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| 1 | Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation显示文摘AIM: Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS: A reporter gene system in HT-29 cells was used to measure levels of NF-KB activation after challenge with bifidobacteria or after bacterial pre-treatment following LPS challenge. IL-8 protein and pro-inflammatory gene expression was investigated using normal HT-29 cells. RESULTS: None of the bifidobacteria tested induced activation of nuclear factor KB (NF-KB) indicating that bifidobacteria themselves do not induce inflammatory events in IECs. However, six out of eight bifidobacteria tested inhibited lipopolysaccharide- (LPS-) induced NFKB activation in a dose- and strain-dependent manner. In contrast, NF-KB activation in response to challenge with tumor necrosis factor-α(TNF-α) was affected by none of the tested bifidobacteria, indicating that the inhibitory effect of bifidobacteria is specific for LPS-induced inflammation in IECs. As shown with two of the six inhibitionpositive bifidobacteria, LPS-induced inhibition of NFKB activation was accompanied by a dose-dependent decrease of interleukin 8 (IL-8) secretion and by lower mRNA levels for IL-8, TNF-a, cyclooxygenase 2 (Cox-2), and intercellular adhesion molecule 1 (ICAM-1). CONCLUSION: Some strains of bifidobacteria are effective in inhibiting LPS-induced inflammation and thus might be appropriate candidates for probiotic intervention in chronic intestinal inflammation. | Christian U Riedel Francis Foata David Philippe Oskar Adolfsson Bernhard J Eikmanns Stephanie Blum | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 2 | Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis显示文摘AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis. | David Philippe Laurent Favre Francis Foata Oskar Adolfsson Genevieve Perruisseau-Carrier Karine Vidal Gloria Reuteler Johanna Dayer-Schneider Christoph Mueller Stéphanie Blum | 2011 | World Journal of Gastroenterology2011，17，4： | 12 |
| 3 | Association between gastrointestinal symptoms and affectivity in patients with bipolar disorder显示文摘AIM To study if anxiety, depression and experience of stress are associated with gastrointestinal(GI) symptoms in patients with bipolar disorder.METHODS A total of 136 patients with bipolar disorder(mean age 49.9 years; 61% women) and 136 controls from the general population(mean age 51.0 years; 60% women) were included in the study. GI symptoms were assessed with The Gastrointestinal Symptom Rating Scale-irritable bowel syndrome(GSRS-IBS), level of anxiety and depression with The Hospital Anxiety and Depression Scale(HADS) and stress-proneness with Perceived Stress Questionnaire. Over a ten year period, all visits in primary care were retrospectively recorded in order to identify functional GI disorders.RESULTS In subjects with low total HADS-score, there were no significant differences in GI-symptoms between patients and controls(GSRS-IBS 7.0 vs 6.5, P = 0.513). In the patients with bipolar disorder there were significant correlations between all GSRS and HADS subscores for all symptom clusters except for 'constipation' and 'reflux'. Factors associated to GI symptoms in the patient group were female sex(adjusted OR = 2.37, 95%CI: 1.07-5.24) and high HADS-Depression score(adjusted OR = 3.64, 95%CI: 1.07-12.4). These patients had also significantly more visits for IBS than patients with low HADS-Depression scores(29% vs 8%, P = 0.008). However, there was no significant differences in consulting behaviour for functional GI disorders between patients and controls(25% vs 17%, P = 0.108).CONCLUSION Female patients and patients with high HADS depression score reported significantly more GI symptoms, whereas patients with low HADS scores did not differ from control subjects. | Pontus Karling Martin Maripuu Mikael Wikgren Rolf Adolfsson Karl-Fredrik Norrback | 2016 | World Journal of Gastroenterology2016，22，38： | 3 |
| 4 | Dense hydroxyapatite-zirconia ceramic composites with high strength for biological applications显示文摘 | Shen ZJ Adolfsson E Nygren M | 2001 | Adv Mater2001，13，3： | 1 |
| 5 | A longitudinal microbiological study on osseointegrated titanium implants in partially edentulous patients显示文摘 | Leonhardt A Adolfsson B Lekholm U | 1993 | Clin Oral Implants Res1993，4，： | 1 |
| 6 | Identifying childfunctioning from an ICF-CY perspective: Everyday life sit-uations explored in measures of participation 显示文摘 | Adolfsson M Malmqvist J Pless M | 2011 | DisabilRehabil2011，33，1314： | 1 |
| 7 | Type 2 diabetic patients' experiences of two different educational approaches:A qualitative study显示文摘 | Adolfsson ET Starrin B Smide B | 2008 | Int J Nurs Stud2008，45，： | 1 |
| 8 | On-line quality monitoring in GMAW显示文摘 | Adolfsson S | 1999 | Welding Journal1999，78，2： | 1 |
| 9 | Major depression in stroke patients: a 3-year longitudinal study显示文摘 | Astrom M Adolfsson R Asplund K | 1993 | Stroke1993，24，7： | 1 |
| 10 | Hormonal response during physical exercise of different intensities in adolescents with type 1 diabetes and healthy controls显示文摘 | Adolfsson P Nilsson S Albertsson-Wikland K | 2012 | Pediatr Diabetes2012，13，8： | 1 |
| 11 | Applicability of general grief theory to Swedish women's experience after early mis carriage, with factor analysis of Bonanno's taxonomy, using the Perinatal Grief Scale显示文摘 | Adolfsson A Larsson P G | 2010 | Ups J Med Sci2010，115，3： | 1 |
| 12 | Insulin pumps in pediatricroutine care improve Long - term metabolic controc without increasing the risk of hypoglycenria显示文摘 | Hanas R Adolfsson P | 2006 | Pediatr Diabetes2006，7，1： | 1 |
| 13 | Major depression in stroke patients: a 3-year longtutinal study显示文摘 | Astrom M Adolfsson R Asplund K | 1993 | Stroke1993，24，： | 1 |
| 14 | The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients显示文摘 | Angst J Adolfsson R Benazzi F | 2005 | JAffect Disord2005，88，： | 1 |
| 15 | The preva- lence of BV in the population on the Aland Islands dur- ing a 15-year period显示文摘 | Eriksson K Adolfsson A Forsum U | 2010 | APMIS2010，118，11： | 1 |
| 16 | Major depression in stroke patients显示文摘 | Astrom M Adolfsson R | 1993 | Stroke1993，24，7： | 1 |
| 17 | Identifying childfunctioning from an ICF-CY perspective: Everyday life sit-uations explored in measures of participation 显示文摘 | Adolfsson M Malmqvist J Pless M | 2011 | DisabilRehabil2011，33，1314： | 1 |
| 18 | Successive memory test performance and priming in Alzheimer's disease:evidence from the word-fragment completion task显示文摘 | Borjesson A Adolfsson R | 2002 | Cortex2002，38，3： | 1 |
| 19 | Insulin pumps in pediatric routine care improve long-term metabolic control without increasing the risk of hypoglycemia 显示文摘 | Hanas R Adolfsson P | 2006 | Pediatr Diabetes2006，7，1： | 1 |
| 20 | Direct amide coupling of no- nactivated carboxylic acids and amines catalysed by zirconium ( Ⅳ ) chloride显示文摘 | Lundberg H Tinnis F Adolfsson H | 2012 | Chem Eur J2012，18，13： | 1 |
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