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| 1 | Atrial fibrillation in patients with gastroesophageal reflux disease: A comprehensive review显示文摘AIM:To analyze the potential relationship between gastroesophageal reflux disease(GERD)and the development of atrial fibrillation(AF).METHODS:Using the key words'atrial fibrillation and gastroesophageal reflux','atrial fibrillation and esophagitis,peptic','atrial fibrillation and hernia,hiatal'the PubMed,EMBASE,Cochrane Library,OVIDSP,WILEY databases were screened for relevant publications on GERD and AF in adults between January 1972-December 2013.Studies written in languages other than English or French,studies not performed in humans,reviews,case reports,abstracts,conference presentations,letters to the editor,editorials,comments and opinions were not taken into consideration.Articles treating the subject of radiofrequency ablation of AF and the consecutive development of GERD were also excluded.RESULTS:Two thousand one hundred sixty-one titles were found of which 8 articles met the inclusion criteria.The presence of AF in patients with GERD was reported to be between 0.62%-14%,higher compared to those without GERD.Epidemiological data provided by these observational studies showed that patients with GERD,especially those with more severe GERD-related symptoms,had an increased risk of developing AF compared with those without GERD,but a causal relationship between GERD and AF could not be established based on these studies.The mechanisms of AF as a consequence of GERD remain largely unknown,with inflammation and vagal stimulation playing a possible role in the development of these disorders.Treatment with proton pomp inhibitors may improve symptoms related to AF and facilitate conversion to sinus rhythm.CONCLUSION:Although links between AF and GERD exist,large randomized clinical studies are required for a better understanding of the relationship between these two entities. | Crina Roman Stanislas Bruley des Varannes Lucian Muresan Alina Picos Dan L Dumitrascu | 2014 | World Journal of Gastroenterology2014，20，28： | 16 |
| 2 | Effect of sustained virological response on long-term clinical outcome in 113 patients with compensated hepatitis C-related cirrhosis treated by interferon alpha and ribavirin显示文摘AIM:To assess the long-term clinical benefit of sustained virological response(SVR)in patients with hepatitis C virus(HCV)cirrhosis treated by antiviral therapy using mostly ribavirin plus interferon either standard or pegylated.METHODS:One hundred and thirteen patients with uncomplicated HCV biopsy-proven cirrhosis,treated by at least one course of antiviral treatment ≥ 3 mo and followed ≥ 30 mo were included.The occurrence of clinical events hepatocellular carcinoma(HCC),decompensation and death was compared in SVR and non SVR patients.RESULTS:Seventy eight patients received bitherapy and 63 had repeat treatments.SVR was achieved in 37 patients(33%).During a mean follow-up of 7.7 years,clinical events occurred more frequently in non SVR than in SVR patients,with a significant difference for HCC(24/76 vs 1/37,P = 0.01).No SVR patient died while 20/76 non-SVR did(P = 0.002),mainly in relation to HCC(45%).CONCLUSION:In patients with HCV-related cirrhosis,SVR is associated with a significant decrease in the incidence of HCC and mortality during a follow-up period of 7.7 years.This result is a strong argument to perform and repeat antiviral treatments in patients with compensated cirrhosis. | Roland El Braks Nathalie Ganne-Carrié Hélène Fontaine Jacques Paries Véronique Grando-Lemaire Michel Beaugrand Stanislas Pol Jean-Claude Trinchet | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 3 | Noninvasive In Vivo Liver Fibrosis Evaluation Using Supersonic Shear Imaging: A Clinical Study on 113 Hepatitis C Virus Patients显示文摘 | éric Bavu Jean-Luc Gennisson Mathieu Couade Jeremy Bercoff Vincent Mallet Mathias Fink Anne Badel Ana?s Vallet-Pichard Bertrand Nalpas Micka?l Tanter Stanislas Pol | 2011 | Ultrasound in Medicine & Biology2011，，9： | 3 |
| 4 | A proterozoic-rift origin for the structure and the evolution of the cratonic Congo basin显示文摘 | Etienne K K Stanislas S M N Francis L | 2011 | EPSL2011，304，1： | 1 |
| 5 | Hepatitis C virus treatment in the real world: optimising treatment and access to therapies显示文摘 | Zoulim Fabien Liang T Jake Gerbes Alexander L Aghemo Alessio Deuffic-Burban Sylvie Dusheiko Geoffrey Fried Michael W Pol Stanislas Rockstroh Ju?rgen Kurt Terrault Norah A Wiktor Stefan | 2015 | Gut2015，，11： | 1 |
| 6 | Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice显示文摘 | Claudia Mitchell Dominique Couton Jean-Pierre Couty Marie Anson Anne-Marie Crain Vinciane Bizet Laurent Rénia Stanislas Pol Vincent Mallet Hélène Gilgenkrantz | 2009 | The American Journal of Pathology2009，，5： | 1 |
| 7 | HIV infection and hepatic enzyme abnormalities: Intricacies of the pathogenic mechanisms显示文摘 | Stanislas P Pascal L Anals VP | 2004 | Clin Infect Dis2004，38，12： | 1 |
| 8 | Hepatitis B virus infection and pregnancy显示文摘 | Stanislas Pol Marion Corouge Hélène Fontaine | 2011 | Clinics and Research in Hepatology and Gastroenterology2011，，10： | 1 |
| 9 | Effect of pregnancy on chronic hepatitis C: a case-control study显示文摘 | Hélène Fontaine Bertrand Nalpas Fran?oise Carnot Christian Bréchot Stanislas Pol | 2000 | The Lancet2000，，9238： | 1 |
| 10 | Intravenous lidoeaine infusion facili- tates acute rehabilitation after laparo- scopic colectomy 显示文摘 | Abdourahamane K Stanislas R L | 2007 | Anesthesiology2007，106，1： | 1 |
| 11 | Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIV-infected patients显示文摘 | Vincent Mallet Pierre Blanchard Virginie Verkarre Ana?s Vallet-Pichard Hélène Fontaine Caroline Lascoux-Combe Stanislas Pol | 2007 | AIDS2007，，2： | 1 |
| 12 | How to optimize HCV therapy in genotype 1 patients with cirrhosis显示文摘 | Marc Bourlière Astrid Wendt Hélène Fontaine Christophe Hézode Stanislas Pol Jean Pierre Bronowicki | 2013 | Liver Int2013，，： | 1 |
| 13 | Noninvasive In Vivo Liver Fibrosis Evaluation Using Supersonic Shear Imaging: A Clinical Study on 113 Hepatitis C Virus Patients显示文摘 | éric Bavu Jean-Luc Gennisson Mathieu Couade Jeremy Bercoff Vincent Mallet Mathias Fink Anne Badel Ana?s Vallet-Pichard Bertrand Nalpas Micka?l Tanter Stanislas Pol | 2011 | Ultrasound in Medicine & Biology2011，，9： | 1 |
| 14 | A synthetic oscillatory network of transcriptional regulators显示文摘 | MICHAEL B E STANISLAS L | 2000 | Nature2000，403，： | 1 |
| 15 | Pathological evolution of hepatitis C virus-“Healthy carriers”显示文摘AIM: To determine factors associated with fibrosis progression in hepatitis C virus (HCV)-infected patients without signifi cant initial pathological lesions. METHODS: Seventy six untreated HCV-infected pa-tients with initially normal liver as defi ned by a Knodell score≤3,with 2 liver biopsies and detectable HCV-RNA were included. Markers of fibrosis progression were assessed. RESULTS: Median duration of infection and time between paired biopsies was 13 (95% CI: 1-28) and 4 (95% CI: 2-16) years respectively. Alanine-transaminase (ALT) activity was normal in 43.4% of cases. 50% demonstrated progression of the necro-in? ammation and 34% of fi brosis after a median time evolution of 4 years (95% CI: 2-16). The median dif-ference in the necro-inflammation and fibrosis score between biopsies was low,1.5 and 0.0 respectively. Univariate analysis showed there was no difference between fibrosis activity or evolution according to genotype or viral load. A higher fibrosis progression (P = 0.03) was observed in patients with body mass index (BMI) > 25. Fibrosis progression correlated with the time interval between biopsies (P = 0.01). A sig-nifi cant progression of activity (1.7 vs 0.4,P < 0.05) or fi brosis (0.9 vs 0.0,P < 0.01) was observed in patients with elevated ALT. There was a signifi cant correlation between activity progression and fi brosis progression (P = 0.003). Multivariate analysis demonstrated that fi brosis progression was associated with elevated ALT,BMI > 25 and the time interval between 2 biopsies. CONCLUSION: There is no fibrosis progression in 66% of patients without signifi cant initial histopatho-logical lesion. Fibrosis progression is associated with elevated ALT and BMI > 25. | Rodolphe Sobesky Pascal Lebray Bertrand Nalpas Anas Vallet-Pichard Hélène Fontaine Jean-Luc Lagneau Stanislas Pol | 2008 | World Journal of Gastroenterology2008，14，24： | 0 |
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