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| 1 | Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis. | Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，35： | 6 |
| 2 | Effect of sustained virological response on long-term clinical outcome in 113 patients with compensated hepatitis C-related cirrhosis treated by interferon alpha and ribavirin显示文摘AIM:To assess the long-term clinical benefit of sustained virological response(SVR)in patients with hepatitis C virus(HCV)cirrhosis treated by antiviral therapy using mostly ribavirin plus interferon either standard or pegylated.METHODS:One hundred and thirteen patients with uncomplicated HCV biopsy-proven cirrhosis,treated by at least one course of antiviral treatment ≥ 3 mo and followed ≥ 30 mo were included.The occurrence of clinical events hepatocellular carcinoma(HCC),decompensation and death was compared in SVR and non SVR patients.RESULTS:Seventy eight patients received bitherapy and 63 had repeat treatments.SVR was achieved in 37 patients(33%).During a mean follow-up of 7.7 years,clinical events occurred more frequently in non SVR than in SVR patients,with a significant difference for HCC(24/76 vs 1/37,P = 0.01).No SVR patient died while 20/76 non-SVR did(P = 0.002),mainly in relation to HCC(45%).CONCLUSION:In patients with HCV-related cirrhosis,SVR is associated with a significant decrease in the incidence of HCC and mortality during a follow-up period of 7.7 years.This result is a strong argument to perform and repeat antiviral treatments in patients with compensated cirrhosis. | Roland El Braks Nathalie Ganne-Carrié Hélène Fontaine Jacques Paries Véronique Grando-Lemaire Michel Beaugrand Stanislas Pol Jean-Claude Trinchet | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 3 | Risk Factors for Hepatocellular Carcinoma in Patients With Alcoholic or Viral C Cirrhosis显示文摘 | Gisèle N’Kontchou Jacques Paries Myint Tin Tin Htar Nathalie Ganne–Carrie Lydie Costentin Véronique Grando–Lemaire Jean–Claude Trinchet Michel Beaugrand | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 2 |
| 4 | Risk Factors for Hepatocellular Carcinoma in Patients With Alcoholic or Viral C Cirrhosis显示文摘 | Gisèle N’Kontchou Jacques Paries Myint Tin Tin Htar Nathalie Ganne–Carrie Lydie Costentin Véronique Grando–Lemaire Jean–Claude Trinchet Michel Beaugrand | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 1 |
| 5 | Lysosomal and mitochondrial pathways in miltefosine-induced apoptosis in U937 cells显示文摘 | Caroline Paris Jacques Bertoglio Jacqueline Bréard | 2007 | Apoptosis2007，，7： | 1 |
| 6 | Phenolic characterization and variability in leaves,stems and roots of Micro-Tom and patio tomatoes, in response to nitrogen limitation 显示文摘 | Romain Larbat C6dric Paris Jacques Le Bot | 2014 | Plant Science2014，224，： | 1 |
| 7 | Phenoliccharacterization and variability in leaves,stems and roots of Micro-Tom and patio tomatoes,in response to nitrogen limitation显示文摘 | Romain Larbat Cedric Paris Jacques Le Bot | 2014 | Plant Science2014，224，： | 1 |
| 8 | 法国航海博物馆显示文摘法国航海博物馆是为了纪念1998年在海上去世的、伟大的航海家埃里克塔巴里而建的.它是洛里昂潜水基地的新的标志。
一个明亮的金属“广场”.由闪光的铝合金板覆盖.这铝合金板的颜色会根据气候的变化而变化,好像悉浮在码头上.在海边形成了一个壮观的建筑。 | Jacques Ferrier Architectures/Paris | 2010 | 中国建筑装饰装修2010，，6： | 0 |
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