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| 1 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 2 | Experimental results for the vapor-liquid equilibria of 0(formaldehyde+1,3,5-trioxane+methanol+salt+water)systems and comparison with predictions显示文摘The salt effect on the vaporliquid phase equilibrium(VLE)of solvent mixtures is of significant interest in the industrial production of 1,3,5trioxane.Experimental data for the VLE of quinary systems(formaldehyde+1,3,5trioxane+methanol+salt+water)and their ternary subsystems(formaldehyde+salt+water),(1,3,5trioxane+salt+water),and(methanol+salt+water)were systematic measured under atmospheric pressure.The salts considered included KBr,NaNO_(3),and CaCl_(2).The extended UNIFAC model was used to describe the VLE of the saltcontaining reactive mixtures.The model parameters were determined from the experimental VLE data of ternary systems or obtained from the literature,and then were used to predict the VLE of systems(1,3,5trioxane+KBr+water),(methanol+KBr+water),(formaldehyde+KBr+water),and(formaldehyde+1,3,5trioxane+methanol+salt+water)with salt=KBr,NaNO_(3),and CaCl_(2).The predicted results showed good agreements with the measured results.Furthermore,the model was used to uncover the salt effect on the VLE of these multisolvent reactive systems. | Xianming Zhang Mengchen Li Yufeng Hu Zhichang Liu Shuqin Mo | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 2 |
| 3 | Kzp Regulates the Transcription of gata2 and pu.1 during Primitive Hematopoiesis in Zebrafish Embryos显示文摘Kaiso 锌包含手指的蛋白质(Kzp ) ,一个导出似母亲的抄写因素,在 zebrafish gastrulation 期间控制 dorsoventral patterning。这里,我们揭开了为在 zebrafish 的 Kzp 的新功能胚胎的原始造血作用。kzp 的弄空包括 erythroid 和 myeloid 系的发展在原始造血作用导致了缺点。在另一方面, kzp 的 overexpression 引起了 gata1, gata2,和 pu.1 的宫外的表示。染色体 immunoprecipitation 试金表明那 Kzp 蛋白质直接绑在 gata1, gata2,和 pu.1 倡导者。有趣地, gata2 的宫外的表示能在弄空 kzp 的 zebrafish 胚胎救 erythroid,然而并非 myeloid 系。Kzp 控制的 gata1 表示在原始红血球生成期间依赖于 gata2。我们的结果显示 Kzp 是一个批评 transcriptional 因素让 gata2 和 pu.1 的表示调制原始造血作用。 | Fang Liu Shaohua Yao Ting Zhang Chun Xiao Yanna Shang Jin Liu Xianming Mo | 2012 | Journal of Genetics and Genomics2012，39，9： | 1 |
| 4 | Controlled hydrothermal synthesis of thin single-crystal tellurium nanobelts and nanotubes显示文摘 | MO Maosong ZENG Jinghui LIU Xianming | 2002 | Adv Mater2002，14，22： | 1 |
| 5 | SCGN deficiency is a risk factor for autism spectrum disorder显示文摘Autism spectrum disorder(ASD)affects 1-2%of all children and poses a great social and economic challenge for the globe.As a highly heterogeneous neurodevelopmental disorder,the development of its treatment is extremely challenging.Multiple pathways have been linked to the pathogenesis of ASD,including signaling involved in synaptic function,oxytocinergic activities,immune homeostasis,chromatin modifications,and mitochondrial functions.Here,we identify secretagogin(SCGN),a regulator of synaptic transmission,as a new risk gene for ASD.Two heterozygous loss-of-function mutations in SCGN are presented in ASD probands.Deletion of Scgn in zebrafish or mice leads to autism-like behaviors and impairs brain development.Mechanistically,Scgn deficiency disrupts the oxytocin signaling and abnormally activates inflammation in both animal models.Both ASD probands carrying Scgn mutations also show reduced oxytocin levels.Importantly,we demonstrate that the administration of oxytocin and anti-inflammatory drugs can attenuate ASD-associated defects caused by SCGN deficiency.Altogether,we identify a convergence between a potential autism genetic risk factor SCGN,and the pathological deregulation in oxytocinergic signaling and immune responses,providing potential treatment for ASD patients suffering from SCGN deficiency.Our study also indicates that it is critical to identify and stratify ASD patient populations based on their disease mechanisms,which could greatly enhance therapeutic success. | Zhe Liu Shuai Tan Lianyu Zhou Li Chen Mingfeng Liu Wang Wang Yingying Tang Qin Yang Sensen Chi Peiyan Jiang Yue Zhang Yonghua Cui Junhong Qin Xiao Hu Shenglong Li Qi Liu Lu Chen Song Li Ezra Burstein Wei Li Xiaohu Zhang Xianming Mo Da Jia | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 6 | Mid1ip1b modulates apical reorientation of non-centrosomal microtubule organizing center in epithelial cells显示文摘In most kinds of animal cells,the centrosome serves as the main microtubule organizing center(MTOC)that nucleates microtubule arrays throughout the cytoplasm to maintain cell structure,cell division and intracellular transport.Whereas in epithelial cells,non-centrosomal MTOCs are established in the apical domain for generating asymmetric microtubule fibers and cilia in epithelial cells for the organ morphogenesis during embryonic development.However,the mechanism by which MTOCs localize to the apical domain in epithelial cells remains largely unknown.Here,we show that Mid1ip1b has a close interaction with g-tubulin protein,the central component of MTOC,and modulates lumen opening of the neural tube,gut,intestine,and kidney of zebrafish.Knockdown or dominant negative effect of Mid1ip1b resulted in failure of lumen formation of the organs as aforementioned.Moreover,the non-centrosomal MTOCs were unable to orientate to the apical domain in Mid1ip1b knockdown epithelial cells,and the centrosomal MTOCs were inaccurately placed in the apical domain,resulting in defective formation of asymmetric microtubules and misplacement of cilia in the apical domain.These data uncover a molecule that controls the proper localization of MTOCs in the apical domain in epithelial cells for organ morphogenesis during embryonic development. | Xin Zhou Chun Xiao Yu Li Yanna Shang Dongqin Yin Siying Li Bo Xiang Ran Lu Yi Ji Yang Wu Wentong Meng Hongyan Zhu Jin Liu Huozhen Hu Xianming Mo Hong Xu | 2018 | Journal of Genetics and Genomics2018，45，8： | 0 |
| 7 | Interfacial reinforcement of core-shell HMX@energetic polymer composites featuring enhanced thermal and safety performance显示文摘The weak interface interaction and solid-solid phase transition have long been a conundrum for 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane(HMX)-based polymer-bonded explosives(PBX).A two-step strategy that involves the pretreatment of HMX to endow—OH groups on the surface via polyalcohol bonding agent modification and in situ coating with nitrate ester-containing polymer,was proposed to address the problem.Two types of energetic polyether—glycidyl azide polymer(GAP)and nitrate modified GAP(GNP)were grafted onto HMX crystal based on isocyanate addition reaction bridged through neutral polymeric bonding agent(NPBA)layer.The morphology and structure of the HMX-based composites were characterized in detail and the core-shell structure was validated.The grafted polymers obviously enhanced the adhesion force between HMX crystals and fluoropolymer(F2314)binder.Due to the interfacial reinforcement among the components,the two HMX-based composites exhibited a remarkable increment of phase transition peak temperature by 10.2°C and 19.6°C with no more than 1.5%shell content,respectively.Furthermore,the impact and friction sensitivity of the composites decreased significantly as a result of the barrier produced by the grafted polymers.These findings will enhance the future prospects for the interface design of energetic composites aiming to solve the weak interface and safety concerns. | Binghui Duan Hongchang Mo Bojun Tan Xianming Lu Bozhou Wang Ning Liu | 2024 | Defence Technology(防务技术)2024，31，1： | 0 |
| 8 | Neurons generated from carcinoma stem cells support cancerprogression显示文摘Recent evidences show that nervous system acts as a crucial part of cancer microenvironment.Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression.The stimulations of both cancer growth and metastasis by members of nervous system such as neurons and glial cells have been demonstrated.However,how the nervous system is built in cancer is largely unknown.Here we show that a fraction of cancer stem cells(CSCs)derived from patients with gastric carcinoma and colorectal carcinoma are capable of producing neurons that are involved in tumor neurogenesis and tumor growth.Cancer stem cell monoclone derived from a single cancer stem cell was able to generate neurons including sympathetic and parasympathetic neurons to take part in the nervous system in cancer tissues.Knocking down the neural cell generating capability of the human CSCs inhibited the growth of xenograft tumors in mouse model.Our data demonstrate that human CSCs are able to produce one of most important components in the cancer microenvironment that are required for cancer development and progression. | Ran Lu Chuanwen Fan Wenqi Shangguan Yuan Liu Yu Li Yanna Shang Dongqin Yin Shengliang Zhang Qiaorong Huang Xue Li Wentong Meng Hong Xu Zongguang Zhou Jiankun Hu Weimin Li Lunxu Liu Xianming Mo | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 9 | Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases显示文摘mRNA vaccines have emerged rapidly in recent years as a prophylactic and therapeutic agent against various diseases including cancer and infectious diseases.Improvements of mRNA vaccines have been underway,among which boosting of efficacy is of great importance.Pam2Cys,a simple synthetic metabolizable lipoamino acid that signals through Toll-like receptor(TLR)2/6 pathway,eliciting both humoral and cellular adaptive immune responses,is an interesting candidate adjuvant.To investigate the enhancement of the efficacies of mRNA vaccines by Pam2Cys,the adjuvant was incorporated into mRNA-lipid nanoparticles(LNPs)to achieve co-delivery with mRNA.Immunization with the resulting mRNA-LNPs(Pam2Cys)shaped up the immune milieu in the draining lymph nodes(dLNs)through the induction of IL-12 and IL-17,among other cytokines.Antigen presentation was carried out mainly by migratory and dLNresident conventional type 2 DCs(cDC2s)and significantly more potent antitumor responses were triggered in both prophylactic and therapeutic tumor models in a CD4^(+) and CD8^(+) T cell-dependent fashion.Accompanying memory antitumor immunity was also established.Moreover,the vaccine also stimulated much more robust humoral and cellular immunity in a surrogate COVID-19 prophylactic model.Last but not the least,the new vaccines exhibited good preliminary safety profiles in murine models.These facts warrant future development of Pam2Cys-incorporated mRNA vaccines or relevant mRNA therapeutics for clinical application. | Yangzhuo Gu Jingyun Yang Cai He Tingmei Zhao Ran Lu Jian Liu Xianming Mo Fuqiang Wen Huashan Shi | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
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