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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | Mechanism of film growth during anodizing of A1-alloy-8090/SiC metal composites显示文摘 | Coleman S L Scott V D Mcenaney B | 1994 | J Mater Sci1994，29，： | 2 |
| 4 | Association of the type 1 pro- tein phosphatase PPl with the A-kinase anchoring pro- tein AKAP220显示文摘 | Schillace R V Scott J D | 1999 | Curr Biol1999，9，： | 1 |
| 5 | Effect of thiouracil-induced hypothyroidism on the humoral immunity of new hampshire chickens 显示文摘 | Scott T Zijpp A V D Glick B | 1985 | Poultry Science1985，64，11： | 1 |
| 6 | Low temperature mechanical properties of scandium-modified Al-Zn-Mg-Cu alloys显示文摘 | SENKOY O N MIRACLE D B MILMAN Y V SCOTT J M LOTSKO D V SIRKO A I | 2002 | Materials Science Forum2002，，： | 1 |
| 7 | Stem-like cells in bone sarcomas: implications for tumorigenesis显示文摘 | Gibbs C P Kukekov V G Reith J D Tchigrinova O Suslov O N Scott E W | 2005 | Neoplasia2005，7，： | 1 |
| 8 | C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR):its frequency and impact on plasma homocysteine concentration in different European populations显示文摘 | Gudnason V Stansbie D Scott J | 1998 | Atherosclerosis1998，136，2： | 1 |
| 9 | 基于G-蛋白偶联受体激酶2抑制剂治疗心力衰竭的合理药物设计(英文)显示文摘G protein-coupled receptors(GPCRs)convert extracellular stimuli in the form of hormones,odorants and light into profound changes in cell homeostasis.Their timely desensitization is critical for cells to rapidly respond to changes in their environment and to avoid damage from sustained signaling.Seven GPCR kinases(GRKs)phosphorylate and regulate the activity of most of the^800 GPCRs in the human genome.Although GRKs normally play an adaptive role,in conditions such as chronic heart failure they are overexpressed and linked to disease progression.GRK2 and GRK5 have thus become important targets for the treatment of heart failure and pathological cardiac hypertrophy,respectively.Our lab has determined atomic structures representing all three vertebrate GRK subfamilies,and is now in the midst of a campaign to develop selective inhibitors of these enzymes using structure-based rational design.We have identified the FDA approved drug paroxetine as a selective GRK2 inhibitor,determined the crystal structure of the GRK2·paroxetine complex and,in collaboration with the Koch lab,showed that the drug improves contractility in myocytes and,most impressively,recovery in postmyocardial infarcted mice.Since then,we have identified additional chemical scaffolds that exhibit even higher potency and/or selectivity for GRK5.Using a'hybrid'inhibitor design approach we have generated GRK selective chemical probes that exhibit improved potency and stability and are able to increase inotropy and dampen the hypertrophic response in cardiomyocytes and small animal models.Structural analysis has revealed the molecular basis for selectivity and potency in many of these compounds,allowing for the design of future generations of GRK chemical probes. | John J TESMER Helen V WALDSCHMIDT Marie C CATO Renee BOULEY Osvaldo CRUZ-RODRIGUEZ Scott D LARSEN | 2017 | 中国药理学与毒理学杂志2017，31，10： | 1 |
| 10 | Structure of precipitate in Al-Cu-Mg-Ag alloy显示文摘 | Kerry S Scott V D | 1985 | Archiwum Nauki o Materialach1985，6，2： | 1 |
| 11 | Joining molybdenum to aluminium by diffusion bonding 显示文摘 | Bushby R S Hicks K P Scott V D | 1996 | Journal of Materials Science1996，31，： | 1 |
| 12 | Nucleation and growth of precipitates in Al-Cu-Mg-Ag alloys显示文摘 | Scott V D Kerry S Trumper R L | 1987 | Materials Science and Technology1987，3，10： | 1 |
| 13 | Improvements in quadriceps sensori- motor function and disability of patients with knee osteoarthritis following a clinically practicable exercise regime显示文摘 | HURLEY M V SCOTT D L | 1998 | BrJRheuma- to11998，37，11： | 1 |
| 14 | Use of complementary and alternative medicine in cancer patients:a European survey显示文摘 | Molassiotis A Fernadez-Ortega P Pud D Ozden G Scott JA Panteli V Margulies A Browall M Magri M Selvekerova S Madsen E Milovics L Bruyns I Gudmundsdottir G Hummerston S Ahmad AM Platin N Keamey N Patiraki E | | 0，，04： | 1 |
| 15 | Methylmercury artifact formation during solid-phase extraction of water samples using sulfhydryl cotton fiber adsorbent显示文摘 | CELO V ANANTH R V SCOTT S L LEAN D R S | 2004 | Analytica Chimica Acta2004，516，12： | 1 |
| 16 | Evaluation of aluminum-copper alloy reinforced with pitch-based carbon fibers显示文摘 | BUSHBY R S SCOTT V D | 1997 | Composites Science and Technology1997，57，1： | 1 |
| 17 | When evidence is not enough:the challenge of implementing fall prevention strategies显示文摘 | Fixsen D Scott V Blase K | 2011 | Journal of Safety Research2011，42，6： | 1 |
| 18 | Nucleation and growth of precipitates in Al-Cu-Mg-Ag alloys显示文摘 | SCOTT V D KERRY S TRUMPER R L | 1987 | Mater Sci Technol1987，3，10： | 1 |
| 19 | Demonstration of a 311 GHz fundamental oscillator using InPHBT technology 显示文摘 | RADISIC V SAWDAI D SCOTT D | 2007 | IEEE Transactions on Microwave Theory and Techniques2007，55，11： | 1 |
| 20 | Structure and orientation relation of precipitates formed in Al-Cu-Mg-Ag alloys显示文摘 | KERRY S SCOTT V D | 1984 | Metal Sci1984，18，6： | 1 |
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