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| 1 | Adipose tissue lipolysis and remodeling during the transition period of dairy cows显示文摘Elevated concentrations of plasma fatty acids in transition dairy cows are significantly associated with increased disease susceptibility and poor lactation performance. The main source of plasma fatty acids throughout the transition period is lipolysis from adipose tissue depots. During this time, plasma fatty acids serve as a source of calories mitigating the negative energy balance prompted by copious milk synthesis and limited dry matter intake.Past research has demonstrated that lipolysis in the adipose organ is a complex process that includes not only the activation of lipolytic pathways in response to neural, hormonal, or paracrine stimuli, but also important changes in the structure and cellular distribution of the tissue in a process known as adipose tissue remodeling. This process involves an inflammatory response with immune cell migration, proliferation of the cellular components of the stromal vascular fraction, and changes in the extracellular matrix. This review summarizes current knowledge on lipolysis in dairy cattle, expands on the new field of adipose tissue remodeling, and discusses how these biological processes affect transition cow health and productivity. | G.Andres Contreras Clarissa Strieder-Barboza William Raphael | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 8 |
| 2 | Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions显示文摘Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal function.Methods: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ductus.Conclusions: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ineffective.However, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol. | Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer Franciele Queiroz Ames Ciomar Aparecida Bersani-Amado Roberto Kenji Nakamura Cuman | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 4 |
| 3 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 4 | Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract显示文摘Metabotropic glutamate receptor subtype 5(mGluR5) is a Group I mGlu subfamily of receptors coupled to the inositol trisphosphate/diacylglycerol pathway. Like other m Glu R subtypes, mGluR5 s contain a phylogenetically conserved, extracellular orthosteric binding site and a more variable allosteric binding site, located on the heptahelical transmembrane domain. The mGluR5 receptor has proved to be a key pharmacological target in conditions affecting the central nervous system(CNS) but its presence outside the CNS underscores its potential role in pathologies affecting peripheral organs such as the gastrointestinal(GI) tract and accessory digestive organs such as the tongue, liver and pancreas. Following identification of mGluR5s in the mouth, various studies have subsequently demonstrated its involvement in mechanical allodynia, inflammation, pain and oral cancer. mGluR5 expression has also been identified in gastroesophageal vagal pathways. Indeed, experimental and human studies have demonstrated that mGluR5 blockade reduces transient lower sphincter relaxation and reflux episodes. In the intestine, mGluR5s have been shown to be involved in the control of intestinal inflammation, visceral pain and the epithelial barrier function. In the liver, mGluR5s have a permissive role in the onset of ischemic injury in rat and mice hepatocytes. Conversely, livers from mice treated with selective negative allosteric modulators and mGluR5 knockout mice are protected against ischemic injury. Similar results have been observed in experimental models of free-radical injury and in vivo mouse models of acetaminophen intoxication. Finally, mGluR5s in the pancreas are associated with insulin secretion control. The picture is, however, far from complete as the review attempts to establish in particular as regards identifying specific targets and innovative therapeutic approaches for the treatment of GI disorders. | Andrea Ferrigno Clarissa Berardo Laura G Di Pasqua Veronica Siciliano Plinio Richelmi Mariapia Vairetti | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 5 | Liver plays a central role in asymmetric dimethylargininemediated organ injury显示文摘Asymmetric-dimethylarginine(ADMA) competes with L-arginine for each of the three isoforms of nitric oxide synthase:endothelial;neuronal;inducible.ADMA is synthesized by protein methyltransferases followed by proteolytic degradation.ADMA is metabolized to citrulline and dimethylamine,by dimethylarginine dimethylaminohydrolase(DDAH) and enters cells through cationic amino-acid transporters extensively expressed in the liver.The liver plays a crucial role in ADMA metabolism by DDAH-1 and,as has been recently demonstrated,it is also responsible for ADMA biliary excretion.A correlation has been demonstrated between plasma ADMA levels and the degree of hepatic dysfunction in patients suffering from liver diseases with varying aetiologies:plasma ADMA levels are increased in patients with liver cirrhosis,alcoholic hepatitis and acute liver failure.The mechanism by which liver dysfunction results in raised ADMA concentrations is probably due to impaired activity of DDAH due to severe inflammation,oxidative stress,and direct damage to DDAH.High plasma ADMA levels are also relevant as they are associated with the onset of multiorgan failure(MOF).Increased plasma concentration of ADMA was identified as an independent risk factor for MOF in critically-ill patients causing enhanced Intensive Care Unit mortality:a significant reduction in nitric oxide synthesis,leading to malperfusion in various organs,eventually culminating in multi organs dysfunction. | Andrea Ferrigno Laura G Di Pasqua Clarissa Berardo Plinio Richelmi Mariapia Vairetti | 2015 | World Journal of Gastroenterology2015，21，17： | 2 |
| 6 | Use of intra-arterial chemotherapy for retinoblastoma:results of a survey显示文摘·AIM: To obtain baseline knowledge about the current use of intra-arterial chemotherapy(SSOAIC) in centers worldwide.·METHODS: A survey including questions about the use of SSOAIC was emailed to retinoblastoma experts.·RESULTS:Seventy-nine(response rate 69.9%) doctors from 63 centers in 35 countries responded. Thirty-one centers from 19 countries use SSOAIC. Twelve performed more than 50 procedures. Melphalan is the most commonly used drug but 15 centers use more than one drug. First line therapy for advanced unilateral disease is the most common use of SSOAIC(74.2%). Centers with larger experience(>50 applications) were less likely using melphalan alone(P =0.06) and significantly more likely using SSOAIC in more situations such as second line in preference to radiotherapy P =0.05. Nineteen(61.2%)stated that SSOAIC improved their results and 21(77.8%)reported less toxicity compared to other treatments.Three centers reported that SSOAIC did not improve their results. There were regional variations in the use of SSOAIC which is used more frequently as secondary treatment in Europe compared to the USA and Japan.Ten centers identified cost is the major limiting factor for SSOAIC.· CONCLUSION: SSOAIC is used in an increasing number of centers worldwide with regional variations.Centers with more experience in SSOAIC use it in more situations including other drugs than melphalan. The majority of the centers using this technique reportedimproved results and few complications. | Nathalia Grigorovski Evandro Lucena Clarissa Mattosinho Andreu Parareda Sima Ferman Jaume Catalá Guillermo Chantada | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 2 |
| 7 | Naturalistic pharmacogenetic study of treatment resistance to typical neuroleptics in European–Brazilian schizophrenics显示文摘 | Fabiana B. Kohlrausch Clarissa S. Gama Maria Inês Lobato Paulo Belmonte-de-Abreu Sidia M. Callegari-Jacques Alejandro Gesteira Francisco Barros ángel Carracedo Mara H. Hutz | 2008 | Pharmacogenetics and Genomics2008，，7： | 1 |
| 8 | Urinary monocyte chemoattractant protein-1 correlates with disease activity in lupus nephritis显示文摘 | Stephen DM Vanita S Clarissa P | 2010 | Pediatr Nephrol2010，25，11： | 1 |
| 9 | Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus 显示文摘 | Leda SBG Clarissa MC Samira SV | 2008 | Prog Neuro-Psychopharmacol Biol Psychiatry2008，32，1： | 1 |
| 10 | Artifacts in brain magnetic resonance imaging due to metallic dental objects显示文摘 | Andre LFC Simone A Clarissa LY | 2009 | Med Oral Patol Oral Cir Bucal2009，14，6： | 1 |
| 11 | Beer constituents as potential cancer chemopreventive agents显示文摘 | Clarissa gerhauser | 2005 | European Journal of Cancer2005，41，： | 1 |
| 12 | Structural evaluation of sugar cane bagasse steam pretreated in the presence of CO2 and SO2显示文摘 | Roberta Cristina Novaes Reis Corrales Fabiana Magalhles T Mendes Clarissa C Perrone | 2012 | Biotechnology for Biofuels2012，5，1： | 1 |
| 13 | Coronoid process of the ulna: paleopathologic and anatomic study with imaging correlation. Emphasis on the anteromedial “facet”显示文摘 | Marcio Freitas Valle de Lemos Weber Diogo Miranda Barbosa Clarissa Belentani Pedro Miguel Negrao Ramos Debra Trudell Donald Resnick | 2009 | Skeletal Radiology2009，，1： | 1 |
| 14 | Functionalization of MWCNT with P(MMA- co -S) copolymers via ATRP: Influence on localization of MWCNT in SAN/PPE 40/60 blends and on rheological and dielectric properties of the composites显示文摘 | Bing Du Ulrich A. Handge Mona Wambach Clarissa Abetz Sofia Rangou Volker Abetz | 2013 | Polymer2013，，22： | 1 |
| 15 | Microstrueture, texture, colour and sensory evaluation of a spreadable processed cheese analogue made with vegetable fat显示文摘 | Clarissa R Cunha Ana Isabel Dias Walkiria H Viotto | 2010 | Food Research International2010，43，： | 1 |
| 16 | Transition of Adolescents With Inflammatory Bowel Disease From Pediatric to Adult Care: A Survey of Adult Gastroenterologists显示文摘 | Elizabeth J Hait Renée M Barendse Janis H Arnold Clarissa Valim Bruce E Sands Joshua R Korzenik Laurie N Fishman | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，1： | 1 |
| 17 | Development of a data collection and management system in West Africa:challenges and sustainability显示文摘Background:Developing and sustaining a data collection and management system(DCMS)is difficult in malariaendemic countries because of limitations in internet bandwidth,computer resources and numbers of trained personnel.The premise of this paper is that development of a DCMS in West Africa was a critically important outcome of the West African International Centers of Excellence for Malaria Research.The purposes of this paper are to make that information available to other investigators and to encourage the linkage of DCMSs to international research and Ministry of Health data systems and repositories.Methods:We designed and implemented a DCMS to link study sites in Mali,Senegal and The Gambia.This system was based on case report forms for epidemiologic,entomologic,clinical and laboratory aspects of plasmodial infection and malarial disease for a longitudinal cohort study and included on-site training for Principal Investigators and Data Managers.Based on this experience,we propose guidelines for the design and sustainability of DCMSs in environments with limited resources and personnel.Results:From 2012 to 2017,we performed biannual thick smear surveys for plasmodial infection,mosquito collections for anopheline biting rates and sporozoite rates and year-round passive case detection for malarial disease in four longitudinal cohorts with 7708 individuals and 918 households in Senegal,The Gambia and Mali.Major challenges included the development of uniform definitions and reporting,assessment of data entry error rates,unstable and limited internet access and software and technology maintenance.Strengths included entomologic collections linked to longitudinal cohort studies,on-site data centres and a cloud-based data repository.Conclusions:At a time when research on diseases of poverty in low and middle-income countries is a global priority,the resources available to ensure accurate data collection and the electronic availability of those data remain severely limited.Based on our experience,we suggest the development of a regional DCMS.This approach is more economical than separate data centres and has the potential to improve data quality by encouraging shared case definitions,data validation strategies and analytic approaches including the molecular analysis of treatment successes and failures. | Jeffrey G.Shaffer Seydou O.Doumbia Daouda Ndiaye Ayouba Diarra Jules F.Gomis Davis Nwakanma Ismaela Abubakar Abdullahi Ahmad Muna Affara Mary Lukowski Clarissa Valim James C.Welty Frances J.Mather Joseph Keating Donald J.Krogstad | 2018 | Infectious Diseases of Poverty2018，7，1： | 1 |
| 18 | Short-term intensive insulin therapy in newly diagnosed type 2 diabetes 显示文摘 | Edmond A R Shardeen I Clarissa W | 2004 | Diabetes Care2004，27，： | 1 |
| 19 | Shortter mimtensiveinsulin therapy in newly diagonseel type I Diabetes 显示文摘 | Edmond AR Sharleen I Clarissa W | 2006 | Diabetes Care2006，27，： | 1 |
| 20 | Leptin induces macro - phage lipid laxly formation by a phosphatidylinositol 3 - kinase and mammalian target of rapamycin - dependent mechanism 显示文摘 | CLARISSA M MAYA M PATRICIA E | 2008 | J Biol Chem2008，283，4： | 1 |
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