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| 1 | Xanthogranulomatous cholecystitis:Difficulty in differentiating from gallbladder cancer显示文摘AIM: To compare cases of xanthogranulomatous cholecystitis(XGC) and advanced gallbladder cancer and discuss the differential diagnoses and surgical options.METHODS: From April 2000 to December 2013, 6 XGC patients received extended surgical resections. During the same period, 16 patients were proven to have gallbladder(GB) cancer, according to extended surgical resection. Subjects chosen for analysis in this study were restricted to cases of XGC with indistinct borders with the liver as it is often difficult to distinguish these patients from those with advanced GB cancer. We compared the clinical features and computed tomography findings between XGC and advanced GB cancer. The following clinical features were retrospectively assessed: age, gender, symptoms, and tumor markers. As albumin and the neutrophil/lymphocyte ratio(NLR) are prognostic in several cancers, we compared serum albumin levels and the NLR between the two groups. The computerized tomography findings were used to compare the two diseases, determine the coexistence of gallstones, the pattern of GB thickening(focal or diffuse), the presence of a hypoattenuated intramural nodule, and continuity of the mucosal line.RESULTS: Based on the preoperative image findings, we suspected GB carcinoma in all cases includingXGC in this series. In addition, by pathological examination, we found that the group of patients with XGC developed inflammatory disease after surgery. Patients with XGC tended to have abdominal pain(4/6, 67%). However, there was no significant difference in clinical symptoms, including fever, between the two groups. Serum albumin and NLR were also similar in the two groups. Serum tumor markers, such as carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9), tended to increase in patients with GB cancer. However, no significant differences in tumor markers were identified. On the other hand, gallstones were more frequently observed in patients with XGC(5/6, 83%) than in patients with GB cancer(4/16, 33%)(P = 0.0116). A hypoattenuated intramural nodule was found in 3 patients with XGC(3/6, 50%), but in only 1 patient with GB cancer(1/16, 6%)(P = 0.0024). The GB thickness, continuous mucosal line, and bile duct dilatation showed no significant differences between XGC and GB cancer.CONCLUSION: Although XGC is often difficult to differentiate from GB carcinoma, it is possible to obtain an accurate diagnosis by careful intraoperative gross observation, and several intraoperative frozen sections. | Hideki Suzuki Satoshi Wada Kenichiro Araki Norio Kubo Akira Watanabe Mariko Tsukagoshi Hiroyuki Kuwano | 2015 | World Journal of Gastroenterology2015，21，35： | 18 |
| 2 | DOG1 is useful for diagnosis of KIT-negative gastrointestinal stromal tumor of stomach显示文摘Approximately 80%-95%of gastrointestinal stromal tumors(GISTs)show positive staining for KIT,while the other 5%-20%show negative staining.If the tumor is negative for KIT,but is positive for CD34,a histological diagnosis is possible.However,if the tumor is negative for KIT,CD34,S-100,and SMA,a definitive diagnosis is often challenging.Recently,Discovered on GIST-1(DOG1)has received considerable attention as a useful molecule for the diagnosis of GIST.DOG1,a membrane channel protein,is known to be overexpressed in GIST.Because the sensitivity and specificity of DOG1 are higher than those of KIT,positive staining for DOG1has been reported,even in KIT-negative GISTs.KITnegative GISTs most commonly arise in the stomach and are mainly characterized by epithelioid features histologically.We describe our experience with a rare case of a KIT-negative GIST of the stomach that was diagnosed by positive immunohistochemical staining for DOG1 in a patient who presented with severe anemia.Our findings suggest that immunohistochemical staining for DOG1,in addition to gene analysis,is useful for the diagnosis of KIT-negative tumors that are suspected to be GISTs. | Takuya Wada Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Myunguchul Kim Wasaburo Koizumi Tetsuo Mikami | 2013 | World Journal of Gastroenterology2013，19，47： | 11 |
| 3 | Delayed perforation after endoscopic submucosal dissection for early gastric cancer: Clinical features and treatment显示文摘Perforation is an important procedural complication of endoscopic submucosal dissection(ESD) for early gastric cancer. Although the incidence of delayed perforation after ESD is low, extreme caution is necessary because many cases require surgical intervention. Among 1984 lesions of early gastric cancer treated in our hospital by ESD in 1588 patients from September 2002 through March 2015, delayed perforation developed in 4 patients(4 lesions, 0.25%). A diagnosis of delayed perforation requires prompt action, including surgical intervention when required. | Takafumi Yano Satoshi Tanabe Kenji Ishido Mizutomo Azuma Takuya Wada Mizuto Suzuki Natsuko Kawanishi Sakiko Yamane Tohru Sasaki Chikatoshi Katada Tetsuo Mikami Natsuya Katada Wasaburo Koizumi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，8： | 4 |
| 4 | Inverted Meckel's diverticulum preoperatively diagnosed using double-balloon enteroscopy显示文摘An inverted Meckel's diverticulum is a rare gastrointestinal congenital anomaly that is difficult to diagnose prior to surgery and presents with anemia, abdominal pain, or intussusception. Here, we report the case of 57-year-old men with an inverted Meckel's diverticulum, who was preoperatively diagnosed using doubleballoon enteroscopy. He had repeatedly experienced epigastric pain for 2 mo. Ultrasonography and computed tomography showed intestinal wall thickening in the pelvis. Double-balloon enteroscopy via the anal route was performed for further examination, which demonstrated an approximately 8-cm, sausage-shaped, submucosal tumor located approximately 80 cm proximal to the ileocecal valve. A small depressed erosion was observed at the tip of this lesion. Forceps biopsy revealed heterotopic gastric mucosa. Thus, the patient was diagnosed with an inverted Meckel's diverticulum, and single-incision laparoscopic surgery was performed. This case suggests that an inverted Meckel's diverticulum should be considered as a differential diagnosis for a submucosal tumor in the ileum. Balloon-assisted enteroscopy with forceps biopsy facilitate a precise diagnosis of this condition. | Kosuke Takagaki Satoshi Osawa Tatsuhiro Ito Moriya Iwaizumi Yasushi Hamaya Hiroe Tsukui Takahisa Furuta Hidetoshi Wada Satoshi Baba Ken Sugimoto | 2016 | World Journal of Gastroenterology2016，22，17： | 2 |
| 5 | Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment显示文摘 | Satoshi Kondo Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Kazuhiro Tsukada Masato Nagino Junji Furuse Hiroya Saito Toshio Tsuyuguchi Masakazu Yamamoto Masato Kayahara Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Satoshi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 2 |
| 6 | Diagnosis of biliary tract and ampullary carcinomas显示文摘 | Kazuhiro Tsukada Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Masato Nagino Satoshi Kondo Junji Furuse Hiroya Saito Toshio Tsuyuguchi Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Hodaka Amano Fumihiko Miura | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 1 |
| 7 | Inhibition of Tumor Growth with Antiangiogenic Cancer Vaccine Using Epitope Peptides Derived from Human Vascular Endothelial Growth Factor Receptor 1显示文摘 | Hidenobu Ishizaki Takuya Tsunoda Satoshi Wada | 2006 | Clin Cancer Res2006，12，19： | 1 |
| 8 | Expert consensus for the treatment of disseminated intravascular coagulation in Japan显示文摘 | Hideo Wada Hidesaku Asakura Kohji Okamoto Toshiaki Iba Toshimasa Uchiyama Kazuo Kawasugi Shin Koga Toshihiko Mayumi Kaoru Koike Satoshi Gando Shigeki Kushimoto Yoshinobu Seki Seiji Madoiwa Ikuro Maruyama Akira Yoshioka | 2009 | Thrombosis Research2009，，1： | 1 |
| 9 | Synthesis of aliphatic polyester by insertion of glycols into polyanhydrides using lipocatalyst 显示文摘 | Hiroshi Yyama Satoshi Wada Shiro Kobayashi | 1999 | Chemistry Letters1999，04，： | 1 |
| 10 | Diagnosis of deep vein thrombosis by plasma solute fibrin or D-dimer显示文摘 | Satoshi Ota Hiedo Wada | 2005 | American Journal of Hematology2005，，： | 1 |
| 11 | Nucleotide excision repair gene polymorphisms may predict acute toxicity in patients treated with chemoradiotherapy for bladder cancer显示文摘 | Shigeru Sakano Yuji Hinoda Miwa Sasaki Takashi Wada Hiroaki Matsumoto Satoshi Eguchi Asano Shinohara Yoshihisa Kawai Tomohiko Hara Kazuhiro Nagao Takahiko Hara Katsusuke Naito Hideyasu Matsuyama | 2010 | Pharmacogenomics2010，，10： | 1 |
| 12 | SIVELESTAT (SELECTIVE NEUTROPHIL ELASTASE INHIBITOR) IMPROVES THE MORTALITY RATE OF SEPSIS ASSOCIATED WITH BOTH ACUTE RESPIRATORY DISTRESS SYNDROME AND DISSEMINATED INTRAVASCULAR COAGULATION PATIENTS显示文摘 | Mineji Hayakawa Kenichi Katabami Takeshi Wada Masahiro Sugano Hirokatsu Hoshino Atsushi Sawamura Satoshi Gando | 2010 | Shock2010，，1： | 1 |
| 13 | Highly Sensitive UV Photodetectors Fabricated Using High- Quality Single-Crystalline CVD Diamond Films显示文摘 | Tokuyuki Teraji Satoshi Yoshizaki Hideki Wada | 2004 | Diamond and Related Materials2004，13，5： | 1 |
| 14 | Detection Of Bone-Type AldalinePhosphatase By Monoclonal Antibodies Reacting With Human Osteosarcoma-AssociatedAntigen显示文摘 | Satoshi Nagoya Toshimitsu Uede Takuro Wada | 1991 | Jpn J Cancer Res1991，82，： | 1 |
| 15 | Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia显示文摘 | Kosei Ishidal Satoshi Ito Naoyuki Wada | 2007 | Molecular Cancer2007，6，62： | 1 |
| 16 | The Relationship Between the Anatomy of the Nuchal Ligament and Postoperative Axial Pain After Cervical Laminoplasty: Cadaver and Clinical Study显示文摘 | Atsushi Ono Yoshikazu Tonosaki Takuya Numasawa Kanichiro Wada Yoshihito Yamasaki Toshihiro Tanaka Gentaro Kumagai Shuichi Aburakawa Kazunari Takeuchi Toru Yokoyama Kazumasa Ueyama Yasuyuki Ishibashi Satoshi Toh | 2012 | Spine2012，，26： | 1 |
| 17 | Stenting and interventional radiology for obstructive jaundice in patients with unresectable biliary tract carcinomas显示文摘 | Toshio Tsuyuguchi Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Kazuhiro Tsukada Masato Nagino Satoshi Kondo Junji Furuse Hiroya Saito Masafumi Suyama Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Hodaka Amano Fumihiko Miur | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 1 |
| 18 | Genomic Structure of the Canalicular Multispecific Organic Anion–Transporter Gene ( MRP2/cMOAT ) and Mutations in the ATP-Binding–Cassette Region in Dubin-Johnson Syndrome显示文摘 | Satoshi Toh Morimasa Wada Takeshi Uchiumi Akihiko Inokuchi Yoshinari Makino Yutaka Horie Yukihiko Adachi Shotaro Sakisaka Michihiko Kuwano | 1999 | The American Journal of Human Genetics1999，，3： | 1 |
| 19 | Isolation of a Novel Human Canalicular Multispecific Organic Anion Transporter, cMOAT2/MRP3, and Its Expression in Cisplatin-Resistant Cancer Cells with Decreased ATP-Dependent Drug Transport显示文摘 | Takeshi Uchiumi Eiji Hinoshita Sei Haga Takanori Nakamura Toshiya Tanaka Satoshi Toh Manabu Furukawa Takeshi Kawabe Morimasa Wada Kazuhiro Kagotani Katsuzumi Okumura Kimitoshi Kohno Shin-ichi Akiyama Michihiko Kuwano | 1998 | Biochemical and Biophysical Research Communications1998，，1： | 1 |
| 20 | Broken symmetry in low-temperature BaTiO3 phases:Strain effects probed by Raman scattering显示文摘 | Minoru Osada Masato Kakihana Satoshi Wada | 1999 | Appl Phys Lett1999，75，21： | 1 |
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