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| 1 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 2 | Dynamical model of HEV with two planetary gear units and its application to optimization of energy consumption显示文摘A hybrid electric vehicle(HEV) that uses multiple planetary gear units with clutches as transmission system is advanced for the powertrain performance, because the operation of the clutches can lead to distinct operating modes, and the induced possible operating modes provide additional freedom to deal with the energy optimal control problem. Under each operating mode, the powertrain mechanical system has specific dynamical behavior. In order to develop model-based optimization schemes that can tackle the transient operations of the vehicle, exact dynamical modeling is investigated focusing on a hybrid powertrain system that uses a two-planetary-gear transmission box with two clutches. It shows that according to the states of the two clutches, the powertrain system has the power-split mode, parallel mode and the electric vehicle(EV) mode. Finally, an analysis for the calculation of the desired driving torque and its application to the dynamic programming(DP)-based energy management indicate the significance of the developed exact dynamical models. | Jiangyan ZHANG Shota INUZUKA Takafumi KOJIMA Tielong SHEN Junichi KAKO | 2019 | Science China(Information Sciences)2019，62，12： | 2 |
| 3 | Accumulation of Somatic Mutations in TP53 in Gastric Epithelium with Helicobacter pylori infection显示文摘 | Takahiro Shimizu Hiroyuki Marusawa Yuko Matsumoto Tadashi Inuzuka Atsuyuki Ikeda Yosuke Fujii Sachiko Minamiguchi Shin’ichi Miyamoto Tadayuki Kou Yoshiharu Sakai Jean E. Crabtree Tsutomu Chiba | 2014 | Gastroenterology2014，，： | 2 |
| 4 | Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated with cell cycle in mammalian cells remains elusive.Here,we report that mammalian cells predominantly utilize the tricarboxylic acid(TCA)cycle in G1 phase,but prefer glycolysis in S phase.Mechanistically,coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2,key TCA cycle enzymes,in a Skp2-dependent manner.As such,depleting SKP2 abolishes cell cycle-dependent fluctuation of IDH1 protein abundance,leading to reduced glycolysis in S phase.Furthermore,elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.Therefore,our study reveals a mechanistic link between two cancer hallmarks,aberrant cell cycle and addiction to glycolysis,and provides the underlying mechanism for the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells. | Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 2 |
| 5 | Basic fibroblast growth factor regulates proliferation and motility of human hepatoma cells by an autocrine mechanism显示文摘 | Motoaki Kin Michio Sata Takato Ueno Takuji Torimura Sadataka Inuzuka Riko Tsuji Kodo Sujaku Masaharu Sakamoto Hiroshi Sugawara Seisyu Tamaki Kyuichi Tanikawa | 1997 | Journal of Hepatology1997，，4： | 2 |
| 6 | Donor-specific blood transfusion prolongs cardiac allograft survival in rats by low nitric oxide production and elevated serum levels of prostaglandin E2显示文摘 | Inuzuka S Koga S Nishikido M | 2002 | Immunol Lett2002，83，2： | 1 |
| 7 | Decreased ex- pression of apelin in placentas from severe pre - eelampsia patients 显示文摘 | INUZUKA H NISHIZAWA H INAGAKI A | 2013 | Hypertens Pregnancy2013，32，4： | 1 |
| 8 | LM03 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in nenrohlastoma显示文摘 | Aoyama M Ozaki H Inuzuka D | 2005 | Cancer Res2005，65，11： | 1 |
| 9 | Surgically amenable epilepsies in children and adolescents:clinical,imaging,electrophysiological,and post-surgical outcome data显示文摘 | Fernandes RMF Inuzuka LM | 2005 | Child Nerv Syst2005，21，： | 1 |
| 10 | A sensitive ELISA for the characterization of two forms of circulating intercellular adhesion molecule-1 in human plasmas显示文摘 | Inuzuka H Seit T Okamoto K | 1995 | Biol Pharm Bull1995，18，： | 1 |
| 11 | Epitaxial growth of diamond thin films on cubic boron nitride {111}surfaces by dc plasma chemical vapor deposition显示文摘 | Koizumi S Murakami T Inuzuka T | 1990 | Appl Phys Lett1990，57，6： | 1 |
| 12 | Transcriptional regulation of nuclear orphan receptor,NOR-1,by Ca(2 +)/calmodulin-dependent protein kinase cascade显示文摘 | Inuzuka H Tokumitsu H Ohkura N | 2002 | FEBS Lett2002，522，13： | 1 |
| 13 | Role of IFN regulatory factor 5transcription factor in antiviral immunity and tumor suppression显示文摘 | Yanai H Chen H Inuzuka T | 2007 | Proc Nat Acad Sci USA2007，104，9： | 1 |
| 14 | Remarkable effect of gefitinib retreatment in a patient with nonsmall cell lung cancer who had a complete response to initial gefitinib 显示文摘 | Yoshimoto A Inuzuka K Kita T | 2007 | Am J bled Sci2007，333，4： | 1 |
| 15 | Marked asymmetry of putaminal pathology in an MSA-P patient with Pisa syndrome显示文摘 | HOZUMI I PIAO Y S INUZUKA T | 2004 | Mov Disord2004，19，4： | 1 |
| 16 | Sinl phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis 显示文摘 | Liu P Gan W Inuzuka H | 2013 | Nat Cell Biol2013，15，11： | 1 |
| 17 | Significance of coexpression of urokinase-type plasminogen activator, and matrix metalloproteinase 3 (stromelysin) and 9 (gelatinase B) in colorectal carcinoma显示文摘 | Inuzuka K Ogata Y Nagase H | 2000 | J Surg Res2000，93，2： | 1 |
| 18 | Identification of a novel splice variant of the human anti-apoptopsis gene survivin显示文摘 | Adel Badran Akira Yoshida Keiko Ishikawa Takanori Goi Akio Yamaguchi Takanori Ueda Manabu Inuzuka | 2003 | Biochemical and Biophysical Research Communications2003，，3： | 1 |
| 19 | Phosphorylation by Aktl promotes cytoplasmic localization of Skp2 and impairs APC-Cdhl -mediated Skp2 destruction 显示文摘 | Gao D Inuzuka H Tseng A | 2009 | Nat Cell Biol2009，11，4： | 1 |
| 20 | Cytotoxic T lymphocyte-mediated cell death in paraneoplastic sensory neuronopathy with anti-Hu antibody显示文摘 | Tanaka M Inuzuka T | 1999 | J Neurol Sci1999，163，2： | 1 |
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