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| 1 | Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge显示文摘While the incidence of gastric cancer has decreased worldwide in recent decades,the incidence of signetring cell carcinoma(SRCC) is rising. SRCC has a specific epidemiology and oncogenesis and has two forms: early gastric cancer,which can be resected endoscopically in some cases and which has a better outcome than non-SRCC,and advanced gastric cancer,which is generally thought to have a worse prognosis and lower chemosensitivity than non-SRCC. However,the prognosis of SRCC and its chemosensitivity with specific regimens are still controversial as SRCC is not specifically identified in most studies and its poor prognosis may be due to its more advanced stage. It therefore remains unclear if a specific therapeutic strategy is justified,as the benefit of perioperative chemotherapy and the value of taxanebased chemotherapy are unclear. In this review we analyze recent data on the epidemiology,oncogenesis,prognosis and specific therapeutic strategies in both early and advanced SRCC of the stomach and in hereditary diffuse gastric cancer. | Simon Pernot Thibault Voron Geraldine Perkins Christine Lagorce-Pages Anne Berger Julien Taieb | 2015 | World Journal of Gastroenterology2015，21，40： | 30 |
| 2 | Colorectal cancer and immunity:what we know and perspectives显示文摘Strong evidence supports the concept of immunosurveillance and immunoediting in colorectal cancer.In particular,the density of T CD8+and CD45+lymphocyte infiltration was recently shown to have a better prognostic value than the classic tumor node metastasis classification factor.Other immune subsets,as macrophages,natural killer cells or unconventionnal lymphocytes,seem to play an important role.Induction of regulatory T cells(Tregs)or immunosuppressive molecules such as PD-1 or CTLA-4 and downregulation of antigen-presenting molecules are major escape mechanisms to antitumor immune response.The development of these mechanisms is a major obstacle to the establishment of an effective immune response,but also to the use of immunotherapy.Although im-munotherapy is not yet routinely used in colorectal cancer,we now know that most treatments used(chemotherapy and biotherapy)have immunomodulatory effects,such as induction of immunogenic cell death by chemotherapy,inhibition of immunosuppression by antiangiogenic agents,and antibody-dependent cytotoxicity induced by cetuximab.Finally,many immunotherapy strategies are being developed and tested in phaseⅠtoⅢclinical trials.The most promising strategies are boosting the immune system with cytokines,inhibition of immunoregulatory checkpoints,vaccination with vectorized antigens,and adoptive cell therapy.Comprehension of antitumor immune response and combination of the different approaches of immunotherapy may allow the use of effective immunotherapy for treatment of colorectal cancer in the near future. | Simon Pernot Magali Terme Thibault Voron Orianne Colussi Elie Marcheteau Eric Tartour Julien Taieb | 2014 | World Journal of Gastroenterology2014，20，14： | 19 |
| 3 | Shape tuning in fully free-from deformation features 显示文摘 | Pernot J P Guillet S Leon J C | 2005 | Journal of Computing and Information Seienee Engineering2005，5，2： | 1 |
| 4 | Application of neural networks to the modelling of some constitutive laws显示文摘 | PERNOT S LAMARQUE C H | 1999 | Neural Networks1999，12，2： | 1 |
| 5 | Effect of Oxy- green wheat ozonation process on bread dough quality and protein solubility 显示文摘 | Violleau F Pernot A G Surel O | 2012 | Journal of Cereal Science2012，55，： | 1 |
| 6 | VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer显示文摘 | Terme M Pernot S Marcheteau E | 2013 | Cancer Res2013，73，2： | 1 |
| 7 | Time-driven activity-based costing for inter-library services:a case study in a university显示文摘 | PERNOT E ROODHOOFT F VAN DEN ABBEELE A | 2007 | The Journal of Academic Librarianship2007，33，5： | 1 |
| 8 | Development of high efficiency 255- 355 nm A1GaN-based light-emitting diodes 显示文摘 | Pernot C Fukahori S Inazu T | 2011 | Phys Status Solidi A2011，208，： | 1 |
| 9 | Progress in SiC bulk growth 显示文摘 | ANIKIN M CHAIX O PERNOT E | 2000 | Materials Science Forum2000，33，833934034： | 1 |
| 10 | Biweekly docetaxel, fluomuracil, lcucovorin, oxaliplatin (TEF) as first - line treatment for advanced gastric cancer and adenocarcinoma of the gastrocsopha- geal junction:safety and efficacy in a muhicenter cohort显示文摘 | PERNOT S MITRY E SAMALIN E | 2014 | Gastric Cancer2014，17，2： | 1 |
| 11 | Electrical Transport in 4H-SiC显示文摘 | Pernot J Zawadzki W | 2001 | J Appl Phys2001，90，4： | 1 |
| 12 | Design and properties of co-continuous nanostructured polymers by reactive blending显示文摘 | Pernot H Baumert M Court F Leibler L | | 0，，： | 1 |
| 13 | Crystal structure of a pepti- doglycan synthesis regulatory factor (PBP3) from Streptoc:cus pneumoni- ae显示文摘 | MORLOT C PERNOT L VERNET T | 2005 | J Biol Chem2005，280，15： | 1 |
| 14 | Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy显示文摘 | Pernot F Heinrich C Barbier L | | 0，，： | 1 |
| 15 | Hypersensitivity pneu- monitis due to isocyanate exposure in an airbag 'welder' 显示文摘 | Lhoumeau A Pernot J Georges M | 2012 | Eur Respir Rev2012，21，124： | 1 |
| 16 | Noninvasive,transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice显示文摘 | Choi J J Pernot M Small S A | | 0，，01： | 1 |
| 17 | Hall electron mobility in diamond显示文摘 | PERNOT J TAVARES C GHEERAERT E | 2006 | Applied Physics Letters2006，89，12： | 1 |
| 18 | Damping identification in multi-degree-of-freedom systems via a wavelet-logarithmic decrement (Ⅱ) : Study of a civil engineering building 显示文摘 | Hans S Ibraim S Pernot C | 2000 | Journal of Sound and Vibration2000，235，3： | 1 |
| 19 | Shape tuning in fully free-form deformation features显示文摘 | PERNOT J P GUILLET S LEON J C | 2005 | Journal of Computing and Information Science in Engineering2005，5，2： | 1 |
| 20 | Filling holes in meshes using a mechanical model to simulate the curvature variation minimization 显示文摘 | PERNOT J P MORARU G VERON P | 2006 | Computer & Graphics2006，30，6： | 1 |
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