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| 1 | Self-transforming ultrathin α-Co(OH)2 nanosheet arrays from metal-organic framework modified graphene oxide with sandwichlike structure for efficient electrocatalytic oxygen evolution显示文摘Developing efficient and low-cost electrocatalysts for oxygen evolution reaction(OER)with high electrochemical activity and durability for diverse renewable and sustainable energy technologies remains challenging.Herein,an ultrasonic-assisted and coordination modulation strategy is developed to construct sandwich-like metal-organic framework(MOF)derived hydroxide nanosheet(NS)arrays/graphene oxide(GO)composite via one-step self-transformation route.Inducing from unsteady state,the dodecahedral ZIF-67 with Co^2+in tetrahedral coordination auto-converts into defect-rich ultrathin layered hydroxides with the interlayered ion NO3-.The self-transforming a-Co(OH)2/GO nanosheet arrays from ZIF-67(Co(OH)2-GNS)change the coordination mode of Co^2+and bring about the exposure of more metal active sites,thereby enhancing the spatial utilization ratio within the framework.As monometal-based electrocatalyst,the optimized Co(OH)2-GNS exhibits remarkable OER catalytic performance evidenced by a low overpotential of 259 mV to achieve a current density of 10 mA·cm-2 in alkaline medium,even exceeding commercial RuO2.During the oxygen evolution process,electron migration can be accelerated by the interfacial/in-plane charge polarization and local electric field,corroborated by the off-axis electron holography.Density functional theory(DFT)calculations further studied the collaboration between ultrathin Co(OH)2 NS and GO,which leads to lower energy barriers of intermediate products and greatly promotes electrocatalytic property. | Mengqiu Huang Weiwei Liu Lei Wang Jiwei Liu Guanyu Chen Wenbin You Jie Zhang Lijun Yuan Xuefeng Zhang Renchao Che | 2020 | Nano Research2020，13，3： | 4 |
| 2 | Engineering the electronic structure on MXenes via multidimensional component interlayer insertion for enhanced electromagnetic shielding显示文摘MXene-based functional electromagnetic interference(EMI)shielding films are highly desirable for mod-ern integrated electronic and telecommunication systems in aerospace,military,artificial intelligence,and smart and wearable electronics field.In this work,3D freestanding Ti_(3)C_(2)T_(x)/CNTs/Ni film assembled by 1D multi-walled carbon nanotubes(MWCNTs)/Ni and 2D Ti_(3)C_(2)T_(x)MXene sheets was synthesized by a facile vacuum filtration process.By electrostatic incorporation,hexagonal nickel plates embed on the CNTs and then the CNTs/Ni insert into the Ti_(3)C_(2)T_(x)layers to form magnetized Ti_(3)C_(2)T_(x)-based functional film with a compact and laminated structure.Due to the outstanding electron migration capacity in the highly conductive Ti_(3)C_(2)T_(x)sheet and multiple internal reflections from porous and segregated structures,the op-timized Ti_(3)C_(2)T_(x)/CNTs/Ni composite films show excellent EMI shielding effectiveness of 67.4 dB with elec-trical conductivity of 744 S cm^(-1).Surprisingly,a magnetization compensation strategy is built to boost the EMI shielding effectiveness with decreased conductivity.Meanwhile,the visual magnetic coupling phenomenon and charge distribution in the heterogeneous interfaces could be observed in the recon-structed electron holography images.Those encouraging results shed light on novel magnetized MXene-based functional films for high-performance EMI shielding. | Mengqiu Huang Lei Wang Biao Zhao Guanyu Chen Renchao Che | 2023 | Journal of Materials Science & Technology2023，，7： | 2 |
| 3 | AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary malignant bone tumor in children and adolescents.Although activator of HSP90 ATPase activity 1(AHA1)is reported to be a potential oncogene,its role in osteosarcoma progression remains largely unclear.Since metabolism reprogramming is involved in tumorigenesis and cancer metastasis,the relationship between AHA1 and cancer metabolism is unknown.In this study,we found that AHA1 is significantly overexpressed in osteosarcoma and related to the prognosis of osteosarcoma patients.AHA1 promotes the growth and metastasis of osteosarcoma both in vitro and in vivo.Mechanistically,AHA1 upregulates the metabolic activity to meet cellular bioenergetic needs in osteosarcoma.Notably,we identifed that isocitrate dehydrogenase 1(IDH1)is a novel client protein of Hsp90 AHA1.Furthermore,the IDH1 protein level was positively correlated with AHA1 in osteosarcoma.And IDH1 overexpression could partially reverse the effect of AHA1 knockdown on cell growth and migration of osteosarcoma.Moreover,high IDH1 level was also associated with poor prognosis of osteosarcoma patients.This study demonstrates that AHA1 positively regulates IDH1 and metabolic activity to promote osteosarcoma growth and metastasis,which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients. | Diwei Zheng Weihai Liu Wenlin Xie Guanyu Huang Qiwei Jiang Yang Yang Jiarong Huang Zihao Xing Mengling Yuan Mengning Wei Yao Li Junqiang Yin Jingnan Shen Zhi Shi | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 4 | Synergistic realization of high efficiency solar desalination and carbon dioxide reduction显示文摘Methods of seawater desalination and carbon dioxide(CO_(2))reduction using clean and renewable energy have attracted much attention withing the reducing fresh water and growing CO_(2)concentration.Here,we propose a synergistic method for solardriven desalination and CO_(2)reduction at the surface of sea using a three-dimensional titanium oxide-gold semiconductor/metal(TiO_(2)-Au NW/NPs(NW:nanowire,NP:nanoparticle))photothermal conversion membrane that can efficiently harvest a broad solar spectrum(200 to 2500 nm,94%)to undertake the conversion of light-to-heat and light-to-electricity.The TiO_(2)-Au NW/NPs membrane demonstrated a high solar vapor conversion efficiency of~90%,CO_(2)reduction yields of 0.066μmol·cm^(-2)CH_(4)and 0.015μmol·cm^(-2)CO within 5 h.In addition,the membrane efficiently evaporated seawater with different salt concentrations to produce drinking water which meet World Health Organization(WHO)and US Environmental Protection Agency(EPA)standards.This work provides an integrated solution for solar desalination and CO_(2)reduction at the surface of sea to reduce the harm to marine life caused by ocean acidification while producing pure water. | Xiaoying Song Pei Wang Yi Huang Xiaoqiang Zhu U-Fat Chio Fang Wang Guanyu Wang Wei Wang Bin Liu | 2023 | Nano Research2023，16，7： | 0 |
| 5 | Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp.c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1a/XBP-1s axis and JNK signaling显示文摘Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease(MAFLD).However,there are few reported lipotoxicity inhibitors.Here,we identified a natural anti-lipotoxicity candidate,HN-001,from the marine fungus Aspergillus sp.C1.HN-001 dose-and time-dependently reversed palmitic acid(PA)-induced hepatocyte death.This protection was associated with IRE-1a-mediated XBP-1 splicing inhibition,which resulted in suppression of XBP-1s nuclear translocation and transcriptional regulation.Knockdown of XBP-1s attenuated lipotoxicity,but no additional ameliorative effect of HN-001 on lipotoxicity was observed in XBP-1s knockdown hepatocytes.Notably,the ER stress and lipotoxicity amelioration was associated with PLA2.Both HN-001 and the PLA2 inhibitor MAFP inhibited PLA2 activity,reduced lysophosphatidylcholine(LPC)level,subsequently ameliorated lipotoxicity.In contrast,overexpression of PLA2 caused exacerbation of lipotoxicity and weakened the anti-lipotoxic effects of HN-001.Additionally,HN-001 treatment suppressed the downstream pro-apoptotic JNK pathway.In vivo,chronic administration of HN-001(i.p.)in mice alleviated all manifestations of MAFLD,including hepatic steatosis,liver injury,inflammation,and fibrogenesis.These effects were correlated with PLA2/IRE-1a/XBP-1s axis and JNK signaling suppression.These data indicate that HN-001 has therapeutic potential for MAFLD because it suppresses lipotoxicity,and provide a natural structural basis for developing anti-MAFLD candidates. | Yong Rao Rui Su Chenyan Wu Xingxing Chai Jinjian Li Guanyu Yang Junjie Wu Tingting Fu Zhongping Jiang Zhikai Guo Congjun Xu Ling Huang | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 6 | Iodine-125 seed implantation in the treatment of malignant tumors显示文摘Malignant tumors are major causes of morbidity and mortality in China.Despite advances in surgical,radiological,chemotherapeutic,molecular targeting,and immunotherapeutic treatments,patients with malignant tumors still have poor prognoses.Low-dose-rate brachytherapy,specifically 125I seed implantation,is beneficial because of its high local delivery dose and minimal damage to surrounding tissues.Consequently,it has gained increasing acceptance as a treatment modality for various malignant tumors.In this study,we explored the fundamental principles,clinical applications,and new technologies associated with 125I radioactive seed implantation. | Pan Hu Jianwen Huang Yanling Zhang Huanqing Guo Guanyu Chen Fujun Zhang | 2023 | Journal of Interventional Medicine2023，6，3： | 0 |
| 7 | Recent Advances of Electrocatalyst and Cell Design for Hydrogen Peroxide Production显示文摘Electrochemical synthesis of H_(2)O_(2) via a selective two-electron oxygen reduction reaction has emerged as an attractive alternative to the current energy-consuming anthraquinone process. Herein, the progress on electrocatalysts for H_(2)O_(2) generation, including noble metal, transition metalbased, and carbon-based materials, is summarized. At first, the design strategies employed to obtain electrocatalysts with high electroactivity and high selectivity are highlighted. Then, the critical roles of the geometry of the electrodes and the type of reactor in striking a balance to boost the H_(2)O_(2) selectivity and reaction rate are systematically discussed. After that, a potential strategy to combine the complementary properties of the catalysts and the reactor for optimal selectivity and overall yield is illustrated. Finally, the remaining challenges and promising opportunities for highefficient H_(2)O_(2) electrochemical production are highlighted for future studies. | Xiao Huang Min Song Jingjing Zhang Tao Shen Guanyu Luo Deli Wang | 2023 | Nano-Micro Letters2023，15，6： | 0 |
| 8 | Insight into the efficiency-stability-cost balanced organic solar cell based on a polymerized nonfused-ring electron acceptor显示文摘Organic solar cells(OSCs)have attracted extensive attention from both academia and industry in recent years due to their remarkable improvement in power conversion efficiency(PCE).However,the Golden Triangle(the balance of efficiency-stability-cost)required for large-scale industrialization of OSCs still remains a great challenge.Here,a new nonfused-ring electron acceptor(NFREA)BF and its polymerized counterpart PBF were designed and synthesized,and their photovoltaic performance,storage stability and material cost were systematically investigated.When blended with a widely-used polymer donor PBDB-T,the PBFbased all-polymer solar cell(all-PSC)displayed a record high PCE of 12.61%for polymerized NFREAs(PNFREAs)with an excellent stability(95.2%of initial PCE after 800 h storage),superior to the BF counterpart.Impressively,PBF-based allPSC possesses the highest industrial figure-of-merit(i-FOM)value of 0.309 based on an efficiency-stability-cost evaluation,in comparison to several representative OSC systems(such as PM6:Y6 and PBDB-T:PZ1).This work provides an insight into the balance of efficiency,stability,and cost,and also indicates that the PNFREAs are promising materials toward the commercial application of OSCs. | Xiaobin Gu Yanan Wei Guanyu Lu Ziyang Han Di Zheng Guanghao Lu Jianqi Zhang Zhixiang Wei Yunhao Cai Xin Zhang Hui Huang | 2023 | Aggregate2023，4，6： | 0 |
| 9 | Clipping discrete multi-tone for peak-power-constraint IM/DD optical systems显示文摘High peak-to-average power ratio(PAPR)is a major drawback of discrete multi-tone(DMT)in peak-power-constraint(PPC)intensity-modulation/direct-detection(IM/DD)optical systems.Symmetric clipping operation is a frequently-used and practical method for mitigating the PAPR of the DMT signal.However,clipping noise is inevitably induced by the symmetric clipping operation,thereby deteriorating the system’s performance.In this paper,we study the statistical characteristics of the clipping noise in detail.Depending on the statistical characteristics,clipping-noise-cancellation(CNC)algorithms are proposed to mitigate the clipping noise in the clipping DMT systems.Theoretically,the clipping noise can be completely removed using the low-density-parity-check-assisted CNC algorithm(LDPC-assisted CNC algorithm).To verify the superiority of the clipping DMT with the CNC algorithm,we conduct an experiment with a50 Gb/s DMT system using 10G-class commercial devices for the scenario of PPC passive optical networks.The receiver sensitivity of the clipping DMT system with the CNC algorithm can reach-24 d Bm at a 20%soft-decision forward-error-correction limit,which is 2.5 d B higher than that of the DMT system without clipping operation.The clipping operation and the CNC algorithm are added after the original digital signal processing,thereby demonstrating the potential to efectively overcome the drawback in DMT signals and other high-PAPR signals. | Ji ZHOU Liangchuan LI Jiale HE Xiaofeng LU Yu BO Guanyu WANG Yuanda HUANG Gengchen LIU Yanzhao LU Shecheng GAO Yuanhua FENG Shancheng ZHAO Weiping LIU Changyuan YU Zhaohui LI | 2023 | Science China(Information Sciences)2023，66，5： | 0 |
| 10 | Integrated proteomic and phosphoproteomic data-independent acquisition data evaluate the personalized drug responses of primary and metastatic tumors in colorectal cancer显示文摘Mass spectrometry(MS)-based proteomics and phosphoproteomics are powerful methods to study the biological mechanisms,diagnostic biomarkers,prognostic analysis,and drug therapy of tumors.Dataindependent acquisition(DIA)mode is considered to perform better than data-dependent acquisition(DDA)mode in terms of quantitative reproducibility,specificity,accuracy,and identification of lowabundance proteins.Mini patient derived xenograft(MiniPDX)model is an effective model to assess the response to antineoplastic drugs in vivo and is helpful for the precise treatment of cancer patients.Kinases are favorable spots for tumor-targeted drugs,and their functional completion relies on signaling pathways through phosphorylating downstream substrates.Kinase-phosphorylation networks or edge interactions are considered more credible and permanent for characterizing complex diseases.Here,we provide a workflow for personalized drug response assessment in primary and metastatic colorectal cancer(CRC)tumors using DIA proteomic data,DIA phosphoproteomic data,and MiniPDX models.Three kinase inhibitors,afatinib,gefitinib,and regorafenib,are tested pharmacologically.The process mainly includes the following steps:clinical tissue collection,sample preparation,hybrid spectral libraries establishment,MS data acquisition,kinase-substrate network construction,in vivo drug test,and elastic regression modeling.Our protocol gives a more direct data basis for individual drug responses,and will improve the selection of treatment strategies for patients without the druggable mutation. | Xumiao Li Yiming Huang Kuo Zheng Guanyu Yu Qinqin Wang Lei Gu Jingquan Li Hui Wang Wei Zhang Yidi Sun Chen Li | 2023 | Biophysics Reports2023，9，2： | 0 |
| 11 | Experimental study on the anti-inflammatory effect of Mongolian medicine Sendeng Decoction on mice with psoriasis显示文摘Psoriasis is a chronic papulosquamous skin disease occurring worldwide caused by varieties of factors.The recipe of Mongolian medicine Sendeng Decoction was recorded in“The Pleasure of the Viewer”compiled by Jigwood Danjinzhamusu.Mongolian medicine clinical experience proved that Sendeng Decoction had good antipyretic,analgesic,anti-inflammatory and anti-rheumatism effect.However,the mechanism of this drug in psoriasis is still unclear.In this study,imiquimod cream(IMQ)was used to construct psoriasis model in 8-week-old male BALB/c mice,and Sendeng Decoction was used to treat the mice with psoriasis.The results showed that PASI score and spleen index decreased after Sendeng Decoction treatment.Meanwhile,HE staining showed that the pathological structure was improved,flow cytometry results showed that the proportion of Treg cells increased and Th17 cells decreased,and results of Western blot showed that the level of p38 MAPK,p-p38 MAPK,p-STAT3 and p-JAK1 decreased observably.More importantly,the above results were most significant in Sendeng's M group,which was similar to MTX group.Our results indicated that Mongolian medicine Sendeng Decoction can effectively relieve the symptoms of psoriasis mice induced by IMQ,mainly by regulating the ratio of Th17/Treg cells through the JAK/STAT and p38 MAPK pathways to reduce the inflammatory state in mice,thereby improving the symptoms of dermatitis. | Li Sun Guanyu Yu Huiming Jiang Kun Shi Doudou Huang Hashen Bao Yanping Huang Limuge Che Meijuan Chen | 2022 | Medicine in Novel Technology and Devices2022，，4： | 0 |
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