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| 1 | 应用表观扩散系数进行星形细胞肿瘤分级:单参数法与双参数法优越性的比较显示文摘目的评估MRI中应用最小表观扩散系数(ADCs),NADC差值进行星形细胞肿瘤分级的实用性。方法医院的伦理审查委员会通过了该项回顾性研究并免除了知情同意书。本研究评估了50例(23例男性,27例女性;平均年龄53岁)新确诊的星形细胞肿瘤病人。2名不了解临床信息的观察者.独立对肿瘤伴或不伴对比增强的实质部分手工设置3~5个感兴趣区(40~60mm^2),进行测量并计算其平均ADCs。选定ADCs的最大及最小值,并计算其间差值即ADC差值。 | R. Murakami T.Hirai T.Sugahara H. Fukuoka R. Toya S. Nishimura 关祥祯(译) 张雪宁(校) | 2009 | 国际医学放射学杂志2009，32，4： | 29 |
| 2 | Long‐term outcomes of endoscopic submucosal dissection for early gastric cancer: A single‐center retrospective study显示文摘 | Takashi Kosaka Masaki Endo Yosuke Toya Yukito Abiko Norihiko Kudara Masaaki Inomata Toshimi Chiba Yasuhiro Takikawa Kazuyuki Suzuki Tamotsu Sugai | 2014 | Digestive Endoscopy2014，，2： | 4 |
| 3 | Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer显示文摘AIM: To investigate the clinical significance of BMP and activin membrane-bound inhibitor (BAMBI) which is a pseudoreceptor of transforming growth factor-beta (TGF-β) type Ⅰreceptors and acts as a negative regulator of TGF-β signaling and expression aberrantly elevated in colorectal cancers (CRCs). We studied BAMBI expression in CRCs. METHODS: We studied BAMBI expression in 183 surgically resected CRCs by immunochemical and immunoblotting analyses using a generated monoclonal anti-BAMBI antibody. Commercially available anti-β-catenin and anti-p53 antibodies were also applied for immunochemical analyses as a comparison control.RESULTS: Immunohistochemical analysis revealed that BAMBI expression was observed in 148 (80.8%), and strong BAMBI expression was observed in 46% of the CRCs. Strong BAMBI expression was positively correlated with histological type, depth of invasion, lymph node metastases, and tumor node metastasis (TNM) stage (P < 0.05). Clear associations were found between BAMBI and β-catenin (P = 0.035) and p53 (P = 0.049) expression. In curatively resected CRC, 5-year recurrence-free survival was 51.9% (P = 0.037) for strong BAMBI expression compared to 79.8% for weak BAMBI expression. In the Cox’s multivariate analysis, lymph node metastases (RR 6.685; P < 0.001) and depth of invasion (RR 14.0; P = 0.013) were signifi cant indicators for recurrence, and strong BAMBI expression (RR 2.26; P = 0.057) tended to be signifi cant. CONCLUSION: BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. BAMBI expression might be applicable in the routine clinical setting of CRC. | Nozomi Togo Susumu Ohwada Shinji Sakurai Hiroyuki Toya Ichiro Sakamoto Tatsuya Yamada Tetsuhiro Nakano Ken Muroya Izumi Takeyoshi Takashi Nakajima Takashi Sekiya Yusuke Yamazumi Tsutomu Nakamura Tetsu Akiyama | 2008 | World Journal of Gastroenterology2008，14，31： | 3 |
| 4 | Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis显示文摘AIM To determine appropriate fecal calprotectin cut-off values for the prediction of endoscopic and histologic remission in Japanese patients with ulcerative colitis(UC). METHODS We performed a cross-sectional observational study of 131 Japanese patients with UC and measured fecal calprotectin levels by fluorescence enzyme immunoassay. The clinical activity of UC was assessed with the partial Mayo score(PMS). Relapse was defined as increase of PMS by 2 points or more in stool frequency or rectal bleeding subscore. The endoscopic and histologic activities of UC were evaluated in 50 patients within a 2-mo period from fecal sampling. Endoscopic activity was determined by Mayo endoscopic subscore, Rachmilewitz endoscopic index, and ulcerative colitis endoscopic index of severity. The histologic grade of inflammation was evaluated with biopsy specimens obtained from the endoscopically most severely inflamed site, according to the scheme by Matts grade and Riley's score.RESULTS Fecal calprotectin levels varied from 1-20783 μg/g. There was a significant correlation between the partial Mayo score and fecal calprotectin levels(r = 0.548, P < 0.001). In 50 patients who underwent colonoscopy with biopsy, levels were significantly correlated with the Mayo endoscopic subscore(r = 0.574, P < 0.001), Rachmilewitz endoscopic index(r = 0.628, P < 0.001), ulcerative colitis endoscopic index of severity(r = 0.613, P < 0.001), Riley's histologic score(r = 0.400, P = 0.006), and Matts grade(r = 0.586, P < 0.001). Receiver-operating characteristic analyses identified the best cut-off value for the prediction of endoscopic remission as 288 μg/g, with an area under the curve of 0.777 or 0.823, while that for histologic remission was 123 or 125 μg/g, with an AUC of 0.881 or 0918, respectively. Of the 131 study patients, 88 patients in clinical remission were followed up 6 mo. During the follow-up period, 19 patients relapsed. The best fecal calprotectin cut-off value for predicting relapse was 175 μg/g.CONCLUSION Fecal calprotectin is a predictive biomarker for endoscopic and histologic remission in Japanese patients with UC. | Jun Urushikubo Shunichi Yanai Shotaro Nakamura Keisuke Kawasaki Risaburo Akasaka Kunihiko Sato Yosuke Toya Kensuke Asakura Takahiro Gonai Tamotsu Sugai Takayuki Matsumoto | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 5 | Endoscopic resection of large colorectal polyps using a clipping method显示文摘 | Dr. Yoshiro Iida M.D. Shoji Miura M.D. Yoshinori Munemoto M.D. Yoshio Kasahara M.D. Yasuyuki Asada M.D. Daishu Toya M.D. Masakiyo Fujisawa M.D | 1994 | Diseases of the Colon & Rectum1994，，2： | 2 |
| 6 | Ectopic pregnancy within a cesarean delivery scar: A case report显示文摘 | Donald L. Fylstra Toya Pound-Chang M.Grant Miller Amy Cooper Kathryn M. Miller | 2002 | American Journal of Obstetrics and Gynecology2002，，2： | 2 |
| 7 | Determination of macrolide antibiotics in meat and fish by liquid chromatography electrospray mass spectrometry显示文摘 | Horie M Takegami H Toya K | 2003 | Anal Chim Acta2003，492，12： | 1 |
| 8 | Occult connective tissue diseases mimicking idiopathic interstitial pneumonias 显示文摘 | Tzelepis GE Toya SP Moutsopoulos HM | 2008 | Eur Respir J2008，31，： | 1 |
| 9 | Evaporation from non-saturated surface and surface moisture availability显示文摘 | Yasuda N Toya T | 1981 | Pap Meteor Geophys1981，32，： | 1 |
| 10 | Anterior transpetrosal-transtentorial approach for sphenopetroclival meningiomas: surgical method and results in 10 patients 显示文摘 | KAWASE T SHIOBARA R TOYA S | 1991 | Neurosurgery1991，28，6： | 1 |
| 11 | Caveolin is an activator of insulin receptor signaling显示文摘 | Yamamoto M Toya Y Schwencke C | 1998 | J Biol Chem1998，273，26： | 1 |
| 12 | A crack along the interface of a circular inclusion embedded in an infinite solid显示文摘 | Toya M | 1974 | J Mech Phys Solids1974，22，： | 1 |
| 13 | Caveolin is an activator of insulin receptor signaling显示文摘 | Yamamoto M Toya Y Schwenche C | 1998 | J Biol Chen1998，273，26： | 1 |
| 14 | Radiotherapy for metastatic bone tumor显示文摘 | Yorozu A Toya K Fukada J | 2003 | Gan To Kagaku Ryoho2003，30，3： | 1 |
| 15 | Occulh connective tissue diseases mimicking idiopathic interstitial pneumonias显示文摘 | Tzelepis GE Toya SP Moutsopoules HM | 2008 | Eur Respir J2008，31，1： | 1 |
| 16 | Statistical analysis of breakdown property between electrode and shied in high voltage vacuum interrupters 显示文摘 | Toya H Hayashi T Kamikawaji T | 1985 | Etz Archiv1985，11，7： | 1 |
| 17 | Development of a method partial discharge detection in extra-high voltagecross-linked polyeth-ylene insulated cable lines显示文摘 | Katsuta G Toya A | | 0，，3： | 1 |
| 18 | The Role of CommunityCollege Financial Aid Councelors in Helping StudentsUnderstand and Utilize Financial Aid显示文摘 | Lyle McKinney Toya Roberts | 2012 | CommunityCollege Journal of Research and Practice2012，，36： | 1 |
| 19 | Development of a method of partial discharge detection in extra-high voltage cross-linked polyethylene insulated cable lines显示文摘 | KATSUTA G TOYA A MURAOKA K | 1992 | IEEE Transactions on Power Delivery1992，7，3： | 1 |
| 20 | Ozone resistance of highly saturated nitfile rubber(HNBR)显示文摘 | Nakagawa T Toya T | 1992 | Journal of Elastomers and Plastics1992，24，3： | 1 |
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