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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Review of screening for pancreatic cancer in high risk individuals显示文摘Pancreatic cancer is difficult to diagnose at an early stage and is associated with a very poor survival.Ten percent of pancreatic cancers result from genetic susceptibility and/or familial aggregation.Individuals from families with multiple affected first-degree relatives and those with a known cancer-causing genetic mutation have been shown to be at much higher risk of developing pancreatic cancer.Recent efforts have focused on detecting disease at an earlier stage to improve survival in these high-risk groups.This article reviews high-risk groups,screening methods,and current screening programs and their results. | Alina Stoita Ian D Penman David B Williams | 2011 | World Journal of Gastroenterology2011，17，19： | 4 |
| 3 | 神经元突触内的非受体型酪氨酸激酶底物(英文)显示文摘非受体型酪氨酸激酶(non-receptor tyrosine kinase,nRTK)是一个较大的激酶家族,其功能是催化蛋白的酪氨酸磷酸化。nRTK家族中的几种常见亚型,比如Src和Fyn,可以在神经系统内表达。近年来的研究表明,神经元的突触部位含有多个nRTK的底物蛋白,这些底物蛋白主要包括谷氨酸受体(离子型和代谢型谷氨酸受体)、突触后构架蛋白、突触前调节蛋白和突触富含的多种蛋白激酶。在基础或刺激的状态下,nRTK可催化这些底物蛋白内特定酪氨酸的磷酸化,从而调节这些底物蛋白的多种生理、生化和生物物理功能。因为突触内的nRTK对突触变化信号非常敏感,所以突触nRTK被认为参与了突触传导活动的强度和效率等方面的调节。 | 毛利民 Ryan Geosling Brian Penman 王强 | 2017 | 生理学报2017，69，5： | 2 |
| 4 | Ratio Analysis and Equity Valuation: From Research to Practice显示文摘 | Doron Nissim Stephen H. Penman | 2001 | Review of Accounting Studies2001，，1： | 2 |
| 5 | EUS-guided celiac block and neurolysis显示文摘 | D. Collins I. Penman G. Mishra P. Draganov | 2006 | Endoscopy2006，，09： | 2 |
| 6 | Gastrin and colorectal cancer: where now?显示文摘 | Penman ID McColl KE | 1998 | Eur J Gastroenterol Heoatol1998，10，4： | 1 |
| 7 | Natural evaporation from open water, bare soil and grass显示文摘 | PENMAN H L | 1948 | Proceedings of the Royal Society of London: Series A1948，193，： | 1 |
| 8 | The Distribution of Earnings News Over Time and Seasonalities in Aggregate Stock Returns显示文摘 | Penman S H | 1987 | Journal of Financial Economics1987，18，2： | 1 |
| 9 | Real-time detection of intermittent misfiring in a voltage-fed PWM inverter induction-motor drive 显示文摘 | Smith K S Ran L Penman J | 1997 | IEEE Transactions on Industrial Electronics1997，44，4： | 1 |
| 10 | Gas and vapour movements in soil: The diffusion of vapours through porous solids显示文摘 | Penman H L | 1940 | Journal of Agricultural Science1940，30，3： | 1 |
| 11 | Evidence for the presence of sex chromosomes in the Nile tilapia ( Oreochromis niloticus ) from synaptonemal complex analysis of XX, XY and YY genotypes显示文摘 | Carrasco L A Penman D J Bromage N | 1999 | Aquaculture1999，173，： | 1 |
| 12 | Accounting Measurement Price-earnings Ratios and the Information Content of Security Prices显示文摘 | Ou J Penman S | 1989 | Journal of Accounting Research1989，，： | 1 |
| 13 | On the embankment dam显示文摘 | Penman A D M | 1986 | Geotechnique1986，36，3： | 1 |
| 14 | Eradication of helicobaceer pylori infection lowers gastric mediated acid secretion by two thirds in patients with duodenal 显示文摘 | EL- omar EM Penman ID Dorrian CA | 1993 | Gut1993，34，： | 1 |
| 15 | The nuclear matrix:Three dimentional architecture andprotein composition显示文摘 | Capco DG Wan KM Penman S | 1982 | Cell1982，29，： | 1 |
| 16 | The use of correlation dimension in condition monitoring of systems with clearance显示文摘 | Carig C Neilson R D Penman J | 2000 | Journal of Sound and Vibration2000，23，1： | 1 |
| 17 | Inter- and intra-observer reliability of the Baumann angle of the humerus in children with supracondylar humeral fractures显示文摘 | Mauricio Silva Rajeev Pandarinath Eugene Farng Samuel Park Cherlyn Caneda Yi-Jen Fong Adam Penman | 2010 | International Orthopaedics2010，，4： | 1 |
| 18 | DNA damageand mutation in human cells exposed to nitric oxide in vitro显示文摘 | Nguyen T Brunson D Crespi CL Penman BW Wishnok JS Tannenbaum SR | 1992 | Proc Natl Acad Sci USA1992，89，7： | 1 |
| 19 | Estimation of ranolazine and eleven PhaseⅠmetabolites in human plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry with selected-ion显示文摘 | Herron WJ Eadie J Penman AD | 1995 | J Chromatogr A1995，712，1： | 1 |
| 20 | Induction Machine Condition Monitoring with Higher Order Spectra 显示文摘 | Neil Arthur Jim Penman | 2000 | IEEE Transactions on Industrial Electronics( S0278 -0046)2000，47，5： | 1 |
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