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| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 2 | Research approaches to mass casualty incidents response:development from routine perspectives to complexity science显示文摘 | Shen Weifeng Jiang Libing Zhang Mao Ma Yuefeng Jiang Guanyu He Xiaojun | 2014 | Chinese Medical Journal2014，，13： | 4 |
| 3 | Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum显示文摘The cerebellum is critical for controlling motor and non-motor functions via cerebellar circuit that is composed of defined cell types, which approximately account for more than half of neurons in mammalsThe molecular mechanisms controlling developmental progression and maturation processes of various cerebellar cell types need systematic investigationHere, we analyzed transcriptome profiles of 21119 single cells of the postnatal mouse cerebellum and identified eight main cell clusters. Functional annotation of differentially expressed genes revealed trajectory hierarchies of granule cells (GCs) at various states and implied roles of mitochondrion and ATPases in the maturation of Purkinje cells (PCs), the sole output cells of the cerebellar cortexFurthermore, we analyzed gene expression patterns and co-expression networks of 28 ataxia risk genes, and found that most of them are related with biological process of mitochondrion and around half of them are enriched in PCs. Our results also suggested core transcription factors that are correlated with interneuron differentiation and characteristics for the expression of secretory proteins in glia cells, which may participate in neuronal modulationThus, this study presents a systematic landscape of cerebellar gene expression in defined cell types and a general gene expression framework for cerebellar development and dysfunction. | Jian Peng Ai-li Sheng Qi Xiao Libing Shen Xiang-Chun Ju Min Zhang Si-Ting He Chao Wu Zhen-Ge Luo | 2019 | Journal of Molecular Cell Biology2019，11，8： | 2 |
| 4 | Efficient and Secure Authentication Scheme with Conditional Privacy-Preserving for VANETs显示文摘The goal of authentication scheme for Vehicular ad hoc networks(VANETs) is to ensure reliability and integrity of message. Due to the timeliness of traffic-related messages and the highly dynamic nature of VANETs, it still is a challenge to solve the three key issues simultaneously, i.e. security, efficiency and conditional privacy-preserving, on the design of authentication scheme for VANETs. To address this challenge, an efficient Conditional privacy-preserving authentication(CPPA) scheme is proposed in this paper. Compared with the most recent proposed CPPA schemes, our proposed scheme markedly decreases the computation costs of the message-signing phase and the message verification phase, while satisfies all security requirements of VANETs and provides conditional privacy-preserving. | XIE Yong WU Libing ZHANG Yubo SHEN Jian | 2016 | Chinese Journal of Electronics2016，25，5： | 2 |
| 5 | Lightweight diesign of automotive front side rails with TWB显示文摘 | SHI Yuliang ZHU Ping SHEN Libing | 2007 | Thin-Walled Structures2007，45，： | 1 |
| 6 | Light- weight Design of Automotive front Side Rails with TWB Concept显示文摘 | Shi Yuliang Zhu Ping Shen Libing | 2007 | Thin-- Walled Structures2007，45，： | 1 |
| 7 | HvWRKY2 acts as an immunity suppressor and targets HvCEBiP to regulate powdery mildew resistance in barley显示文摘Plants use a sophisticated immune system to perceive pathogen infection and activate immune responses in a tightly controlled manner.In barley,Hv WRKY2 acts as a repressor in barley disease resistance to the powdery mildew fungus,Blumeria graminis f.sp.hordei(Bgh).However,the molecular features of Hv WRKY2 in its DNA-binding and repressor functions,as well as its target genes,are uncharacterized.We show that the W-box binding of Hv WRKY2 requires an intact WRKY domain and an upstream sequence of~75 amino acids,and the Hv WRKY2 W-box binding activity is linked to its repressor function in disease resistance.Chromatin immunoprecipitation(ChIP)-seq analysis identified HvCEBiP,a putative chitin receptor gene,as a target gene of Hv WRKY2 in overexpressing transgenic barley plants.ChIP-qPCR and Electrophoretic Mobility Shift Assay(EMSA)verified the direct binding of Hv WRKY2 to a W-boxcontaining sequence in the HvCEBiP promoter.Hv CEBiP positively regulates resistance against Bgh in barley.Our findings suggest that Hv WRKY2 represses barley basal immunity by directly targeting pathogen-associated molecular pattern(PAMP)recognition receptor genes,suggesting that Hv CEBiP and likely chitin signaling function in barley PAMP-triggered immune responses to Bgh infection. | Deshui Yu Renchun Fan Ling Zhang Pengya Xue Libing Liao Meizhen Hu Yanjun Cheng Jine Li Ting Qi Shaojuan Jing Qiuyun Wang Arvind Bhatt Qian-Hua Shen | 2023 | The Crop Journal2023，11，1： | 1 |
| 8 | Redirecting soluble antigen for MHC class I cross‐presentation during phagocytosis显示文摘 | Aswin Hari Anutosh Ganguly Libing Mu Shevaun P. Davis Melanie D. Stenner Raymond Lam Fay Munro Inana Namet Enaam Alghamdi Tobias Fürstenhaupt Wei Dong Pascal Detampel Lian Jun Shen Matthias W. Amrein Robin M. Yates Yan Shi | 2015 | Eur. J. Immunol2015，，： | 1 |
| 9 | Light weight design of automotive front side rails with TWB concept 显示文摘 | Shi Yuliang Zhu Ping Shen Libing | 2007 | Thin-Walled Structures2007，45，： | 1 |
| 10 | Epider mal stem cells cultured on collagen modified chitin membrane induce in situ tissue regeneration of full- thickness skin defects in mice显示文摘 | SHEN YAN DAI LIBING LI XIAOJIAN | 2014 | PLOS ONE2014，9，2： | 1 |
| 11 | Light- weight Design of Automotive Front Side Rails with TWB Concept显示文摘 | Shi Yuliang Zhu Ping Shen Libing | 2007 | Thin-Walled Structures2007，45，： | 1 |
| 12 | Characterization of uncommon portosystemic collateral circulations inpatients with hepatic cirrhosis显示文摘 | Qin Wu Lijun Shen Jindong Chu Xuemei Ma Bo Jin Fanping Meng Jinpin Chen Yanling Wang Libing Wu Jun Han Wenhui Zhang Wei Ma Huaming Wang Hanwei Li | 2015 | Oncology Letters2015，，1： | 1 |
| 13 | Draft Genome of White-blotched River Stingray Provides Novel Clues for Niche Adaptation and Skeleton Formation显示文摘The white-blotched river stingray(Potamotrygon leopoldi)is a cartilaginous fish native to the Xingu River,a tributary of the Amazon River system.As a rare freshwater-dwelling cartilaginous fish in the Potamotrygonidae family in which no member has the genome sequencing information available,P.leopoldi provides the evolutionary details in fish phylogeny,niche adaptation,and skeleton formation.In this study,we present its draft genome of 4.11 Gb comprising 16,227 contigs and 13,238 scaffolds,with contig N50 of 3937 kb and scaffold N50 of 5675 kb in size.Our analysis shows that P.leopoldi is a slow-evolving fish that diverged from elephant sharks about 96 million years ago.Moreover,two gene families related to the immune system(immunoglobulin heavy constant delta genes and T-cell receptor alpha/delta variable genes)exhibit expansion in P.leopoldi only.We also identified the Hox gene clusters in P.leopoldi and discovered that seven Hox genes shared by five representative fish species are missing in P.leopoldi.The RNA sequencing data from P.leopoldi and other three fish species demonstrate that fishes have a more diversified tissue expression spectrum when compared to mammals.Our functional studies suggest that lack of the gc gene encoding vitamin D-binding protein in cartilaginous fishes(both P.leopoldi and Callorhinchus milii)could partly explain the absence of hard bone in their endoskeleton.Overall,this genome resource provides new insights into the niche adaptation,body plan,and skeleton formation of P.leopoldi,as well as the genome evolution in cartilaginous fishes. | Jingqi Zhou Ake Liu Funan He Yunbin Zhang Libing Shen Jun Yu Xiang Zhang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 14 | Effects of Microbial Fertilizers in Improving Acidic Tobacco-planting Soil and Tobacco Leaf Quality显示文摘[Objectives]This study was conducted to improve acidic soil and enhance the quality of tobacco leaves.[Methods]The effects of different microbial fertilizers on improving acidic tobacco-planting soil and tobacco leaf quality were investigated through plot experiments.[Results]The application of microbial fertilizers could improve the pH value of acidic soil,and composite microbial agent A showed the best application effect.The application of bio-organic fertilizer was beneficial to improving the contents of available phosphorus and available boron in acidic soil.The application of composite microbial agent A was beneficial to improving the contents of available phosphorus and available potassium in acidic soil,and could promote the growth of tobacco plants and improve the economic traits of flue-cured tobacco and the coordination of chemical components in tobacco leaves.The application of composite microbial agent B led to a downward trend in the content of available boron in acidic soil.The application of composite microbial agent B could promote the absorption of nutrients by tobacco plants,and improve their disease resistance and the quality of tobacco leaves.Due to the differences in functional microorganisms contained,the application effects of different microbial fertilizers in improving acidic tobacco-planting soil and improving tobacco leaf quality varied.Overall,the application of microbial fertilizers could increase soil pH,activate soil nutrients,promote tobacco growth,enhance disease resistance,increase tobacco output value,and improve tobacco quality.Microbial fertilizers have good application prospects in improving acidic soil and improving tobacco quality.[Conclusions]The application of microbial fertilizers to improve acidic tobacco-planting soil can ensure the normal growth and development of tobacco plants and the improvement of tobacco leaf quality,achieving high-quality and sustainable development of Zhaotong tobacco. | Xia NI Shungang SHEN Xianyi ZENG Dewen LI Yeming FU Min CHEN Chaokai YU Libing QI Ying-guo RUAN Changchong ZI Haohan GONG Guangjun HU Mengsheng ZHANG Xu ZHANG Shu PENG Hongbing LI | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
| 15 | Identification of Germline Mutations in East‑Asian Young Never‑Smokers with Lung Adenocarcinoma by Whole‑Exome Sequencing显示文摘Recently,an increasing number of young never-smokers are diagnosed with lung cancer.The aim of this study is to investigate the genetic predisposition of lung cancer in these patients and discover candidate pathogenic variants for lung adenocarcinoma in young never-smokers.Peripheral blood was collected from 123 never-smoking east-Asian patients diagnosed with lung adenocarcinoma before the age of 40.Whole-exome sequencing(WES)was conducted on genomic DNA extracted from peripheral blood cells.As a result,3,481 single nucleotide variants were identified.By bioinformatical tools and the published gene list associated with genetic predisposition of cancer,pathogenic variants were detected in ten germline genes:ATR,FANCD2,FANCE,GATA2,HFE,MSH2,PDGFRA,PMS2,SDHB,and WAS.Patients with pathogenic variants were more likely to occur in females(9/10,90.0%)and have stage IV lung adenocarcinoma(4/10,40%).Furthermore,germline muta-tions in 17 genes(ASB18,B3GALT5,CLEC4F,COL6A6,CYP4B1,C6orf132,EXO1,GATA4,HCK,KCP,NPHP4,PIGX,PPIL2,PPP1R3G,RRBP1,SALL4,and TTC28),which occurred in at least two patients,displayed potentially pathogenic effects.Gene ontology analysis further showed that these genes with germline mutations were mainly located in nucleo-plasm and associated with DNA repair-related biological processes.The study provides spectrum of pathogenic variants and functional explanation for genetic predisposition of lung adenocarcinoma in young never-smokers,which sheds a light on prevention and early diagnosis of lung cancer. | Fangqiu Fu Xiaoting Tao Zhonglin Jiang Zhendong Gao Yue Zhao Yuan Li Hong Hu Libing Shen Yihua Sun Yang Zhang | 2023 | Phenomics2023，3，2： | 0 |
| 16 | Electrochemical Regulation of Antibacterial Activity Using Ferrocene-Containing Antibiotics显示文摘The widespread use of antibiotics causes the accumulation of a large amount of antibiotics in the environment.Excessively active antibiotics in the environment results in the emergence of bacterial resistance.Building smart antibiotics capable of reversible regulation between active and inactive states on demand is a promising approach to address this issue.Herein,a ferrocene-containing quaternary ammonium compound has been developed for electrochemical redox-controlled bacterial inhibition.The reversible switch of the reduced and oxidized ferrocene groups between hydrophobic and hydrophilic states triggers the assembly and disassembly of the micelles while modulating the interactions of antibiotic molecules with the bacteria membrane,providing a new way to regulate antibacterial activity.In addition,the alternate use of reduced and oxidized antibiotics exhibits a favorable effect in preventing bacterial resistance.Thus,an unconventional strategy is offered to prevent the build-up of active bactericide in the environment and decrease bacterial resistance. | Song Shen Yiming Huang Anran Yuan Fengting Lv Libing Liu Shu Wang | 2021 | CCS Chemistry2021，3，11： | 0 |
| 17 | Forecasting the development of the COVID-19 epidemic by nowcasting: when did things start to get better?显示文摘Background:Now the coronavirus disease 2019(COVID-19)epidemic becomes a global phenomenon and its development concerns billions of peoples1 lives.The development of the COVID-19 epidemic in China could be used as a reference for the other countries,control strategy.Methods:We used a classical susceptible-infected-recovered(SIR)model to forecast the development of the COVID-19 epidemic in China by nowcasring.The linear regression analyses were employed to predict the COVID-19 epidemic’s inflexion point.Finally,we used a susceptible-exposed-infected-recovered(SEIR)model to simulate the development of the COVID-19 epidemic in China throughout 2020.Results:Our nowcasts show that the COVID-19 transmission rate started to slow down on January 30.The linear regression analyses further show that the inflexion point of this epidemic would arrive between February 17 and 18.The final SEIR model simulation forecasted that the COVID-19 epidemic would probably infect about 82,000 people and last throughout 2020 in China.We also applied our method to USA's and global COVID-19 data and the nowcasts show that the development of COVID-19 pandemic is not optimistic in the rest of 2020.Conclusion:The COVID-19 epidemic's scale in China is much smaller than the previous estimations.After implemented strict control and prevention measures,such as city lockdown,it took a week to slow down the COVID-19 transmission and about four weeks to really mitigate the COVID-19 prevalence in China. | Yuehui Zhang Lin Chen Qili Shi Zhongguang Luo Libing Shen | 2021 | Quantitative Biology2021，9，1： | 0 |
| 18 | 6-20 Development of SECRAL II Ion Source at IMP in 2016显示文摘SECRAL II is the second fully superconducting ECR ion source developed at IMP.It’s almost the duplicate of SECRAL,except for the cryogenic system[1].SECRAL II has integrated LHe recondensation system,which has the dynamic cooling capacity of more than 5 W.The main parameters of SECRAL I&II are shown in Table 1.The magnets of SECRAL II has been successfully fabricated and tested in 2015.In 2016,SECRAL II has been commissioned at 18 and 28 GHz with O and Xe ion beams,which has given very promising results. | Guo Junwei Sun Liangting Zhang Wenhui Shen Zhen Feng Yucheng Fang Xing Zhang Xuezhen Ma Hongyi Yang Yao Li Libing Chang Jianjun Wang Pengpeng Zhao Huanyu Zhao Hongwei | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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