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| 1 | Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified显示文摘Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the treatment of several acid-related disorders. PPIs are generally well tolerated but, through the long-term reduction of gastric acid secretion, can increase the risk of an imbalance in gut microbiota composition (i.e., dysbiosis). The gut microbiota is a complex ecosystem in which microbes coexist and interact with the human host. Indeed, the resident gut bacteria are needed for multiple vital functions, such as nutrient and drug metabolism, the production of energy, defense against pathogens, the modulation of the immune system and support of the integrity of the gut mucosal barrier. The bacteria are collected in communities that vary in density and composition within each segment of the gastrointestinal (GI) tract. Therefore, every change in the gut ecosystem has been connected to an increased susceptibility or exacerbation of various GI disorders. The aim of this review is to summarize the recently available data on PPI-related microbiota alterations in each segment of the GI tract and to analyze the possible involvement of PPIs in the pathogenesis of several specific GI diseases. | Giovanni Bruno Piera Zaccari Giulia Rocco Giulia Scalese Cristina Panetta Barbara Porowska Stefano Pontone Carola Severi | 2019 | World Journal of Gastroenterology2019，25，22： | 4 |
| 2 | Multimedia computer-based measures of basic science and clinical skills 显示文摘 | Issenberg SB Scalese RJ | 2004 | Med Educ2004，38，5： | 1 |
| 3 | A systematic review of the Charlson comorbidity index using Canadian administrative databases:a perspective on risk adjustment in critical care research显示文摘 | Needham DM Scales DC Laupacis A | | 0，，01： | 1 |
| 4 | Simulation Technology for Skills Training and Competency Assessment in Medical Education显示文摘 | Ross J. Scalese MD Vivian T. Obeso MD S. Barry Issenberg MD | 2008 | Journal of General Internal Medicine2008，，1： | 1 |
| 5 | Simulation technol- ogy for skills training and competency assessment in med- ical education显示文摘 | Scalese R J Oheso VT lssenberg SB | 2012 | Journal of General Internal Medicine2012，6，9： | 1 |
| 6 | Multimedia computer-based measures of basic science and clinical skills显示文摘 | ISSENBERG S B SCALESE R J | 2004 | Med Edu2004，38，5： | 1 |
| 7 | The effect of tra-cheostomy timing during critical illness on long-term sur-vival显示文摘 | Scales DC Thiruchelvam D Kiss A | | 0，，09： | 1 |
| 8 | Flavonoids as antioxidant agents: importance of their interaction with biomembranes 显示文摘 | SAIJA A SCALESE M LANZA M | 1995 | Free Radical Biol Med1995，19，4： | 1 |
| 9 | Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes显示文摘 | Shima DT Scales SJ Kreis TE | | 0，，15： | 1 |
| 10 | Prevalence and real clinical impact of Cupressus sempervirens and Juniperus communis sensitisations in Tuscan “Maremma”,Italy显示文摘 | Sposato B Scalese M | 2011 | Allergologia Immunopathol2011，，： | 1 |
| 11 | Endoprosthetic replacement of the proximal humerus显示文摘 | Ross AC Wilson JN Scales JT | | 0，，04： | 1 |
| 12 | A systematic review of the Charlson comorbidity index using Canadian administrative databases:a perspective on risk adjustment in critical care research显示文摘 | Needham DM Scales DC Laupacis A | | 0，，1： | 1 |
| 13 | Simulation technology for skills training and competency assessment in medical education显示文摘 | Scalese RJ Obeso VT Issenberg SB | 2008 | J Gen Intern Med2008，23，1： | 1 |
| 14 | Simulation technology for skills training and competency assessment in medical edu- cation 显示文摘 | Scalese RJ Obeso VT Issenberg SB | 2008 | J Gen Intern Med2008，23，1： | 1 |
| 15 | Simulation Technology for Skills Training and Competency Assessment in Medical Education显示文摘 | Ross J. Scalese Vivian T. Obeso S. Barry Issenberg | 2008 | Journal of General Internal Medicine2008，，： | 1 |
| 16 | Beyond the'village'rhetoric:Creating healthy communities for children and adolescents显示文摘 | Benson P.L Leffert N Scales P.C Blyth D.A | | 0，，03： | 1 |
| 17 | Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways显示文摘 | Liyun Sang Julie J. Miller Kevin C. Corbit Rachel H. Giles Matthew J. Brauer Edgar A. Otto Lisa M. Baye Xiaohui Wen Suzie J. Scales Mandy Kwong Erik G. Huntzicker Mindan K. Sfakianos Wendy Sandoval J. Fernando Bazan Priya Kulkarni Francesc R. Garcia-Gonza | 2011 | Cell2011，，4： | 1 |
| 18 | A paracrine requirement for hedgehog signalling in cancer显示文摘 | Yauch RL Gould SE Scales SJ | | 0，，7211： | 1 |
| 19 | The contribution of the developmental assets framework to positive youth development theory and practice显示文摘 | Benson P.L Scales P.C Syvertsen A.K | | 0，，： | 1 |
| 20 | Simulation in health care education 显示文摘 | Issenberg SB Scalese RJ | 2008 | Perspect Biol Med2008，51，1： | 1 |
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