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| 1 | Serrated neoplasia of the colorectum显示文摘Serrated polyps of the colorectum form a group of related lesions which include aberrant crypt foci (ACF), conventional hyperplastic polyps, mixed (admixed) polyps, serrated adenomas and sessile serrated adenomas. In recent years the molecular differences between these morphologically similar lesions have been highlighted, and their differing biological potential has been realised. In particular, the sessile serrated adenoma has become recognised as the precursor lesion to a group of sporadic colorectal carcinomas characterised by morphological and molecular features distinct from conventional adenomas. These recent findings have challenged the long held paradigm that all colorectal carcinomas arise via the traditional adenoma-carcinoma sequence. In addition, they present a major challenge for the early detection and management of colorectal cancer, which is no longer regarded as a homogeneous entity. | Nathan T Harvey Andrew Ruszkiewicz | 2007 | World Journal of Gastroenterology2007，13，28： | 4 |
| 2 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 3 | Real-time histology with the endocytoscope显示文摘Endoscopic Imaging has progressed tremendously over the last few decades. Novel imaging technologies such as high-resolution and high-magnification white light endoscopy, narrow band imaging, optimal band imaging, auto? ourescence imaging and optical coherence tomography not only aid the endoscopist in detecting malignant or pre-malignant lesions but also assist in predicting histology. Recently, the introduction of Endocytoscopy (EC) and Confocal Endomicroscopy has taken us into a new realm of diagnostic endoscopy. With the ability to magnify up to 1000 ×, cellular structures can be visualized in real-time. This advance in technology could potentially lead to a paradigm shift negating the need to obtain biopsies. EC is, however, still in the early stages of development and further research needs to be carried out before it can be accepted as standard practice. This review will focus on the diagnostic utility of the Endocytoscope. | Rajvinder Singh Swee Lin Chen Yi Mei William Tam Devinder Raju Andrew Ruszkiewicz | 2010 | World Journal of Gastroenterology2010，16，40： | 3 |
| 4 | Methylation of TIMP3 in esophageal squamous cell carcinoma显示文摘AIM: To measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China.METHODS: Cancer cell lines were treated with or without the demethylating reagent 5-aza-2’-deoxycytidine. Methylation of the TIMP3 promoter was assessed in three regions by melt curve analysis and its expression was assessed by real-time RT-PCR. Tumors and proximal resection margins were obtained from 64 patients with esophageal squamous cell carcinoma from a region of high incidence in China. Methylation was assessed by melt curve analysis and expression by immunohistochemistry.RESULTS: Methylation in one of the three promoter regions assessed correlated with gene silencing in esophageal cell lines. A degree of methylation of TIMP3 was found in only four esophageal squamous cell carcinomas, and partial loss of TIMP3 protein expression in just one.CONCLUSION: Methylation and loss of expression of TIMP3 occurs infrequently in esophageal squamous cell carcinoma in a region of high incidence in China. | Eric Smith Neville J De Young Zi-Qiang Tian Maria Caruso Andrew R Ruszkiewicz Jun-Feng Liu Glyn G Jamieson Paul A Drew | 2008 | World Journal of Gastroenterology2008，14，2： | 2 |
| 5 | IGFBP7 is associated with poor prognosis in oesophageal adenocarci- noma and is regulated by promoter DNA methylation显示文摘 | Smith E Ruszkiewicz AR Jamieson GG | 2014 | Br J Cancer2014，110，3： | 1 |
| 6 | Claudin-1 Expression Is Elevated in Colorectal Cancer Precursor Lesions Harboring the BRAF V600E Mutation显示文摘 | Maria Caruso Kim Y.C. Fung James Moore Gemma V. Brierley Leah J. Cosgrove Michelle Thomas Glenice Cheetham Emma Brook Louise M. Fraser Teresa Tin Ha Tran Andrew Ruszkiewicz | 2014 | Translational Oncology2014，，： | 1 |
| 7 | Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation显示文摘 | Worthley D L Ruszkiewicz A Davies R | 2009 | Stem Cells2009，27，6： | 1 |
| 8 | BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status 显示文摘 | Li WQ Kawakami K Ruszkiewicz A | 2006 | Mol Cancer2006，5，： | 1 |
| 9 | Improving the accuracy of TNM staging in esophageal cancer: a pathological review of resected specimens 显示文摘 | Thompson SK Ruszkiewicz AR Jamieson GG | 2008 | Ann Surg Oncol2008，15，： | 1 |
| 10 | Expression of the CXCR3ligand I-TAC by hepatocytes in chronic hepatitis C and its correlation with hepatic inflam m ation显示文摘 | H elbig KJ Ruszkiewicz A Sem endric L | 2004 | H epatology2004，39，5： | 1 |
| 11 | Decrease of glutathione content in the prefrontal cortical mitochondria of rats with acute hepatic encephalopathy: prevention by histidine显示文摘 | Ruszkiewicz J Frgko I Hilgier W | 2013 | Metab Brain Dis2013，28，： | 1 |
| 12 | The folate pool in colorectal cancer is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase显示文摘 | Kawakami K Ruszkiewicz A Bennett G | 2003 | Clinical Cancer Research2003，9，161： | 1 |
| 13 | BRAF mutations are associated with distinctive clinical,pathological and molecular features of colorectal cancer independently of microsatellite instability status显示文摘 | Li WQ Kawakami K Ruszkiewicz A | | 0，，： | 1 |
| 14 | Improving the accuracy of TNM staging in esophageal cancer:a pathological review of resected specimens显示文摘 | Thompson SK Ruszkiewicz AR Jamieson GG | | 0，，12： | 1 |
| 15 | IGFBP7 is associ?ated with poor prognosis in oesophageal adenocarcinoma and is regulated by promoter DNA methylation显示文摘 | Smith E Ruszkiewicz AR Jamieson GG | 2013 | BrJ Cancer2013，110，3： | 1 |
| 16 | Gastrointesinal: Patchy distribution of Coeliac Disease diagnosed with narrow band imaging and optical magnification显示文摘 | R Singh SL Chen Yi Mei M Jayanna A Ruszkiewicz | 2013 | J Gastroenterol Hepatol2013，，3： | 1 |
| 17 | The folate pool in colo-rectal cancers is associated with DNA hypermethylation and with apolymorphism in methylenetetrahydrofolate reductase 显示文摘 | Kawakami K Ruszkiewicz A Bennett G | 2003 | Clin Can-cer Res2003，9，： | 1 |
| 18 | The Iodinecatalysed Conversion of Sucrose into 5-Hydroxymethyl -fururaldehyde 显示文摘 | BONNER T G BOURNE E J RUSZKIEWICZ M | 1960 | Journal of the Chemical Society1960，，： | 1 |
| 19 | Rising incidence of early‐onset colorectal cancer in A ustralia over two decades: Report and review显示文摘 | Joanne P Young Aung Ko Win Christophe Rosty Ingrid Flight David Roder Graeme P Young Oliver Frank Graeme K Suthers Peter J Hewett Andrew Ruszkiewicz Ehud Hauben Barbara‐Ann Adelstein Susan Parry Amanda Townsend Jennifer E Hardingham Timothy J Price | 2015 | J Gastroenterol Hepatol2015，，： | 1 |
| 20 | Decrease of glutathione content in the prefrontal cortical mitochondria of rats with acute hepatic encephalopathy:prevention by histidine显示文摘 | Ruszkiewicz J Fresko I Hilgier W | 2013 | Metab Brain Dis2013，28，1： | 1 |
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