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| 1 | Assessment of vascular invasion in gastric cancer: A comparative study显示文摘AIM: To evaluate and compare detection of lymphatic and blood vessel invasion (LVI and BVI) by hematox-ylin-eosin (HE) and immunohistochemistry (IHC) in gastric cancer specimens, and to correlate with lymph node status. METHODS: IHC using D2-40 (a lymphatic endothelial marker) and CD34 (a pan-endothelial marker) was performed to study LVI and BVI in surgical specimens froma consecutive series of 95 primary gastric cancer cases. The results of the IHC study were compared with the detection by HE using McNemar test and kappa index. The morphologic features of the tumors and the presence of LVI and BVI were related to the presence of lymph node metastasis. A χ2 test was performed to obtain associations between LVI and BVI and other prognostic factors for gastric cancer. RESULTS: The detection rate of LVI was considerably higher than that of BVI. The IHC study identified eight false-positive cases and 13 false-negative cases for LVI, and 24 false-positive cases and 10 false-negative cases for BVI. The average Kappa value determined was moderate for LVI (k=0.50) and low for BVI (k=0.20). Both LVI and BVI were statistically associated with the presence of lymph node metastasis (HE: P=0.001, P=0.013, and IHC: P=0.001, P=0.019). The mor-phologic features associated with LVI were location of the tumor in the distal third of the stomach (P=0.039), Borrmann's macroscopic type (P=0.001), organ inva-sion (P=0.03) and the depth of tumor invasion (P=0.001). The presence of BVI was related only to the depth of tumor invasion (P=0.003). CONCLUSION: The immunohistochemical identification of lymphatic and blood vessels is useful for increasing the accuracy of the diagnosis of vessel invasion and for predicting lymph node metastasis. | Letícia Trivellato Gresta Ismael Alves Rodrigues-Júnior Lúcia Porto Fonseca de Castro Geovanni Dantas Cassali Mnica Maria Demas lva-res Cabral | 2013 | World Journal of Gastroenterology2013，19，24： | 8 |
| 2 | 对心血管MRI研究发现经皮冠状动脉介入术后肌钙蛋白浓度升高直接代表心肌不可逆损伤的程度 | Selvanayagam J.B. Porto I. Channon K. A.P. Banning 刘文秀 | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，8： | 5 |
| 3 | Transcriptome analyses of the Dof-like gene family in grapevine reveal its involvement in berry, flower and seed development显示文摘The Dof(DNA-binding with one finger)protein family spans a group of plant transcription factors involved in the regulation of several functions,such as plant responses to stress,hormones and light,phytochrome signaling and seed germination.Here we describe the Dof-like gene family in grapevine(Vitis vinifera L.),which consists of 25 genes coding for Dof.An extensive in silico characterization of the VviDofL gene family was performed.Additionally,the expression of the entire gene family was assessed in 54 grapevine tissues and organs using an integrated approach with microarray(cv Corvina)and real-time PCR(cv Pinot Noir)analyses.The phylogenetic analysis comparing grapevine sequences with those of Arabidopsis,tomato,poplar and already described Dof genes in other species allowed us to identify several duplicated genes.The diversification of grapevine DofL genes during evolution likely resulted in a broader range of biological roles.Furthermore,distinct expression patterns were identified between samples analyzed,corroborating such hypothesis.Our expression results indicate that several VviDofL genes perform their functional roles mainly during flower,berry and seed development,highlighting their importance for grapevine growth and production.The identification of similar expression profiles between both approaches strongly suggests that these genes have important regulatory roles that are evolutionally conserved between grapevine cvs Corvina and Pinot Noir. | Danielle Costenaro da Silva Vítor da Silveira Falavigna Marianna Fasoli Vanessa Buffon Diogo Denardi Porto Georgios Joannis Pappas Jr Mario Pezzotti Giancarlo Pasquali Luís Fernando Revers | 2016 | Horticulture Research2016，3，1： | 5 |
| 4 | Iron overload and immunity显示文摘在在人并且在老鼠涉及铁动态平衡的控制的基因的描述的进步改进了铁超载并且它影响的房间的定义。在免疫上与最大的效果涉及铁超载的房间是巨噬细胞。然而,吸引人的证据在显示实质的铁超载被连接到古典主义地与免疫系统联系的基因的最后 12 年里出现了。这评论提供基因和相关的蛋白质的更改熨在天生的免疫系统的房间表示的新陈代谢,并且探讨这个系统怎么处于铁超载的临床的状况被影响的问题。在铁和适应免疫的主要房间之间的关系, T 淋巴细胞,将也被考察。探讨这的大多数研究在人的最后一个问题在世袭 Hemochromatosis 的临床的模型被执行。数据将也被考察表明实质上涉及适应有免疫力的回答的分子的混乱怎么导致铁超载的自发的开发并且他们怎么充当铁超载的修饰词。 | Graca Porto Maria De Sousa | 2007 | World Journal of Gastroenterology2007，13，35： | 3 |
| 5 | Oligomeric Procyanidins Induce Generation of Reactive Oxygen Species and Collapse of Mitochchondrial Membrane Potential in Glioblastoma Cell Lines显示文摘Objective The aim of the present study was to clarify the mechanism underlying glioma cell death upon oligomeric procyanidins (F2) exposure. Methods The cytotoxicity of F2 on U87 (human malignant glioblastoma cell line) and C6 (rat glioma cell line) cancer cells was evaluated, and changes of mitochondrial membrane potential (MMP) and production of reactive oxygen species (ROS) in drug-treated cells were monitored. Moreover, morphological changes associated with F2-induced cells death were examined. Results F2 induced a concentration-dependent increase in ROS production and decrease in MMP. Furthermore, pre-incubation with N-acetylcysteine (NAC) and rotenone (Rt), resulted in partial inhibition of F2-induced ROS generation and marked attenuation of cell death and the cytoplasmic vacuolization induced by F2. In addition, pretreatment with Rt markedly attenuated the MMP loss in F2-treated cells. However, pretreatment with NAC only markedly attenuated the MMP loss in F2-treated C6 cells. Conclusion The increase in ROS level is at least one of mechanisms associated with F2-induced glioma cell death as well as the cytoplasmic vacuolization formation that contribute to the cytotoxicity of F2 in glioma cells. | ZHANG Feng-jiao1, YANG Jing-yu1, MOU Yan-hua1, SUN Bao-shan2, WANG Ji-ming3, WANG Fang1, WU Chun-fu1 1. Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China 2. Estaco Vitivinícola Nacional, Instituto National de Investigaco Agrária, Dois Portos 2565-191, Portugal 3. Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick Maryland 21702, USA | 2009 | Chinese Herbal Medicines2009，1，1： | 3 |
| 6 | KIR and a specific HLA-C gene are associated with susceptibility and resistance to hepatitis B virus infection in a Brazilian population显示文摘 | Patricia Araujo Giovana Goncalves Flavia Latini Orlando Ferreira Luis Cristovao Porto Jose Augusto Barreto Manoel Joao Castelo Girao Ricardo Sobhie Diaz | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 7 | Persistent Activation of Nuclear Factor Kappa-B Signaling Pathway in Patients With Unstable Angina and Elevated Levels of C-Reactive Protein显示文摘 | Giovanna Liuzzo Matteo Santamaria Luigi M. Biasucci Michela Narducci Valeria Colafrancesco Annalisa Porto Salvatore Brugaletta Michela Pinnelli Vittoria Rizzello Attilio Maseri Filippo Crea | 2007 | Journal of the American College of Cardiology2007，，2： | 2 |
| 8 | 情境领导Ⅱ管理模式在巴西乒乓球队教练训练管理工作中的应用(英文)显示文摘本研究包含以下几方面内容:1.情境领导Ⅱ型模式在巴西乒乓球队训练管理工作中及教练员对运动员的领导关系中的应用情况调查。2.根据运动员的表现,运动员的满意程度,以及教练与运动员之间的相互关系来分析教练员的后续领导行为是否受前阶段管理工作的影响。3.分析运动员的调查结果与相应教练员调查结果的一致性,及其领导管理行为是否为运动队管理多元模式中的一种。研究对象与方法:调查对象为61名巴西12~18岁乒乓球运动员和10名乒乓球教练,这些队员和教练均为国家级水平,研究中以运动员满意度问卷形式和运动领导管理标准进行评估。研究结果: 教练员先前的领导行为影响运动员对教练员的看法,以及运动员的满意程度、教练与运动员相互之间的关系等。那些运动成绩较好的、经验相对丰富的、教练监督指导得比较多的运动员,他们的问卷答案与教练员的问卷结果有很高的一致性。对教练员的训练教导工作和民主行为方面,男子运动员的答案要比女子运动员表现出较高的一致性。女运动员对教练员的个别对待方式与民主行为表现出较好的满意度。运动员的问卷结果与相应教练员的调查结果的一致性在很大程度上依赖于训练过程中产生的良好效果与运动员的满意度,这反映了多元领导模式的规则。另外,虽然我们的研究并没有很好地? | Luiz Henrique Porto Vilani Dietmar Martin Samulski | 2005 | 体育科研2005，26，3： | 2 |
| 9 | Mechanochemical synthesis of hercynite显示文摘 | Pablo M. Botta Esteban F. Aglietti José M. Porto López | 2002 | Materials Chemistry and Physics2002，，1： | 2 |
| 10 | 青少年乒乓运动员的焦虑和运动成绩关系(英文)显示文摘多维焦虑理论认为认知和躯体焦虑对运动成绩会产生不同的影响。根据这个理论,运动员在赛前具有较高的认知焦虑水平或躯体焦虑水平出现极端值(过高或过低)或自信心较低时,他们将取得较差的运动成绩。先前的研究还认为焦虑与运动成绩间的关系还取决于所要完成动作的特点。不同的运动技能有各自最佳的焦虑水平。总的来说,焦虑水平较高有利于完成体力消耗较大的运动项目。而焦虑水平较低时,则有利于完成精确类项目。就乒乓球项目而言,它既需要体力又需要精确性,因此,本研究调查分析了乒乓球运动员赛前焦虑水平与运动成绩间的关系。研究对象:36 名青少年乒乓球运动员,男、女运动员各18 名,平均年龄为12.28±0.74岁。研究方法:采用运动竞赛状态焦虑量表(CSAI-2C)。让运动员在参加地区赛第一场比赛的赛前30分填写问卷。研究结果:认知状态焦虑水平不能用来预测运动员的成绩。获胜运动员和失利运动员赛前的躯体状态焦虑和自信心没有差异。这表明本研究没有支持多维焦虑理论的假设,或许是乒乓球运动的特点和运动员的个体差异比运动员的焦虑水平对运动成绩的影响更大。因此,如果运动员的个人特点与他们的技术风格相适应,不同焦虑水平的运动员都可能取得好成绩。 | Cristina Akiko Iizuka Welber Marinovic Afonso Antonio Machado Luiz Henrique Porto Vilani | 2005 | 体育科研2005，26，3： | 2 |
| 11 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 12 | Maternal corticotropin-releasing hormone levels in the early third trimester predict length of gestation in human pregnancy显示文摘 | WADHWA P D PORTO M GARITE T J | 1998 | Am J Obstet Gynecol1998，179，4： | 1 |
| 13 | Placental Corticotropin-releasing hormone (CRH),spontaneous preterm birth,and fetal growth restriction:a prospective investigation显示文摘 | Wadhwa PD Garite TJ Porto M | 2004 | Am J Obstet Gynecol2004，191，4： | 1 |
| 14 | Enamel mineralization in the absence of maturation stage ameloblasts 显示文摘 | Porto IM Merzel J de Sousa FB | 2009 | Arch O ral Biol2009，54，4： | 1 |
| 15 | Analysis of o- mega 3 fatty acid in natural and enrich chicken eggs by capillary zone electrophoresis 显示文摘 | Porto B L Souza M N Oliveira M A | 2011 | Analytical Sciences2011，27，5： | 1 |
| 16 | Granular Vulvovaginitis Syndrome in Nelore pubertal and post pubertal replacement heifers under tropical conditions: role of Mycoplasma spp., Ureaplasma diversum and BHV-1显示文摘 | M. L. Gambarini T. L. Kunz B. D. Oliveira Filho R. N. G. Porto C. M. G. Oliveira W. M. E. D. Brito M. A. O. Viu | 2009 | Tropical Animal Health and Production2009，，7： | 1 |
| 17 | Smoothmusde cells in human atheroscle-rotic plaques secrete and proliferate in response to high mobility group box 1 protein显示文摘 | Porto A Palumbo R Pieroni M | 2006 | FASEB J2006，20，： | 1 |
| 18 | Ultrasound-assisted extraction coupled with under vacuum distillation of flavour compounds from spearmint (carvone-rich) plants: Comparison with conventional hydrodistillation 显示文摘 | Porto C D Decorti D | 2009 | Ultrasonics sonochemistry2009，16，6： | 1 |
| 19 | The Toxoplasma gondii bradyzoite antigens BAG1 and MAG1 induce early humoral and cell-mediated immune responses upon human infection 显示文摘 | Di Cristina M Del Porto P Buffolano W | 2004 | Microbes Infect2004，6，2： | 1 |
| 20 | Optimal location of control valves in pipe networks by genetic algorithm显示文摘 | REIS L F R PORTO R M | 1997 | ASCE Journal of Water Resources Planning and Management1997，123，6： | 1 |
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