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| 1 | Overexpression of TaNAC69 Leads to Enhanced Transcript Levels of Stress Up-Regulated Genes and Dehydration Tolerance in Bread Wheat显示文摘NAC 蛋白质是植物特定的抄写因素并且充实,成员们在对干旱应力的植物反应包含了。在这研究,我们用 Affymetrix 小麦染色体数组数据集和量的 RTPCR 在面包小麦分析了 TaNAC69 的表达式侧面。TaNAC69 表示断然与对不能生活、关於生命的压力的小麦回答被联系并且密切与很多个压力被相关起来调整的基因。在转基因的小麦的 TaNAC69 的功能的分析证明干旱可诱导的 HvDhn4s 倡导者导致了的一棵大麦驾驶的 TaNAC69 在转基因的线的叶子和根标记 TaNAC69 的干旱可诱导的 overexpression。HvDhn4s : 更生产的 TaNAC69 转基因的线在联合的温和的盐应力和水限制条件下面射击生物资源,在聚乙烯下面的有的更长的根和更多根生物资源导致乙二醇的脱水。有 TaNAC69 的组成的 overexpression 的转基因的线的分析证明提高的表示几个压力铺平起来调整的基因。DNA 有约束力的试金表明 TaNAC69 和它的米饭相当或相同的事物(ONAC131 ) 能够到三米饭基因的倡导者元素的绑定(chitinase, ZIM,和 glyoxalase 我) 并且 Arabidopsis glyoxalase 我家庭基因,它是 TaNAC69 起来调整的压力基因的相当或相同的事物。这些数据建议 TaNAC69 涉及调整应力起来调整的基因和小麦改编到干旱应力。 | Gang-Ping Xue Heather M. Way Terese Richardson Janneke Drenth Priya A. Joyce C.Lynne Mclntyre | 2011 | Molecular Plant2011，4，4： | 25 |
| 2 | Regulation of the G1 phase of the mammalian cell cycle显示文摘In any multi-cellular organism, the balance between cell division and cell death maintains a constant cell number. Both cell division cycle and cell death are highly regulated events. Whether the cell will proceed through the cycle or not, depends upon whether the conditions required at the checkpoints during the cycle are fulfilled. In higher eucaryotic cells, such as mammalian cells, signals that arrest the cycle usually act at a G1 checkpoint. Cells that pass this restriction point are committed to complete the cycle. Regulation of the GI phase of the cell cycle is extremely complex and involves many different families of proteins such as retinoblastoma family cyclin dependent kinases, cyclins, and cyclic kinase inhibitors. | DONJERKOVIC DUBRRAVKA DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD) | 2000 | Cell Research2000，10，1： | 18 |
| 3 | Usefulness of a scoring system in the interpretation of histology in neonatal cholestasis显示文摘AIM:To ascertain the usefulness of a histological scoring system devised to assist in the interpretation of liver histology in neonatal cholestasis(NC) .METHODS:Liver biopsy specimens obtained from infants with NC referred to a tertiary pediatric unit in Malaysia were prospectively studied.The first author,blinded to the final diagnosis,devised the histological diagnosis based on a 7-feature(portal ductal proliferation,bile plugs in portal ductules,portoportal bridging,lymphocytic infiltration in portal region,multinucleated hepatocytes,neutrophilic infiltration,hepatocellular swelling) ,15-point(0 to 15) scoring system.The author classified the histological diagnosis as either biliary atresia(BA) or neonatal hepatitis(NH,all other diagnoses) ,and subsequently compared the author's diagnosis with the final diagnosis.RESULTS:Eighty-four biopsy specimens obtained from 78 patients were reviewed.Without the scoring system,BA was correctly diagnosed by the author histologically in 30 cases,labelled as NH in 3.For other diagnoses,BA was excluded correctly in 33 cases and mislabeled as BA in 2 cases.The overall sensitivity for BA was 91%,specificity 86% and accuracy 88%.With the scoring system,a score of ≥ 7 had the best diagnostic utility to differentiate BA from other intrahepatic cholestasis histologically(sensitivity 88%,specificity 94%,accuracy 92%) .Four patients with a score < 7 had BA,and 3 patients with a score ≥ 7 had NH.CONCLUSION:A 7-feature,15-point histological scoring system had good diagnostic accuracy in the interpretation of liver histology in neonatal cholestasis. | Way Seah Lee Lai Meng Looi | 2009 | World Journal of Gastroenterology2009，15，42： | 11 |
| 4 | Relationship Between Measured Friction Coefficients and Two Tread Groove Design Parameters for Footwear Pads显示文摘The shoe sole geometrical design parameters are believed to be important factors affecting the coefficient of friction (COF) between the shoe/floor interface. This study is concerned with the relationship between the measured COF and the tread groove orientation and width on the footwear pad. Friction meas-urements using the Brungraber Mark Ⅱ slipmeter were conducted. Six tread groove width/orientations de-signs on the footwear pads under 27 footwear material/floor/contamination conditions were tested. The re-sults show that tread orientation and width affect the measured COF significantly. Wider grooved footwear pads result in higher COF values and footwear pads with tread grooves perpendicular to the friction meas-urement direction have higher COF values. A regression model using measured COF as the dependent variable and tread groove width, groove orientation, footwear material, floor, and contamination conditions as independent variables was established. The models are significant at p<0.0001 with R2 of 0.97, which may be used in predicting the COF at the shoe-floor interface. | LI Kai Way CHEN Chin Jung LIN Ching-Hua HSU Yao Wen | 2006 | Tsinghua Science and Technology2006，11，6： | 11 |
| 5 | Mobile Ubiquitous Service Environment显示文摘The Mobile Ubiquitous Service Environment (MUSE),established through the coordination and integration of mobile telecommunications and ubiquitous network,in the pursuit of Always Best Experience (ABE),represents the major development trend for the next generation mobile wireless network. Research on MUSE will involve the integration of the computing model system,service platform system,operating system and terminal structure system,all of which involve exploration and innovation of a new networking structure,its control and management as well as way of measuring. The change in network resources triggers the change in network computing models. To let readers have a basic understanding of MUSE,this lecture introduces it in four sections. This section focuses on the development and demand analysis of the service platform. | Zhang Ping,Ji Yang,Feng Zhiyong (Research Center for Wireless New Technology,Beijing University of Posts and Telecommunications,Beijing 100876,China) The Mobile Ubiquitous Service Environment (MUSE),established through the coordination and integration of mobile telecommunications and ubiquitous network,in the pursuit of Always Best Experience (ABE),represents the major development trend for the next generation mobile wireless network. Research on MUSE will involve the integration of the computing model system,service platform system,operating system and terminal structure system,all of which involve exploration and innovation of a new networking structure,its control and management as well as way of measuring. The change in network resources triggers the change in network computing models. To let readers have a basic understanding of MUSE,this lecture introduces it in four sections. This section focuses on the development and demand analysis of the service platform. | 2007 | ZTE Communications2007，5，2： | 10 |
| 6 | Differential gene expression profiling in the developed ovaries between the parthenogenetic and bisexual female rice water weevils,Lissorhoptrus oryzophilus Kuschel(Coleoptera:Curculionidae)显示文摘The rice water weevil,Lissorhoptrus oryzophilus Kuschel(Coleoptera:Curculionidae),reproduces by sex in the Southeastern United States,but reproduces by parthenogenesis in California and other invaded regions in Asia and Europe.The objective of this study was to create a parthenogenetic gene expression profile of the rice water weevil in order to gain a better insight into the molecular mechanisms of parthenogenesis in the weevil.Suppression subtractive hybridization(SSH) technique was employed for profiling differential gene expression in the developed ovary between the parthenogenetic and bisexual female rice water weevils.A total of 70 contigs were obtained,and the BLASTX search identified putatively 28 genes with differential functions.According to the cytological process of parthenogenesis,the tubulin alpha-1 chain and signal transduction genes etc.were selected for real time quantitative RT-PCR analyses,and their possible functions related to the molecular mechanism of parthenogenesis were discussed.The tubulin alpha-1 chain and some signal transduction genes may be related to the molecular mechanisms of parthenogenesis of the rice water weevil. | YANG Pu ZHOU WenWu ZHANG Qin CHENG JiaAn ZHU ZengRongx WAY MO | 2009 | Chinese Science Bulletin2009，54，20： | 8 |
| 7 | The Trans-Pacific Partnership:A High Barrier Agreement?显示文摘TPP is not only a simple FTA but a 'Sample Agreement' that has high hope from USTR (Office of the United States Trade Representative).There are those who are concerned that the TPP is an attempt by the United States to promote American hegemony.What is the true aim of TPP? Why does the United States push forward it? This article will offer some insights. | Edwin Way | 2012 | China's Foreign Trade2012，，4： | 7 |
| 8 | Activation-induced cell death in B lymphocytes显示文摘Upon encountering the antigen (Ag), the immune system can either develop a specific immune response or enter a specific state of unresponsiveness, tolerance. The response of B cells to their specific Ag can be activation and proliferation, leading to the immune response, or anergy and activation-induced cell death (AICD), leading to tolerance. AICD in B lymphocytes is a highly regulated event initiated by crosslinking of the B cell receptor (BCR). BCR engagement initiates several signaling events such as activation of PLCr, Ras, and PI3K, which generally speaking, lead to survival. However, in the absence of survival signals (CD40 or IL-4R engagement), BCR crosslinking can also promote apoptotic signal transduction pathways such as activation of effector caspases, expression of pro-apoptotic genes, and inhibition of pro-survival genes. The complex interplay between survival and death signals determines the B cell fate and, consequently, the immune response. | DONJERKOVIC DUBRAVKA, DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD, 20855. USA) | 2000 | Cell Research2000，10，3： | 6 |
| 9 | New approaches to characterizing urban air particles in central London显示文摘Atmospheric particles in central London during July 1996 have been apportioned to sources by two complimentary techniques: (1) morphological characteristics, determined using high power light microscopy; (2) chemical composition determined by energy dispersive spectroscopy. During the study period, the majority of particles were found to be either biological in origin, or from vehicle related combustion processes. Trends in the latter group of particles are explored further. Numbers of particles per cubic metre were determined at an hourly resolution over a period of six days, and were found to be significantly correlated with other traffic pollutants such as benzene and 1,3 butadiene, although there is no relationship with mass of PM10 as measured by a nearby UK Government monitoring station. We suggest in this paper that numbers of particles from car exhausts are more representative of traffic pollution than current estimates which use monitoring by mass. | A.W. Mackay *, X. Long *, N.L. Rose *, R.W. Battarbee Environmental Change Research Centre, University College London, 26 Bedford Way, London. WC1H0AP, UK | 1999 | Journal of Environmental Sciences1999，11，3： | 6 |
| 10 | Structural Applications of NiAl显示文摘Alloys based on NiAl offer significant payoffs as structural materials in gas turbine applications due to a unique range of physical and mechanical properties These properties include high melting temperature. low density. high thermal conductivity. and excellent environmental resistance Very significant improvements in the strength and ductility of NiAl single crystals have been achieved through alloying. Tensile strength and stress rupture properties which compete with current Ni-base Superalloys have been achieved through precipitation of an ordered L21 Heusler phase in NiAl single crystals Room temperature tensile ductility as high as 6% has been produced in NiAl single crystals containing less than 0.5% (atomic) of Fe. Ga or Mo. However. a single alloy with both room temperature ductility and sufficient high temperature strength has not yet been developed. While activity to develop on alloy with both high temperature strength and room temperature ductility continues. the Current approach also emphasizes design and test methodologies which can accept a material with limited ductility and damage tolerance More work is required on measuring and understanding strain rate sensitivity and impact behaviour While several significant challenges still remain. excellent progress has been made in many areas, and the prognosis for using NiAl alloys as high temperature structural materials is | R.Darolia(GE Aircraft Engines, 1 Neumann Way, Cincinnati, OH 45215, USA) | 1994 | Journal of Materials Science & Technology1994，10，3： | 4 |
| 11 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 12 | 免疫功能正常的复发性后天性眼弓形体病1例(英文)显示文摘目的:报告1例免疫功能正常的患者患复发性后天性眼弓形体病的异常恶化及治疗后视力的改善。方法:病例报告。结果:比沙亚族女孩,21岁,其它方面健康,有与猫接触史,表现为右眼无痛、渐进性视力模糊2wk。视力右眼6/15,左眼6/6。眼底检查呈右眼后极部局灶性视网膜炎,伴视盘肿胀充血,双眼周边陈旧性视网膜脉络膜疤痕。经弓形虫血清检查证实其右眼患复发性眼弓形虫病。起初,患者对复方新诺明和阿奇霉素两种药物反应良好。然而在治疗过程中患者右眼弓形体病两次恶化,右眼视力下降到6/60,随后进行持续6wk的口服阿奇霉素和逐渐减量的皮质类固醇药物治疗,右眼弓形虫性视网膜炎治愈,随访1a未见复发。患者最终视力,右眼6/30,左眼6/6。结论:患复发性后天性眼弓形体病在免疫功能正常的个体并不常见。延误诊断和治疗导致永久性失明。及时、充分的治疗和良好的治疗依从性对防止并发症毁坏视觉极其重要。 | Wai Seng Chiang Tat Way Leslie Wong Mohtar Ibrahim | 2011 | 国际眼科杂志2011，11，10： | 3 |
| 13 | DEVELOPMENT OF SOIL EROSION INDEX MODEL IN TAIWAN WATERSHEDS显示文摘With steep terrain and excessive rainfall, Taiwan is affected by severe soil erosion caused by summer typhoons and storms that bring intensive rainfall and rapid flows,. However, the actual erosion is much less than the value predicted by the USLE because the soil erosion types in Taiwan are different from those in America which has mild slope and dry weather. Developing a soil erosion index model applicable to Taiwan is the important goal of this research. Five factors, namely, soil texture, rainfall type, slope steepness, ground cover and land use, are included in this model. Soil index factor is measured by Km from the USLE model, and other index factors are calculated from local field data. The soil erosion index model (SEIM) is as follows: SE=6x10-7AIfor AI≤50 SE = 0.233AI1.8 for AI > 50 where AI is the total index value, and SE is the soil erosion quantity (ton/ha/yr). After being properly calibrated and verified, SEIM proves to be useful in planning soil and water conservation, and assessing soil erosion impacts in Taiwan. | Su-Chin CHEN, Seasir CHIEN and Cheng-Daw HSIEH Professor, Department of Soil and Water Conservation National Chung-Hsing University, Taichung, 402 Taiwan, China Engineer, Water Way Section, Hand County Government, 260 Taiwan, China Doctoral Student, Ins | 2001 | International Journal of Sediment Research2001，16，1： | 3 |
| 14 | Isochaihulactone protects PC12 cell against H2O2 induced oxidative stress and exerts the potent anti- aging effects in D-galactose aging mouse model显示文摘 | Sung-liang YU Shih-bin LIN Yung-luen Yu Min-hui CHIEN Kuo-jung SU Ching-ju LIN Tzong-der WAY Giou-teng YIANG Chai-ching LIN De-chuan CHAN Horng-jyh HARN Yi-lin Sophia CHEN | 2010 | Acta Pharmacologica Sinica2010，31，12： | 3 |
| 15 | Variable outcome in infantile-onset inflammatory bowel disease in an Asian cohort显示文摘AIM Infantile-onset inflammatory bowel disease(IO-IBD) with the onset of disease before 12 mo of age, is a different disease entity from childhood IBD. We aimed to describe the clinical features, outcome and role of mutation in interleukin-10(IL-10) and interleukin-10 receptors(IL-10R) in Asian children with IO-IBD. METHODS All cases of IO-IBD, defined as onset of disease before 12 mo of age, seen at University Malaya Medical Center, Malaysia were reviewed. We performed mutational analysis for IL10 and IL10 R genes in patients with presenting clinical features of Crohn's disease(CD).RESULTS Six [13%; CD = 3, ulcerative colitis(UC) = 2, IBDunclassified(IBD-U) = 1] of the 48 children(CD = 25; UC = 23) with IBD have IO-IBD. At final review [median(range) duration of follow-up: 6.5(3.0-20) years], three patients were in remission without immunosuppression [one each for post-colostomy(IBD-U), after standard immunosuppression(CD), and after total colectomy(UC)]. Three patients were on immunosuppression:one(UC) was in remission while two(both CD) had persistent disease. As compared with later-onset disease, IO-IBD were more likely to present with bloody diarrhea(100% vs 55%, P = 0.039) but were similar in terms of an associated autoimmune liver disease(0% vs 19%, P = 0.31), requiring biologics therapy(50% vs 36%, P = 0.40), surgery(50% vs 29%, P = 0.27), or achieving remission(50% vs 64%, P = 0.40). No mutations in either IL10 or IL10 R in the three patients with CD and the only patient with IBD-U were identified.CONCLUSION The clinical features of IO-IBD in this Asian cohort of children who were negative for IL-10 or IL-10 R mutations were variable. As compared to childhood IBD with onset of disease after 12 mo of age, IO-IBD achieved remission at a similar rate. | Way Seah Lee Ruey Terng Ng Koon-Wing Chan Yu-Lung Lau | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 16 | Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8^+ T cells during pregnancy显示文摘Listeria monocytogenes (Lm ) 为发展中的胎儿在怀孕和疾病的后果期间是有为全身的母亲的感染的唯一的倾向的一个细胞内部的细菌。给与出生前的 Lm 感染联系的高死亡,为在怀孕的极其脆弱的经期期间扩充保护的免疫的策略着急地被需要。此处,保护由在对随后的剧毒的 Lm 出生前的感染的怀孕被评估以前,管理的稀释 Lm 交谈了。因为显著地更多的细菌从母亲的纸巾被恢复,我们证明对在非怀孕的老鼠的第二等的 Lm 感染的保护严厉地在 allogeneic 怀孕期间被节制,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。更重要地,因为各在怀孕和天真的怀孕控制以前与稀释 Lm 接种的老鼠在怀孕期间在 Lm 感染以后从单个 concepti 显示出近完全的胎儿的再吞和病原体恢复, preconceptual priming 不在 utero 侵略或胎儿的消耗量免于。显著地,对有在 allogeneic 怀孕的 preconceptual priming 的出生前的 Lm 感染的保护的缺乏在 syngeneic 怀孕期间被恢复。因此,母亲胎儿的抗原不和在出生前的 Lm 感染以后对胎儿的复杂并发症支配 preconceptual 种痘的低效率,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。 | Dayna R Clark Vandana Chaturvedi Jeremy M Kinder Tony T Jiang Lijun Xin James M Ertelt Sing Sing Way | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 17 | 液相色谱-紫外-核磁共振-质谱:多信息分离方法(英文)显示文摘The availability of liquid chromatography ultraviolet nuclear magnetic resonance mass spectrometry (LC UV NMR MS)integrated systems is providing greater information content and confidence for a variety of sample types, such asdrug metabolites, natural products, impurities, and degradants. A wide range of experimental strategies can be pur sued,highlighting the flexibility and performance possible with this multihyphenated technique. | Iain Green (Varian, Inc., 3120 Hansen Way, Palo Alto, CA 94303, U.S.A.) | 2003 | 波谱学杂志2003，20，4： | 3 |
| 18 | COMPARISON OF MAX-MIN APPROACH AND NN METHOD FOR RELIABILITY OPTIMIZATION OF SERIES-PARALLEL SYSTEM显示文摘Two heuristics, the max-min approach and the Nakagawa and Nakashima method, are consideredfor the redundancy allocation problem with series-parallel structure. The max-min approach canformulate the problem as an integer linear programming problem instead of an integer nonlinearproblem. This paper presents a comparison between those methods from the standpoint of solutionquality and computational complexity. The experimental results show that the max-min approach issuperior to the Nakagawa and Nakashima method in terms of solution quality in small-scale problems,but analysis of computational complexity shows that the max-min approach is inferior to other greedyheuristics. | Hsiang LEE Way KUO Chunghun HA | 2003 | Systems Science and Systems Engineering2003，12，1： | 2 |
| 19 | Pigment gallstone pathogenesis: Slime production by biliary bacteria is more important than beta-glucuronidase production显示文摘 | Lygia Stewart M.D. Rosio Ponce Adair L. Oesterk J. McLeod Griffiss M.D. Lawrence W. Way M.D | 2000 | Journal of Gastrointestinal Surgery2000，，5： | 2 |
| 20 | The α_Mβ_2 integrin and its role in neutrophil function显示文摘Neutrophils are the first cell type to arrive at the in-jury sites and play a critical role in host defense, by virtueof its ability to adhere and transmigrate through endothe-lium, to phagocytose foreign pathogens, and to producefree oxygen radicals and proteolytic enzymes. Yet, inap-propriate neutrophil activation causes tissue damage andvarious inflammatory diseases. These physiological andpathological functions of neutrophils depend on the en-gagement of certain surface receptors, especially αMβ2,the ma jor β2 integrin receptor present on neutrophil sur-face. Understanding of the molecular mechanisms under-lying ligand binding by αMβ2, as well as the roles of αMβ2-ligand interactions in neutrophil functions will enable usto regulate more precisely neutrophil activities: that is,to promote their host defense functions, and at the sametime to minimize their deleterious effects on normal cells. | ZHANG LI (Department of Vascular Biology, American Red Cross,Holland La6oratory, 15601 Crabbs Branch Way, Rockville,MD 20855 USA)Tel: 301-738-0657 Fax: 301-738-0465e-mail: zhangl@u8a.redcross. org | 1999 | Cell Research1999，9，3： | 2 |
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