 wt.%),distinct Nb depletion and high Th/Yb ratios.Thus they were likely gen-erated in a normal island-arc setting.Therefore,the association of MORB,NEB,and HAB in the study area may be due to the subduction of a mid-oceanic ridge,and the Diyanmiao ophiolite is proposed to be formed in the forearc setting of a mid-oceanic ridge subduction system. | Yang Cheng Qinghui Xiao Tingdong Li Liquan Xu Yuxu Fan Yan Li Lingjun Guo Jinli Pang Weiming Yuan | 2021 | Journal of Earth Science2021，32，1： | 6 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 4 | Detection of QTL for six yield-related traits in oilseed rape (Brassica napus) using DH and immortalized F2 populations显示文摘 | Wei Chen Yan Zhang Xueping Liu Baoyuan Chen Jinxing Tu Fu Tingdong | 2007 | Theoretical and Applied Genetics2007，，6： | 1 |
| 5 | Detection of QTL for six yield-related traits in oilseed rape (Brassica napus) using DH and immortalized F2 populations显示文摘 | Wei Chen Yan Zhang Xueping Liu Baoyuan Chen Jinxing Tu Fu Tingdong | 2007 | Theoretical and Applied Genetics2007，，6： | 1 |
| 6 | Geochemistry and Tectonic History of Seamount Remnants in the Xingshuwa Subduction Accretionary Complex of the Xar Moron Area,Eastern Margin of the Central Asian Orogenic Belt显示文摘This study focuses on the geology,geochemistry,zircon U-Pb geochronology and tectonic settings of the three types of seamount basalts from the Xingshuwa subduction accretionary complex in the Xar Moron area,eastern margin of the Central Asian Orogenic Belt(CAOB).The seamount remnants are composed of carbonate’cap’sediments,large volumes of pillow and massive basalts,carbonate breccia slope facies and radiolarian cherts.Group 1 basalts are characterized by high contents of P2 O5 and TiO2 with alkaline affinity and LREE enrichment,indicating that they are derived from intraplate magma.Group 2 basalts display N-MORB LREE depletion patterns,indicating that they were formed at a mid-ocean ridge.Group 3 basalts have shown distinct Nb depletion and high Th/Yb ratios,indicating that they were generated in an island arc tectonic setting.The zircon U-Pb age of Group 1 basalt sample XWT18-131 is 576.4±9.4 Ma,suggesting that the oceanic island seamount was the product of intraplate magmatism related to a mantle plume or’hot spot’in the late Neoproterozoic.The zircon U-Pb age of Group 2 basalt sample XWT18-132 is 483±22 Ma,indicating that the Paleo-Asian Ocean(PAO)was continuously expanding in the Early Ordovician.The zircon U-Pb age of Group 3 basalt sample XWT18-101 is 240.5±8.2 Ma,suggesting that this area underwent the evolutionary path of ocean-continent transition,developing towards continentalization during the Middle Triassic.Thus,we believe that there was both mantle plume-related intraplate magmatism and intraoceanic subduction during the evolution of the PAO,the CAOB possibly being an evolutionary model of an intraoceanic subduction and mantle plume magmatism complex. | CHENG Yang XIAO Qinghui LI Tingdong LI Yan FAN Yuxu XU Liquan GUO Lingjun PANG Jinli | 2021 | Acta Geologica Sinica(English Edition)2021，95，4： | 1 |
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