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175篇 您的检索式:作者名="Hardingham"
    题名 作者 年代 出处 被引量
1端粒酶逆转录酶在结肠癌组织中表达的临床意义显示文摘背景与目的:尽管能够在70%~90%的恶性肿瘤细胞中可检测到端粒酶活性,但其活性与恶性肿瘤患者预后的关系仍存在争议。本研究旨在探讨端粒酶逆转录酶(humantelomerasereversetranscriptase,hTERT)在结肠癌组织中表达的临床意义。方法:用定量实时RT-PCR检测59例大肠癌标本的癌组织和癌旁非癌组织hTERT表达。结果:癌组织和癌旁非癌组织hTERT表达与临床病理学特征无相关性。32例DukesA和B期患者中,18例(56%)癌组织hTERT表达低于0.6,14例(44%)表达高于0.6,前者的预后较后者好。20例(62%)癌组织/癌旁非癌组织hTERT表达差异低于0.5,12例(38%)表达差异高于0.5,前者的预后较后者好。27例DukesC和D期患者中,癌组织hTERT表达和癌组织/癌旁非癌组织hTERT表达差异对预测患者的预后无意义。结论:结肠癌组织hTERT表达和癌组织/癌旁非癌组织hTERT表达差异可作为DukesA和B期结肠癌患者预后的指标之一。李力人 万德森 潘志忠 Jenny Hardingham Nick Rieger Peter Hewett 周志伟 陈功 2004癌症2004,23,z1:2
2Immunobead-PCR:A technique for the detection of circulating tumor cells using immunomagnetic beads and the polymerase chain reaction显示文摘Hardingham JE Kotasek D Farmer B 1993Cancer Res1993,53,:2
3The Yin and Yang of NMDA receptor Signaling显示文摘Hardingham GE Hilmar B 2003Trends in Neurosciences2003,26,2:1
4The role of nitric oxide and GluR1 in presynaptic and postsynaptic components of neocortical potentiation显示文摘Hardingham N Fox K 0,,:1
5Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways显示文摘Hardingham GE Fukunaga Y Bading H 2002Nat Neurosci2002,5,5:1
6Stem cell marker ol- faetomedin 4 : critical appraisal of its characteristics and role in tumorigenesis显示文摘Grover P-K -Hardingham JE Cummins AG 2010Cancer Metastasis Rev2010,29,4:1
7Stem cell marker 01- factomedin 4: Critical appraisal of its characteristics and role in tumorigenesis 显示文摘Grover PK Hardingham JE Cummins AG 2010Cancer Metast Rev2010,29,4:1
8Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes 显示文摘Hardingham GE Lipton SA 2011Antioxid Redox Signal2011,14,:1
9Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways显示文摘Hardingham GE Fukunaga Y Bading H 2002Nat Neurosci2002,5,5:1
10Collagen-in- duced arthritis in the rat: modification of immune and ar- thritic responses by free collagen and immune anti-colla- gen antiserum显示文摘Stains NA Hardingham T Smith M 1981Immunolog1981,44,4:1
11Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevaeizumab 显示文摘Price TJ Hardingham JE Lee CK 2013Cancer Med2013,2,3:1
12Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression 显示文摘HARDINGHAM G E CHANLA S JOHNSON C M 1997Nature1997,385,6613:1
13Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways显示文摘Hardingham GE Fukunaga Y Bading H 2002Nat Neurosci2002,5,5:1
14Tissue engineering :chondrocytes and cartilage显示文摘Hardingham T Tew S Murdoch A 2002Arthritis Res2002,43,:1
15Molecular detection of blood borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease显示文摘Jenbifer E Hardingham Peler J 2000In J Cancer2000,89,:1
16Synaptic versus extra- synaptic NMDA receptor signaling : implications for neurodegenerative disorders 显示文摘HARDINGHAM G E BADING H 2010Nat Rev Neurosci2010,11,10:1
17Notch signaling during chon- drogenesis of human bone marrow stem cells 显示文摘Oldershaw RA Hardingham TE 2010Bone2010,46,2:1
18Synaptic versus extrasynaptic NMDA receptor signalling:implications for neurodegenerative disorders显示文摘Hardingham GE Bading H 2010Nat Rev Neurosci2010,11,:1
19The Yin and Yang of NMDA receptor signaling显示文摘Hardingham G E Hilmar B 2003Trends Neurosciences2003,26,2:1
20The effect of videl-based perceptual training on the tennis return of serve显示文摘Farrow D Chivers P Hardingham C & Sachse S 1998International Journal of Sport Psychology1998,29,3:1
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