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| 1 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 2 | Towards Corporate Professionalization: The Case of Project Management, Management Consultancy and Executive Search 显示文摘 | Daniel Muzio Damian Hodgson James Faulconbridge Jonathan Bea- verstock Sarah Hall | 2011 | Current Sociology2011，，4： | 1 |
| 3 | Molecular Characterization of Endometrial Cancer: A Correlative Study Assessing Microsatellite Instability, MLH1 Hypermethylation, DNA Mismatch Repair Protein Expression, and PTEN, PIK3CA, KRAS, and BRAF Mutation Analysis显示文摘 | Lisa M. Peterson Benjamin R. Kipp Kevin C. Halling Sarah E. Kerr David I. Smith Tammy J. Distad Amy C. Clayton Fabiola Medeiros | 2012 | International Journal of Gynecological Pathology2012，，3： | 1 |
| 4 | Employability during unemployment: Adaptability, career identity and human and social capital显示文摘 | Sarah McArdle Lea Waters Jon P. Briscoe Douglas T. (Tim) Hall | 2007 | Journal of Vocational Behavior2007，，2： | 1 |
| 5 | Ionizing radiation biomarkers for potential use in epidemiological studies显示文摘 | Eileen Pernot Janet Hall Sarah Baatout Mohammed Abderrafi Benotmane Eric Blanchardon Simon Bouffler Houssein El Saghire Maria Gomolka Anne Guertler Mats Harms-Ringdahl Penny Jeggo Michaela Kreuzer Dominique Laurier Carita Lindholm Radhia Mkacher Roel Quin | 2012 | Mutation Research-Reviews in Mutation Research2012，，2： | 1 |
| 6 | Pronecrotic mixed lineage kinase domain‐like protein expression is a prognostic biomarker in patients with early‐stage resected pancreatic adenocarcinoma显示文摘 | Lauren E. Colbert Sarah B. Fisher Claire W. Hardy William A. Hall Burcu Saka Joseph W. Shelton Aleksandra V. Petrova Matthew D. Warren Brooke G. Pantazides Khanjan Gandhi Jeanne Kowalski David A. Kooby Bassel F. El‐Rayes Charles A. Staley N. Volkan Adsay | 2013 | Cancer2013，，： | 1 |
| 7 | Identification of new genetic risk factors for prostate cancer显示文摘有证据,到前列腺癌症(PCa ) 的基因倾向的实质的部分可能由于被染色体宽的协会研究发现的更低的外显率基因。我们最近进行了如此的研究,染色体的七个新区域连接了到 PCa 风险被识别了。三这些 loci 包含候选人危险性基因:MSMB, LMTK2 和 KLK2/3。MSMB 和 KLK2/3 基因可能为 PCa 屏蔽,和 LMTK2 基因是有用的可能提供一个潜在的治疗学的目标。和从另外的组的结果,现在有 23 germline 被报导了的基因变体。这些结果有潜力被发展进基因测试。然而,我们认为测试出售到公众是早熟的,当 PCa 风险不能在这个阶段和要发展的适当屏蔽协议需要充分被评估。后续确认学习,以及学习探索基因侧面测试的心理含意,将重要在以前推出进保健。 | Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O'Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons' Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles | 2009 | Asian Journal of Andrology2009，11，1： | 1 |
| 8 | Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden显示文摘 | Paul McGale Sarah C. Darby Per Hall Jan Adolfsson Nils-Olof Bengtsson Anna M. Bennet Tommy Fornander Bruna Gigante Maj-Britt Jensen Richard Peto Kazem Rahimi Carolyn W. Taylor Marianne Ewertz | 2011 | Radiotherapy and Oncology2011，，2： | 1 |
| 9 | Employability during unemployment: Adaptability, career identity and human and social capital显示文摘 | Sarah McArdle Lea Waters Jon P. Briscoe Douglas T. (Tim) Hall | 2007 | Journal of Vocational Behavior2007，，2： | 1 |
| 10 | 露丝·凯利显示文摘前不久,英国盲人内政大臣布伦基特因绯闻和滥用职权的丑闻而辞职,从而引发了内阁一系列重要人事变动,其中最引人注目的是36岁的新任教育大臣露丝·凯利。凯利素有'电子脑'的绰号,被誉为'经济奇才',有人甚至说她可能成为工党的第一位女首相。她不仅事业有成,还是个'超级妈妈',现年36岁的她育有4个7岁以下的孩子。她是如何平衡事业与家庭间的关系呢?请看我们选译的英国《卫报》的这篇人物介绍。 | Sandra Laville Sarah Hall 陈树培 | 2005 | 英语文摘2005，0，3： | 0 |
| 11 | 润肤剂引起的烧伤显示文摘一位72岁行动不便且患有帕金森病痴呆的男性,因上半身烧伤到急诊科就诊。该患者吸烟,而且他的看护者每天给他全身涂抹润肤剂长期维持治疗湿疹。主治医生证实,这名患者被烧伤是由于他的香烟接触到右臂的睡衣时迅速燃烧造成的。 | Matthew J Ridd Sarah Hall Majella E Lane Amanda Roberts Hywel C Williams 王誉涵(译) | 2022 | 英国医学杂志中文版2022，25，6： | 0 |
| 12 | 21 st Century Schooling: Engaging Critical Need Teachers in Discourse on Classroom Management and Discipline显示文摘 | Marjorie Hall Haley Sherry L. Steeley Sarah Eqab | 2015 | US-China Education Review(A)2015，5，4： | 0 |
| 13 | Alleviative effects of Cannabis flower on migraine and headache显示文摘Objective: Few studies to date have measured the real-time effects of consumption of common and commercially available Cannabis products for the treatment of headache and migraine under naturalistic conditions. This study examines, for the first time, the effectiveness of using dried Cannabis flower, the most widely used type of Cannabis product in the United States, in actual time for treatment of headache-and migraine-related pain and the associations between different product characteristics and changes in symptom intensity following Cannabis use.Methods: Between 06/10/2016 and 02/12/2019, 699 people used the Releaf Application to record realtime details of their Cannabis use, including product characteristics and symptom intensity levels prior to and following self-administration;data included 1910 session-level attempts to treat headache-(1328 sessions) or migraine-related pain(582 sessions). Changes in headache-or migraine-related pain intensity were measured on a 0–10 scale prior to, and immediately, following Cannabis consumption.Results: Ninety-four percent of users experienced symptom relief within a two-hour observation window. The average symptom intensity reduction was 3.3 points on a 0–10 scale(standard deviation = 2.28,Cohen's d = 1.58), with males experiencing greater relief than females(P < 0.001) and a trend that younger users(< 35 years) experience greater relief than older users(P = 0.08). Mixed effects regression models showed that, among the known(i.e., labeled) product characteristics, tetrahydrocannabinol levels 10% and higher are the strongest independent predictors of symptom relief, and this effect is particularly prominent in headache rather than migraine sufferers(P < 0.05), females(P < 0.05) and younger users(P < 0.001). Females and younger users also appear to gain greater symptom relief from flower labeled as ‘‘C. indica' rather than ‘‘C. sativa' or other hybrid strains.Conclusion: These results suggest that whole dried Cannabis flower may be an effective medication for treatment of migraine-and headache-related pain, but the effectiveness differs according to characteristics of the Cannabis plant, the combustion methods, and the age and gender of the patient. | Sarah SStith Jegason PDiviant Franco Brockelman Keenan Keeling Branden Hall Storri Lucern Jacob M.Vigil | 2020 | Journal of Integrative Medicine2020，18，5： | 0 |
| 14 | Preparation and printability of ultrashort self-assembling peptide nanoparticles显示文摘Nanoparticles(NPs)have left their mark on the field of bioengineering.Fabricated from metallic,magnetic,and metal oxide materials,their applications include drug delivery,bioimaging,and cell labeling.However,as they enter the body,the question remains-where do they go after fulfilling their designated function?As most materials used to produce NPs are not naturally found in the body,they are not biodegradable and may accumulate overtime.There is a lack of comprehensive,long-term studies assessing the biodistribution of non-biodegradable NPs for even the most widely studied NPs.There is a clear need for NPs produced from natural materials capable of degradation in vivo.As peptides exist naturally within the human body,their non-toxic and biocompatible nature comes as no surprise.Ultrashort peptides are aliphatic peptides designed with three to seven amino acids capable of self-assembling into helical fibers within macromolecular structures.Using a microfluidics flow-focusing approach,we produced different peptide-based NPs that were then three-dimensional(3D)printed with our novel printer setup.Herein,we describe the preparation method of NPs from ultrashort self-assembling peptides and their morphology in both manual and 3D-printed hydrogels,thus suggesting that peptide NPs are capable of withstanding the stresses involved in the printing process. | Sarah Ghalayini Hepi Hari Susapto Sophie Hall Kowther Kahin Charlotte A.E.Hauser | 2019 | International Journal of Bioprinting2019，5，2： | 0 |
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