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| 1 | Entrapping multifunctional dendritic nanoparticles into a hydrogel for local therapeutic delivery and synergetic immunochemotherapy显示文摘Developing multifunctional nanoparticles to support new therapy models is apromising and challenging task to address the current dilemma on antitumortreatment. Herein, we incorporated multifunctional dendritic nanoparticles intoa poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,Lqactide-co-glycolide)(PLGA-PEG-PLGA) triblock copolymers thermosensitive injectable hydrogelmatrix to construct a localized drug delivery system for combining chemotherapyand immunotherapy. The multifunctional dendritic nanoparticles were designedwith following expectations: i, Dendritic scaffolds provide a hydrophobic interiorto load the anticancer drug, doxorubicin (DOX), for chemotherapy; and ii,dendritic scaffolds are used to build arginine-rich molecules to provide theinducible nitric oxide synthase (iNOS) substrate, L-Arg, to M1 macrophages,which can produce the cytotoxic substance nitric oxide (NO) and subsequentlyinduce tumor cell destruction through immunotherapy. It is noteworthy that thedendritic nanoparticles-in-hydrogel delivery system is able to gel at physiologicaltemperature and serves as a warehouse for the sustained release of the drug.Ultimately, this system showed great efficacy in treating 4T1 cells-xenograftedBALB/C mice (86.62% tumor growth inhibition). Therefore, this localized drugdelivery system combining chemotherapy and immunotherapy provides a novelapproach for cancer therapy. | Lei Jiang Yang Ding Xialin Xue Sensen Zhou Cheng Li Xiaoke Zhang Xiqun Jiang | 2018 | Nano Research2018，11，11： | 3 |
| 2 | Hundred-Joule-level,nanosecond-pulse Nd:glass laser system with high spatiotemporal beam quality显示文摘A 100-J-level Nd:glass laser system in nanosecond-scale pulse width has been constructed to perform as a standard source of high-fluence-laser science experiments. The laser system, operating with typical pulse durations of 3–5 ns and beam diameter 60 mm, employs a sequence of successive rod amplifiers to achieve 100-J-level energy at 1053 nm at3 ns. The frequency conversion can provide energy of 50-J level at 351 nm. In addition to the high stability of the energy output, the most valuable of the laser system is the high spatiotemporal beam quality of the output, which contains the uniform square pulse waveform, the uniform flat-top spatial fluence distribution and the uniform flat-top wavefront. | Sensen Li Yulei Wang Zhiwei Lu Lei Ding Yi Chen Pengyuan Du Dexin Ba Zhenxing Zheng Xin Wang Hang Yuan Chengyu Zhu Weiming He Dianyang Lin Yongkang Dong Dengwang Zhou Zhenxu Bai Zhaohong Liu Can Cui | 2016 | High Power Laser Science and Engineering2016，4，1： | 3 |
| 3 | The influence of YS-I on the Dll4-Notchl signaling pathway显示文摘在这研究,我们在表明小径的 Dll4-Notch1 调查了角色和 p43 和 YS-1 (recombinant 人 p43 蛋白质) 的分子的机制。p43 蛋白质指向的活跃、小介入的 RNA 和 recombinant plasmid 被用来感染人的脐的静脉 endothelial 房间(HUVEC ) 。三维的发芽模型, endothelial 房间移植试金,并且发芽并且试管形成试金被用来在 angiogenesis 推出 p43 和 YS-1 的函数。半量的反向的抄写聚合酶链反应和西方的污点分析被执行在在 HUVEC 发信号的 Dll4-Notch1 检测 p43 的效率。它被发现 p43 的那 silencing 和 overexpression 能 upregulate Dll4 槽口并且刺激 angiogenesis。p43 在 angiogenesis 起一个复杂作用。当集中在 100 nM 下面时,它支持 angiogenesis;相反,当集中是超过 100 nM 时,它禁止 angiogenesis。在这研究,我们发现 p43 的表示水平在 60 nM 下面。然而, recombinant 人 p43 蛋白质, YS-1,发芽的禁止的 endothelial 房间,和 YS-1 的 500 g/ml 稀释了 Dll4-Notch1 发信号的激活。这些结果建议 YS-1 能直接通过 Dll4-Notch1 信号 transduction 小径禁止 angiogenesis,当 p43 在这条发信号的小径起一个 modulating 作用时。 | Li Sun Qingqing Yang Ping Wang Datao Liu Wenlu Liang Sensen Lin Shengtao Yuan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 1 |
| 4 | Vinorelbine inhibits angiogenesis and 95D migration via reducing hypoxic fibroblast stromal cell-derived factor 1 secretion 显示文摘 | Dongdong Fang Li Sun Sensen Lin | 2012 | Exp Biol Med2012，237，23： | 1 |
| 5 | Spatial beam shaping for high-power frequency tripling lasers based on a liquid crystal spatial light modulator显示文摘 | Sensen Li Yulei Wang Zhiwei Lu Lei Ding Can Cui Yi Chen Du Pengyuan Dexin Ba Zhenxing Zheng Hang Yuan Lei Shi Zhenxu Bai Zhaohong Liu Chengyu Zhu Yongkang Dong Luoxian Zhou | 2016 | Optics Communications2016，，： | 1 |
| 6 | Amplification of 200-ps high-intensity laser pulses via frequency matching stimulated Brillouin scattering显示文摘Laser pulses of 200 ps with extremely high intensities and high energies are sufficient to satisfy the demand of shock ignition,which is an alternative path to ignition in inertial confinement fusion(ICF).This paper reports a type of Brillouin scheme to obtain high-intensity 200-ps laser pulses,where the pulse durations are a challenge for conventional pulsed laser amplification systems.In the amplification process,excited Brillouin acoustic waves fulfill the nonlinear optical effect through which the high energy of a long pump pulse is entirely transferred to a 200-ps laser pulse.This method was introduced and achieved within the SG-Ⅲprototype system in China.Compared favorably with the intensity of 2 GW/cm^2 in existing ICF laser drivers,a 6.96-GW/cm^2 pulse with a width of 170 ps was obtained in our experiment.The practical scalability of the results to larger ICF laser drivers is discussed. | Hang Yuan Yulei Wang Qiang Yuan Dongxia Hu Can Cui Zhaohong Liu Sensen Li Yi Chen Feng Jing Zhiwei Lu | 2019 | High Power Laser Science and Engineering2019，7，3： | 1 |
| 7 | Assessing the conservation impact of Chinese indigenous chicken populations between ex-situ and in-situ using genome-wide SNPs显示文摘Conservation programs require rigorous evaluation to ensure the preservation of genetic diversity and viability of conservation populations. In this study, we conducted a comparative analysis of two indigenous Chinese chicken breeds, Gushi and Xichuan black-bone, using whole-genome SNPs to understand their genetic diversity, track changes over time and population structure. The breeds were divided into five conservation populations(GS1, 2010, ex-situ;GS2, 2019, ex-situ;GS3, 2019, in-situ;XB1, 2010, in-situ;and XB2, 2019, in-situ) based on conservation methods and generations. The genetic diversity indices of three conservation populations of Gushi chicken showed consistent trends, with the GS3 population under in-situ strategy having the highest diversity and GS2 under ex-situ strategy having the lowest. The degree of inbreeding of GS2 was higher than that of GS1 and GS3. Conserved populations of Xichuan black-bone chicken showed no obvious changes in genetic diversity between XB1 and XB2. In terms of population structure, the GS3 population were stratified relative to GS1 and GS2. According to the conservation priority, GS3 had the highest contribution to the total gene and allelic diversity in GS breed, whereas the contribution of XB1 and XB2 were similar. We also observed that the genetic diversity of GS2 was lower than GS3, which were from the same generation but under different conservation programs(in-situ and ex-situ). While XB1 and XB2 had similar levels of genetic diversity. Overall, our findings suggested that the conservation programs performed in ex-situ could slow down the occurrence of inbreeding events, but could not entirely prevent the loss of genetic diversity when the conserved population size was small, while in-situ conservation populations with large population size could maintain a relative high level of genetic diversity. | Wenting Li Chaoqun Gao Zhao Cai Sensen Yan Yanru Lei Mengya Wei Guirong Sun Yadong Tian Kejun Wang Xiangtao Kang | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 8 | SCGN deficiency is a risk factor for autism spectrum disorder显示文摘Autism spectrum disorder(ASD)affects 1-2%of all children and poses a great social and economic challenge for the globe.As a highly heterogeneous neurodevelopmental disorder,the development of its treatment is extremely challenging.Multiple pathways have been linked to the pathogenesis of ASD,including signaling involved in synaptic function,oxytocinergic activities,immune homeostasis,chromatin modifications,and mitochondrial functions.Here,we identify secretagogin(SCGN),a regulator of synaptic transmission,as a new risk gene for ASD.Two heterozygous loss-of-function mutations in SCGN are presented in ASD probands.Deletion of Scgn in zebrafish or mice leads to autism-like behaviors and impairs brain development.Mechanistically,Scgn deficiency disrupts the oxytocin signaling and abnormally activates inflammation in both animal models.Both ASD probands carrying Scgn mutations also show reduced oxytocin levels.Importantly,we demonstrate that the administration of oxytocin and anti-inflammatory drugs can attenuate ASD-associated defects caused by SCGN deficiency.Altogether,we identify a convergence between a potential autism genetic risk factor SCGN,and the pathological deregulation in oxytocinergic signaling and immune responses,providing potential treatment for ASD patients suffering from SCGN deficiency.Our study also indicates that it is critical to identify and stratify ASD patient populations based on their disease mechanisms,which could greatly enhance therapeutic success. | Zhe Liu Shuai Tan Lianyu Zhou Li Chen Mingfeng Liu Wang Wang Yingying Tang Qin Yang Sensen Chi Peiyan Jiang Yue Zhang Yonghua Cui Junhong Qin Xiao Hu Shenglong Li Qi Liu Lu Chen Song Li Ezra Burstein Wei Li Xiaohu Zhang Xianming Mo Da Jia | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 9 | Rice OsUBR7 modulates plant height by regulating histone H2B monoubiquitination and cell proliferation显示文摘Plant height is an important agronomic trait for lodging resistance and yield.Here,we report a new plantheight-related gene,OsUBR7 in rice(Oryza sativa L.);knockout of OsUBR7 caused fewer cells in internodes,resulting in a semi-dwarf phenotype.OsUBR7 encodes a putative E3 ligase containing a plant homeodomain finger and a ubiquitin protein ligase E3 component N-recognin 7(UBR7)domain.OsUBR7 interacts with histones and monoubiquitinates H2B(H2Bub1)at lysine148 in coordination with the E2 conjugase OsUBC18.OsUBR7 mediates H2Bub1 at a number of chromatin loci for the normal expression of target genes,including cell-cycle-related and pleiotropic genes,consistent with the observation that cell-cycle progression was suppressed in the osubr7 mutant owing to reductions in H2Bub1 and expression levels at these loci.The genetic divergence of OsUBR7 alleles among japonica and indica cultivars affects their transcriptional activity,and these alleles may have undergone selection during rice domestication.Overall,our results reveal a novel mechanism that mediates H2Bub1 in plants,and UBR7 orthologs could be utilized as an untapped epigenetic resource for crop improvement. | Yangyi Zheng Sensen Zhang Yanqiu Luo Fuquan Li Jiantao Tan Bin Wang Zhe Zhao Huifang Lin Tingting Zhang Jianhong Liu Xupeng Liu Jingxin Guo Xianrong Xie Letian Chen Yao-Guang Liu Zhizhan Chu | 2022 | Plant Communications2022，3，6： | 0 |
| 10 | Fundamental understanding of high-capacity lithium-excess cathodes with disordered rock salt structure显示文摘As a new class of lithium rich cathodes,disordered rock-salt cathodes have been of primary interest,because of their ability to deliver a promisingly high capacity up to 300 mAh/g.Nevertheless,some fundamental issues are yet to be fully understood and a comprehensive mastering of their solid-state chemistry,kinetics and thermal stability is required.Here,we select a high capacity cation-disordered positive electrode-Li_(1.2)Ni_(0.4)Nb_(0.4)O_(2)as a model compound to study intrinsic reaction mechanism,including charge compensation mechanism,kinetics,thermal stability,and structural evolution.By combining soft and hard X-ray absorption spectroscopy(XAS),X-ray photoelectron spectroscopy(XPS)with operando and exsitu differential scanning calorimetry(DSC),galvanostatic intermittent titration technique(GITT),cyclic voltammetry(CV),and X-ray diffraction(XRD),we present holistic information on disordered rock-salt cathode.This work provides beneficial insights into designing and tailoring new positive electrodes with disordered rock-salt structure. | Hao Lin Beatriz Moreno Kamil Kucuk Sensen Zhang Shankar Aryal Zheng Li Carlo U.Segre Jassiel Rodriguez Dhanya Puthusseri Lirong Cai Xuechen Jiao Vilas G.Pol | 2021 | Journal of Materials Science & Technology2021，，15： | 0 |
| 11 | Double-Doped Carbon-Based Electrodes with Nitrogen and Oxygen to Boost the Areal Capacity of Zinc-Bromine Flow Batteries显示文摘Ensuring a stable power output from renewable energy sources,such as wind and solar energy,depends on the development of large-scale and long-duration energy storage devices.Zinc–bromine fl ow batteries(ZBFBs)have emerged as cost-eff ective and high-energy-density solutions,replacing expensive all-vanadium fl ow batteries.However,uneven Zn deposition during charging results in the formation of problematic Zn dendrites,leading to mass transport polarization and self-discharge.Stable Zn plating and stripping are essential for the successful operation of high-areal-capacity ZBFBs.In this study,we successfully synthesized nitrogen and oxygen co-doped functional carbon felt(NOCF4)electrode through the oxidative polymerization of dopamine,followed by calcination under ambient conditions.The NOCF4 electrode eff ectively facilitates effi cient“shuttle deposition”of Zn during charging,signifi cantly enhancing the areal capacity of the electrode.Remarkably,ZBFBs utilizing NOCF4 as the anode material exhibited stable cycling performance for 40 cycles(approximately 240 h)at an areal capacity of 60 mA h/cm^(2).Even at a high areal capacity of 130 mA h/cm^(2),an impressive energy effi ciency of 76.98%was achieved.These fi ndings provide a promising pathway for the development of high-areal-capacity ZBFBs for advanced energy storage systems. | Xiaoyun Sun Deren Wang Haochen Hu Xin Wei Lin Meng Zhongshan Ren Sensen Li | 2024 | Transactions of Tianjin University2024，30，1： | 0 |
| 12 | Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism显示文摘TRPML1 隧道是非选择的 group-2 有 Ca 2+ 的短暂受体潜力(TRP ) 隧道渗透。主要在所有哺乳动物的房间类型的迟了的内涵体和 lysosome 定位了, TRPML1 在 endocytosis,膜 trafficking,和 lysosome 生物的续生说的过程是不可缺少的。TRPML1 的变化引起严重 lysosomal 存储混乱叫的 mucolipidosis 类型 IV (MLIV ) 。在现在的学习,我们在类脂化合物 nanodiscs 和 Amphipols 决定了亩 musculus TRPML1 (mTRPML1 ) 的 cryo 电子显微镜学(cryo 他们) 结构。在 Amphipols 的 mTRPML1 的二个不同状态被加到关上的状态,在哪个能在激活和规定之上代表二不同证实上。polycystin-mucolipin 领域(PMD ) 可以察觉到 luminal/extracellular 刺激并且向上经历一个行动在 endocytosis 期间打手势,因此在 TRPML1 触发全面 conformational 变化。基于结构的比较,我们建议 TRPML1 被 pH, Ca 2+, 和 phosphoinositides 以一种联合方式调整以便提供动态 endocytosis 过程。 | Sensen Zhang Ningning Li Wenwen Zeng Ning Gao Maojun Yang | 2017 | Protein & Cell2017，8，11： | 0 |
| 13 | Petrogenesis and Tectonic Implications of the Paleoproterozoic A-Type Granites in the Xiong’ershan Area along the Southern Margin of the North China Craton显示文摘Paleoproterozoic A-type granites are widely distributed in the southern margin of the North China Craton(SNCC),providing important information for understanding the Paleoproterozoic tectonic regimes in this area.This paper reports newly obtained whole-rock compositions and zircon U-Pb ages for the Tieluping syenogranite porphyry(TLP)and Huoshenmiao alkali granite porphyry(HSM)in the SNCC.Zircons from the TLP and HSM have U-Pb ages of 1805±12 and 1792±14 Ma,respectively.These ages are taken to date the emplacement of these intrusions.They had high total alkali contents(K_(2)O+Na_(2)O>7.13 wt.%),with high 10000×Ga/Al ratios(3.06–3.41)and Zr+Y+Nb+Ce values(709 ppm–910 ppm)as well as high zircon saturation temperatures(864–970℃),indicative of A-type granite affinities.High Y/Nb(1.75–3.32),Ce/Nb(7.72–9.72),and Yb/Ta(2.89–5.60)ratios suggested that TLP and HSM belonged to the A2-type granite.The negative whole rockε_(Nd)(t)values(−8.4 to−6.6)and negative zirconε_(Hf)(t)values(−15.9 to−6.3)confirmed that TLP and HSM were likely generated by the partial melting of an ancient continental crust.TheεHf(t)(−7.4 to+4.0)values of inherited zircons in the TLP suggested that they were derived from the partial melting of Archean basement rocks.Considering the geochemical similarity of the 1.80 Ga A-type granitoids in the SNCC,we propose that the TLP and HSM were formed in a post-collisional regime that was likely associated with the break-off of the Paleoproterozoic subducted slab.Upwelling of the asthenosphere provided huge heat to generate the regional 1.80 Ga A-type granite in the SNCC. | Jinhong Xu Yuping Jiang Shuli Hu Zhengwei Zhang Chengquan Wu Chaofei Zheng Xiyao Li Ziru Jin Sensen Zhang Yatao Zhou | 2024 | Journal of Earth Science2024，35，2： | 0 |
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