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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 3 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 4 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 5 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 6 | Ankle Fractures in the Elderly: What You Get Depends on Where You Live and Who You See显示文摘 | Kenneth J Koval Jon Lurie Weiping Zhou Michael B Sparks Robert V Cantu Scott M Sporer James Weinstein | 2005 | Journal of Orthopaedic Trauma2005，，9： | 2 |
| 7 | Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene显示文摘 | Basler K Oesch B Scott M | 1986 | Cell1986，46，3： | 1 |
| 8 | Scrapie injected murine neuroblastoma cells produce proteaseresistant prion proteins 显示文摘 | Butler D A Scott M R D Prusiner S B | 1988 | J Virol1988，62，： | 1 |
| 9 | Random-peptide librar-ies and antigen-fragment libraries for epitope mappingand the development of vaccines and diagnostics显示文摘 | Irving M B Pan O Scott J K | 2001 | Curr Opin Chem Biol2001，5，3： | 1 |
| 10 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 11 | Low temperature mechanical properties of scandium-modified Al-Zn-Mg-Cu alloys显示文摘 | SENKOY O N MIRACLE D B MILMAN Y V SCOTT J M LOTSKO D V SIRKO A I | 2002 | Materials Science Forum2002，，： | 1 |
| 12 | Transformational leader behaviors and their effects on followers' trust in leader,satisfaction,and organizational citizenship behaviors显示文摘 | Podsakoff Scott B Philip M | 1990 | The leadership Quarterly1990，1，2： | 1 |
| 13 | Fluid percussion baro- trauma chamber: a new in vitro model for traumatic brain injury 显示文摘 | Scott R Shepard M D Jamshid B G | 1991 | J Surgical R es1991，51，5： | 1 |
| 14 | Disappearance of patulin from apple juice fermented by Saccharomyces spp显示文摘 | HARWIG J SCOTT P M KENNEDY B P C | | 0，，01： | 1 |
| 15 | Stress-strain be- havior of concrete confined by overlapping hoops at low and high strain rates 显示文摘 | Scott B D Park R Priestley M J N | 1982 | ACI Journal1982，79，1： | 1 |
| 16 | Three-dimensionally ordered macroporous Li4Ti5O12:effect of wall structure on electrochemical properties显示文摘 | Erin M S Scott J B Jung H K | 2006 | Chem Mater2006，18，2： | 1 |
| 17 | Evidence for differences between winter wheat cultivars in acquisition of soil on inter nitrogen and uptake and utilization of applied fertilizer nitrogen显示文摘 | Foulkes M J Sylvester B R Scott R K | 1998 | Journal Agronomy Science of Canada1998，139，： | 1 |
| 18 | Stress-Strain Behavior of Concrete Confine by Overlapping Hoops at Low and High Strain Rates显示文摘 | Scott B D Park R Priestley M J N | 1982 | ACI Journal1982，79，2： | 1 |
| 19 | Chemical Oxygen Demand Analysis of Waste Water Using Trivalent Mangunese Oxidant with Chloride Removal by Sodium Bismuthate Pretreatment显示文摘 | DONALD G M SCOTT V B WAYNE T B | 2001 | Water Environment Research2001，73，1： | 1 |
| 20 | Development of inhibitors of the aspartyl protease renin for the treatment of hypertension显示文摘 | Scott B B McGeehan G M Harrison R K | 2006 | Curr ProteinPept Sci2006，7，： | 1 |
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