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| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 2 | Bmi-1, stem cells and cancer显示文摘Bmi-1,一个 polycomb 基因家庭成员,在房间周期规定,房间不减,和房间老朽起一个重要作用。最近,众多的研究证明了 Bmi-1 涉及自强的规定和干细胞的区别。然而,位于这个生物过程下面的分子的机制仍然保持大部分不清楚。在现在的评论,我们作为基因表示的一个 transcriptional 管理者总结了 Bmi-1 的函数,与干细胞的特别参考。 | Lili Jiang Jun Li Libing Song | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 28 |
| 3 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 4 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 5 | Efficacy and safety of Yinchenwuling powder for hyperlipidemia: a systematic review and Meta-analysis显示文摘OBJECTIVE:To assess the clinical effectiveness and adverse effects of Yinchenwuling powder(YCWLP)in the treatment of hyperlipidemia using Meta-analysis.METHODS:Seven electronic databases were searched for randomized controlled trials designed to evaluate the clinical effectiveness of YCWLP for hyperlipidemia published in any language prior to February 2015.Two reviewers independently identified articles,extracted data,assessed quality,and cross-checked the results.Revman 5.3 was used to analyze the data.RESULTS:Only five randomized controlled trials with poor methodology were included in the analy-sis.The five trials compared YCWLP with conventional lipid-lowering drugs.Meta-analysis indicated that YCWLP was more effective at the levels of total cholesterol and triglycerides,while increasing the level of high-density lipoprotein cholesterol without serious adverse effects.However,it was not more effective than lipid-lowering drugs in reducing low-density lipoprotein cholesterol and improving hemorheology.CONCLUSION:YCWLP appeared to improve lipid levels.However,given the high risk of bias among the trials,we could not conclude that YCWLP was beneficial to patients with hyperlipidemia.More rigorous trials are required to provide stronger evidence for the conclusion. | Yao Haiqiang Zhang Zengliang Wang Ji Zuo Jiacheng Chen Yu Zhu Libing Li Xiaoke Yang Zheng Wang Zisong Sun Ranran Xu Xuanxuan Li Changming Wu Yanling Li Lingru Wang Qi | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 11 |
| 6 | Application and safety assessment for nano-composite materials in food packaging显示文摘The technical breakthroughs and rapid developments in nanotechnologies enabling goods and products based on nanomaterials (NMs) has come to media and public attention as potentially one of the most significant technological advances of our time. Among these technical applications, nano-composite food packaging, which combines the NMs and conventional packaging, is at the forefront of applications in nanotechnologies, leading the whole industrial chain based on nanotechnologies with high speed development. Taking into account the status of the nano-composites applied in food packaging and present development trends, this review is focused on summarizing the basic applications of the nano-composites in food packaging as well as its risk assessment. The status summaries and the conclusions derived from this review are of benefit to manufacturers which produce the nano-composites used in food packaging, to general consumers and to governmental administration entities. | HAN Wei YU YanJun LI NingTao WANG LiBing | 2011 | Chinese Science Bulletin2011，56，12： | 10 |
| 7 | miR-486 sustains NF-KB activity by disrupting multiple NF-KB-negative feedback loops显示文摘 | Libing Song Chuyong Lin Hul Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2013 | Cell Research2013，23，2： | 6 |
| 8 | Optimized pre-treatment of high strength food waste digestate by high content aluminum-nanocluster based magnetic coagulation显示文摘Coagulation-based pre-treatment efficiency of high strength digestate of food waste(HSDFW) anaerobic digestion is negated by organic ligand-catalyzed decomposition of coagulants. In this study, an efficient HSDFW pre-treatment method, magnetic seeds(MS) coagulation, was employed by using highly stable Keggin Al_(30) nanocluster(PAC_(30)), MS and polyacrylamide(PAM), and its operation was optimized by evaluating the performance of removing turbidity, total suspended solids(TSS), chemical oxygen demand(COD), and total phosphorous(TP) phosphate. Results showed that at the optimum dosage of 4.82 g/L, PAC_(30) demonstrated excellent removals as high as 98.93% ± 0.1% of turbidity, 98.04% ± 0.1% of TSS, 58.28% ± 0.3% of total COD, 99.98% ± 0.01% of TP and 99.50% ± 0.01% of dissolved phosphate, respectively. Apparent molecular weight(AMW) and three-dimensional excitation-emission matrix(3 D-EEM) fluorescence spectroscopy analyses demonstrated more efficient removal of dissolved organic matter(DOM), particularly non-biodegradable and hydrophobic components by PAC_(30) than commercial coagulant. The sedimentation was much improved from 40 min by coagulation/flocculation to about 5 min settling by MS coagulation. The PAC_(30) based magnetic coagulation(MC) presents theoretical guidance on a cost-effective and much less footprint pre-treatment alternative for high strength wastewater. | Tharindu Ritigala Hailu Demissie Yanlin Chen Jiaxi Zheng Libing Zheng Jinxing Zhu Hua Fan Jiao Li Dongsheng Wang Sujithra KWeragoda Rohan Weerasooriya Yuansong Wei | 2021 | Journal of Environmental Sciences2021，33，6： | 4 |
| 9 | Petrogenesis of Paleoproterozoic Luyashan charnockitic rocks in Shanxi Province: Constraints from Geochemistry and Nd isotope显示文摘Luyashan charnockite pluton 主要由二长岩, adamellite , charnockite 和 syenogranite 组成,它被 TiO 2, P 2 O 5, K 2 O , Zr , Nb , Y , Pb , La , Ce , Ba 和更高的 K 2 O/Na 2 MgO , CaO , Mg #, Th , U 和更低的 Sr 的 O 和弄空 Ba 和 Rb Ba 。在 Zr, Nb, Ce 和 SiO 2 之间的否定关联从我类型花岗石是不同的。同位素地 Luyashan charnockite plutons 在 Nd 同位素是相对一致的,显示起始的 εNd(t)( 到 -6.97) 和 Nd 的 -5.93 弄空披风模型年龄(到 2.78 Ga 的 2.67 Ga ) 。这些特征显示那 Luyashan charnockitic 岩浆从先存在导出晚太古代的外壳的来源并且与公司 2-rich 液体的在特别高的温度下面的可能的 mafic granulites 的部分融化。石榴石在部分融化期间是一个主要剩余阶段。原来的干燥 charnockitic 岩浆在早结晶化期间经历了辉石,斜长石,磷灰石,和钛铁矿的水晶分别。geochemical 证据建议 Luyashan charnockitic 岩浆可能在碰撞以后的热松驰被产生并且高举在主要碰撞以后的构造背景(∼
1850 妈) 在东方、西方的大陆人块之间。 | LIU Chaohui LIU Shuwen LI Qiugen WANG Yueran DANG Qingning GU Libing YANG Bin ZHAO Fengsan | 2006 | Progress in Natural Science:Materials International2006，16，2： | 3 |
| 10 | Dimericbiscognienynes B and C: New diisoprenyl-cyclohexene-type meroterpenoid dimers from Biscogniauxia sp.显示文摘Dimericbiscognienynes B and C(1 and 2), two new diisoprenyl-cyclohexene-type meroterpenoid dimers,were isolated from Biscogniauxia sp. 71-10-1-1. Their structures, including the absolute configurations,were determined by spectroscopic analyses and ECD experiments. Meroterpenoids are special natural products that originate from mixed terpenoid-nonterpenoid pathway. As a member of meroterpenoid family, diisoprenyl-cyclohexene/ane-type meroterpenoids composed of two isoprenyl chains(C5 unit)and a cyclohexene/ane moiety(C6 unit), featuring diverse skeleton structures with wide range of bioactivities. In these reported diisoprenyl-cyclohexene/ane-type meroterpenoids, only three dimers were identified. The discovery of the two new dimers added members of this rare class of meroterpenoids. | Huan Zhao Meizhi Wang Guodong Chen Dan Hu Enqing Li Yibo Qu Libing Zhou Liangdong Guo Xinsheng Yao Hao Gao | 2019 | Chinese Chemical Letters2019，30，1： | 3 |
| 11 | Synergistic effect enhances the peroxidase-like activity in platinum nanoparticle-supported metal—organic framework hybrid nanozymes for ultrasensitive detection of glucose显示文摘The metal—organic frameworks(MOFs)are expected as ideal biomimetic enzymes for colorimetric glucose detection because of their large surface areas,well defined pore structures,tunable chemical composition,and multi-functional sites.However,the intrinsically chemical instability and low mimetic enzyme activity of MOFs hinder the application of them in imitating the enzyme reactions.In this work,we demonstrated a metal-MOF synergistic catalysis strategy,by loading Pt nanoparticles(Pt NPs)on MIL-88B-NH2(Fe-MOF)to increase peroxidase-like activity for the detection of glucose.The induced electrons transfer from Pt atom to Fe atom accelerated the redox cycling of Fe^(3+)/Fe^(2+),improved the overall efficiency of the peroxidase-like reaction,and enabled the efficient and robust colorimetric glucose detection,which was proved by both experiments and density functional theory(DFT)calculation.Additionally,the sensitivity and chemical stability of this synergistic effect strategy to detect the glucose are not affected by the complex external factors,which represented a great potential in fast,easy,sensitive,and specific recognition of clinical diabetes. | Jing Li Jie Zhao Shengqiang Li Yang Chen Weiqiang Lv Jiahui Zhang Libing Zhang Zhen Zhang Xiaoquan Lu | 2021 | Nano Research2021，14，12： | 2 |
| 12 | An Improved Markov Chain Model Based on Autocorrelation and Entropy Techniques and Its Application to State Prediction of Water Resources显示文摘According to the relationships among state transition probability matrixes with different step lengths, an improved Markov chain model based on autocorrelation and entropy techniques was introduced. In the improved Markov chain model, the state transition probability matrixes can be adjusted. The steps of the historical state of the event, which was significantly related to the future state of the event, were determined by the autocorrelation technique, and the impact weights of the event historical state on the event future state were determined by the entropy technique. The presented model was applied to predicting annual precipitation and annual runoff states, showing that the improved model is of higher precision than those existing Markov chain models, and the determination of the state transition probability matrixes and the weights is more reasonable. The physical concepts of the improved model are distinct, and its computation process is simple and direct, thus, the presented model is sufficiently general to be applicable to the prediction problems in hydrology and water resources. | ZHOU Ping ZHOU Yuliang JIN Juliang LIU Li WANG Zongzhi CHENG Liang ZHANG Libing | 2011 | Chinese Geographical Science2011，21，2： | 2 |
| 13 | An improved multi-attribute decision-making based network selection algorithm for heterogeneous vehicular network显示文摘1 Introduction With sharply rising quantity of urban vehicles over the past few decades,traffic jams and safety have gradually become outstanding problems.In recent years,Vehicular Ad hoc Network(VANET)is appeared and utilized to solve traffic related issues.It is a type of self-organized and open-structured network,and provides Vehicle-to-Everything(V2X)communications.Almost all kinds of applications in VANET rely on efficient data transmission and interaction[1-3]. | Lei NIE Bo LIU Peng LI Heng HE Libing WU | 2022 | Frontiers of Computer Science2022，16，3： | 2 |
| 14 | miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β显示文摘 | Libing Song Quan Huang Kun Chen Liping Liu Chuyong Lin Ting Dai Chunping Yu Zhiqiang Wu Jun Li | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 2 |
| 15 | A Novel Driving and Control System for Direct-wheel- driven Electric Vehicle显示文摘 | Guilin Tao Zhiyum Ma Libing Zhou Langru Li | 2005 | IEEE Transactions on Magnetics (S0018-9464)2005，41，1： | 1 |
| 16 | Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability显示文摘Increasing multidrug-resistant(MDR) superbugs emerge worldwide causing a public health crisis. Consequently, it is urgent to find new antibiotics with efficient broad-spectrum antimicrobial activity. By virtue of versatility in molecular design, a new peptide-like cell membrane-broken molecule, oligo-(7,7′-bifluoren-benzo[c][1,2,5]thiadiazole)(OFBT) possessing a conjugated backbone and eight pendant guanidyl moieties was designed and synthesized. OFBT exhibits favorable broad-spectrum of antimicrobial activity to pathogens including Gram-negative and Gram-positive bacteria, and fungi with the minimum inhibitory concentration(MIC)below 3.0 μM. Moreover, OFBT exhibits high selectivity for pathogens over human cells to make it a promising broad spectrum antimicrobial agent. | Hui Chen Meng Li Zhang Liu Rong Hu Shengliang Li Yuan Guo Fengting Lv Libing Liu Yilin Wang Yuanping Yi Shu Wang | 2018 | Science China Chemistry2018，61，1： | 1 |
| 17 | Simultaneous and sensitive determination of multiplex chemical residues based on multicolor quantum dot probes显示文摘 | Chifang Peng Zhuokun Li Yinyue Zhu Wei Chen Yuan Yuan Liqiang Liu Qiusheng Li Dinghua Xu Ruirui Qiao Libing Wang Shuifang Zhu Zhengyu Jin Chuanlai Xu | 2009 | Biosensors and Bioelectronics2009，，12： | 1 |
| 18 | Potential Submarine Geologic Hazards at the Entrance of the Pearl River Estuary in the Northern South China Sea显示文摘The potential submarine geologic hazards were distinguished and categorized at the entrance of the Pearl River Estuary in the northern South China Sea, based upon the analysis of side scan sonar and sub-bottom profiler surveying data of about 2500 km long, in an area about 2000 km^2 around the Wanshan Archipelago. The data obtained in the survey has the highest spatial resolution by far, which could reveal more detailed distributions and characteristics of the geologic hazards than before. In the study region, three paleo-channels that were buried about 10–30 m below the seabed were found; more than 10 shallow gas areas were discovered. The sand waves found in the region were generally small and located near the islands, and twenty pockmarks found on the seabed were mostly concentrated to north of Zhuzhou island. There are also many man-made obstacles in the region, such as wreckages, pipeline, etc. In this paper we provide a detailed distribution map of the submarine geologic hazards in this region for the first time, and discuss their formation and harmfulness, which will provide a scientific basis for marine engineering construction, marine geologic disaster prevention and mitigation. | ZHANG Zhiqiang WEI Zhiqiang HE Huizhong WEI Wei QIAN Libing LI Tuanjie | 2016 | Journal of Ocean University of China2016，15，4： | 1 |
| 19 | HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression显示文摘 | De Huang Tingting Li Xinghua Li Long Zhang Linchong Sun Xiaoping He Xiuying Zhong Dongya Jia Libing Song Gregg L. Semenza Ping Gao Huafeng Zhang | 2014 | Cell Reports2014，，6： | 1 |
| 20 | Influence of design parameters on end effect in long primary doub- le-sided linear induction motor 显示文摘 | YANG Tong ZHOU Libing LI Langru | 2011 | IEEE Transactions on Plasma Science2011，39，1： | 1 |
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