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| 1 | Generation of insulin-producing β-like cells from human iPS cells in a defined and completely xeno-free culture system显示文摘因为他们的区别能力,人的导致的 pluripotent 茎(臀部) 细胞为生产胰岛素的胰腺的细胞的产生被认为潜在的来源。在这研究,我们开发了一个五步的 xeno 免费的文化系统高效地在 vitro 区分臀部房间进生产胰岛素的房间。我们发现高少量集中为明确地首先导致区别进胰腺、十二指肠的 homeobox-1 (PDX1 ) 是关键的积极胰腺的祖先然后进 neurogenin 3 (NGN3 ) 表示胰腺的内分泌的祖先,当压制区别进肝或肠的房间时。我们也发现 3-isobutyl-1-methylxanthine (IBMX ) 的联合, exendin-4,和菸碱为进胰岛素的区别是重要的表示了各种各样的胰腺的房间标记的单人赛积极的房间。最尤其是,区分的房间包含了响应各种各样的胰岛素促泌素和葡萄糖的高水平被释放的内长的 C 肽水池。因此,我们的结果表明在 xeno 免费的条件下面产生导出臀部的胰腺的房间的可行性并且加亮他们的潜力与类型 1 糖尿病对待病人。 | Hussain Md. Shahjalal Nobuaki Shiraki Daisuke Sakano Kazuhide Kikawa Soichiro Ogaki Hideo Baba Kazuhiko Kume Shoen Kume | 2014 | Journal of Molecular Cell Biology2014，8，5： | 6 |
| 2 | Neural network reactive force field for C,H,N,and O systems显示文摘Reactive force fields have enabled an atomic level description of a wide range of phenomena,from chemistry at extreme conditions to the operation of electrochemical devices and catalysis.While significant insight and semi-quantitative understanding have been drawn from such work,the accuracy of reactive force fields limits quantitative predictions.We developed a neural network reactive force field(NNRF)for CHNO systems to describe the decomposition and reaction of the high-energy nitramine 1,3,5-trinitroperhydro-1,3,5-triazine(RDX).NNRF was trained using energies and forces of a total of 3100 molecules(11,941 geometries)and 15 condensed matter systems(32,973 geometries)obtained from density functional theory calculations with semi-empirical corrections to dispersion interactions.The training set is generated via a semi-automated iterative procedure that enables refinement of the NNRF until a desired accuracy is attained.The root mean square(RMS)error of NNRF on a testing set of configurations describing the reaction of RDX is one order of magnitude lower than current state of the art potentials. | Pilsun Yoo Michael Sakano Saaketh Desai Md Mahbubul Islam Peilin Liao Alejandro Strachan | 2021 | npj Computational Materials2021，，1： | 3 |
| 3 | The Exercise of Interfirm Power and Its Repercussions in U S - Japanese Channel Relationships 显示文摘 | Johnson J L Sakano | 1993 | Journal of Marketing1993，，： | 1 |
| 4 | The EBV action in tonsils and adenoids显示文摘 | ENDO L H SAKANO E CAMARGO L A | 2003 | Int Congress Series2003，1257，： | 1 |
| 5 | Primary retroperitoneal pure choriocarcinoma显示文摘 | Okubo Y Fukui I Sakano Y | 1995 | Nippon Hinyokika Gakkai Zasshi1995，86，12： | 1 |
| 6 | Genes encoding small heat shock protein of the silkworm(Bomby,x mot/) 显示文摘 | Sakano D Li B Xia Q Y | 2006 | Bioseience Biotechnolo- gy Biochemistry2006，70，： | 1 |
| 7 | Biological reaction to a- lumina, zirconia, titanium and polyethylene particles implanted onto murine calvaria显示文摘 | Warashina H Sakano S Kitamura S | 2003 | Biomaterials2003，24，21： | 1 |
| 8 | Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage 显示文摘 | Sakano K Oikawa S Hiraku Y | 2002 | Free Radical Biology and Medicine2002，33，5： | 1 |
| 9 | De tection of Epstein-Barr virus and subsets of lymphoid cells in adenoid tissue of children under 2 years of age显示文摘 | ENDO L H VASSALLO J SAKANO E | 2002 | Int J Pediatr Otorhinolaryngol2002，66，： | 1 |
| 10 | The exercise of interfirm power and its repercussions in US-Japanese channel rela- tionships显示文摘 | Johnson J L Sakano T Cote J A | 1993 | Journal of Marketing1993，57，2： | 1 |
| 11 | Pedicle bone grafting versus transtrochanteric rotational osteotomy for avascular necrosis of the femoral head显示文摘 | Hasegawa Y Sakano S lwase T | 2003 | J Bone Joint Surg Br2003，85，： | 1 |
| 12 | A structural equations analysis of revealed and stated travel mode and activity choices显示文摘 | SAKANO R BENJAMIN J M | 2008 | Transportmetrica2008，4，2： | 1 |
| 13 | Exercise-induced acute renal failure with renal hypouricemia:a case report and a review of the literature显示文摘 | Ohta T Sakano T Ogawa T | 2002 | Clin Nephrol2002，58，： | 1 |
| 14 | Genes encoding small heat shock protein of the silkworm 显示文摘 | Sakano D Li B Xia Q Y | 2006 | Bomience Biotechnolo- Biochemis- try2006，70，： | 1 |
| 15 | Exercise-induced acute renal failure associated with renal hypouricaemia:results of a questionnaire-based survey in Japan显示文摘 | Toshiyuki Ohta Takashi Sakano Takashi Igarashi | 2004 | Nephrology Dialysis Transplantation2004，19，： | 1 |
| 16 | Success through Commitment and Trust : The Soft Side of Strategic Alliance Management 显示文摘 | Cullen J B Johnson J L Sakano T | 2000 | Journal of World Business2000，35，： | 1 |
| 17 | Video-assisted thora- coscopic surgery for intralobar pulmonary sequestration 显示文摘 | Tanaka T Ueda K Sakano H | 2003 | Surgery2003，133，2： | 1 |
| 18 | Polymorphisms in DNA repair and metabolic genes in bladder cancer 显示文摘 | Sanyal S Festa F Sakano S | 2004 | Carcinogenesis2004，25，5： | 1 |
| 19 | Polymorphisms in DNA repair and metabolic genes in bladder cancer显示文摘 | Sanyal S Festa F Sakano S | 2004 | Carcinogenesis2004，25，5： | 1 |
| 20 | Revision of biochemical pH-stat: Involvement of alternative pathway metabolism显示文摘 | SAKANO K | 1998 | Plant and Cell Physiology1998，39，5： | 1 |
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