|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China显示文摘The coronavirus disease 2019(COVID-19)pandemic is a global crisis,and medical systems in many countries are overwhelmed with supply shortages and increasing demands to treat patients due to the surge in cases and severe illnesses.This study aimed to assess COVID-19-related essential clinical resource demands in China,based on different scenarios involving COVID-19 spreads and interventions.We used a susceptible–exposed–infectious–hospitalized/isolated–removed(SEIHR)transmission dynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essential healthcare resources needed.We found that,under strict non-pharmaceutical interventions(NPIs)or mass vaccination of the population,China would be able to contain community transmission and local outbreaks rapidly.However,under scenarios involving a low intensity of implemented NPIs and a small proportion of the population vaccinated,the use of a peacetime–wartime transition model would be needed for medical source stockpiles and preparations to ensure a normal functioning healthcare system.The implementation of COVID-19 vaccines and NPIs in different periods can influence the transmission of COVID-19 and subsequently affect the demand for clinical diagnosis and treatment.An increased proportion of asymptomatic infections in simulations will not reduce the demand for medical resources;however,attention must be paid to the increasing difficulty in containing COVID-19 transmission due to asymptomatic cases.This study provides evidence for emergency preparations and the adjustment of prevention and control strategies during the COVID-19 pandemic.It also provides guidance for essential healthcare investment and resource allocation. | Ting Zhang Qing Wang Zhiwei Leng Yuan Yang Jin Yang Fangyuan Chen Mengmeng Jia Xingxing Zhang Weiran Qi Yunshao Xu Siya Chen Peixi Dai Libing Ma Luzhao Feng Weizhong Yang | 2021 | Engineering2021，7，7： | 7 |
| 2 | Improved oxygen reduction reaction via a partially oxidized Co-CoO catalyst on N-doped carbon synthesized by a facile sand-bath method显示文摘High active and durable non-noble metal electrocatalysts are urgently developed to satisfy the high performance oxygen reduction reaction(ORR). We successfully synthesized Co-CoOx anchored on nitrogen-doped carbon via a facile sand-bath method(SBM), i.e., Co-CoOx/N-C(SBM). The as-obtained Co-CoOx/N-C(SBM) exhibited overwhelming superiorities to Co-CoO/N-C prepared by conventional heat treatment(CHT), particularly in electrochemical performance of ORR. Although Co-CoOx/N-C(SBM)showed smaller specific surface area of 276.8 m^2/g than that of 939.5 m^2/g from Co-CoO/N-C(CHT), the Co-CoOx/N-C(SBM) performed larger pore diameter and more Co_3O_4 active component resulting in better ORR performance in 0.1 mol/L KOH solution. The Co-CoO_x/N-C(SBM) delivered onset potential of 0.91 V vs. RHE, mid-wave potential of 0.85 V vs. RHE and limited current density of 5.46 mA/cm^2 much better than those of the Co-CoO/N-C(CHT). Furthermore, Co-CoOx/N-C(SBM) showed greater stability and better methanol tolerance superior to the commercial 20 wt% Pt/C. | Libing Hu Feng Yu Huifang Yuan Gang Wang Mincong Liu Lina Wang Xueyan Xue Banghua Peng Zhiqun Tian Bin Dai | 2019 | Chinese Chemical Letters2019，30，3： | 4 |
| 3 | Defective ZnS nanoparticles anchored in situ on N-doped carbon as a superior oxygen reduction reaction catalyst显示文摘Defect engineering has been used to develop low-cost and effective catalysts to boost oxygen reduction reactions.However,the development of catalysts that use metal cation vacancies as the active sites for oxygen reduction reaction is lacking.In this study,ZnS nanoparticles on N-doped carbon serve as an oxygen reduction reaction catalyst.These catalysts were prepared via a one-step method at 900℃.Amazingly,the high-resolution transmission electron microscope image revealed obvious defects in the ZnS nanoparticles.These facilitated the catalyst synthesis,and the product displayed good electrocatalytic performance for the oxygen reduction reaction in an alkaline medium,including a lower onset potential,lower mid-wave potential,four electron transfer process,and better durability compared with 20 wt%Pt/C.More importantly,the density functional theory results indicated that using the Zn vacancies in the prepared catalyst as active sites required a lower reaction energy to produce OOH*from*OO toward oxygen reduction reaction.Therefore,the proposed catalyst with Zn vacancies can be used as a potential electrocatalyst and may be substitutes for Pt-based catalysts in fuel cells,given the novel catalyst’s resulting performance. | Libing Hu Zengxi Wei Feng Yu Huifang Yuan Mincong Liu Gang Wang Bangfiua Peng Bin Dai Jianmin Ma | 2019 | Journal of Energy Chemistry2019，28，12： | 3 |
| 4 | Overwhelming electrochemical oxygen reduction reaction of zinc-nitrogen-carbon from biomass resource chitosan via a facile carbon bath method显示文摘Developing high efficiency and low cost electrocatalysts is critical for the enhancement of oxygen reduction reaction(ORR),which is the fundamental for the development and commercialization of renewable energy conversion technology.Herein,zinc-nitrogen-carbon(Zn-N-C)was prepared by using biomass resource chitosan via a facile carbon bath method.The obtained Zn-N-C delivered a high specific surface area(794.7 cm^2/g)together with pore volume(0.49 cm^3/g).During the electrochemical evaluation of oxygen reduction reaction(ORR),Zn-N-C displayed high activity for ORR with an onset pote ntial E0=0.96 VRHE and a half wave potential E1/2=0.86 VRHE,which were more positive than those of the comme rcial 20 wt%Pt/C benchmark catalyst(E0=0.96 VRHE and E1/2=0.81 VRHE).In addition,the ZnN-C catalyst also had a better stability and methanol tolerance than those of the Pt/C catalyst. | Libing Hu Feng Yu Fu Wang Shengchao Yang Banghua Peng Long Chen Gang Wang Juan Hou Bin Dai Zhi-Qun Tian | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 5 | miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β显示文摘 | Libing Song Quan Huang Kun Chen Liping Liu Chuyong Lin Ting Dai Chunping Yu Zhiqiang Wu Jun Li | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 2 |
| 6 | Oligo(p-phenylenevinylene)-rhodium complex as intracellular catalyst for enhancing biosynthesis of polyhydroxybutyrate biomaterials显示文摘Microbial synthesis utilizes sustainable resources to produce valuable chemicals,as a potential alternative to petroleum-based chemical industry.Although metabolic engineering is an efficient method to enhance the biosynthesis efficacy of microorganisms,it requires complicated biological procedures.Herein,we report a facile intracellular catalysis system for augmenting the production of bio-based material in microorganism.Covalent linking of oligo(p-phenylenevinylene)(OPV)and cyclopentadienyl rhodium(Ⅲ)bipyridine offers intracellular metal catalyst(OPV-Rh).The OPV-Rh complex displayed certain resistance to toxic biomolecules,which guaranteed its catalytic activity in complicated biological systems.With uptake by Gramnegative bacterium Ralstonia eutropha H16(R.eutropha H16),the OPV-Rh complex promotes the transformation of intracellular NADP+to NADPH,which further enhances the biosynthesis of polyhydroxybutyrate(PHB)by this microorganism.This work demonstrates that synthetic metal catalyst can be employed for regulating microbial biosynthesis intracellularly. | Nan Dai Hao Zhao Wen Yu Fengting Lv Libing Liu Shu Wang | 2021 | Science China Chemistry2021，64，1： | 2 |
| 7 | Golgi phosphoprotein 3 ( GOLPH3 ) promotes hepatocellular carcinoma cell aggressiveness by activating the NF ‐κ B pathway显示文摘 | Ting Dai Dongsheng Zhang Muyan Cai Chanjuan Wang Zhiqiang Wu Zhe Ying Jueheng Wu Mengfeng Li Dan Xie Jun Li Libing Song | 2015 | Pathol2015，，3： | 1 |
| 8 | Epider mal stem cells cultured on collagen modified chitin membrane induce in situ tissue regeneration of full- thickness skin defects in mice显示文摘 | SHEN YAN DAI LIBING LI XIAOJIAN | 2014 | PLOS ONE2014，9，2： | 1 |
| 9 | Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair显示文摘BRCA2,a clinical prognostic factor,is significantly up-regulated in mRNA level,while its protein expression is often decreased in sporadic breast cancer.However,how BRCA2 protein expressions are suppressed in these tumors remains unknown.In this study,we demonstrated that miR-1245 directly suppressed BRCA23′-UTR and translation,impaired homologous recombination(HR)-mediated repair,reduced DNA damage-induced Rad51 nuclear foci,and rendered cells hypersensitive to g-irradiation(IR),ul-timately inducing high chromosomal abnormalities in normal breast cells and breast cancer cells.Conversely,inhibiting miR-1245 in breast cancer cells enhanced BRCA2 levels and induced resistance to IR.Furthermore,we demonstrated that c-myc up-regulated miR-1245 expression via direct binding to the miR-1245 promoter,which led to down-regulation of BRCA2 and reduction in HR efficiency.Significantly,miR-1245 levels in primary breast tumors correlated with c-myc overexpression and BRCA2 suppression.These findings uncover a BRCA2 regulatory and signaling pathway in sporadic breast cancer and support a functionally and clinically relevant epigenetic mechanism in cancer pathogenesis. | Libing Song Ting Dai Yingjun Xie Chanjuan Wang Chuyong Lin Zhiqiang Wu Zhe Ying Jueheng Wu Mengfeng Li Jun Li | 2012 | Journal of Molecular Cell Biology2012，4，2： | 0 |
| 10 | Willingness of Caregivers to Have Their Children Vaccinated with Pneumococcal Vaccines in the Context of an Innovative Immunization Strategy—Weifang City,Shandong Province,2021显示文摘Summary What is already known about this topic?Pneumococcal diseases(PDs)pose a serious health threat to children.Vaccination is the most costeffective intervention to prevent PDs,but pneumococcal vaccines coverage among children is low in China.What is added by this report?This study investigated the willingness of children’s caregivers to have their children vaccinated with pneumococcal vaccines under an innovative policy to offer 1-dose of the 13-valent pneumococcal conjugate vaccines at no charge to families.The research found that 70.51%of caregivers were willing to have their infants receive pneumococcal vaccines and that reducing the cost of vaccines may increase caregivers’willingness.What are the implications for public health practice?This is the first evaluation in China of acceptance of pneumococcal vaccines among children under a 1-dose,cost-free policy.The results provide scientific evidence for updating local and national pneumococcal immunization strategies to promote the use of the pneumococcal vaccine. | Yuan Yang Ting Zhang Yan Wang Libing Ma Shuyun Xie Jian Zhou Weiran Qi Qing Wang Peixi Dai Yuanze Du Luzhao Feng Chunping Wang Weizhong Yang | 2022 | China CDC weekly2022，4，20： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员