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| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | 高分辨率合成孔径雷达卫星反演风场资料在中国近海风能资源评估中的应用研究显示文摘由于海上测风非常昂贵,实地测风资料严重不足,而卫星反演海面风场资料可以有效地弥补这一缺陷,对近海风能资源评估具有至关重要的意义。近年来,欧洲太空局2002年3月发射的Envisat卫星搭载合成孔径雷达(SAR)图像产品在欧洲近海风能资源评估中得到了广泛应用。文中探讨了空间分辨率约1 km×1 km的SAR卫星反演海面风场资料应用于杭州湾近海风能资源评估的技术方法,通过杭州湾海域的实测风速与SAR卫星反演海面风速数据的对比分析发现:(1)14个实测站点中13个站的相对误差小于20%,其中7个站的相对误差小于10%,平均标准差为2.29 m/s;(2)以SAR卫星反演风速数据为基础计算的风能参数(形状参数和尺度参数)与实测数据计算结果的一致性较高;(3)将该数据同化进入WRF数值模式中,与控制试验相比,大部分检验站点的风速相关系数明显提高,标准差和相对误差也得到改善。SAR卫星反演风场资料可用于中国的近海风能资源评估。 | 常蕊 朱蓉 周荣卫 叶冬 张晓伟 Merete Badger Charlotte Bay Hasager | 2014 | 气象学报2014，72，3： | 19 |
| 3 | Speeded-Up Robust Features (SURF)显示文摘 | Herbert Bay Andreas Ess Tinne Tuytelaars Luc Van Gool | 2007 | Computer Vision and Image Understanding2007，，3： | 14 |
| 4 | Explicit classes of permutation polynomials of F_3^(3m)显示文摘Permutation polynomials have been an interesting subject of study for a long time and have applications in many areas of mathematics and engineering. However, only a small number of specific classes of permutation polynomials are known so far. In this paper, six classes of linearized permutation polynomials and six classes of nonlinearized permutation polynomials over F33m are presented. These polynomials have simple shapes, and they are related to planar functions. | DING CunSheng1, XIANG Qing2, YUAN Jin3 & YUAN PingZhi4 1 Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, China 2 Department of Mathematical Sciences, University of Delaware, Newark, DE 19716, USA 3 Department of Computing, Macquarie University, NSW 2109, Australia 4 School of Mathematics, South China Normal University, Guangzhou 510631, China | 2009 | Science China Mathematics2009，52，4： | 8 |
| 5 | Smear positive pulmonary tuberculosis among diabetic patients at the Dessie referral hospital, Northeast Ethiopia显示文摘Background:Tuberculosis(TB)is an infectious disease which is still a major cause of morbidity and mortality throughout the world.People with diabetes mellitus(DM)have a three times higher risk of developing active TB than people without diabetes.However,there is not enough credible information on the burden of pulmonary tuberculosis(PTB)among DM patients in Ethiopia,in general,and in the city of Dessie,in particular.Therefore,this study aims to determine the prevalence and associated risk factors of smear positive PTB among diabetic patients at a referral hospital in Dessie.Methods:A cross-sectional study was conducted from February 2012 to April 2012.Patient demographic characteristics were collected using a pre-tested standard questionnaire format.Spot-morning-spot sputum specimens were collected from the study participants and examined for acid-fast bacilli using direct microscopy by the Ziehl-Neelsen staining technique.Data was entered and analyzed using the SPSS version 16 statistical software and p-value<0.05 was considered as statistically significant.Results:Out of 225 TB suspected diabetic patients,52%were males and 48%were females.Their ages ranged from 12 to 82 years,with a mean age of 47.2 years.Urban residence(AOR:5.5;95%CI:1.07-28.20),history of TB(AOR:13.4;95%CI:2.74-65.73),contact with TB patients in the family(AOR:9.4;95%CI:1.822-48.50),and long duration of DM(AOR:8.89;95%CI:1.88-58.12)were independently associated with the development of active TB in people living with DM.Conclusions:The prevalence of smear positive PTB was 6.2%in TB suspected diabetic patients,which is higher compared with the general population(0.39%).Patients with a previous history of contact with TB patients,as well as those who had prolonged diabetes,were more prone to have PTB.Therefore,screening of diabetic patients for PTB infection during follow-up is necessary. | Hiwot Amare Aschalew Gelaw Belay Anagaw Baye Gelaw | 2013 | Infectious Diseases of Poverty2013，2，1： | 7 |
| 6 | Diagnosis of interatrial block显示文摘 | Antoni Bay, s de Luna Adrian Baranchuk Luis Alberto Escobar Robledo Albert Masso van Roessel Manuel Martinez-Selles | 2017 | Journal of Geriatric Cardiology2017，14，3： | 6 |
| 7 | Treatment of Budd-Chiari syndrome with a focus on transjugular intrahepatic portosystemic shunt显示文摘AIM:To evaluate long-term complications and survival in patients with Budd-Chiari syndrome (BCS) referred to a Danish transjugular intrahepatic portosystemic shunt (TIPS) centre.METHODS:Twenty-one consecutive patients from 1997-2008 were retrospectively included [15 women and 6 men,median age 40 years (range 17-66 years)].Eighteen Danish patients came from the 1.8 million catchment population of Aarhus University Hospital and three patients were referred from Scandinavian hospitals.Management consisted of tests for underlying haematological,endocrinological,or hypercoagulative disorders parallel to initiation of specific treatment of BCS.RESULTS:BCS was mainly caused by thrombophilic (33%) or myeloproliferative (19%) disorders.Fortythree percents had symptoms for less than one week with ascites as the most prevalent finding.Fourteen (67%) were treated with TIPS and 7 (33%) were manageable with treatment of the underlying condition and diuretics.The median follow-up time for the TIPS-treated patients was 50 mo (range 15-117 mo),and none required subsequent liver transplantation.Ascites control was achieved in all TIPS patients with a marked reduction in the dose of diuretics.A total of 14 TIPS revisions were needed,mostly of uncovered stents.Two died during follow-up:One non-TIPS patient worsened after 6 mo and died in relation to transplantation,and one TIPS patient died 4 years after the TIPS-procedure,unrelated to BCS.CONCLUSION:In our BCS cohort TIPS-treated patients have near-complete survival,reduced need for diuretics and compared to historical data a reduced need for liver transplantation. | Anders Bay Neumann Stine Degn Andersen Dennis Tφnner Nielsen Peter Holland-Fischer Hendrik Vilstrup Henning Grφnbk | 2013 | World Journal of Hepatology2013，5，1： | 5 |
| 8 | Nursing education in China:Meeting the global demand for quality healthcare显示文摘With a predicted global nursing shortage,ensuring the provision of quality healthcare has become a pressing concern.In China,these concerns include the need to produce nurses trained to a level to support advancing nursing practice and a healthcare system that supports the growth and retention of nurses in China.This paper argues that the standard of nursing education in China plays a crucial role in preparing graduates to meet the health demands of China's growing population and the role that China can play into the future in the global progression of nursing.Collaboration between nursing authorities,educators,and legislators is required to support the progression of nursing worldwide. | Carol Chunfeng Wang Lisa Whitehead Sara Bayes | 2016 | International Journal of Nursing Sciences2016，3，1： | 5 |
| 9 | Some antecedents and effects of trust in virtual communities显示文摘 | Catherine M Ridings David Gefen Bay Arinze | 2002 | Journal of Strategic Information Systems2002，，3： | 4 |
| 10 | Prediction of sudden death in elderly patients with heart failure显示文摘最,心失败(HF ) 联系了死亡由于突然的心脏的死亡(SCD ) 和变得更坏的 HF,特别地在减少的喷射的情况中部分。预言并且阻止 SCD 是一个重要目标,但是最工作不包括或有先进年龄的很少病人,和在有 HF 的老病人的 SCD 的预防仍然是争论的。处于 SCD 的年度率的最近的减小最近被描述了,但是如果这在先进年龄病人也是真的,它不是清楚的。尽管医生们经常有有 HF 的老病人主要死于泵失败的感觉,年龄与 SCD 被联系,低估 SCD 的重要性。被联系了到 SCD 的另外的临床的变量是症状,纽约心协会功能的类, ischemic 原因,和 comorbidities (长期的妨碍的肺的疾病,肾的机能障碍和糖尿病) 。应该也被考虑的一些测试结果被让喷射室部分和直径, natriuretic 肽,非支撑的室的心悸亢进和自治畸形。所有这些标记的联合可能是最好的选择预言 SCD。不同风险分数被描述了并且尽管为老人口没有特定的,当一个风险预言者和一些与吝啬的年龄在人口被开发,最包括年龄 > 65 年。最后,强调这些分数应该能预言 SCD 的任何类型作为是重要的尽管大多数由于 tachyarrhythmias, bradyarrhythmias 也起一个作用,特别地在情况中老。 | Ana Ayesta Helena Martinez-Sellest Antonio Bayes de Luna Manuel Martinez-Selles | 2018 | Journal of Geriatric Cardiology2018，15，2： | 4 |
| 11 | Landslide initiation and runout susceptibility modeling in the context of hill cutting and rapid urbanization: a combined approach of weights of evidence and spatial multicriteria显示文摘Rainfall induced landslides are a common threat to the communities living on dangerous hillslopes in Chittagong Metropolitan Area, Bangladesh. Extreme population pressure, indiscriminate hill cutting, increased precipitation events due to global warming and associated unplanned urbanization in the hills are exaggerating landslide events. The aim of this article is to prepare a scientifically accurate landslide susceptibility map by combining landslide initiation and runout maps. Land cover, slope, soil permeability, surface geology, precipitation, aspect, and distance to hill cut, road cut, drainage and stream network factor maps were selected by conditional independence test. The locations of 56 landslides were collected by field surveying. A weight of evidence(Wo E) method was applied to calculate the positive(presence of landslides) and negative(absence of landslides) factor weights. A combination of analytical hierarchical process(AHP) and fuzzymembership standardization(weighs from 0 to 1) was applied for performing a spatial multi-criteria evaluation. Expert opinion guided the decision rule for AHP. The Flow-R tool that allows modeling landslide runout from the initiation sources was applied. The flow direction was calculated using the modified Holmgren's algorithm. The AHP landslide initiation and runout susceptibility maps were used to prepare a combined landslide susceptibility map. The relative operating characteristic curve was used for model validation purpose. The accuracy of Wo E, AHP, and combined susceptibility map was calculated 96%, 97%, and 98%, respectively. | RAHMAN Md.Shahinoor AHMED Bayes DI Liping | 2017 | Journal of Mountain Science2017，14，10： | 4 |
| 12 | Microwave-Assisted Solid Phase Organic Synthesis. Application to Indole Library Construction显示文摘 | DAI Wei-Min*1,2, SUN Li-Ping2, GUO Dian-Shun2, HUANG Xiang-Hong2 1.Department of Chemistry, Zhejiang University, Hangzhou 310027, China 2.Combinatorial Chemistry Laboratory, The Biotechnology Research Institute and Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China | 2004 | 合成化学2004，12，z1： | 3 |
| 13 | Surface modification of porous antireflective coatings for solar glass covers显示文摘 | G. San Vicente R. Bayón N. Germán A. Morales | 2010 | Solar Energy2010，，4： | 2 |
| 14 | LINEAR AND HYPERBRANCHED POLYMERS WITH HIGH THERMAL STABILITY AND LUMINESCENCE EFFICIENCY显示文摘New acetylene monomers, 6-{[(1-naphthylethynyl-4-phenyl)carbonyl]oxy}-l-phenyl-l-hexyne (1), 2,5-diethynylthiophene (3), and 4,4′-diethynylbiphenyl (6) were synthesized. Homopolymerization of 1 and copolycyclotrimerizations of 3and 6 with 1-heptyne and l-octyne have been achieved with WCI6- and TaC15-Ph4Sn catalysts, respectively, giving soluble linear disubstituted polyacetylene (2) and hyperbranched polyarylenes (5 and 8) with high molecular weights (up to 1.2 ×105) in high yields (upto 98%). The structures and properties of the polymers are characterized and evaluated by IR, NMR,TGA, UV, photoluminescence (PL), and electroluminescence (EL) analyses. All the polymers possess high thermal stability and emit strong blue light upon photoexcitation. The intensity of the emitted light is greater than that of poly(1-phenyl-1-octyne), a well-known highly luminescent disubstituted polyacetylene. Little aggregation-induced red shift in the PL was observed in the thin films of the polymers. By constructing a multi-layer EL device, high EL quantum yield (0.18%) has been achieved in 2, which are the best results for substituted polyacetylenes attainable so far. | Jacky Wing Yip Lam Jing-dong Luo Han Peng Zhi-liang Xie Kai-tian Xue Yu-ping Dong Lin Cheng Cheng-feng Qiu Hoi Sing Kwok Ben-zhong Tang Departments of Chemistry and Electrical & Electronic Engineering Hong Kong University of Science & Technology Clear Water Bay, Kowloon, Hong Kong China | 2001 | Chinese Journal of Polymer Science2001，19，6： | 2 |
| 15 | Genomic resources for the brown planthopper, Nilaparvata lugens: Transcriptome pyrosequencing and microarray design显示文摘棕色的 planthopper, Nilaparvata lugens 是在整个亚洲的栽培米饭的一个害虫并且用杀虫药剂或抵抗米饭变化被控制。这种开发了抵抗到杀虫药剂的许多班,遗传因子型开发了那对先前是剧毒的抵抗米饭栽培变种。昆虫使用 detoxification 酶的一间套房,包括保卫自己对的细胞色素 P450s,谷胱甘肽 S-transferases 和 carboxyl/cholinesterases 种第二等的代谢物和杀虫剂。Roche 454-FLX 站台上的 Pyrosequencing 被用来生产补充存在 Sanger 的数据集定序的一个实质的表示顺序标签(EST ) 在 GenBank 的 EST。一个总数 78 959 读与 37 392 公开地可得到的 Sanger EST 被相结合;这些集合了进 8 911 contigs 和 10 620 单条。分发的分析试验有为生物进程和分子的函数的基因本体论的唯一的基因(拖船) 建议 454 并且 Sanger EST 汇编 N 是广泛地代表性的。lugens transcriptome。planthopper transcriptome 被发现包含编码 P450s,九个编码谷胱甘肽 S-transferases 和这些的 26 编码 carboxyl/cholinesterases 和许多的 31 条拖船的褐通常认为地涉及 xenobiotics 的 detoxification。Agilent eArray 站台被用来构造为 19 000 个 unigene 序列与探针占据的 oligonucleotide microarray,包括知道编码 detoxification 酶的所有那些。在这研究开发的 genomic 资源将对学习这个庄稼害虫的社区有用并且将帮助阐明位于杀虫药剂抵抗和 planthopper 改编下面到抵抗米饭栽培变种的分子的机制。 | Chris Bass Martin Bay Hebsgaard Joseph Hughes | 2012 | Insect Science2012，19，1： | 2 |
| 16 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 17 | Gold nanoparticles in cancer therapy显示文摘特别地,最近的年里的纳米技术的快速的前进在 nanoparticle 研究的领域里造成了发芽兴趣它在医药竞技场的申请。金 nanoparticles (AuNPs ) 的性质的更好的理解上的常常膨胀的 knowledge based 结合了纳米技术的边疆常常正在被质问的无情的试验工具。目前,似乎是对到癌症的管理的 AuNPs 的申请的提高的兴趣,包含诊断,监视并且疾病的治疗。这些努力被承担希望为象癌症那样的 multifactorial 疾病革命化治疗和治疗策略的当前的方法。这评论将在癌症管理集中于 AuNPs 的当前的应用。 | Zhao-Zhin Joanna LIM Jia-En Jasmine LI Cheng-Teng NG Lin-Yue Lanry YUNG Boon-Huat BAY | 2011 | Acta Pharmacologica Sinica2011，32，8： | 2 |
| 18 | Theory of single point incremental forming显示文摘 | P.A.F. Martins N. Bay M. Skjoedt M.B. Silva | 2008 | CIRP Annals - Manufacturing Technology2008，，1： | 2 |
| 19 | Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial显示文摘 | Bernard Escudier Anna Pluzanska Piotr Koralewski Alain Ravaud Sergio Bracarda Cezary Szczylik Christine Chevreau Marek Filipek Bohuslav Melichar Emilio Bajetta Vera Gorbunova Jacques-Olivier Bay Istvan Bodrogi Agnieszka Jagiello-Gruszfeld Nicola Moore | 2007 | The Lancet . 2007 (9605)2007，，： | 2 |
| 20 | Atrial fibrillation in the elderly显示文摘 | Manuel Martinez-Selles Antonio Bayes de Lun | 2017 | Journal of Geriatric Cardiology2017，14，3： | 2 |
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