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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | The spatio-temporal variation of wintertime subtidal currents in the western Taiwan Strait显示文摘A new data set of observations by six cruises of ship-mounted acoustic doppler current profiler(SADCP) and three 40 d long bottom-mounted ADCPs(BADCPs) is employed to reveal the spatiotemporal variability of tidal and subtidal currents in the western Taiwan Strait(TWS) during winter season. The results confirm the existence of intense cotidal lines for M_2 tidal current, which is located north of 25°N. In this case, no existence of an amphidromic point can be identified. It is also revealed that the counter-wind current(CWC) can extend through the whole western TWS and even occupy the entire water column during winter monsoon relaxation. However,this CWC is observed to be thoroughly overwhelmed by the downwind China coastal current(CCC) during the two big monsoon bloom events in the winter of 2007, and the CCC consequently extends southward throughout the western TWS instead. Most importantly, the variation of the spatial extent for the CWC and the CCC in the western TWS is found to be well explained by the first two modes of the vector empirical orthogonal function(VEOF) analysis, that is, it is mainly controlled by a wind-driven quasi barotropic current as the first mode and slightly modulated by a relatively weak background current with a first-order baroclinic structure as the second mode. | SHEN Junqiang QIU Yun GUO Xiaogang PAN Aijun ZHOU Xiwu | 2017 | Acta Oceanologica Sinica2017，36，11： | 5 |
| 3 | Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan,China显示文摘Most COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity,but it remains unclear how long it can maintain and how efficiently it can prevent the reinfection of the emerging SARS-CoV-2 variants.Here,we tested the sera from 248 COVID-19 convalescents around 1 year post-infection in Wuhan,the earliest known epicenter.SARS-CoV-2 immunoglobulin G(IgG)was well maintained in most patients and potently neutralizes the infection of the original strain and the B.1.1.7 variant.However,varying degrees of immune escape was observed on the other tested variants in a patient-specific manner,with individuals showing remarkably broad neutralization potency.The immune escape can be largely attributed to several critical spike mutations.These results suggest that SARS-CoV-2 can elicit long-lasting immunity but this is escaped by the emerging variants. | Qianyun Liu Qing Xiong Fanghua Mei Chengbao Ma Zhen Zhang Bing Hu Junqiang Xu Yongzhong Jiang Faxian Zhan Suhua Zhou Li Tao Xianying Chen Ming Guo Xin Wang Yaohui Fang Shu Shen Yingle Liu Fang Liu Li Zhou Ke Xu Changwen Ke Fei Deng Kun Cai Huan Yan Yu Chen Ke Lan | 2022 | The Innovation2022，3，1： | 3 |
| 4 | Zero-forcing blind equalization based on subspace estimation for multiuser systems显示文摘 | Shen Junqiang Ding Zhi | 2001 | IEEE transactions on communications2001，49，2： | 1 |
| 5 | Zero - forcing biked equalization based on subspace estimation for multiuser systems显示文摘 | Shen Junqiang Ding Zhi | 2001 | IEEE Transactions on Communications2001，49，2： | 1 |
| 6 | Direct Blind MMSE Channel Equalization Based on Second Order Statistics显示文摘 | Junqiang Shen Zhi Ding | 2000 | IEEE Trans Signal Processing2000，48，： | 1 |
| 7 | Zero-forcing blind equalization based on subspace estimation for multiuser systems显示文摘 | Shen Junqiang Ding Zhi | 2001 | IEEE Transactions on Conmumications2001，49，2： | 1 |
| 8 | Observation of continental shelf wave propagating along the eastern Taiwan Strait during Typhoon Meranti 2016显示文摘This study is the fi rst to depict typhoon-induced continental shelf wave(CSW)propagation in the eastern Taiwan Strait(TWS)during the passage of Typhoon Meranti in 2016 using tidal gauge data and along-track satellite altimeter data.The strong amplitude response of sea level oscillations(within the range of 0.30–0.54 m)as a free,barotropic CSW after Meranti,which impacted the TWS,was clearly detected in time and frequency(in bands of 64–81 h)using wavelet and cross-wavelet analyses.The measured group and phase speeds were consistent with the dispersion curves for CSW with the fi rst-mode derived from the cross-shelf sections of the eastern TWS,with the mean speeds reaching 3 and 5.6±0.7 m/s,respectively.Coincidentally,the typhoon-induced sea level anomaly(SLA)was also captured by the satellite altimeter before this CSW entered into the TWS.Using the theoretical cross-shore CSW modes to fi t the SLA data,the results indicated that the fi rst three wave modes can interpret this CSW event appeared in the southern TWS very well,with the fi rst mode being the dominant one. | Junqiang SHEN Shanwu ZHANG Junpeng ZHANG Mingzhang ZENG Wendong FANG | 2021 | Journal of Oceanology and Limnology2021，39，1： | 1 |
| 9 | Zero-forcing blind equalization based on subspace estimation for multiuser systems 显示文摘 | Shen Junqiang Ding Zhi | 2001 | IEEE transactions on communications2001，49，2： | 1 |
| 10 | Magnetic-electric composite coating with oriented segregated structure for enhanced electromagnetic shielding显示文摘Manipulation of the internal architecture is essential for electromagnetic interference(EMI)shielding performance of metal-based coatings,which can address the electromagnetic pollution in large-size,complex geometries,and harsh environments.In this work,oriented segregated structure with conductive networks embedded in magnetic matrix was achieved in Fe-based amorphous coatings via Ni-Cu-P functionalization of(Fe_(0.76)Si_(0.09)B_(0.1)P_(0.05))_(99)Nb_(1)amorphous powder precursors and then thermal spraying them onto aluminum(Al)substrate.Benefiting from the unique magnetic-electric structure,the coating@Al composite delivered prominent EMI shielding performance.The EMI shielding effectiveness(SE)of modified coating@Al composite is~41 dB at 8-12 GHz,doubling the value of Al substrate and is 15 dB greater than that of Ni-Cu-P-free coating@Al composite.Microstructure analysis showed that the introduced Ni−Cu−P insertions forcefully suppress the serious oxidation of the magnetic precursors during thermal spraying and form a dense conductive network in the magnetic matrix.Electron holography observation and electromagnetism simulation clarified that the modified coating can effectively trap and attenuate the incident radiations because of the electric loss from Ni−Cu−P conductive network,magnetic loss from Fe-based amorphous coating,and the electromagnetic interactions in the oriented segregated architectures.Moreover,the optimized thermal isolation and mechanical properties brought by structural improvement enable the coating to shield complex parts in thermal shock and mechanical loading environments.Our work gives an insight on the design strategies for metal-based EMI shielding materials and enriches the fundamental understanding of EMI shielding mechanisms. | Jijun Zhang Zexuan Wang Jiawei Li Yaqiang Dong Aina He Guoguo Tan Qikui Man Bin Shen Junqiang Wang Weixing Xia Jun Shen Xin-min Wang | 2022 | Journal of Materials Science & Technology2022，，1： | 1 |
| 11 | AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary malignant bone tumor in children and adolescents.Although activator of HSP90 ATPase activity 1(AHA1)is reported to be a potential oncogene,its role in osteosarcoma progression remains largely unclear.Since metabolism reprogramming is involved in tumorigenesis and cancer metastasis,the relationship between AHA1 and cancer metabolism is unknown.In this study,we found that AHA1 is significantly overexpressed in osteosarcoma and related to the prognosis of osteosarcoma patients.AHA1 promotes the growth and metastasis of osteosarcoma both in vitro and in vivo.Mechanistically,AHA1 upregulates the metabolic activity to meet cellular bioenergetic needs in osteosarcoma.Notably,we identifed that isocitrate dehydrogenase 1(IDH1)is a novel client protein of Hsp90 AHA1.Furthermore,the IDH1 protein level was positively correlated with AHA1 in osteosarcoma.And IDH1 overexpression could partially reverse the effect of AHA1 knockdown on cell growth and migration of osteosarcoma.Moreover,high IDH1 level was also associated with poor prognosis of osteosarcoma patients.This study demonstrates that AHA1 positively regulates IDH1 and metabolic activity to promote osteosarcoma growth and metastasis,which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients. | Diwei Zheng Weihai Liu Wenlin Xie Guanyu Huang Qiwei Jiang Yang Yang Jiarong Huang Zihao Xing Mengling Yuan Mengning Wei Yao Li Junqiang Yin Jingnan Shen Zhi Shi | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 12 | Oxidations of two-dimensional semiconductors:Fundamentals and applications显示文摘Since the discovery of graphene,two-dimensional(2D)semiconductors have been attracted intensive interest due to their unique properties.They have exhibited potential applications in next generation electronic and optoelectronic devices.However,most of the 2D semiconductor are known to suffer from the ambient oxidation which degrade the materials and therefore hinder us from the intrinsic materials’properties and the optimized performance of devices.In this review,we summarize the recent progress on both fundamentals and applications of the oxidations of 2D semiconductors.We begin with the oxidation mechanisms in black phosphorus,transition metal dichalcogenides and transition metal monochalcogenides considering the factors such as oxygen,water,and light.Then we show the commonly employed passivation techniques.In the end,the emerging applications utilizing controlled oxidations will be introduced. | Junqiang Yang Xiaochi Liu Qianli Dong Yaqi Shen Yuchuan Pan Zhongwang Wang Kui Tang Xianfu Dai Rongqi Wu Yuanyuan Jin Wei Zhou Song Liu Jian Sun | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 13 | Estimate of contribution of near-inertial waves to the velocity shear in the Bay of Bengal based on mooring observations from2013 to 2014显示文摘Near-inertial motions contribute most of the velocity shear in the upper ocean.In the Bay of Bengal(BoB),the annual-mean energy flux from the wind to near-inertial motions in the mixed layer in 2013 is dominated by tropical cyclone(TC)processes.However,due to the lack of long-term observations of velocity profiles,our knowledge about interior near-inertial waves(NIWs)as well as their shear features is limited.In this study,we quantified the contribution of NIWs to shear by integrating the wavenumber-frequency spectra estimated from velocity profiles in the upper layers(40-440 m)of the southern Bo B from April 2013 to May 2014.It is shown that the annual-mean proportion of near-inertial shear out of the total is approximately 50%,and the high contribution is mainly due to the enhancement of the TC processes during which the near-inertial shear accounts for nearly 80%of the total.In the steady monsoon seasons,the near-inertial shear is dominant to or at least comparable with the subinertial shear.The contribution of NIWs to the total shear is lower during the summer monsoon than during the winter monsoon owing to more active mesoscale eddies and higher subinertial shear during the summer monsoon.The Doppler shifting of the M_(2)internal tide has little effect on the main results since the proportion of shear from the tidal motions is much lower than that from the near-inertial and subinertial motions. | Shanwu Zhang Yun Qiu Hangyu Chen Junqiang Shen Junpeng Zhang Jing Cha Fuwen Qiu Chunsheng Jing | 2021 | Acta Oceanologica Sinica2021，40，11： | 0 |
| 14 | Leakage and wear characteristics of carbon seals for aero-engines显示文摘Experimental investigation has been performed to study the leakage and wear characteristics of carbon seal working at high circumferential speed. To expand the scope of application, two newly designed carbon seals were compared: #1 Carbon Seal(CS1) with the inner diameter of136 mm and including 4 segments, #2 Carbon Seal(CS2) with the inner diameter of 212 mm and including 6 segments. Air leakage tests were firstly conducted in the Medium-speed Seal Test Rig. The pressure ratio changed from 1.04 to 2.02 with the rotating speed varying from 0 to18300 r/min. Of paramount concern was the durability test, including 300 h running time accumulated by three different working conditions, which was separately implemented on each carbon seal.The morphology variation of the friction surface, wear and leakage were recorded. Results indicated that the leakage monotonously increases with the pressure ratio and decreases with the rotating speed. Comparing with CS1, more typical features exist on the friction surface of CS2, which are generated by more severe wear. Continually, leakage characteristics deteriorate. Furthermore, fitted formula has been educed for the life prediction of carbon seal, which could provide some supports for aero-engine design. | Guoqing LI Shen ZHANG Zhong KANG Yanfeng ZHANG Xingen LU Junqiang ZHU | 2022 | Chinese Journal of Aeronautics2022，35，11： | 0 |
| 15 | A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease显示文摘Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson s disease,but the regulato ry mechanism remains elusive.Prohibitin-2(PHB2)is a newly discove red autophagy receptor in the mitochondrial inner membrane,and its role in Parkinson’s disease remains unclear.Protein kinase R(PKR)-like endoplasmic reticulum kinase(PERK)is a factor that regulates cell fate during endoplasmic reticulum stress.Parkin is regulated by PERK and is a target of the unfolded protein response.It is unclear whether PERK regulates PHB2-mediated mitophagy thro ugh Parkin.In this study,we established a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse model of Parkinson’s disease.We used adeno-associated virus to knockdown PHB2 expression.Our res ults showed that loss of dopaminergic neurons and motor deficits were aggravated in the MPTP-induced mouse model of Parkinson’s disease.Ove rexpression of PHB2 inhibited these abnormalities.We also established a 1-methyl-4-phenylpyridine(MPP+)-induced SH-SY5Y cell model of Parkinson’s disease.We found that ove rexpression of Parkin increased co-localization of PHB2 and microtubule-associated protein 1 light chain 3,and promoted mitophagy.In addition,MPP+regulated Parkin involvement in PHB2-mediated mitophagy through phosphorylation of PERK.These findings suggest that PHB2 participates in the development of Parkinson’s disease by intera cting with endoplasmic reticulum stress and Parkin. | Yongjiang Zhang Shiyi Yin Run Song Xiaoyi Lai Mengmeng Shen Jiannan Wu Junqiang Yan | 2024 | Neural Regeneration Research2024，19，8： | 0 |
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