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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 3 | 高危型HPVE6/E7 mRNA原位杂交对102例宫颈、外阴、肛周及头颈部肿瘤PCR、DNA原位杂交和p16免疫组化染色结果的验证(英)显示文摘调节致癌蛋白E6/E7异常表达在人乳头状瘤病毒的致癌过程中具有一定作用。HPV E6/E7 mRNA原位杂交(RISH)检测包括18种常见高危类型(HR-RISH/HR-HPV RNA 18 ISH),在肛门与生殖器肿瘤中尚未得到广泛的研究。作者对HPV相关肛门与生殖器及头颈部肿瘤中,PCR、P16免疫组化染色和HPV DNA原位杂交检测结果与HR-RISH结果进行比较。共搜集102例病理结果异常病例,其中宫颈鳞状上皮内病变(16 CIN1,25 CIN3,3 AIN1,12 AIN3,9 VIN3)及浸润性鳞状细胞癌(17宫颈癌,2外阴肿瘤,18头颈部肿瘤)及10例病理结果为正常宫颈和15例宫颈慢性炎症(对照组)。 | Mills AM Dirks DC Poulter MD 曹琪(译) 张建中(校) | 2017 | 诊断病理学杂志2017，24，11： | 16 |
| 4 | PREPARATION AND PROPERTIES OF RARE EARTH HYDROXIDES AND OXIDES ULTRAFINE POWDERS IN ALCOHOL显示文摘PREPARATIONANDPROPERTIESOFRAREEARTHHYDROXIDESANDOXIDESULTRAFINEPOWDERSINALCOHOL￥XiangTingDONG;ZongRuiLIU;KuiShengYANG;JingHeL... | Dong, XT Liu, ZR Yang, KS Liu, JH Hong, GY Yu, DC | 1995 | Chinese Chemical Letters1995，6，11： | 11 |
| 5 | Synthesis and Properties of Cerium Oxide Nanometer Powders by Pyrolysis of Amorphous Citrate显示文摘CeO2 nanometer powders of different sizes were prepared at low temperature by pyrolysis of amorphous citrate. XRD patterns show that CeO2 is cubic in structure, space group Oh5-FM3M·TEM indicates that the prepared CeO2 is spherical in shape, and the particle size distribution is in narrow range. It was found that calcination temperature is a more important factor affecting the crystallite size of CeO2 than calcining time, the smaller the particle. the bigger the crystallattice distortion, the worse the crystal growth. Solubility test of CeO2 in nitric acid reveals that the surface activity of CeO2 decreases with the increasing particle sizes. IR spectra analysis shows that the absorption of Ce-O bond is shifted to higher energy with the decrease of CeO2 particle sizes. | Dong, XT Hong, GY Yu, DC Yu, DS | 1997 | Journal of Materials Science & Technology1997，13，2： | 11 |
| 6 | Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘 | Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y | 2006 | 中国生物学文摘2006，20，10： | 10 |
| 7 | Protective effect of early enteral feeding on postburn impairment of liver function and its mechanism in rats显示文摘AIM To study the protective effect of earlyenteral feeding(EEF)on the postburnimpairment of liver function and its mechanism.METHODS Wistar rats with 30% of total bodysurface area(TBSA)full-thickness burn wereemployed.The effects of EEF on the postburnchanges of gastric intramucosal pH,endotoxinlevels in portal vein,water contents of hepatictissue,blood concentrations of tumor necrosisfactor(TNF-α),plasma activities of alanineaminotransferase(ALT)and asparateaminotransferase(AST),as well as the bloodcontents of total(TB)and direct bilirubin(DB),total protein(TP)and albumin(ALB)wereserially determined within 48h postburn.RESULTS EEF could significantly improvegastric mucosal acidosis,reduce portal veinendotoxin level and water content of hepatictissue,as well as plasma concentrations of TNF-α at all timepoints after severe burns(P<0.01);postburn elevation of the plasma activities ofALT,AST and the contents of TB,DB wereeffectively prevented,whereas the plasmaconcentrations of TP and ALB were markedlyincreased 24 h and 48 h posturn in EEF groupcompared with that of the burn without EEFgroup(P<0.01).CONCLUSION EEF has significant beneficialeffects on the improvement of hepatic function in rats after severe burn,and is probably relatedwith an increase in splanchnic blood flow,reduction of the absorption of gut-originendotoxin and the consequent release ofinflammatory mediators. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 10 |
| 8 | LDA测量方截面U型旋转通道速度分布显示文摘为了深入了解旋转涡轮叶片内冷通道中的流动特性 ,用激光多谱勒测速仪 (LDA)测量了旋转U型通道中的平均速度分布。通道的横截面积为 5 0mm× 5 0mm ,弯管的平均半径与水利直径的比值为 0 6 5 ,旋转轴与弯管的曲率轴平行。在Re=10 5 时分别测量了转动数Ro =0 ,0 2和 - 0 2三种旋转状态下的速度分布。在这三种情况下弯管内侧θ =90°至下游一定范围内都有流动的分离出现。由于不同的旋转状态二次流的方向和强弱不同 ,导致了分离区大小和通道中速度分布的不同。 | 吉洪湖 LAUNDER BE JACKSON DC | 2001 | 推进技术2001，22，3： | 7 |
| 9 | Reduced gastric acid production in burn shock period and its significance in the prevention and treatment of acute gastric mucosal lesions显示文摘AIM To investigate the changes of gastric acidproduction and its mechanism in shock period ofsevere burn in rats.METHODS A rat model with 30% TBSA full-thickness burn injury was employed and thegastric acid production,together with gastricmucosal blood flow(GMBF)and energy charge(EC)were measured serially within 48hpostburn.RESULTS The gastric acid production in theacute shock period was markedly inhibited aftersevere burn injury.At the 3rd h postburn,thegastric juice volume,total acidity and acidoutput were already significantly decreased(P<0.01),and reached the lowest point,0.63mL/L±0.20mL/L,10.81mmol/L±2.58mmol/L and 2.23mmol/h±0.73mmol/hrespectively,at the 12th h postburn.Althoughrestored to some degree 24 h after thermalinjury,the variables above were stillstatistically lower,compared with those ofcontrol animals at the 48th h postburn.TheGMBF and EC were also significantly reducedafter severe burns,consistent with the trend ofgastric acid production changes.CONCLUSION Gastric acid production,as wellas GMBF and EC was predominantly decreased in the early postburn stage,suggesting that gastricmucosal ischemia and hypoxia with resultantdisturbance in energy metabolism,but notgastric acid proper,might be the decisive factorin the pathogenesis of AGML after thermalinjury,and that the preventive use of anti-aciddrugs during burn shock period wasunreasonable in some respects.Therefore,taking effective measures to improve gastricmucosal blood perfusion as early as possiblepostburn might be more preferable for the AGMLprevention and treatment. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 10 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 11 | 棉纺织工人棉尘及内毒素暴露对肺功能慢性影响的研究显示文摘目的探索棉尘及其内毒素长期暴露对棉纺织工人肺功能慢性改变的影响。方法选择某市棉纺织厂的447名棉纺工人及作为对照组的472名丝绸纺织工人,从1981年开始,分别于1986、1992、1996、2001和2006年进行为期25年的跟踪调查,以第一秒用力呼气容积(FEV1)的慢性改变作为肺功能改变的主要指标,采用广义估计方程估计累积棉尘中内毒素暴露对棉纺织工人慢性肺功能改变的影响。结果棉纺织工人内毒素暴露与FEV1降低间存在约5年的滞后期,棉纺织工人5年滞后累积内毒素暴露量每增加1 000 EU/m3,可使慢性FEV1每年减少0.99 ml(P<0.05),每停止暴露1年可以使FEV1恢复7.12 ml(P<0.05)。结论棉纺织工人的长期棉尘及内毒素暴露会造成肺功能的慢性降低;累积内毒素暴露与工人FEV1降低间存在滞后效应,而近期的累积内毒素暴露与工人FEV1慢性降低间关系不显著。 | 石晶 Christiani DC 戴和莲 杭晶卿 张洪熙 金龙哲 丁辉 | 2011 | 环境与健康杂志2011，28，2： | 6 |
| 12 | Antidiarrhoeal activity of leaf methanolic extract of Rauwolfia serpentina显示文摘Objective:To evaluate the antidiarrhoeal property of methanol extract of the leaves of Rauwolfia serpentina(R. serpentina) in experimental diarrhoea induced by castor oil in mice.Methods:Doses of 100, 200 and 400 mg/kgR. serpentinaleaf methanol extracts were administered to castor oil induced diarrhoea mice to determine its antidiarrhoeal activity.Results:All doses of the extract and the reference drug atropine sulphate(3 mg/kg, i.p.) produced a dose-dependent reduction in intestinal weight and fluid volume. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to diphenoxylate Hcl(5 mg/kg, p.o.).Conclusions:The results show that the extract of R. serpentin a leaves has a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine. | Ezeigbo II Ezeja MI Madubuike KG Ifenkwe DC Ukweni IA Udeh NE Akomas SC | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 4 |
| 13 | Amyloid-beta at sublethal level impairs BDNF-induced arc expression in cortical neurons.显示文摘 | Wang DC Chen SS Lee YC Chen TJ. | 2006 | 中国生物学文摘2006，20，9： | 4 |
| 14 | OX40 (CD134) engagement drives differentiation of CD4+T cells to effector cells显示文摘 | Huddleston CA Weinberg AD Parker DC | 2006 | Eur J Immunol2006，36，5： | 4 |
| 15 | ERODIBILITY CRITERION FOR AUXILIARY SPILLWAYS OF DAMS显示文摘The ability to reliably design auxiliary spillways has become a pressing requirement because of the very large number of dams involved. An empirical classification index representing the erosional resistance of the overall range of particulate, jointed, and intact earth materials is presented and correlated for a number of practical cases from Arkansas and Kansas in the United States of America and from South Africa with the specific stream power of flows observed to be associated with various degrees of erosion. The United States Department of Agriculture data base and the format in which the dare were prepared for the purposes herein, are deseribed in detail. The modes of erosion that occur in spillways are defined.Guidelines are provided for evaluating the failure status of an erosion damaged spillway that enables determination of whether the incident specific stream power exceeded, equalled, or fell below the erosional resistance of various sections of the ground profile affected. The correlation function between specific stream power and erodibility index provides the required design criterion. | Hendrik A. D. Kirsten (Steffen, Robertson, and Kirsten, Ine., Box 55291 Northlands 2116, S. Africa)John S. Moore(Natural Resources Conservation Service, USDA, Box 2890, Washington, DC 20013)Louis H. Kirsten(Civil & Structural Engineering Dept., Iscor Mini | 2000 | International Journal of Sediment Research2000，15，1： | 4 |
| 16 | 旋转方截面U型通道分离流二阶相关分量测量显示文摘为了深入了解旋转涡轮叶片内冷通道中的紊流特性 ,并为CFD研究提供实验数据 ,用激光多普勒测速仪 (LDA)测量了旋转U型通道中分离流的雷诺应力分量。通道的转轴与弯道的曲率轴平行 ,测量是在与转轴垂直的对称平面中进行的 ,流动状态为Re=10 0 ,0 0 0 ,Ro =0 ,0 2和 - 0 2。直接测量的分量为u2 x,u2 z和uxuz,结果表明旋转对紊流分布的形式有很强的影响。在测量的三种旋转状态中Ro =0 2的正转和Ro =0 2的负转分别具有最低和最高的紊流强度。根据测量到的信息估算了雷诺应力uiuj的产生率 。 | 吉洪湖 Launder BE Jackson DC | 2001 | 推进技术2001，22，4： | 4 |
| 17 | 枫树黄萎病接种方法研究显示文摘在枫树苗期黄萎病几种接种方法中,以浓度为1.8×106个分生孢子/mL的孢子悬浮液浸根接种效果最好,具有接种操作简便、定量、发病快和随机等特点;灌根接种效果最差。土壤接种能反映大田自然发病的优点,接种量为2%(W/W)的麦草培养菌比甜菜籽培养菌接种效果好,直播比移栽的植株接种效果好。结果表明,根据株高、发病率和定植率来评价接种效应是可行的。 | 杨家荣 Harr.,DC | 1994 | 西北林学院学报1994，9，2： | 3 |
| 18 | Synchrotron radiation X-ray diffraction in situ study of fine-grained minerals in shock veins of Suizhou meteorite显示文摘The synchrotron radiation X-ray diffraction technique developed for in situ study ahigh pressure and temperature has also been used to investigate microscopic mineral inclusionsin ultrahigh-pressure metamorphic rocks and deep-mantle samples. Present study added twomore examples of successful utilization of synchrotron radiation X-ray diffraction technique for insitu investigations of fine-grained (0.5―30 μm in size) minerals in very thin shock melt veins othe Suizhou meteorite: ( i ) X-ray diffraction measurement of extremely small-sized vein matrixminerals, and (ii) identification of the micron-sized new mineral tuite embedded in the vein matrixIt has been revealed that the fine-grained vein matrix consists of well crystallized garnet, kamacite and troilite, and the powder diffraction pattern consisting of 17 lines with d-values, intensities( I ), relative intensities (I/Io) and Miller indices, as well as the cell parameters for the new mineratuite has also been successfully obtained. The result of present investigations has enriched thecontent of dynamic high-pressure mineralogy and that of Earth’s mantle geochemistry. | XIE Xiande1, SHU Jinfu2 & CHEN Ming1 1. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China 2. Geophysical Laboratory, Carnegie Institution of Washington, Washington, DC, 20015, USA Correspondence should be addressed to Xie Xiande | 2005 | Science China Earth Sciences2005，48，6： | 3 |
| 19 | SEDIMENT DAMAGES AND RECENT TRENDSIN THE UNITED STATES显示文摘In the United States, cropland erosion has decreased by an estimated one billion tons or 42 Percent for the period 1982 to 1997 (USDA NRCS, 1998) through erosion reduction provisions of the Food Security Actof 1985 and the ongoing soil conservation programs administered by the United States Department ofAgriculture’s Soil Conservation Service (USDA-SCS), which became the Natural Resources ConservationService (USDA-NRCS) in 1997.The U.S. Geological Survey has measured suspended sediment loads at strearn gages from 198O through1989 and showed primarily decreases of from 1 to 12 percent for most regions and increases for only threeregions, ranging from 2 to l2 percent.A Reservoir Sediment Information System (RESIS) was created so that decades of dare on reservoir sediment deposits could be evaluated (Atwood, 1994, Steffen, 1994; Atwood and Steffen, 1994). Theresults of analyses show a major increase in unit-area sediment deposition rates during the period 1970through 1985, which may be attributable to increased cropland acreage, a switch from diversified farming tointensive monocultUred crops, with widespread adoption of soybeans. The most recent measured ratesshow that 25 percent of the United States reservoirs would be at least half-filled with sediment by 2O18,although there is a significant data gap since 1985. Relatively few reservoirs were surveyed since 1985 dueto lack of funding priority and increased survey labor costs. | Jerry M. Bernard (National Geologist) Thomas A. Iivari(Senior Hydrologist, United States Department of Agriculture-Natura ResourcesConservation Service, Washington, DC) | 2000 | International Journal of Sediment Research2000，15，2： | 3 |
| 20 | NF-kappa B controls cell growth and differentiation through transcriptional regulation of cyclin D1 显示文摘 | Guttridge DC Albanese C Reuther JY | 1999 | Mol-Cell-Biol1999，19，： | 2 |
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