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| 1 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 2 | Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy: a single center study显示文摘 | Yukio Osaki Yoshihide Ueda Hiroyuki Marusawa Jun Nakajima Toru Kimura Ryuichi Kita Hiroki Nishikawa Sumio Saito Shinichiro Henmi Azusa Sakamoto Yuji Eso Tsutomu Chiba | 2012 | Journal of Gastroenterology2012，，4： | 3 |
| 3 | Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells显示文摘 | Makiko Takada Michiro Otaka Taiji Takahashi Yuko Izumi Kumiko Tamaki Tomoyoshi Shibuya Naoto Sakamoto Taro Osada Sou Yamamoto Ryuichi Ishida Masaru Odashima Hideaki Itoh Sumio Watanabe | 2010 | Life Sciences2010，，13： | 2 |
| 4 | Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment显示文摘 | Kazuma Fujimoto Mitsuhiro Fujishiro Mototsugu Kato Kazuhide Higuchi Ryuichi Iwakiri Choitsu Sakamoto Shinichiro Uchiyama Atsunori Kashiwagi Hisao Ogawa Kazunari Murakami Tetsuya Mine Junji Yoshino Yoshikazu Kinoshita Masao Ichinose Toshiyuki Matsui | 2014 | Digestive Endoscopy2014，，： | 2 |
| 5 | Construction of PC-based intelligent CAD system for cold forging process design-integration of CAD system and development of input method 显示文摘 | Souji Sakamoto Tsutao Katayama Ryuichi Yokogawa Takahiro Kimura | 2001 | Journal of Materials Processing Technology2001，119，13： | 1 |
| 6 | Construction of PC-based intelligent CAD system for cold forging process design-integration of CAD system and development of input method显示文摘 | Sakamoto Souji Katayama Tsutao Yokogawa Ryuichi | 2001 | Journal of Materials Processing Technology2001，119，： | 1 |
| 7 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 8 | Conformal radiation therapy for portal vein tumor thrombosis of hepatocellular carcinoma显示文摘 | Ryo Toya Ryuji Murakami Yuji Baba Ryuichi Nishimura Shoji Morishita Osamu Ikeda Koichi Kawanaka Toru Beppu Shinichi Sugiyama Takashi Sakamoto Yasuyuki Yamashita Natsuo Oya | 2007 | Radiotherapy and Oncology2007，，3： | 1 |
| 9 | p53 immunohistochemical expression and patient prognosis in esophageal squamous cell carcinoma显示文摘 | Asuka Murata Yoshifumi Baba Masayuki Watanabe Hironobu Shigaki Keisuke Miyake Ryuichi Karashima Yu Imamura Satoshi Ida Takatsugu Ishimoto Shiro Iwagami Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Hideo Baba | 2013 | Medical Oncology2013，，4： | 1 |
| 10 | Suppression of autophagy by CUB domain‐containing protein 1 signaling is essential for anchorage‐independent survival of lung cancer cells显示文摘 | Takamasa Uekita Satoko Fujii Yuri Miyazawa Akinori Hashiguchi Hitosi Abe Michiie Sakamoto Ryuichi Sakai | 2013 | Cancer Sci2013，，7： | 1 |
| 11 | Effect of treatment with branched‐chain amino acids during sorafenib therapy for unresectable hepatocellular carcinoma显示文摘 | Haruhiko Takeda Hiroki Nishikawa Eriko Iguchi Yoshiaki Ohara Azusa Sakamoto Sumio Saito Norihiro Nishijima Akihiro Nasu Hideyuki Komekado Ryuichi Kita Toru Kimura Yukio Osaki | 2014 | Hepatol Res2014，，3： | 1 |
| 12 | Construction of PC- based intelligent CAD system for cold forging process design-integration of CAD system and development of input method 显示文摘 | Souji Sakamoto Tsutao Katayama Ryuichi Yok ogawa Takahiro Kimura | 2001 | Journal of Materials Processing Technology2001，119，13： | 1 |
| 13 | Medical Markup Language (MML) for XML-based Hospital Information Interchange显示文摘 | Kenji Araki Katsuhiro Ohashi Shunji Yamazaki Yasuyuki Hirose Yoshinori Yamashita M.D. Ryuichi Yamamoto Kazushi Minagawa Norihiro Sakamoto Hiroyuki Yoshihara | 2000 | Journal of Medical Systems2000，，3： | 1 |
| 14 | p53 immunohistochemical expression and patient prognosis in esophageal squamous cell carcinoma显示文摘 | Asuka Murata Yoshifumi Baba Masayuki Watanabe Hironobu Shigaki Keisuke Miyake Ryuichi Karashima Yu Imamura Satoshi Ida Takatsugu Ishimoto Shiro Iwagami Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Hideo Baba | 2013 | Medical Oncology2013，，4： | 1 |
| 15 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 16 | Observation of Impurity Accumulation After Hydrogen Multi-Pellet Injection in Large Helical Device显示文摘Impurity accumulation is studied for neutral beam-heated discharges after hydrogen multi-pellet injection in Large Helical Device (LHD).Iron density profiles are derived from radial profiles of EUV line emissions of FeXV-XXIV with the help of the collisional-radiative model.A peaked density profile of Fe23+ is simulated by using one-dimensional impurity transport code.The result indicates a large inward velocity of -6m/s at the impurity accumulation phase.However,the discharge is not entirely affected by the impurity accumulation,since the concentration of iron impurity,estimated to be 3.3×10-5 to the electron density,is considerably small.On the other hand,a flat profile is observed for the carbon density of C6+,which is derived from the Z eff profile,indicating a small inward velocity of -1m/s.These results suggest atomic number dependence in the impurity accumulation of LHD,which is similar to the tokamak result. | 董春凤 Shigeru MORITA Motoshi GOTO 王二辉 Gen MOTOJIAMA Izumi MURAKAMI Ryuichi SAKAMOTO Norimasa YAMAMOTO | 2013 | Plasma Science and Technology2013，15，3： | 0 |
| 17 | Improvement of Plasma Performance Using Carbon Pellet Injection in Large Helical Device显示文摘 | Shigeru MORITA Motoshi GOTO Kenichi NAGAOKA Chunfeng DONG Hangyu ZHOU Zhengying CUI Yunbo DONC Xiang GAO TKatsumi IDA Katsunori IKED Osamu KANEKO Shiyao LIN Haruhisa NAKANO Masaki OSAKABE Ryuichi SAKAMOTO Yasuhiko TAKEIRI Ang TI Katsuyoshi TSUMORI Mikiro YOSHINUMA LHD experiment group | 2011 | Plasma Science and Technology2011，13，3： | 0 |
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