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| 1 | Helicobacter pylori : Friend or foe?显示文摘Helicobacter pylori(H. pylori) is a Gram-negative spiral bacterium that is present in nearly half the world's population. It is the major cause of peptic ulcer disease and a recognized cause of gastric carcinoma. In addition, it is linked to non-ulcer dyspepsia, vitamin B12 deficiency, iron-deficient anemia and immune thrombocytopenic purpura. These conditions are indications for testing and treatment according to current guidelines. An additional indication according to the guidelines is 'anyone with a fear of gastric cancer' which results in nearly every infected person being eligible for eradication treatment. There may be beneficial effects of H. pylori in humans, including protection from gastroesophageal reflux disease and esophageal adenocarcinoma. In addition, universal treatment will be extremely expensive(more than $32 billion in the United States), may expose the patients to adverse effects such as anaphylaxis and Clostridium difficile infection, as well as contributing to antibiotic resistance. There may also be an as yet uncertain effect on the fecal microbiome. There is a need for robust clinical data to assist in decision-making regarding treatment of H. pylori infection. | Stephen David Howard Malnick Ehud Melzer Malka Attali Gabriel Duek Jacob Yahav | 2014 | World Journal of Gastroenterology2014，20，27： | 15 |
| 2 | The association between orthostatic hypertension and all-cause mortality in hospitalized elderly persons显示文摘BackgroundLittle 在长期的死亡上对 orthostatic 高血压(OHT ) 和它的效果的流行被知道在老。我们评估了 OHT 的流行,它在 1852 个病人的就医的老 patients.MethodsOut 的死亡上的效果在 31/12/1999 和 31/12/2000 之间承认了到一个尖锐衰老老人病房,有一个平均数的 474 个病人(48% 男性) 81.5 ± 变老;6.8 年在这研究被注册。血压(BP ) 在一个仰卧、站的位置在日子期间被测量三次。有在站之上的收缩或心脏舒张的 BP 层次的至少一增加的病人与 OHT 被诊断。病历,物理考试和实验室参数从医药记录被检索。死亡数据直到 18 th 2014 年 6 月从 Interior.ResultsFour 的部的计算机化的系统被检索 107 个病人(86%) 与 OHT 被诊断。没有 OHT,那些有一个更低的身体团索引并且是更可能的男性,吸烟者,与 OHT 与那些相比有 Parkinsons 疾病和更少的充血的心失败的更高的率。有 OHT 的病人让更好的幸存没有 OHT,比那些评价(P = 0.024 ) 。为有 OHT 的在那些的死亡的危险比率(HR ) 适应了年龄,多重风险因素是:0.67 [95% 信心间隔(CI ) :0.51 − 0.87 ] 并且 0.73 (95% CI:0.55 − 0.97 ) 分别地;一个类似的趋势被有 OHT 的老病人有的 gender.ConclusionHospitalized 在敏感分析注意更好的幸存率比那些没有 OHT。 | Avraham Weiss Yichayaou Beloosesky Alon Grossman Agata Shlesinge Nira Koren-Morag Ehud Grossman | 2016 | Journal of Geriatric Cardiology2016，13，3： | 10 |
| 3 | 围手术期患者的安全:正确的患者、正确的手术、正确的部位——一项多因素、跨部门的干预性研究显示文摘背景为围手术期患者提供安全的环境非常重要。基于这一点,我们在围手术期实施了“患者安全第一”的政策。方法在干预性研究的第一阶段(2001—2002年),我们首先制定并实施干预性研究中组织和教育方面的内容。2003至2005年为研究的实施阶段。根据我们的零忍受原则,在手术等候区内一旦发现患者的麻醉或手术准备工作中有重大差错,该患者就被送回病房(失败),并等到差错得到纠正后再进行手术。结果共有15856例患者参加了研究。在研究实施阶段的3年中,有112例患者被送回病房(0.71%)。与2003年的数据相比,2004年和2005年发生的重大错误明显减少,且有统计学意义(2003、2004和2005年的数据分别为1.04%、0.59%和0.49%)。而且,逐步逻辑回归方法分析结果显示,手术前准备不充分所致重大错误的发生率逐年下降,具有统计学意义(比值比=1.48,95%CI:1.16~1.87)。此外,在2003、2004和2005年中,各年的失败发生平均间隔时间分别为6.6、11.2和14.7天(P〈0.03)。最后,不仅患者手术前准备工作在研究期间有显著改善(P〈0.0001);而且,使患者手术前准备工作评分为100%的可能性也有明显增加(P〈0.001)。结论教育和提高认识能减少围手术期的错误发生率。但是,即使有详细规划的制度,也无法达到无差错的环境。因此,检查和全面分析应该持续不断地进行。 | Edna Zohar Yossi Noga Ehud Davidson Margalit Kantor Brian Fredman 周全红(译) 江伟(校) | 2008 | 麻醉与镇痛2008，4，4： | 5 |
| 4 | RAAS and adrenergic genes in heart failure: Function, predisposition and survival implications显示文摘It is well appreciated that several neurohormones and signaling cascades are activated that promote long-term deterioration of cardiac function and structure. Activation of the renin-angiotensin-aldosterone system (RAAS) and the adrenergic system is closely related to heart failure. Common gene variants that encode neurohormonal, adrenergic and intracellular proteins have been demonstrated to modulate the course and consequences of heart failure. However, the literature is replete with conflicting results and it remains uncertain as to whether particular gene variants predispose heart failure. Therefore, the main purpose of this review was to discuss the effects of single nucleotide polymorphisms (SNPs) that are located in genes encoding elements of the RAAS and the adrenergic system on the predisposition to and survival from heart failure. Most studies indicate that common SNPs encoding elements of the RAAS and the adrenergic system do not predispose individuals to heart failure. Conversely, it has been demonstrated that ARB1 Arg389Gly, GRK5 Gln41Leu, ACE I/D, CYP11B2 C-344T and AGTR1 A+1166C modulate pharmacological responses and have a considerable impact on cardiacrelated survival. It should not be expected, however, that a single polymorphism determines survival, given that multiple gene products and environmental factors contribute to the pathogenesis of heart failure. Therefore, future studies should consider the interaction effects of multiple genes in populations that are as homogeneous as possible with respect to environmental characteristics. | Alberto J Alves Nir Eynon José Oliveira Ehud Goldhammer | 2010 | World Journal of Cardiology2010，2，7： | 3 |
| 5 | Oral mixture of autologous colon-extracted proteins for the Crohn's disease: A double-blind trial显示文摘AIM: To evaluate the safety and efficacy of oral administration of AlequelTM, an autologous proteincontaining colon extract.a randomized,placebo-controlled,double-blind trial.Patients were orally administered with autologous protein-containing colon extract three doses of autologous study drug per week for 15 wk,for a total of45 doses.Patients were followed for safety parameters.Remission was defined as a Crohn’s disease activity index(CDAI)score of less than or equal to 150.All patients were followed for changes in subsets of T cells by fluorescence-activated cell sorting analysis.RESULTS:Analysis was performed on a total number of evaluable patients of 14 in the study drug group and15 in the placebo group.Treatment was well tolerated by all patients.No major treatment-related adverse events were reported or observed in any of the treated patients during the feeding or follow-up periods.Between weeks 6 and 9 of the study,six of the 14(43%)evaluable subjects who received the study drug achieved a CDAI of 150 or lower.In contrast,five of the 15(33%)evaluable subjects in the placebo group achieved remission.Between weeks 9 and 12,the remission rates were 50%and 33%for the drug group and placebo group,respectively.Among the drug-treated subjects who achieved remission,the effect of the drug was judged as stable in eight of the 14 subjects as measured by at least two CDAI scores indicating remission in the 15-wk treatment period.A decreased percentage of peripheral natural killer T regulatory cells(a decrease of 28%vs an increase of 16%)and an increased ratio of CD4+/CD8+T lymphocytes(an increase of 11%vs a decrease of9%)were noted in subjects with a significant clinical response.CONCLUSION:Oral administration of the autologous colonic extract could be a safe and effective for the treatment of patients with moderate to severe Crohn’s disease. | Eran Israeli Ehud Zigmond Gadi Lalazar Athalia Klein Nilla Hemed Eran Goldin Yaron Ilan | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 6 | Antioxidant therapy for chronic hepatitis C after failure of interferon:Results of phase Ⅱ randomized,double-blind placebo controlled clinical trial显示文摘AIM:TO assess the safety and efficacy of antioxidant therapy for patients with chronic hepatitis C virus(HCV) infection. METHODS:One hundred chronic HCV infection patients failed in interferon treatment were enrolled and randomly assigned to receive combined intravenous and oral antioxidants or placebo,or oral treatment alone. Primary end points were liver enzymes,HCV-RNA levels and histology. RESULTS:Combined oral and intravenous antioxidant therapy was associated with a significant decline in ALT levels in 52% of patients who received antioxidant therapy vs 20% of patients who received placebo(P= 0.05).Histology activity index(HAI)score at the end of treatment was reduced in 48% of patients who received antioxidant therapy vs 26% of patients who received placebo(P=0.21).HCV-RNA levels decreased by 1-log or more in 28% of patients who received antioxidant therapy vs 12% who received placebo(P=NS).In partⅡof the trial,oral administration of antioxidants was not associated with significant alterations in any of the end points. CONCLUSION:Antioxidant therapy has a mild beneficial effect on the inflammatory response of chronic HCV infection patients who are non-responders to interferon. Combined antiviral and antioxidant therapy may be beneficial for these patients. | Ezra Gabbay Ehud Zigmond Orit Pappo Nila Hemed Mina Rowe George Zabrecky Robert Cohen Yaron Ilan | 2007 | World Journal of Gastroenterology2007，13，40： | 2 |
| 7 | Trends in Management and Outcome of Hospitalized Patients With Acute Stroke and Transient Ischemic Attack: The National Acute Stroke Israeli (NASIS) Registry显示文摘 | David Tanne Silvia Koton Noa Molshazki Uri Goldbourt Tamar Shohat Rakefet Tsabari Ehud Grossman Natan M. Bornstein | 2012 | Stroke2012，，： | 2 |
| 8 | Non-imaging-guided fine-needle aspiration of liver lesions:aretrospective study of 279 patients显示文摘RESULTSBasedonhistologic,cytologicandclinicalfindings,finalliverdiagnoseswerereachedin265patients,ofwhom171hadmalignantand94... | Yeouda Edoute 1,4 , Ehud Malberger 2,4 , Orly Tibon Fisher 2 and Nimer Assy 3,4 | 1999 | World Journal of Gastroenterology1999，5，2： | 2 |
| 9 | Tracking by Affine Kernel Transformations Using Color and Boundary Cues显示文摘 | Ido L Michael L Ehud R | 2009 | IEEE Trans on Pattern Analysis and Machine Intelligence2009，31，1： | 1 |
| 10 | Cardiac Magnetic Resonance With T2-Weighted Imaging Improves Detection of Patients With Acute Coronary Syndrome in the Emergency Department显示文摘 | Ricardo C. Cury Khalid Shash John T. Nagurney Guido Rosito Michael D. Shapiro Cesar H. Nomura Suhny Abbara Fabian Bamberg Maros Ferencik Ehud J. Schmidt David F. Brown Udo Hoffmann Thomas J. Brady | 2008 | Circulation2008，，8： | 1 |
| 11 | Improved Design of the Vivaldi Antenna 显示文摘 | EHUD G | 1988 | IEEE Proceedings1988，135，2： | 1 |
| 12 | Interaction of Drastic and In- cremental Innovations: Economic Development through Schumpeterian Waves显示文摘 | XIANGKANG Y EHUD Z | 2001 | Economie Applique2001，，54： | 1 |
| 13 | Fast geodesic active contours显示文摘 | Roman Goldenberg Ron Kimmel Ehud Rivlin | 2001 | IEEE Transactions on Image Processing2001，10，10： | 1 |
| 14 | Social learning in recurring games显示文摘 | JACKSON M EHUD K | 1997 | Games and Economic Behavior1997，21，12： | 1 |
| 15 | The Encapsulated Nuclear Heat Source (ENHS) Reactor Core Design 显示文摘 | Ser Gihong Ehud Greenspan Yeong II Kim | 2005 | Nuclear Technology2005，149，1： | 1 |
| 16 | Acupuncturetreatment in geriatric rehabilitation: A retrospective study显示文摘 | Adi Barad Yair Maimon Ehud Miller | 2008 | Journal of Acupuncture and Medridian Studies2008，1，1： | 1 |
| 17 | Microglia in diseases of the central nervous system显示文摘 | Peter T Nelson Lorinda A Soma Ehud Lavi | 2002 | Annals of Medicine2002，，7： | 1 |
| 18 | Detection of Pancreatic Carcinoma (Diagnostic Value of K-ras Mutations in Circulating DNA from Serum)显示文摘 | Livia Theodor Ehud Melzer Michael Sologov Gila Idelman Eitan Friedman Simon Bar-Meir | 1999 | Digestive Diseases and Sciences1999，，10： | 1 |
| 19 | Does increased oxidative stress caused hypertension显示文摘 | Ehud G | 2008 | Diabetes care2008，31，： | 1 |
| 20 | What Maintains Energy Supply at Peak Aerobic Exercise in Trained and Untrained Older Men显示文摘 | MORAN S Ehud G | 2007 | Gerontology2007，53，： | 1 |
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