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| 1 | Ultrasensitive detection of cancer biomarker microRNA by amplification of fluorescence of lanthanide nanoprobes显示文摘癌症 biomarker microRNAs (miRNAs ) 的敏感察觉具有为癌症诊断和治疗的重要重要性。尽管如此,在存在 miRNA 生物鉴定的察觉敏感被 miRNA 的结构的特征严重地限制(包括小长度和高顺序相同) 因为大多数这些方法基于目标扩大。此处,我们经由 nanoprobe 的唯一的策略向低丰富的 miRNA 的敏感、特定的察觉汇报一条新奇途径提高溶解的荧光扩大,展示分子的烽火结构的一根俘获探针在被设计。借助于这策略, miRNA-21 与象 1.38 fM 一样低的察觉限制从 10 fM 在一个线性范围被检测到 100 下午。最新发达的生物传感器的高选择被对一个目标的好歧视与单个底的失配表明。而且,这试金被用于低于 10.1% 在 90.2%-108% 的范围和变化的系数与恢复增加进胎儿的牛的浆液样品的 miRNA-21 的察觉,显示它到在新窗户中的 RNA 免疫分析和早癌症 diagnosis.Open | Lianyu Lu Datao Tu Yan Liu Shanyong Zhou Wei Zheng Xueyuan Chen | 2018 | Nano Research2018，11，1： | 6 |
| 2 | A strategy for accurate detection of glucose in human serum and whole blood based on an upconversion nanoparticles-polydopamine nanosystem显示文摘 | Yan Liu Datao Tu Wei Zheng Lianyu Lu Wenwu You Shanyong Zhou Ping Huang Renfu Li Xueyuan Chen | 2018 | Nano Research2018，11，6： | 5 |
| 3 | Amine-functional- ized lanthanide-doped KGdF4 nanocrystals as potential optical/ magnetic muhimodal bioprobes 显示文摘 | Ju Qiang Tu Datao Liu Yongsheng | 2011 | Journal of the American Chemical Society2011，134，2： | 1 |
| 4 | Lanthanide-doped inorganic nanocrystals as luminescent biolabels显示文摘 | Ju Qiang Tu Datao Liu Yongsheng | 2012 | Combinato-rial Chemistry High Throughput Screening2012，15，7： | 1 |
| 5 | Active inductor shunt peaking in high-speed VCSEL driver design显示文摘An all-transistor active-inductor shunt-peaking structure has been used in a prototype of 8 Gbps highspeed VCSEL driver which is designed for the optical link in ATLAS liquid Argon calorimeter upgrade.The VCSEL driver is fabricated in a commercial 0.25μm Silicon-on-Sapphire(SoS)CMOS process for radiation tolerant purpose.The all-transistor active-inductor shunt-peaking is used to overcome the bandwidth limitation from the CMOS process.The peaking structure has the same peaking efect as the passive one,but takes a small area,does not need linear resistors and can overcome the process variation by adjust the peaking strength via an external control.The design has been taped out,and the prototype has been proven by the preliminary electrical test results and bit error ratio test results.The driver achieves 8 Gbps data rate as simulated with the peaking.We present the all-transistor active-inductor shunt-peaking structure,simulation and test results in this paper. | 梁福田 GONG Datao HOU Suen LIU Chonghan LIU Tiankuan SU Da-Shung TENG Ping-Kun XIANG Annie YE Jingbo 金革 | 2013 | Chinese Physics C2013，37，11： | 1 |
| 6 | The influence of YS-I on the Dll4-Notchl signaling pathway显示文摘在这研究,我们在表明小径的 Dll4-Notch1 调查了角色和 p43 和 YS-1 (recombinant 人 p43 蛋白质) 的分子的机制。p43 蛋白质指向的活跃、小介入的 RNA 和 recombinant plasmid 被用来感染人的脐的静脉 endothelial 房间(HUVEC ) 。三维的发芽模型, endothelial 房间移植试金,并且发芽并且试管形成试金被用来在 angiogenesis 推出 p43 和 YS-1 的函数。半量的反向的抄写聚合酶链反应和西方的污点分析被执行在在 HUVEC 发信号的 Dll4-Notch1 检测 p43 的效率。它被发现 p43 的那 silencing 和 overexpression 能 upregulate Dll4 槽口并且刺激 angiogenesis。p43 在 angiogenesis 起一个复杂作用。当集中在 100 nM 下面时,它支持 angiogenesis;相反,当集中是超过 100 nM 时,它禁止 angiogenesis。在这研究,我们发现 p43 的表示水平在 60 nM 下面。然而, recombinant 人 p43 蛋白质, YS-1,发芽的禁止的 endothelial 房间,和 YS-1 的 500 g/ml 稀释了 Dll4-Notch1 发信号的激活。这些结果建议 YS-1 能直接通过 Dll4-Notch1 信号 transduction 小径禁止 angiogenesis,当 p43 在这条发信号的小径起一个 modulating 作用时。 | Li Sun Qingqing Yang Ping Wang Datao Liu Wenlu Liang Sensen Lin Shengtao Yuan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 1 |
| 7 | Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis显示文摘Dear Editor,Stem cell therapy holds enormous and revolutionary promise to treat various age-related diseases,such as diabetes,heart failure,and Parkinson’s disease.However,low retention and survival rate of delivered stem cells,partially due to immunological rejection,constitute major hurdles for the clinical implementation of stem cell therapy(Lei et al.,2021a).Since mounting evidence showed that several types of stem cells mainly exert their therapeutic effects through the secretion of paracrine effects,exosomes,which are released by stem cells and execute most paracrine functions,have begun to draw attention in the field(Tran and Damaser,2015).Exosomes are membrane-enclosed vesicles with an average diameter of∼100 nanometers secreted by the cells,containing cytokines. | Jinghui Lei Xiaoyu Jiang Wei Li Jie Ren Datao Wang Zhejun Ji Zeming Wu Fang Cheng Yusheng Cai Zheng-Rong Yu Juan Carlos Izpisua Belmonte Chunyi Li Guang-Hui Liu Weiqi Zhang Jing Qu Si Wang | 2022 | Protein & Cell2022，13，3： | 1 |
| 8 | Single-cell transcriptome reveals core cell populations and androgen-RXFP2 axis involved in deer antler full regeneration显示文摘Deer antlers constitute a unique mammalian model for the study of both organ formation in postnatal life and annual full regeneration.Previous studies revealed that these events are achieved through the proliferation and differentiation of antlerogenic periosteum(AP)cells and pedicle periosteum(PP)cells,respectively.As the cells resident in the AP and the PP possess stem cell attributes,both antler generation and regeneration are stem cell-based processes.However,the cell composition of each tissue type and molecular events underlying antler development remain poorly characterized.Here,we took the approach of single-cell RNA sequencing(scRNA-Seq)and identified eight cell types(mainly THY1^(+)cells,progenitor cells,and osteochondroblasts)and three core subclusters of the THY1^(+)cells(SC2,SC3,and SC4).Endothelial and mural cells each are heterogeneous at transcriptional level.It was the proliferation of progenitor,mural,and endothelial cells in the activated antler-lineage-specific tissues that drove the rapid formation of the antler.We detected the differences in the initial differentiation process between antler generation and regeneration using pseudotime trajectory analysis.These may be due to the difference in the degree of stemness of the AP-THY1+and PP-THY1^(+)cells.We further found that androgen-RXFP2 axis may be involved in triggering initial antler full regeneration.Fully deciphering the cell composition for these antler tissue types will open up new avenues for elucidating the mechanism underlying antler full renewal in specific and regenerative medicine in general. | Hengxing Ba Xin Wang Datao Wang Jing Ren Zhen Wang Hai-Xi Sun Pengfei Hu Guokun Zhang Shengnan Wang Chao Ma Yusu Wang Enpeng Wang Liang Chen Tianbin Liu Ying Gu Chunyi Li | 2022 | Cell Regeneration2022，11，1： | 0 |
| 9 | Bottlebrush inspired injectable hydrogel for rapid prevention of postoperative and recurrent adhesion显示文摘Postsurgical adhesion is a common clinic disease induced by surgical trauma,accompanying serious subsequent complications.Current non-surgical approaches of drugs treatment and biomaterial barrier administration only show limited prevention effects and couldn’t effectively promote peritoneum repair.Herein,inspired by bottlebrush,a novel self-fused,antifouling,and injectable hydrogel is fabricated by the free-radical polymerization in aqueous solution between the methacrylate hyaluronic acid(HA-GMA)and N-(2-hydroxypropyl)methacrylamide(HPMA)monomer without any chemical crosslinkers,termed as H-HPMA hydrogel.The H-HPMA hydrogel can be tuned to perform excellent self-fused properties and suitable abdominal metabolism time.Intriguingly,the introduction of the ultra-hydrophilic HPMA chains to the H-HPMA hydrogel affords an unprecedented antifouling capability.The HPMA chains establish a dense hydrated layer that rapidly prevents the postsurgical adhesions and recurrent adhesions after adhesiolysis in vivo.The H-HPMA hydrogel can repair the peritoneal wound of the rat model within 5 days.Furthermore,an underlying mechanism study reveals that the H-HPMA hydrogel significantly regulated the mesothelial-to-mesenchymal transition(MMT)process dominated by the TGF-β-Smad2/3 signal pathway.Thus,we developed a simple,effective,and available approach to rapidly promote peritoneum regeneration and prevent peritoneal adhesion and adhesion recurrence after adhesiolysis,offering novel design ideas for developing biomaterials to prevent peritoneal adhesion. | Jushan Gao Jinpeng Wen Datao Hu Kailai Liu Yuchen Zhang Xinxin Zhao Ke Wang | 2022 | Bioactive Materials2022，7，10： | 0 |
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