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| 1 | Complications of hip fractures: A review显示文摘Nowadays, fracture surgery represents a big part of the orthopedic surgeon workload, and usually has associated major clinical and social cost implications. These fractures have several complications. Some of these are medical, and other related to the surgical treatment itself. Medical complications may affect around 20% of patients with hip fracture. Cognitive and neurological alterations, cardiopulmonary affections(alone or combined), venous thromboembolism, gastrointestinal tract bleeding, urinary tract complications, perioperative anemia, electrolytic and metabolic disorders, and pressure scars are the most important medical complications after hip surgery in terms of frequency, increase of length of stay and perioperative mortality. Complications arising from hip fracture surgery are fairly common, and vary depending on whether the fracture is intracapsular or extracapsular. The main problems in intracapsular fractures are biological: vascularization of the femoral head, and lack of periosteum-a major contributor to fracture healing- in the femoral neck. In extracapsularfractures, by contrast, the problem is mechanical, and relates to load-bearing. Early surgical fixation, the role of anti-thromboembolic and anti-infective prophylaxis, good pain control at the perioperative, detection and management of delirium, correct urinary tract management, avoidance of malnutrition, vitamin D supplementation, osteoporosis treatment and advancement of early mobilization to improve functional recovery and falls prevention are basic recommendations for an optimal maintenance of hip fractured patients. | Pedro Carpintero Jose Ramón Caeiro Rocío Carpintero Angela Morales Samuel Silva Manuel Mesa | 2014 | World Journal of Orthopedics2014，5，4： | 31 |
| 2 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 3 | Role of nickel-regulated small RNA in modulation of Helicobacter pylori virulence factors显示文摘Helicobacter pylori(H.pylori)is a Gram-negative bacterium that infects about half of the world's population.H.pylori infection prevails by several mechanisms of adaptation of the bacteria and by its virulence factors including the cytotoxin associated antigen A(CagA).CagA is an oncoprotein that is the protagonist of gastric carcinogenesis associated with prolonged H.pylori infection.In this sense,small regulatory RNAs(sRNAs)are important macromolecules capable of inhibiting and activating gene expression.This function allows sRNAs to act in adjusting to unstable environmental conditions and in responding to cellular stresses in bacterial infections.Recent discoveries have shown that nickelregulated small RNA(NikS)is a post-transcriptional regulator of virulence properties of H.pylori,including the oncoprotein CagA.Notably,high concentrations of nickel cause the reduction of NikS expression and consequently this increases the levels of CagA.In addition,NikS expression appears to be lower in clinical isolates from patients with gastric cancer when compared to patients without.With that in mind,this minireview approaches,in an accessible way,the most important and current aspects about the role of NikS in the control of virulence factors of H.pylori and the potential clinical repercussions of this modulation. | Fabrício Freire de Melo Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Lorena Sousa de Carvalho Cláudio Lima Souza Márcio Vasconcelos Oliveira | 2022 | World Journal of Clinical Cases2022，10，31： | 2 |
| 4 | Design of a control system using linear matrix inequalities for the active vibration control of a plate 显示文摘 | Samuel da silva Vicente lopes junio | 2006 | Journal of Intelligent Material Systems and Structures2006，170，： | 1 |
| 5 | Inter- and intra-observer reliability of the Baumann angle of the humerus in children with supracondylar humeral fractures显示文摘 | Mauricio Silva Rajeev Pandarinath Eugene Farng Samuel Park Cherlyn Caneda Yi-Jen Fong Adam Penman | 2010 | International Orthopaedics2010，，4： | 1 |
| 6 | The characteristic polynomial of the Laplacian of graphs in (a,b) -linear classes显示文摘 | Carla Silva Oliveira Nair Maria Maia de Abreu Samuel Jurkiewicz | 2002 | Linear Algebra and Its Applications2002，，1： | 1 |
| 7 | 黄粉虫替代蛋白质饲料对太平洋白虾(凡纳滨对虾)消化性能的影响显示文摘试验旨在评估黄粉虫粉(MM)作为凡纳滨对虾养殖中蛋白质来源的可行性。饲料分为正常饲料和试验饲粮,试验饲料中包含正常饲料85%和MM 15%,两种饲料中均含有氧化铬0.5%作为惰性标记,试验采用表观消化率系数(ADC)对两种饲料进行检测。为评估MM消化价值,对虾饲料中采用鱼粉替代MM,替代比例分别为0%、25%、50%、75%和100%,在清水中饲养6周后,对生长参数和整个虾体成分进行评估。干物质ADC为45.9%,能量ADC为66.5%,粗蛋白质ADC为76.1%,必须氨基酸ADC为72%~86%。MM中蛋氨酸为第一限制性氨基酸。饲料中添加MM后,各组间对虾的体增重、特定生长率、采食量、饲料转化率、存活率和蛋白质合成率均无显著变化(P>0.05),虾体蛋白质含量无显著差异(P>0.05)。而随着鱼粉替代比例上升,虾体脂含量从1.13%升至1.88%。结果表明,黄粉虫粉可作为凡纳滨对虾饲料中的替代蛋白质饲料,但添加时应注意补充蛋氨酸。 | Panini R L Freitas L E L Guimarǎes A M Rios C da Silva M F O Vieira F N Fracalossi D M Samuels R I | 2017 | 饲料博览2017，0，7： | 1 |
| 8 | Introduction of digestive a-amylase in larvae of Zabrotes subfasciatus (Coleoptera: Bruchidae) in response to ingestion of common bean a-amylase inhibitor 显示文摘 | Silva C P Terra W R de Sa M F G Samuels R I | 2001 | Journal of Insect Physiology2001，47，： | 1 |
| 9 | Dam- age detection in a benchmark structure using Ar-Arx models and statistical pattern recognition显示文摘 | Samuel da Silva Dias Jfinior M Lopes Junior V | 2007 | Journal of the Brazilian Socie- ty of Mechanical Sciences and Engineering2007，29，2： | 1 |
| 10 | Influence of Helicobacter pylori oncoprotein CagA in gastric cancer:A critical-reflective analysis显示文摘Gastric cancer is the fifth most common malignancy and third leading cancerrelated cause of death worldwide.Helicobacter pylori is a Gram-negative bacterium that inhabits the gastric environment of 60.3%of the world’s population and represents the main risk factor for the onset of gastric neoplasms.CagA is the most important virulence factor in H.pylori,and is a translocated oncoprotein that induces morphofunctional modifications in gastric epithelial cells and a chronic inflammatory response that increases the risk of developing precancerous lesions.Upon translocation and tyrosine phosphorylation,CagA moves to the cell membrane and acts as a pathological scaffold protein that simultaneously interacts with multiple intracellular signaling pathways,thereby disrupting cell proliferation,differentiation and apoptosis.All these alterations in cell biology increase the risk of damaged cells acquiring pro-oncogenic genetic changes.In this sense,once gastric cancer sets in,its perpetuation is independent of the presence of the oncoprotein,characterizing a“hit-and-run”carcinogenic mechanism.Therefore,this review aims to describe H.pylori-and CagA-related oncogenic mechanisms,to update readers and discuss the novelties and perspectives in this field. | Fabrício Freire de Melo Hanna Santos Marques Samuel Luca Rocha Pinheiro Fabian Fellipe Bueno Lemos Marcel Silva Luz Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira | 2022 | World Journal of Clinical Oncology2022，13，11： | 1 |
| 11 | Design of a control system using linear matrix inequalities for the active vibration control of a plate显示文摘 | Samuel da Silva Vicente Lopes Junio | 2006 | Journal of Intelligent Material Systems and Structures2006，17，1： | 1 |
| 12 | Oncolytic virus therapy in cancer: A current review显示文摘In view of the advancement in the understanding about the most diverse types of cancer and consequently a relentless search for a cure and increased survival rates of cancer patients,finding a therapy that is able to combat the mechanism of aggression of this disease is extremely important.Thus,oncolytic viruses(OVs)have demonstrated great benefits in the treatment of cancer because it mediates antitumor effects in several ways.Viruses can be used to infect cancer cells,especially over normal cells,to present tumor-associated antigens,to activate“danger signals”that generate a less immune-tolerant tumor microenvironment,and to serve transduction vehicles for expression of inflammatory and immunomodulatory cytokines.The success of therapies using OVs was initially demonstrated by the use of the genetically modified herpes virus,talimogene laherparepvec,for the treatment of melanoma.At this time,several OVs are being studied as a potential treatment for cancer in clinical trials.However,it is necessary to be aware of the safety and possible adverse effects of this therapy;after all,an effective treatment for cancer should promote regression,attack the tumor,and in the meantime induce minimal systemic repercussions.In this manuscript,we will present a current review of the mechanism of action of OVs,main clinical uses,updates,and future perspectives on this treatment. | Jonathan Santos Apolonio Vinicius Lima de Souza Goncalves Maria Luisa Cordeiro Santos Marcel Silva Luz Joao Victor Silva Souza Samuel Luca Rocha Pinheiro Wedja Rafaela de Souza Matheus Sande Loureiro Fabricio Freire de Melo | 2021 | World Journal of Virology2021，10，5： | 1 |
| 13 | Frequency of extracolonic tumors in Brazilian families with Lynch syndrome: analysis of a hereditary colorectal cancer institutional registry显示文摘 | Felipe Carneiro Silva Ligia Petrolini Oliveira érika Monteiro Santos Wilson Toshihiko Nakagawa Samuel Aguiar Junior Mev Dominguez Valentin Benedito Mauro Rossi Fábio Oliveira Ferreira | 2010 | Familial Cancer2010，，： | 1 |
| 14 | Influence of graphite nodules geometrical features on fatigue life of high-strength nodular cast iron 显示文摘 | Nuno Costa Nuno Machado Filipe Samuel Silva | 2008 | Joumal of Materials Engineering and Performance2008，17，3： | 1 |
| 15 | ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells显示文摘 | Fabíola Traina Patricia M.B. Favaro Samuel de Souza Medina Adriana da Silva Santos Duarte Sheila Maria Brochado Winnischofer Fernando F. Costa Sara T.O. Saad | 2006 | BBA - Molecular Basis of Disease2006，，9： | 1 |
| 16 | Immunotherapy in glioblastoma treatment:Current state and future prospects显示文摘Glioblastoma remains as the most common and aggressive malignant brain tumor,standing with a poor prognosis and treatment prospective.Despite the aggressive standard care,such as surgical resection and chemoradiation,median survival rates are low.In this regard,immunotherapeutic strategies aim to become more attractive for glioblastoma,considering its recent advances and approaches.In this review,we provide an overview of the current status and progress in immunotherapy for glioblastoma,going through the fundamental knowledge on immune targeting to promising strategies,such as Chimeric antigen receptor T-Cell therapy,immune checkpoint inhibitors,cytokine-based treatment,oncolytic virus and vaccine-based techniques.At last,it is discussed innovative methods to overcome diverse challenges,and future perspectives in this area. | Samuel Luca Rocha Pinheiro Fabian Fellipe Bueno Lemos Hanna Santos Marques Marcel Silva Luz Luís Guilherme de Oliveira Silva Clara Faria Souza Mendes dos Santos Karolaine da Costa Evangelista Mariana Santos Calmon Matheus Sande Loureiro Fabrício Freire de Melo | 2023 | World Journal of Clinical Oncology2023，14，4： | 1 |
| 17 | Endotoxin-induced acute lung injury is dependent upon oxidative response显示文摘 | Eduardo Tavares Lima Trajano Cinthya Sternberg Maurí cio Caetano Marco Auré lio Santos Silva Luí s Cristó v? o Porto Juliana Carvalho Santos Marcelo Lima Ribeiro Clarissa Bichara Magalh? es Walter Araú jo Zin Clá udia Farias Benjamim Samuel Santos Valen? | 2011 | Inhalation Toxicology2011，，： | 1 |
| 18 | Influence of graphite nodules geometrical features on fatigue life of high-strength nodular cast iron显示文摘 | Nuno Costa Nuno Machado Filipe Samuel Silva | 2008 | JMEPEG2008，17，： | 1 |
| 19 | The effects of water availability on root growth and morphology in an Amazon rainforest显示文摘 | Daniel B. Metcalfe Patrick Meir Luiz Eduardo O. C. Arag?o Antonio C. L. Costa Alan P. Braga Paulo H. L. Gon?alves Joao Athaydes Silva Junior Samuel S. Almeida Lorna A. Dawson Yadvinder Malhi Mathew Williams | 2008 | Plant and Soil (-)2008，，1： | 1 |
| 20 | Role of non-Helicobacter pylori gastric Helicobacters in helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma显示文摘Marginal zone lymphomas rank as the third most prevalent form of non-Hodgkin B-cell lymphoma,trailing behind diffuse large B-cell lymphoma and follicular lymphoma.Gastric mucosa-associated lymphoid tissue lymphoma(GML)is a low-grade B-cell neoplasia frequently correlated with Helicobacter pylori(H.pylori)-induced chronic gastritis.On the other hand,a specific subset of individuals diagnosed with GML does not exhibit H.pylori infection.In contrast to its H.pylori-positive counterpart,it was previously believed that H.pylori-negative GML was less likely to respond to antimicrobial therapy.Despite this,surprisingly,increasing evidence supports that a considerable proportion of patients with H.pylori-negative GML show complete histopathological remission after bacterial eradication therapy.Nonetheless,the precise mechanisms underlying this treatment responsiveness are not yet fully comprehended.In recent years,there has been growing interest in investigating the role of non-H.pylori gastric helicobacters(NHPHs)in the pathogenesis of H.pylori-negative GML.However,additional research is required to establish the causal relationship between NHPHs and GML.In this minireview,we examined the current understanding and proposed prospects on the involvement of NHPHs in H.pylori-negative GML,as well as their potential response to bacterial eradication therapy. | Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Kádima Nayara Teixeira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，32： | 0 |
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