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| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 2 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 3 | Efficacy and safety of Yinchenwuling powder for hyperlipidemia: a systematic review and Meta-analysis显示文摘OBJECTIVE:To assess the clinical effectiveness and adverse effects of Yinchenwuling powder(YCWLP)in the treatment of hyperlipidemia using Meta-analysis.METHODS:Seven electronic databases were searched for randomized controlled trials designed to evaluate the clinical effectiveness of YCWLP for hyperlipidemia published in any language prior to February 2015.Two reviewers independently identified articles,extracted data,assessed quality,and cross-checked the results.Revman 5.3 was used to analyze the data.RESULTS:Only five randomized controlled trials with poor methodology were included in the analy-sis.The five trials compared YCWLP with conventional lipid-lowering drugs.Meta-analysis indicated that YCWLP was more effective at the levels of total cholesterol and triglycerides,while increasing the level of high-density lipoprotein cholesterol without serious adverse effects.However,it was not more effective than lipid-lowering drugs in reducing low-density lipoprotein cholesterol and improving hemorheology.CONCLUSION:YCWLP appeared to improve lipid levels.However,given the high risk of bias among the trials,we could not conclude that YCWLP was beneficial to patients with hyperlipidemia.More rigorous trials are required to provide stronger evidence for the conclusion. | Yao Haiqiang Zhang Zengliang Wang Ji Zuo Jiacheng Chen Yu Zhu Libing Li Xiaoke Yang Zheng Wang Zisong Sun Ranran Xu Xuanxuan Li Changming Wu Yanling Li Lingru Wang Qi | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 11 |
| 4 | miR-486 sustains NF-KB activity by disrupting multiple NF-KB-negative feedback loops显示文摘 | Libing Song Chuyong Lin Hul Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2013 | Cell Research2013，23，2： | 6 |
| 5 | Effect of non-solvent additives on the morphology,pore structure, and direct contact membrane distillation performance of PVDF-CTFE hydrophobic membranes显示文摘Four common types of additives for polymer membrane preparation including organic macromolecule and micromolecule additives, inorganic salts and acids, and the strong non-solvent H2 O were used to prepare poly(vinylidene fluoride-co-chlorotrifluoroethylene)(PVDF-CTFE) hydrophobic flat-sheet membranes. Membrane properties including morphology, porosity, hydrophobicity, pore size and pore distribution were investigated, and the permeability was evaluated via direct contact membrane distillation(DCMD) of 3.5 g/L Na Cl solution in a DCMD configuration. Both inorganic and organic micromolecule additives were found to slightly influence membrane hydrophobicity. Polyethylene glycol(PEG),organic acids, Li Cl, Mg Cl2, and Li Cl/H2 O mixtures were proved to be effective additives to PVDF-CTFE membranes due to their pore-controlling effects and the capacity to improve the properties and performance of the resultant membranes. The occurrence of a pre-gelation process showed that when organic and inorganic micromolecules were added to PVDF-CTFE solution, the resultant membranes presented a high interconnectivity structure. The membrane prepared with dibutyl phthalate(DBP) showed a nonporous surface and symmetrical cross-section. When H2 O and Li Cl/H2 O mixtures were also used as additives, they were beneficial for solid–liquid demixing, especially when Li Cl/H2 O mixed additives were used. The membrane prepared with 5% Li Cl + 2% H2 O achieved a flux of24.53 kg/(m2·hr) with 99.98% salt rejection. This study is expected to offer a reference not only for PVDF-CTFE membrane preparation but also for other polymer membranes. | Libing Zheng Zhenjun Wu Yong Zhang Yuansong Wei Jun Wang | 2016 | Journal of Environmental Sciences2016，28，7： | 5 |
| 6 | An Efficient Multi-hop Broadcast Protocol for Emergency Messages Dissemination in VANETs显示文摘Black-burst based multi-hop broadcast protocols are effective means to disseminate Emergency messages(EMs)in Vehicular ad hoc networks(VANETs).However,Clear to broadcast(CTB)collision will happen and reduce propagation speed.Aiming at this problem,we propose a Black-burst and multi-channel based multihop broadcast(BMMB)protocol.Vehicles with multiple antennas can transmit and sense black-burst at different channels simultaneously based on multi-channel technology.Compared with existing black-burst based methods,BMMB shortens the iterative procedure to find out the optimal segment.Only one relay vehicle can be rapidly selected within the optimal segment without CTB collision.BMMB enables alternative broadcast methods,i.e.,unidirectional broadcast and multi-directional broadcast for straight roads and intersections respectively.Theoretical analysis is done for performance evaluation of BMMB,and simulation results demonstrate that BMMB performs better in terms of average one-hop delay and propagation speed. | WU Libing NIE Lei FAN Jing HE Yanxiang LIU Qin WU Dan | 2017 | Chinese Journal of Electronics2017，26，3： | 4 |
| 7 | Exploration of Multifocal Rod Electroretinograms Recording in Human显示文摘Purpose:To test the feasibility of recording rod multifocal electroretinograms (ERG) in humans and observe appropriate recording conditions.Methods: Multifocal rod ERG were recorded using a stimulus array of 61 equalsized hexagons in two normal subjects after the dark adaptation. Flashes were blue (W47B). Blank frames between two successive flashes of hexagons varied from 0 to 14. Length of the m-sequence, bandwidth, flash frequency, flash intensities and background intensities were changed to obtain appropriate recording conditions for the clinical use.Results:Multifocal rod ERG were clearly recordable and well formed. They had an early implicit time, very small negative wave and a late implicit time, large positive wave. The positive wave was bimodal, whose timing and waveform were similar to the full-field rod ERG. The local response amplitudes can be suppressed with increase in flash frequency or background intensity, decrease in flash intensity or the size of stimulus elements.Conclusions: Multifocal rod ERG can be recorded in human and can provide topographical maps of retinal function that have clinical usage. 212-1 m-sequence length, 3F blank frames and 3~ 300 Hz bandwidth were suggested to appropriate recording conditions. | Changzheng Chen, Lezheng Wu, De-Zheng Wu, Shixian Long Jiongji Liang, Futian Jiang, Libing JiangZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2002 | 眼科学报2002，18，3： | 3 |
| 8 | Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum显示文摘The cerebellum is critical for controlling motor and non-motor functions via cerebellar circuit that is composed of defined cell types, which approximately account for more than half of neurons in mammalsThe molecular mechanisms controlling developmental progression and maturation processes of various cerebellar cell types need systematic investigationHere, we analyzed transcriptome profiles of 21119 single cells of the postnatal mouse cerebellum and identified eight main cell clusters. Functional annotation of differentially expressed genes revealed trajectory hierarchies of granule cells (GCs) at various states and implied roles of mitochondrion and ATPases in the maturation of Purkinje cells (PCs), the sole output cells of the cerebellar cortexFurthermore, we analyzed gene expression patterns and co-expression networks of 28 ataxia risk genes, and found that most of them are related with biological process of mitochondrion and around half of them are enriched in PCs. Our results also suggested core transcription factors that are correlated with interneuron differentiation and characteristics for the expression of secretory proteins in glia cells, which may participate in neuronal modulationThus, this study presents a systematic landscape of cerebellar gene expression in defined cell types and a general gene expression framework for cerebellar development and dysfunction. | Jian Peng Ai-li Sheng Qi Xiao Libing Shen Xiang-Chun Ju Min Zhang Si-Ting He Chao Wu Zhen-Ge Luo | 2019 | Journal of Molecular Cell Biology2019，11，8： | 2 |
| 9 | Efficient and Secure Authentication Scheme with Conditional Privacy-Preserving for VANETs显示文摘The goal of authentication scheme for Vehicular ad hoc networks(VANETs) is to ensure reliability and integrity of message. Due to the timeliness of traffic-related messages and the highly dynamic nature of VANETs, it still is a challenge to solve the three key issues simultaneously, i.e. security, efficiency and conditional privacy-preserving, on the design of authentication scheme for VANETs. To address this challenge, an efficient Conditional privacy-preserving authentication(CPPA) scheme is proposed in this paper. Compared with the most recent proposed CPPA schemes, our proposed scheme markedly decreases the computation costs of the message-signing phase and the message verification phase, while satisfies all security requirements of VANETs and provides conditional privacy-preserving. | XIE Yong WU Libing ZHANG Yubo SHEN Jian | 2016 | Chinese Journal of Electronics2016，25，5： | 2 |
| 10 | An improved multi-attribute decision-making based network selection algorithm for heterogeneous vehicular network显示文摘1 Introduction With sharply rising quantity of urban vehicles over the past few decades,traffic jams and safety have gradually become outstanding problems.In recent years,Vehicular Ad hoc Network(VANET)is appeared and utilized to solve traffic related issues.It is a type of self-organized and open-structured network,and provides Vehicle-to-Everything(V2X)communications.Almost all kinds of applications in VANET rely on efficient data transmission and interaction[1-3]. | Lei NIE Bo LIU Peng LI Heng HE Libing WU | 2022 | Frontiers of Computer Science2022，16，3： | 2 |
| 11 | A V2I communication-based pipeline model for adaptive urban traffic light scheduling显示文摘Adaptive traffic light scheduling based on realtime traffic information processing has proven effective for urban traffic congestion management. However, fine-grained information regarding individual vehicles is difficult to acquire through traditional data collection techniques and its accuracy cannot be guaranteed because of congestion and harsh environments. In this study, we first build a pipeline model based on vehicle-to-infrastructure communication, which is a salient technique in vehicular adhoc networks. This model enables the acquisition of fine-grained and accurate traffic information in real time via message exchange between vehicles and roadside units. We then propose an intelligent traffic light scheduling method (ITLM) based on a “demand assignment” principle by considering the types and turning intentions of vehicles. In the context of this principle, a signal phase with more vehicles will be assigned a longer green time. Furthermore, a green-way traffic light scheduling method (GTLM) is investigated for special vehicles (e.g., ambulances and fire engines) in emergency scenarios. Signal states will be adjusted or maintained by the traffic light control system to keep special vehicles moving along smoothly. Comparative experiments demonstrate that the ITLM reduces average wait time by 34%-78% and average stop frequency by 12%-34% in the context of traffic management. The GTLM reduces travel time by 22%^44% and 30%-55% under two types of traffic conditions and achieves optimal performance in congested scenarios. | Libing WU Lei NIE Samee U. KHAN Osman KHALID Dan WU | 2019 | Frontiers of Computer Science2019，13，5： | 2 |
| 12 | miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β显示文摘 | Libing Song Quan Huang Kun Chen Liping Liu Chuyong Lin Ting Dai Chunping Yu Zhiqiang Wu Jun Li | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 2 |
| 13 | Golgi phosphoprotein 3 ( GOLPH3 ) promotes hepatocellular carcinoma cell aggressiveness by activating the NF ‐κ B pathway显示文摘 | Ting Dai Dongsheng Zhang Muyan Cai Chanjuan Wang Zhiqiang Wu Zhe Ying Jueheng Wu Mengfeng Li Dan Xie Jun Li Libing Song | 2015 | Pathol2015，，3： | 1 |
| 14 | Influence of Interlayer Cations on Organic Intercalation of Montmorillonite显示文摘 | Wu Limei Liao Libing Lv Guocheng | 2015 | Journal of Colloid and Interface Science2015，454，： | 1 |
| 15 | A mobile edge computing-based applications execution framework for Internet of Vehicles显示文摘Mobile edge computing(MEC)is a promising technology for the Internet of Vehicles,especially in terms of application offloading and resource allocation.Most existing offloading schemes are sub-optimal,since these offloading strategies consider an application as a whole.In comparison,in this paper we propose an application-centric framework and build a finer-grained offloading scheme based on application partitioning.In our framework,each application is modelled as a directed acyclic graph,where each node represents a subtask and each edge represents the data flow dependency between a pair of subtasks.Both vehicles and MEC server within the communication range can be used as candidate offloading nodes.Then,the offloading involves assigning these computing nodes to subtasks.In addition,the proposed offloading scheme deal with the delay constraint of each subtask.The experimental evaluation show that,compared to existing non-partitioning offloading schemes,this proposed one effectively improves the performance of the application in terms of execution time and throughput. | Libing WU Rui ZHANG Qingan LI Chao MA Xiaochuan SHI | 2022 | Frontiers of Computer Science2022，16，5： | 1 |
| 16 | The effect of interlayer cations on the expansion of vermiculite显示文摘 | Huo Xiaoxu Wu Limei Liao Libing | 2012 | Pow- der Techn2012，224，： | 1 |
| 17 | A novel and efficient source-path discovery and maintenance method for application layer multicast显示文摘 | Jianqun Cui Naixue Xiong Jong Hyuk Park Keming Jia Libing Wu | 2012 | Computers and Electrical Engineering2012，，： | 1 |
| 18 | Robust adap- tive fault - tolerant control for uncertain linear systems with actu- ator failures 显示文摘 | Wu Libing Zhang Zhiguo Zhang Daqing | 2012 | lET Control Theory Appl2012，6，10： | 1 |
| 19 | Pre-judgment and Incomplete Allocation Approach for Query Result Cache显示文摘Query result caching is a crucial technique employed in search engines, reducing the response time and load of the search engines. As search engines continuously update their indexes, the query results in long-lived cache entries may become stale. It is important to provide the refresh mechanism to enhance the degree of freshness of cached results. We present a pre-judgment approach to improve the freshness of the result cache and design an incomplete allocation algorithm. We introduce the queryTime-to-live(TTL) and term-TTL structure to pre-judge the result cache. The query-TTL is used to pre-check the likelihood of a cache hit and term-TTL is applied to maintain all terms of the latest posting list. For the cache structure, we design a Queue-Hash structure and develop the corresponding incomplete allocation algorithm. The preliminary results demonstrate that our approaches can improve the freshness of cached results and decrease processing overhead compared with no pre-judgment approaches. | QIAN Libing JI Zhenzhou FU Zhongchuan WU Qianqian SONG Guangjia | 2016 | Chinese Journal of Electronics2016，25，6： | 1 |
| 20 | miR-182 as a Prognostic Marker for Glioma Progression and Patient Survival显示文摘 | Lili Jiang Pu Mao Libing Song Jueheng Wu Jieting Huang Chuyong Lin Jie Yuan Lianghu Qu Shi-Yuan Cheng Jun Li | 2010 | The American Journal of Pathology2010，，： | 1 |
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