|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | DOG1 is useful for diagnosis of KIT-negative gastrointestinal stromal tumor of stomach显示文摘Approximately 80%-95%of gastrointestinal stromal tumors(GISTs)show positive staining for KIT,while the other 5%-20%show negative staining.If the tumor is negative for KIT,but is positive for CD34,a histological diagnosis is possible.However,if the tumor is negative for KIT,CD34,S-100,and SMA,a definitive diagnosis is often challenging.Recently,Discovered on GIST-1(DOG1)has received considerable attention as a useful molecule for the diagnosis of GIST.DOG1,a membrane channel protein,is known to be overexpressed in GIST.Because the sensitivity and specificity of DOG1 are higher than those of KIT,positive staining for DOG1has been reported,even in KIT-negative GISTs.KITnegative GISTs most commonly arise in the stomach and are mainly characterized by epithelioid features histologically.We describe our experience with a rare case of a KIT-negative GIST of the stomach that was diagnosed by positive immunohistochemical staining for DOG1 in a patient who presented with severe anemia.Our findings suggest that immunohistochemical staining for DOG1,in addition to gene analysis,is useful for the diagnosis of KIT-negative tumors that are suspected to be GISTs. | Takuya Wada Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Myunguchul Kim Wasaburo Koizumi Tetsuo Mikami | 2013 | World Journal of Gastroenterology2013，19，47： | 11 |
| 2 | Delayed perforation after endoscopic submucosal dissection for early gastric cancer: Clinical features and treatment显示文摘Perforation is an important procedural complication of endoscopic submucosal dissection(ESD) for early gastric cancer. Although the incidence of delayed perforation after ESD is low, extreme caution is necessary because many cases require surgical intervention. Among 1984 lesions of early gastric cancer treated in our hospital by ESD in 1588 patients from September 2002 through March 2015, delayed perforation developed in 4 patients(4 lesions, 0.25%). A diagnosis of delayed perforation requires prompt action, including surgical intervention when required. | Takafumi Yano Satoshi Tanabe Kenji Ishido Mizutomo Azuma Takuya Wada Mizuto Suzuki Natsuko Kawanishi Sakiko Yamane Tohru Sasaki Chikatoshi Katada Tetsuo Mikami Natsuya Katada Wasaburo Koizumi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，8： | 4 |
| 3 | Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication显示文摘AIM To clarify the association between aldo-keto reductase family 1 member B10(AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus eradication.METHODS In this study,we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response(SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios(HRs) of AKR1B10 expression for hepatocellular carcinoma(HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank test.RESULTS Of the 303 chronic hepatitis C patients,153(50.5%) showed scarce hepatic AKR1B10 expression,quantified as 0%,which was similar to the expression in control normal liver tissues. However,the remaining 150 patients(49.5%) exhibited various degrees of AKR1B10 expression in the liver,with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years(range 1.0-10.0 years),8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression(≥ 8%) was an independent risk factor for HCC development(HR = 15.4,95%CI: 1. 8- 1 3 2. 5,P = 0. 0 1 2). T h e 5- y e a r c u m u l a t i v e incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression,respectively(P < 0.001). During the follow-up period after viral eradication,patients expressing high levels of AKR1B10 expressed markedly higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 expression.CONCLUSION Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR. | Ayato Murata Takuya Genda Takafumi Ichida Nozomi Amano Sho Sato Hironori Tsuzura Shunsuke Sato Yutaka Narita Yoshio Kanemitsu Yuji Shimada Katsuharu Hirano Katsuyori Iijima Ryo Wada Akihito Nagahara Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，33： | 2 |
| 4 | A two-stage operation for thoracic esophageal cancer: esophagectomy and subsequent reconstruction by a free jejunal flap显示文摘 | Yasuhiro Okumura Kazuhiko Mori Yukinori Yamagata Takashi Fukuda Ikuo Wada Nobuyuki Shimizu Sachiyo Nomura Takuya Iida Makoto Mihara Yasuyuki Seto | 2014 | Surgery Today2014，，2： | 1 |
| 5 | Inhibition of Tumor Growth with Antiangiogenic Cancer Vaccine Using Epitope Peptides Derived from Human Vascular Endothelial Growth Factor Receptor 1显示文摘 | Hidenobu Ishizaki Takuya Tsunoda Satoshi Wada | 2006 | Clin Cancer Res2006，12，19： | 1 |
| 6 | Up‐regulated aldo‐keto reductase family 1 member B10 in chronic hepatitis C: association with serum alpha‐fetoprotein and hepatocellular carcinoma显示文摘 | Shunsuke Sato Takuya Genda Katsuharu Hirano Hironori Tsuzura Yutaka Narita Yoshio Kanemitsu Tetsu Kikuchi Katsuyori Iijima Ryo Wada Takafumi Ichida | 2012 | Liver Int2012，，9： | 1 |
| 7 | The Relationship Between the Anatomy of the Nuchal Ligament and Postoperative Axial Pain After Cervical Laminoplasty: Cadaver and Clinical Study显示文摘 | Atsushi Ono Yoshikazu Tonosaki Takuya Numasawa Kanichiro Wada Yoshihito Yamasaki Toshihiro Tanaka Gentaro Kumagai Shuichi Aburakawa Kazunari Takeuchi Toru Yokoyama Kazumasa Ueyama Yasuyuki Ishibashi Satoshi Toh | 2012 | Spine2012，，26： | 1 |
| 8 | Inhibition of Glioma Cell Proliferation by Neural Stem Cell Factor显示文摘 | Tsuyoshi Suzuki Shuichi Izumoto Kouichi Wada Yasunori Fujimoto Motohiko Maruno Mami Yamasaki Yonehiro Kanemura Takuya Shimazaki Hideyuki Okano Toshiki Yoshimine | 2005 | Journal of Neuro - Oncology2005，，3： | 1 |
| 9 | Genetic Differences in the Osteogenic Differentiation Potency According to the Classification of Ossification of the Posterior Longitudinal Ligament of the Cervical Spine显示文摘 | Hitoshi Kudo Ken-Ichi Furukawa Toru Yokoyama Atsushi Ono Takuya Numasawa Kanichiro Wada Sunao Tanaka Toru Asari Kazumasa Ueyama Shigeru Motomura Satoshi Toh | 2011 | Spine2011，，12： | 1 |
| 10 | Spinal Cord Shift on Magnetic Resonance Imaging at 24 Hours After Cervical Laminoplasty显示文摘 | Takashi Shiozaki Hironori Otsuka Yoshihiro Nakata Toru Yokoyama Kazunari Takeuchi Atsushi Ono Takuya Numasawa Kanichiro Wada Satoshi Toh | 2009 | Spine2009，，3： | 1 |
| 11 | Clinicopathological Features of Recurrence in Patients After 10-year Disease-free Survival Following Curative Hepatic Resection of Hepatocellular Carcinoma显示文摘 | Masaki Kaibori Shoji Kubo Hiroaki Nagano Michihiro Hayashi Seiji Haji Takuya Nakai Morihiko Ishizaki Kosuke Matsui Takahiro Uenishi Shigekazu Takemura Hiroshi Wada Shigeru Marubashi Koji Komeda Fumitoshi Hirokawa Yasuyuki Nakata Kazuhisa Uchiyama A-Hon Kw | 2013 | World Journal of Surgery2013，，4： | 1 |
| 12 | Surgical Anatomy of the Nuchal Muscles in the Posterior Cervicothoracic Junction: Significance of the Preservation of the C7 Spinous Process in Cervical Laminoplasty显示文摘 | Atsushi Ono Yoshikazu Tonosaki Toru Yokoyama Shuichi Aburakawa Kazunari Takeuchi Takuya Numasawa Kanichiro Wada Takashi Kachi Satoshi Toh | 2008 | Spine2008，，11： | 1 |
| 13 | Limitation of activities of daily living accompanying reduced neck mobility after laminoplasty preserving or reattaching the semispinalis cervicis into axis显示文摘 | Kazunari Takeuchi Toru Yokoyama Atsushi Ono Takuya Numasawa Kanichiro Wada Taito Itabashi Satoshi Toh | 2008 | European Spine Journal2008，，3： | 1 |
| 14 | Prediction of liver stiffness hepatocellular carcinoma in chronic hepatitis C patients on interferon‐based anti‐viral therapy显示文摘 | Yutaka Narita Takuya Genda Hironori Tsuzura Shunsuke Sato Yoshio Kanemitsu Sachiko Ishikawa Tetsu Kikuchi Katsuharu Hirano Katsuyori Iijima Ryo Wada Takafumi Ichida | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 15 | Simple Foot Tapping Test as a Quantitative Objective Assessment of Cervical Myelopathy显示文摘 | Takuya Numasawa Atsushi Ono Kanichiro Wada | 2012 | Spine2012，37，： | 1 |
| 16 | Improvement of a Real Gas-Sensor for the Origin of Methane Selectivity Degradation by l-XAFS Investigation显示文摘We have directly investigated the chemical state of the Pd species in a real l-gas sensor device by examining the l-fluorescence X-ray absorption fine structure. The l-gas sensor device was heavily damaged by a heating process in which the temperature was ill-controlled, resulting in decrease of methane selectivity. We found that the Pd O in the fresh l-gas sensor was reduced to Pd metal particles as the methane selectivity decreased. Based on the investigation results, we modified the device structure so as to heat up homogeneously. The lifetime of the sensor was then successfully increased by more than 5 years. | Takahiro Wada Naoyoshi Murata Takuya Suzuki Hiromitsu Uehara Hiroaki Nitani Yasuhiro Niwa Motohiro Uo Kiyotaka Asakura | 2015 | Nano-Micro Letters2015，7，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员