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| 1 | 应用可扩展的套索回归模型对间皮瘤进行生存期预测:临床预测指标的使用和初始性能的说明显示文摘目的对恶性胸膜间皮瘤(MPM)进行准确的预后预测具有一定困难。我们研究一套健全的计算模型来量化常规可用临床数据的预后价值,它们构成了已发布的MPM预测模型的基础。 | 王臻(译) 施焕中(校) Andrew C Kidd Michael McGettrick Selina Tsim Daniel L Halligan Max Bylesjo Kevin G Blyth | 2018 | 英国医学杂志中文版2018，21，6： | 11 |
| 2 | 基于OPAQ的城市空气质量预报系统研究显示文摘空气质量预测在国内的关注度日益提高,传统的空气质量预测系统通常运用数值化学传输模型,利用物理方程来计算污染物的扩散、沉降和化学反应。而化学传输模型的预测准确性很大程度上需要依赖详细的污染源排放信息和气象模型的输出结果。基于统计模型的OPAQ空气质量预报业务系统,采用人工神经网络算法,可预测各污染物的日均值或日最大值。并对北京空气质量预报的结果进行了评价,OPAQ空气质量预报业务系统对空气质量预测的准确性较高,能够利用较低的计算资源得到较为准确的预测结果。与数值预报相比,OPAQ空气质量预报业务系统不需要大量的基础数据作为输入,可弥补数值预报的不足,并成为数值预报的有力补充。 | 王淑莹 许荣 尹翠芳 Bino Maiheu Stijn Janssen Lisa Blyth | 2016 | 中国环境监测2016，32，3： | 10 |
| 3 | Marked elevation of B-type natriuretic peptide in patients with heart failure and preserved ejection fraction显示文摘Marked elevations of B-type natriuretic peptide(BNP)are not generally seen in patients with heart failure and preserved ejection fraction(HFpEF).The objective of this study was to examine the clinical and laboratory characteristics of a large cohort of patients with HFpEF and markedly elevated BNP.A retrospective examination of 421inpatients at a university hospital admitted with a diagnosis of HFpEF was performed.Clinical and echocardiographic data in 4 groups of patients with levels of BNP≤100 pg/mL,100-400 pg/mL,400-1,000 pg/mL and>1,000 pg/mL were compared.Patients with HFpEF and BNP>1,000 pg/mL(28%of the population)were characterized by impaired renal function and greater use of anti-hypertensive medications.A subset of these patients with BNP>1,000 pg/mL had normal renal function(21%)and were significantly older,more frequently female,and tended to have lower ejection fractions.Conversely,patients with HFpEF and BNP≤100 pg/mL were younger and had preserved renal function.BNP was inversely related to the likelihood of subsequent admission for heart failure,but not to myocardial infarction or death.In conclusion:BNP>1,000 pg/mL is seen in almost 1/3 of patients hospitalized with HFpEF.This elevation of BNP often reflects impaired renal function,but can also be seen in patients with preserved renal function but relatively impaired systolic function. | Samuel Tate Andrea Griem Blythe Durbin-Johnson Clifton Watt Saul Schaefer | 2014 | The Journal of Biomedical Research2014，28，4： | 7 |
| 4 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 5 | Alcohol-induced protein hyperacetylation: Mechanisms and consequences显示文摘Although the clinical manifestations of alcoholic liver disease are well-described, little is known about the molecular basis of liver injury. Recent studies have indicated that ethanol exposure induces global protein hyperacetylation. This reversible, posttranslational modification on the ε-amino groups of lysine residues has been shown to modulate multiple, diverse cellular processes ranging from transcriptional activation to microtubule stability. Thus, alcoholinduced protein hyperacetylation likely leads to major physiological consequences that contribute to alcohol-induced hepatotoxicity. Lysine acetylation is controlled by the activities of two opposing enzymes, histone acetyltransferases and histone deacetylases. Currently, efforts are aimed at determining which enzymes are responsible for the increased acetylation of specifi c substrates. However, the greater challenge will be to determine the physiological ramifications of protein hyperacetylation and how they might contribute to the progression of liver disease. In this review, we will fi rst list and discuss the proteins known to be hyperacetylated in the presence of ethanol. We will then describe what is known about the mechanisms leading to increased protein acetylation and how hyperacetylation may perturb hepatic function. | Blythe D Shepard Pamela L Tuma | 2009 | World Journal of Gastroenterology2009，15，10： | 3 |
| 6 | Forecasting available parking space with largest Lyapunov exponents method显示文摘The techniques to forecast available parking space(APS) are indispensable components for parking guidance systems(PGS). According to the data collected in Newcastle upon Tyne, England, the changing characteristics of APS were studied. Thereafter, aiming to build up a multi-step APS forecasting model that provides richer information than a conventional one-step model, the largest Lyapunov exponents(largest LEs) method was introduced into PGS. By experimental tests conducted using the same dataset, its prediction performance was compared with traditional wavelet neural network(WNN) method in both one-step and multi-step processes. Based on the results, a new multi-step forecasting model called WNN-LE method was proposed, where WNN, which enjoys a more accurate performance along with a better learning ability in short-term forecasting, was applied in the early forecast steps while the Lyapunov exponent prediction method in the latter steps precisely reflect the chaotic feature in latter forecast period. The MSE of APS forecasting for one hour time period can be reduced from 83.1 to 27.1(in a parking building with 492 berths) by using largest LEs method instead of WNN and further reduced to 19.0 by conducted the new method. | 季彦婕 汤斗南 郭卫红 BLYTHE T.Phil 王炜 | 2014 | Journal of Central South University2014，21，4： | 3 |
| 7 | Alcohol-induced alterations of the hepatocyte cytoskeleton显示文摘The hepatocyte cytoskeleton consists of three fi lamentous networks: microtubules, actin microfi laments and keratin intermediate filaments. Because of the abundance of the proteins that comprise each system and the central role each network plays in a variety of cellular processes, the three fi lament systems have been the focus of a host of studies aimed at understanding the progression of alcohol-induced liver injury. In this review, we will briefly discuss the hepatic organization of each cytoskeletal network and highlight some components of each system. We will also describe what is known about ethanol-induced changes in the dynamics and distributions of each cytoskeletal system and discuss what is known about changes in protein expression levels and post-translational modifi cations. Finally, we will describe the possible consequences of these cytoskeletal alterations on hepatocyte function and how they might contribute to the progression of liver disease. | Blythe D Shepard Pamela L Tuma | 2010 | World Journal of Gastroenterology2010，16，11： | 2 |
| 8 | Projected effectiveness of HIV detection during early infection and rapid ART initiation among MSM and transgender women in Peru: A modeling study显示文摘Background:The Sabes study,a treatment as prevention intervention in Peru,tested the hypothesis that initiating antiretroviral therapy(ART)early in HIV infection when viral load is high,would markedly reduce onward HIV transmission among high-risk men who have sex with men(MSM)and transgender women(TW).We investigated the potential population-level benefits of detection of HIV early after acquisition and rapid initiation of ART.Methods:We designed a transmission dynamic model to simulate the HIV epidemic among MSM and TW in Peru,calibrated to data on HIV prevalence and ART coverage from 2004 to 2011.We assessed the impact of an intervention starting in 2018 in which up to 50%of the new infections were diagnosed within three months of acquisition and initiated on ART within 1 month of diagnosis.We estimated the impact of the intervention over 20 years using the cumulative prevented fraction of new HIV infections compared to scenarios without intervention.Findings:Our model suggests that only 19%of the infected MSM and TW are virally suppressed in 2018 and 35%e40%of the new HIV infections are transmitted from contacts with acutely-infected partners.An intervention reaching 10%of all acutely infected MSM and TW is projected to prevent 13.3%[Uncertainty interval:11.9%e14.3%]of the new infections over 20 years and reduce HIV incidence in 2038 by 24%.Reaching 50%of all acutely infected MSM and TWwill increase the prevalence of viral suppression in 2038 to 59%and prevent 41%of expected infections over 20 years.Reaching 50%of the high-risk MSM and TW in acute phase would reduce HIV incidence in 2038 by 60%and prevent 36%of new infections between 2018 and 2038.Conclusions:Early detection of HIV infections and rapid initiation of ART among MSM is desirable as it would increase the effectiveness of the HIV prevention program in Peru.Targeting high-risk MSM and TW will be highly efficient. | Dobromir Dimitrov Daniel Wood Angela Ulrich David A.Swan Blythe Adamson Javier R.Lama Jorge Sanchez Ann Duerr | 2019 | Infectious Disease Modelling2019，4，1： | 2 |
| 9 | Bacterial pathogens in Hawaiian coastal streams—Associations with fecal indicators, land cover, and water quality显示文摘 | Emily J. Viau Kelly D. Goodwin Kevan M. Yamahara Blythe A. Layton Lauren M. Sassoubre Siobhán L. Burns Hsin-I Tong Simon H.C. Wong Yuanan Lu Alexandria B. Boehm | 2011 | Water Research2011，，11： | 2 |
| 10 | 随钻声波测井新技术显示文摘工程师根据声波测井仪记录的声波资料以更高的安全系数提高钻井效率,优化完井方式。LWD声波测井仪是在上世纪90年代中期问世的,能够记录纵波资料,但不能记录所有地层的横波资料。新型LWD声波测井仪能记录以前无法得到的横渡资料,工程师正在利用横渡资料优化钻井作业,确定最佳钻进方向,识别具有更好完井特征的岩层。 | Jeff Alford Matt Blyth Ed Tollefsen John Crowe Julio Loreto Saeed Mohammed Vivian Pistre Adrian Rodriguez-Herrera | 2013 | 国外测井技术2013，，2： | 2 |
| 11 | GE公司Tier3机车柴油机的设计与开发显示文摘为了应对美国环保局(EPA)1998年发布的机车排放标准(2000年生效),GE公司开始着手GEVO发动机的开发。开发这种新的发动机平台是为了满足美国环保局和其他立法机构未来的排放法规要求,以及满足客户所需要的高可靠性、低运行成本的要求。创新系列机车自2005年开始投放市场以来,已有超过2000台Tier2达标机车交货,已经证明,该机车采用的GEVO发动机是非常可靠、高效的。为满足Tier2排放标准要求而设计的GEVO发动机是非常成功的,最近,为满足美国EPA Tier3机车排放标准要求,对其又进行了修改。通过改进喷油方法、减少机油消耗和改进进气系统,发动机PM(颗粒物)排放量减少了50%;同时,NOx的排放量保持不变,而且也没有对燃油经济性构成损害。PM减排目标是通过机油消耗的减少和喷油控制方法的改进而达到的。机油消耗量的减少是通过采用一套更得力的活塞环组和缸套表面的优化而实现的。为了判定各种动力组件结构设计特点带来的影响并选择最终的动力组结构,采用了一套瞬时的机油消耗测量系统。该系统使我们对不同运行条件下(即低负荷工况、过渡工况和高负荷工况)的机油迁移机理有了深刻的理解。通过采用新的高压共轨燃油喷射系统,可以更灵活地调节燃油的喷射和控制喷射压力,从而进一步降低了颗粒物排放量。燃油消耗率的损失是通过提高增压器效率和采用提前关闭进气门以及优化喷油方法来弥补的。最终的结构经过了大量的试验台试验和现场耐久性试验的验证。本文将对GE公司下一代机车柴油机的发展过程和设计特点加以介绍。 | Neil X. Blythe W. Doug Glenn 李臣 | 2011 | 国外内燃机车2011，，5： | 2 |
| 12 | On idempotent-generated subsemigroups of principally ordered regular semigroups显示文摘 | BLYTH T S PINTO G A | 2003 | Semigroup Forum2003，67，1： | 1 |
| 13 | Regular semigroups with a multiplicative inverse transversal 显示文摘 | BLYTH T S MCFADDEN R B | 1982 | Proc Roy Soc Edinburgh1982，92，： | 1 |
| 14 | Nicholson's blowflies revisited显示文摘 | Gurney W S C Blythe S P Nisbet R M | 1980 | Nature1980，，287： | 1 |
| 15 | Nicholsoffs blowflies revisited显示文摘 | Gurney W S C Blythe S P Nisbet R M | 1980 | Nature1980，287，： | 1 |
| 16 | Iatrogenic nerve injury with the Russell-Taylor humeral nail显示文摘 | Blyth M J Macleod CM Asante DK Kinninmonth AW | 2003 | Injury2003，34，： | 1 |
| 17 | Validation of serum markers for blood-brain barrier disruption in traumatic brain injury显示文摘 | Blyth B J Farhavar A Gee C | 2009 | Neurotrauma2009，26，9： | 1 |
| 18 | Electrified viscous thin film flow over topography 显示文摘 | TSELUIKO D BLYTH M G PAPAGEORGIOU D T | 2008 | Journal of Fluid Mechanics2008，597，6： | 1 |
| 19 | Principally ordered regular semigroups显示文摘 | BLYTH T S PINTO G A | 1990 | Glasgow Math J1990，32，2： | 1 |
| 20 | Australia Vocational Education and Training-Training Packages,Australian National Training Authority显示文摘 | | 2004 | JournaI of Vocational Education and Training2004，，12： | 1 |
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