2篇
您的检索式：作者名="Diwei Zheng"
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| 1 | Self-delivery of a peptide-based prodrug for tumor- targeting therapy显示文摘一个新奇自我交付的 prodrug 系统为指向肿瘤的治疗被制作。在这 nanosystem, Arg-Gly-Asp-Ser (问候) tetrapeptide 被用来改进治疗学的索引到 integrin-overexpressing 肿瘤房间。antitumorous 药 camptothecin 被 20-O-succinyl 连接进一步添加到离氨酸的氨基的组并且 controllably 经由 hydrolytic 释放了劈开。进纤丝状的 nano 建筑学自我装配的 Prodrug 分子并且在皮下地被注入老鼠以后完成了自我交货的能力。赞成的恐水病的肉豆蔻酸酸的介绍自己组装并且提高了 prodrugs 的细胞的成为主观。在 vitro 并且在 vivo,研究证明自我装配的 nanofibers 能有效地指向 integrinoverexpressing 肿胀的房间并且经由调停 RGD 的特定的指向禁止肿瘤生长。因此,纤丝状的结构由于差的房间举起使治疗学的功效保持低的传统的想法能被质问。 | Mengyun Peng Siyong Qin Huizhen Jia Diwei Zheng Lei Rong Xianzheng Zhang | 2016 | Nano Research2016，9，3： | 2 |
| 2 | AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary malignant bone tumor in children and adolescents.Although activator of HSP90 ATPase activity 1(AHA1)is reported to be a potential oncogene,its role in osteosarcoma progression remains largely unclear.Since metabolism reprogramming is involved in tumorigenesis and cancer metastasis,the relationship between AHA1 and cancer metabolism is unknown.In this study,we found that AHA1 is significantly overexpressed in osteosarcoma and related to the prognosis of osteosarcoma patients.AHA1 promotes the growth and metastasis of osteosarcoma both in vitro and in vivo.Mechanistically,AHA1 upregulates the metabolic activity to meet cellular bioenergetic needs in osteosarcoma.Notably,we identifed that isocitrate dehydrogenase 1(IDH1)is a novel client protein of Hsp90 AHA1.Furthermore,the IDH1 protein level was positively correlated with AHA1 in osteosarcoma.And IDH1 overexpression could partially reverse the effect of AHA1 knockdown on cell growth and migration of osteosarcoma.Moreover,high IDH1 level was also associated with poor prognosis of osteosarcoma patients.This study demonstrates that AHA1 positively regulates IDH1 and metabolic activity to promote osteosarcoma growth and metastasis,which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients. | Diwei Zheng Weihai Liu Wenlin Xie Guanyu Huang Qiwei Jiang Yang Yang Jiarong Huang Zihao Xing Mengling Yuan Mengning Wei Yao Li Junqiang Yin Jingnan Shen Zhi Shi | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
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